USRE39196EExpiredUtilityPatentIndex 99
Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
Assignee: MASSACHUSETTS INST TECHNOLOGYPriority: Jan 16, 1997Filed: Jan 11, 2002Granted: Jul 18, 2006
Est. expiryJan 16, 2017(expired)· nominal 20-yr term from priority
C04B 35/6262A61F 2310/00293C04B 2235/5409C04B 2235/3225C04B 2235/549C04B 2235/785A61L 27/32F16C 2240/64C04B 2235/77A61L 2400/12A61F 2310/00796C04B 2235/3246C04B 2235/668C04B 35/645C04B 2235/656B82Y 30/00C04B 35/62675C04B 2235/6567C04B 2235/5445C04B 2235/3244A61L 27/12C04B 2235/3212C04B 2235/96C04B 2235/3217C04B 35/447C04B 35/488C04B 35/46Y10S977/776A61F 2/30767C04B 2235/80C03C 14/00C03C 4/0007C04B 2235/3232C04B 2235/6562A61F 2310/00239C01B 25/32C04B 2235/608C04B 35/117C04B 2235/5454C04B 2235/9653C03C 4/0021
99
PatentIndex Score
75
Cited by
49
References
105
Claims
Abstract
Methods for synthesis of nanocyrstalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having aveage crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m 2 /g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
Claims
exact text as granted — not AI-modified1. A composition, comprising particulate apatate having an aveage apatite crystal size of less than 100 nm, wherein the crystal is a spherical.
2. The composition of claim 1 comprising particulate apatite having an average apatite crystal size of less than 50 nm.
3. The composition of claim 1 comprising partiuclate apatite having an average apatite crystal size of less than 30 nm.
4. The composition of claim 1 comprising partiuclate apatite having an average apatite crystal size of less than 30 nm.
5. The composition of claim 1 wherien the partiuclate apatite is densified.
6. The composition of claim 1 comprising apatite having an average particle size of less than 1 μm.
7. The composition of claim 1 comprising apatite having an aveage particle size of less than 0.5 μm.
8. The composition of claim 1 comprising apatite having an average particle size of less than 0.25 μm.
9. A composition comprising particulate apatite having a surface area of at least 40 m 2 /g and a spherical crystal.
10. The composition of claim 7 comprising particulate apatite having a surface area of at least 100 m 2 /g.
11. The composition of claim 9 comprising particulate apatite having a surface area of at least 150 m 2 g.
12. The composition of claim 9 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1000° C. for at least 2 hours.
13. The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1000° C. for at least 2 hours.
14. The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1000° C. for at least 2 hours.
15. The composition of claim 12 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1100° C. for at least 2 hours.
16. The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1100° C. for at least 2 hours.
17. The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1100° C. for at least 2 hours.
18. The composition of claim 12 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1200° C. for at least 2 hours.
19. The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1200° C. for at least 2 hours.
20. The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1200° C. for at least 2 hours.
21. The composition of claim 12 that undergoes apatite phase decomposition of less than 10% when exposed to conditions of at least 1300° C. for at least 2 hours.
22. The composition of claim 12 that undergoes apatite phase decomposition of less than 5% when exposed to conditions of at least 1300° C. for at least 2 hours.
23. The composition of claim 12 that undergoes apatite phase decomposition of less than 3% when exposed to conditions of at least 1300° C. for at least 2 hours.
24. An article having a dimension of at least 0.5 cm made up of the composition of claim 1 .
25. The article of claim 24 wherein the particulate apatite is consolidated.
26. The article of claim 24 , formed into the shape of a prosthesis.
27. The article of claim 24 that is a prosthesis.
28. The article of claim 24 comprising an exterior coating on a prosthesis.
29. The article of claim 28 comprising an exterior coating, on a prosthesis, of at least 0.5 micron in thickness.
30. The article of claim 24 wherein a theoretical density of at least 90%.
31. The article of claim 24 having a theoretical density of at least 95%.
32. The article of claim 24 having a theoretical density of at least 98%.
33. An article having a dimension of at least 0.5 cm made up of the composition of claim 9 .
34. The article of claim 33 having a porosity of at least 20%.
35. The article of claim 33 having a porosity of at least 50%.
36. The article of claim 33 having a porosity of at least 50%.
37. The article of claim 33 having a porosity of at least 75%.
38. The densified article of claim 33 having compressive strength of at least about 150 MPa.
39. The densified article of claim 38 , having a density of at least about 98 %.
40. The densified article of claim 33 having compressive strength of at least about 500 MPa.
41. The densified article of claim 33 having compressive strength of at least about 700 MPa.
42. The densified article of claim 38 , having a density of at least about 90%.
43. The densified article of claim 38 , having a density of at least about 95%.
44. The article of claim 24 that is a part of a prosthesis.
45. An article comprising a densified apatite structure having a dimension of at least 0 . 5 cm and an average XRD crystal size of less than 250 nm, wherein the apatite structure undergoes phase decomposition of less than 10 % when exposed to conditions of at least 1300 ° C. for at least 2 hours and has a compressive strength of at least 150 MPa.
46. The article of claim 45 , wherein the densified apatite structure has a density of at least about 90 % .
47. The article of claim 46 , wherein the densified apatite structure has a density of at least about 98 % .
48. The article of claim 45 , wherein the densified apatite structure has a compressive strength of at least about 500 MPa.
49. The article of claim 48 , wherein the densified apatite structure has a compressive strength of at least about 700 MPa.
