USRE39057EExpiredUtility

Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same

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Assignee: UNIV PENNSYLVANIAPriority: Jun 25, 1996Filed: Apr 22, 2004Granted: Apr 4, 2006
Est. expiryJun 25, 2016(expired)· nominal 20-yr term from priority
Inventors:James A. Hoxie
C07K 16/2866A61K 38/00
85
PatentIndex Score
11
Cited by
84
References
9
Claims

Abstract

The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same.

Claims

exact text as granted — not AI-modified
1. An antibody which binds to a cellular chemokine receptor protein essential for immunodeficiency virus entry into a cell wherein said chemokine receptor protein is not CD 4  CXCR4 . 
     
     
       2. The antibody of  claim 1 , wherein said immunodeficiency virus is selected from the group consisting of HIV-1, HIV-2 and SIV. 
     
     
       3. The antibody of  claim 1 , wherein said protein is a cellular protein which is an HIV receptor protein. 
     
     
       4. The antibody of  claim 1 , wherein said protein is a cellular cofactor for a cellular protein which is a HIV receptor protein. 
     
     
       5. The antibody of  claim 4 , wherein said protein is selected from the group consisting of CXCR4 and CCR5. 
     
     
       6. The antibody of  claim 5 , wherein said protein is CXCR4. 
     
     
       7. The antibody of  claim 1 , wherein said antibody is selected from the group consisting of a monoclonal antibody and a synthetic antibody. 
     
     
       8. The antibody of  claim 7 , wherein said antibody is a monoclonal antibody. 
     
     
       9. The antibody of  claim 8 , wherein said antibody is MAB 12G5.

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