Treatment of skin disorders

Abstract

An effective treatment for skin disorders characterized by abnormal skin cell behavior, including a pharmaceutically effective amount of Halofuginone. Skin disorders which can be treated include keloids, hypertrophic scars, psoriasis, acne, seborrhea and alopecia. Halofuginone can reduce or eliminate clinical symptoms of these disorders, as well as substantially prevent the formation of keloids and hypertrophic scars.

1. A method for the treatment of psoriasis in a subject, the method comprising the step of administering to the subject a pharmaceutically effective amount of a compound having a formula: 
                 
 
       wherein:
 n is  1  or  2 ;  
 R 1  is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy;  
 R 2  is a member of the group consisting of hydroxy, acetoxy and lower alkoxy, and  
 R 3  is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl.  
 
     
     
       2. The method of  claim 1 , wherein said compound is Halofuginone. 
     
     
       3. The method of  claim 1 , wherein said compound is administered to the subject by a route selected from the group consisting of oral, parenteral and topical. 
     
     
       4. The method of  claim 3 , wherein said compound is administered to the subject by topical application. 
     
     
       5. The method of  claim 4 , wherein said compound is contained in a pharmaceutical carrier selected from the group consisting of a lotion, an ointment, a gel, a cream, a liquid and a spray. 
     
     
       6. The method of  claim 5 , wherein the step of administering said compound to the subject is performed until symptoms of psoriasis are absent in the subject.