50. The article of claim 45 , wherein the phase decomposition is less than 5 % .
51. The article of claim 45 , wherein the densified apatite structure has an average XRD crystal size of less than 150 nm.
52. The article of claim 45 , wherein the densified apatite structure comprises an auxiliary strcutural additive.
53. The article of claim 52 , wherein the auxiliary structure additive comprises a ceramic additive.
54. The article of claim 53 , wherein the ceramic additive comprises a metal oxide.
55. The article of claim 54 , wherein the metal oxide comprises zirzonia.
56. The article of claim 52 , wherein the auxiliary structural additive is nanocrystalline.
57. The article of claim 52 , wherein the auxiliary structural additive is a metal or alloy.
58. The article of claim 52 , wherein the auxiliary structural additive is present in an amount of between about 1 % and about 50 % by volume.
59. The article of claim 45 , wherein the densified apatite structure comprises carbonated apatite.
60. The article of claim 45 , wherein the article is at least part of a prosthesis.
61. The article of claim 60 , wherein the article is a prosthesis.
62. The article of claim 45 , wherein the article comprises an exterior coating on a prosthesis.
63. The article of claim 45 , wherein the article is a bioactive implant.
64. The article of claim 63 , wherein the bioactive implant is an orthopedic or dental implant.
65. The article of claim 59 , wherein the carbonated apatite is a reactive layer on a bioceramic capable of enhancing bioactivity for bone growth.
66. An article comprising an apatite structure having a dimension of at least 0 . 5 cm, a density of at least about 98 % , a compressive strength of at least about 500 MPa, an average XRD crystal size of less than 250 nm, and wherein the apatite structure undergoes phase decomposition of less than 10 % when exposed to conditions of at least 1300 ° C. for at least 2 hours.
67. The article of claim 66 , wherein the apatite structure has a compressive strength of at least about 700 MPa.
68. The article of claim 66 , wherein the phase decomposition is less than 5 % .
69. The article of claim 66 , wherein the apatite structure has an average XRD crystal size of less than 150 nm.
70. The article of claim 66 , wherein the article is a prosthesis.
71. The article of claim 66 , wherein the article is at least part of a prosthesis.
72. The article of claim 66 , wherein the article comprises an exterior coating on a prosthesis.
73. The article of claim 66 , wherein the article is a bioactive implant.
74. The article of claim 73 , wherein the bioactive implant is an orthopedic or dental implant.
75. The article of claim 66 , wherein the apatite structure comprises an auxiliary structural additive.
76. The article of claim 75 , wherein the auxiliary structural additive comprises a ceramic additive.
77. The article of claim 76 , wherein the ceramic additive comprises a metal oxide.
78. The article of claim 77 , wherein the metal oxide comprises zirconia.
79. The article of claim 75 , wherein the auxiliary structural additive is nanocrystalline.
80. The article of claim 75 , wherein the auxiliary structural additive is a metal or alloy.
81. The article of claim 75 , wherein the auxiliary structural additive is added in an amount of between about 1 % and about 50 % by volume.
82. The article of claim 66 , wherein the apatite structure comprises carbonated apatite.
83. The article of claim 82 , wherein the carbonated apatite is a reactive layer on a bioceramic capable of enhancing bioactivity for bone growth.
84. An article comprising a consolidated apatite structure having a dimension of at least 0 . 5 cm, an average XRD crystal size of less than 250 nm, and a porosity of at least 20 % , wherein the apatite structure undergoes phase decomposition of less than 10 % when exposed to conditions of at least 1300 ° C. for at least 2 hours.
85. The article of claim 84 , wherein the consolidated apatite structure has a porosity of at least 50 % .
86. The article of claim 85 , wherein the consolidated apatite sturcture has a porosity of at least 75 % .
87. The article of claim 84 , wherein the consolidated apatite structure has a compressive strength of at least about 150 MPa.
88. The article of claim 84 , wherein the phase decomposition is less than 5 % .
89. The article of claim 84 , wherein the consolidated apatite structure has an average XRD crystal size of less than 150 nm.
90. The article of claim 84 , wherein the consolidated apatite structure comprises an auxiliary structural additive.
91. The article of claim 90 , wherein the auxiliary structural additive comprises a ceramic additive.
92. The article of claim 91 , wherein the ceramic additive comprises a metal oxide.
93. The article of claim 92 , where in the metal oxide comprises zirconia.
94. The article of claim 90 , wherein the auxiliary structural additive is nanocrystalline.
95. The article of claim 90 , wherein the auxiliary structural additive is a metal or alloy.
96. The article of claim 90 , wherein the auxiliary structural additve is present in an amount of between about 1 % and about 50 % by volume.
97. The article of claim 84 , wherein the consolidated apatite structure comprises carbonated apatite.
98. The article of claim 97 , wherein the carbonated apatite is a reactive layer on a bioceramic capable of enhancing bioactivity for bone growth.
99. The article of claim 84 , wherein the consolidated apatite structure is formed from an admixture of particulate apatite with an organic species.
100. The article of claim 99 , wherein the organic species is a self- assembling surfactant or a polymer.
101. The article of claim 84 , wherein the article is at least part of a prosthesis.
102. The article of claim 101 , wherein the article is a prosthesis.
103. The article of claim 101 , wherein the article comprises an exterior coating on a prosthesis.
104. The article of claim 84 , wherein the article is a bioactive implant.
105. The article of claim 104 , wherein the bioactive implant is an orthopedic or dental implant.Cited by (0)
No later patents cite this yet.
References (0)
No backward citations on record.