Liquid specimen container and attachable testing modules

Abstract

A biological fluid collection container comprising a cup member, a lid assembly removably mounted to the cup member comprising a housing with a downwardly extending cylindrical skirt, a luer lock with a throughgoing bore extending from one side of the lid housing. A hollow tube extends from the other side of the lid housing adjacent the luer lock and is axially aligned with the throughgoing bore of the luer lock. The hollow tube is provided with a plurality of throughgoing holes leading into its lumen along its surface to provide for a sampling along various liquid level layers of the biological fluid specimen collected in the cup member so that when the biological fluid specimen is removed from the cup member a representative sampling is obtained.

1. An apparatus comprising:
 a plurality of specimen collection containers defining a fluid flow path, intermediate ones of the containers along the fluid flow path each having an inlet and an outlet, and at least one container having chromatographic bed material for capturing particulate matter and cells.    
     
     
       2. The apparatus of  claim 1 , further comprising:
 at least one specimen collection container having a membrane for capturing cells.    
     
     
       3. The apparatus of  claim 1 , wherein the container having said chromatographic bed material for capturing particulate matter includes chromatographic bed material for determining the presence of a specific analyte. 
     
     
       4. The apparatus of  claim 1 , wherein the container having said chromatographic bed material for capturing particulate matter includes chromatographic bed material for determining the presence of a multiple analyte. 
     
     
       5. The apparatus of  claim 1 , wherein one of said intermediate containers has a filter membrane disposed between its inlet and its outlet for capturing cells. 
     
     
       6. The apparatus of  claim 5 , wherein one said specimen collection containers along the flow path is a specimen cup, said specimen cup communicating with the inlet of said intermediate container having said filter membrane, the outlet of said intermediate container having said filter membrane communicating with the inlet of another one of said intermediate containers, and the outlet of said another intermediate container communicating with a pump; and wherein said pump is one of said specimen collection containers along the flow path. 
     
     
       7. The apparatus of  claim 5 , wherein cells captured by the membrane are captured in a single layer. 
     
     
       8. The apparatus of  claim 1 , wherein the container having said chromatographic bed material is an intermediate container and includes a membrane; and wherein said chromatographic bed material can pass freely through the outlet of said intermediate container. 
     
     
       9. The apparatus of  claim 8 , wherein the container having chromatographic bed material is an intermediate container and includes a membrane for preventing the chromatographic bed material from passing through its inlet. 
     
     
       10. The apparatus of  claim 1 , further comprising:
 a pump communicating with a final one of the outlets along the fluid flow path.    
     
     
       11. The apparatus of  claim 1 , further comprising:
 a specimen cup communicating with an initial one of the inlets along the fluid flow path.    
     
     
       12. The apparatus of  claim 11 , wherein the specimen cup includes a lid having a tube extending into the specimen cup, said tube having at least two perforations at different longitudinal points along its length. 
     
     
       13. An apparatus comprising:
 a first housing having a first inlet and a first outlet, said first housing defining a first portion of a fluid flow path and having a filter membrane disposed between the first inlet and the first outlet for capturing cells in the fluid flow path; and    a second housing having a second inlet and a second outlet, said second housing defining a second portion of the fluid flow path and having a chromatography element disposed between the second inlet and the second outlet.    
     
     
       14. The apparatus of  claim 13 , further comprising:
 a specimen cup for communicating with the first inlet along the fluid flow path.    
     
     
       15. The apparatus of  claim 14 , wherein the specimen cup includes a lid having a tube extending into the specimen cup, said tube having at least two perforations at different longitudinal points along its length. 
     
     
       16. The apparatus of  claim 14 , wherein the specimen cup is removable from the apparatus. 
     
     
       17. The apparatus of  claim 13 , further comprising:
 a pump for communicating with the first outlet along the fluid flow path.    
     
     
       18. The apparatus of  claim 13 , further comprising:
 a specimen cup for communicating with the second inlet along the fluid flow path.    
     
     
       19. The apparatus of  claim 13 , further comprising:
 a pump for communicating with the second outlet along the fluid flow path.    
     
     
       20. The apparatus of  claim 13 , wherein the second housing includes a membrane; and wherein said chromatography element can pass freely through the second outlet. 
     
     
       21. An apparatus comprising:
 a first housing having a first inlet and a first outlet, said first housing also having a filter membrane disposed between the first inlet and the first outlet for capturing cells;    a second housing having a second inlet and a second outlet, said second housing having chromatographic bed material disposed between the second inlet and the second outlet; and    a specimen container having a lid suitable for fluid communication with the first inlet or the second inlet, said lid having a tube extending into the specimen container, said tube having at least two perforations at different longitudinal points along its length;    wherein the lid is in direct fluid communication with the first inlet or the second inlet, and the first outlet is in direct fluid communication with the second inlet or the second outlet is in direct fluid communication with the first inlet, respectively.    
     
     
       22. An apparatus comprising:
   a plurality of specimen collection containers defining a fluid flow path, intermediate ones of said plurality of specimen containers each having an inlet and an outlet, wherein at least one of said plurality of specimen containers has chromatographic bed material for capturing at least one analyte.      
     
     
       23. The apparatus of  claim 22 , wherein a first of said intermediate containers has a filter disposed between its inlet and its outlet.  
     
     
       24. The apparatus of  claim 23 , wherein one of said specimen collection containers is a specimen cup, wherein said specimen cup is in fluid communication with the inlet of said first of said intermediate containers, wherein the outlet of said first of said intermediate containers is in fluid communication with the inlet of a second of said intermediate containers, and wherein the outlet of said second of said intermediate containers is in fluid communication with a pump.  
     
     
       25. The apparatus of  claim 24 , wherein the pump is a syringe.  
     
     
       26. The apparatus of  claim 22 , wherein the container having chromatographic bed material is one of said intermediate containers, and wherein said chromatographic bed material can pass freely through the outlet of said intermediate container.  
     
     
       27. The apparatus of  claim 26 , wherein said container having chromatographic bed material includes a filter, wherein the filter of said container having chromatographic bed material is positioned at the inlet of said container having chromatographic bed material, and wherein said filter prevents said chromatographic bed material from passing through the inlet of said container having said chromatographic bed material.  
     
     
       28. The apparatus of  claim 26 , wherein said chromatographic bed material is a plurality of beads.  
     
     
       29. The apparatus of  claim 22 , wherein one of said specimen collection containers is a pump, and wherein said pump is in fluid communication with the outlet of a final of said intermediate containers.  
     
     
       30. The apparatus of  claim 29 , wherein said pump is a syringe.  
     
     
       31. An apparatus comprising:
   a plurality of specimen collection containers defining a fluid flow path, intermediate containers of said plurality of specimen containers each having an inlet and an outlet; wherein at least one of said plurality of specimen containers has a filter for capturing cells, and wherein said plurality of specimen containers includes a pump which is in fluid communication with the outlet of a final of said intermediate containers.      
     
     
       32. The apparatus of  claim 31 , wherein one of said specimen collection containers is a specimen cup, wherein said specimen cup is in fluid communication with the inlet of a first of said intermediate containers, wherein the outlet of said first of said intermediate containers is in fluid communication with the inlet of said final of said intermediate containers.  
     
     
       33. The apparatus of  claim 32 , wherein the pump is a syringe.  
     
     
       34. The apparatus of  claim 32 , wherein the at least one of said specimen containers having a filter for capturing cells is the first of said intermediate containers.  
     
     
       35. The apparatus of  claim 34 , further comprising:
   a slide, wherein the filter of said at least one of said specimen containers having a filter for capturing cells can be removed from said at least one of said specimen containers having a filter and positioned on the slide.      
     
     
       36. The apparatus of  claim 32 , further comprising:
   a lid removably secured to said specimen cup; and        a luer lock, wherein said first of said intermediate containers is affixed to the lid, wherein the outlet of said first of said intermediate containers is connected to the inlet of the final of said intermediate containers by said luer lock.      
     
     
       37. An apparatus comprising:
   a first housing having a first inlet and a first outlet, said first housing defining a first portion of a fluid flow path and having a filter disposed between the first inlet and the first outlet; and        a second housing having a second inlet and a second outlet, said second housing defining a second portion of the fluid path and having chromatographic bed material disposed between the second inlet and the second outlet.      
     
     
       38. The apparatus of  claim 37 , further comprising:
   a specimen cup in fluid communication with the first inlet.      
     
     
       39. The apparatus of  claim 38 , wherein the specimen cup includes a lid through which the first inlet communicates with the specimen cup via a tube which extends into the specimen cup, and wherein said tube has at least two perforations at different longitudinal points along its length.  
     
     
       40. The apparatus of  claim 39 , wherein the specimen cup is removable from the apparatus.  
     
     
       41. The apparatus of  claim 37 , further comprising:
   a pump in fluid communication with the second outlet.      
     
     
       42. The apparatus of  claim 41 , wherein the pump is a syringe.  
     
     
       43. The apparatus of  claim 37 , further comprising:
   a filter,      
       
         wherein the chromatographic bed material is a plurality of beads, wherein the plurality of beads are capable of capturing at least one analyte, and wherein the filter prevents the plurality of beads from passing through the inlet of said second housing.