Substituted heterocycle fused gamma-carbolines

Abstract

The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R 1 , R 5 , R 6a , R 6b , R 7 , R 8 , R 9 , X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

1. A compound of formula (I): 
                 
 
       or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein:
 b is a single bond;  
 X is —O—, —S—, —S(═O)—, or —S(═O) 2 —;  
 R 1  is selected from 
 H,  
 C(═O)R 2 ,  
 C(═O)OR 2 ,  
 C 1-8  alkyl,  
 C 2-8  alkenyl,  
 C 2-8  alkynyl,  
 C 3-7  cycloalkyl,  
 C 1-6  alkyl substituted with 0-2 R 2 ,  
 C 2-6  alkenyl substituted with 0-2 R 2 ,  
 aryl substituted with 0-2 R 2 , and  
 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from 
 F, Cl, CH 2 F, CHF 2 , CF 3 ,  
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloakyl,  
 phenyl substituted with 0-5 R 42 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 41 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 42 ;  
 
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is selected from H; 
 H, —OH, —NR 46 R 47 , —CF 3 ,  
 C 1-4  alkyl, C 1-4  alkoxy, C 3-4  haloalkyl, and  
 aryl substituted with O-3 R 44 ;  
 
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  haloalkyl, C 1-8  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 0-2 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O) NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 ) NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 8  is selected from 
 —OH, —CN, —NO 2 ,  
 C 2-8  alkenyl, C 2-8  alkynyl, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 1-2 R 33 ,  
 C 2-4  alkenyl substituted with 0-2 R 13 ,  
 C 2-4  alkynyl substituted with 0-1 R 11 ,  
 C 3-10  carbocyclic group substituted wit 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O) NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 ) NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 —CN, —NO 2 ,  
 C 2-8  alkenyl, C 2-8  alkynyl, C 1-8  alkoxy, C 3-10  cycloalkyl,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O) NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 ) NR 12 R 13 , S(O)R 12 , S(O)NR 12 R 13 , SO(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 12 , at each occurrence, is independently selected from C 1-4  alkyl substituted with 0-1 R 12a , 
 C 2-4  alkenyl substituted with 0-1 R 12a ,  
 C 2-4  alkynyl substituted with 0-1 R 12a ,  
 C 3-6  cycloalkyl substituted with 0-3 R 33 ,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12a , at each occurrence, is independently selected from phenyl substituted with 0-5 R 33 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl; 
 alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R14)—;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-3 R 16 ;  
 
 R 14 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 R 15 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 R 16 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  haloalkyl,  
 
 C 1-3  haloalkyl-oxy-, and C 1-3  alkyloxy;  
 R 32 , at each occurrence, is independently selected from H, OH, halo, CF 3 , SO 2 R 45 , NR 46 R 47 , and C 1-4  alkyl;  
 R 33 , at each occurrence, is independently selected from H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-6  alkyl, C 2-4  alkenyl, C 2-6  alkynyl,  
 C 2-6  cycloalkyl, C 1-4  haloalkyl, C 1-4  haloalkyl-oxy-, C 1-4  alkyloxy,  
 C 1-4  alkylthio-, C 1-4  alkyl-C(═)—, C 1-4  alkyl-C(═O)NH—, C 1-4  alkyl-OC(═)—,  
 C 1-4  alkyl-C(═O)O—, C 3-6  cycloalkyl-oxy-, C 3-6  cycloalkylmethyl-oxy-;  
 C 1-4  alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and  
 C 2-6  alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;  
 R 41 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47  , NO 2 , CN; C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl C 1-4  alkyl substituted with 0-1 R 43 ;  
 aryl substituted with 0-3 R 42 , and 
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 42 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 ,  
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ;  
 aryl substituted with 0-3 R 44 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 43  is C 2-6  cycloalkyl or aryl substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , C 1-4  alkyl, and C 1-4  alkoxy;  
 R 45  is C 1-4  alkyl;  
 R 46 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 R 47 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 k is 1 or 2;  
 m is 0, 1, or 2; and  
 n is 1, 2, or 3;  
 provided when m is 0 or 1 then k is 1 or 2;  
 provided when m is 2 then k is 1.  
 
     
     
       2. A compound of  claim 1  wherein:
 X is —O— or —S—;  
 R 1  is selected from H, 
 C(═O)R 2 ,  
 C(═O)OR 2 ,  
 C 1-6  alkyl,  
 C 2-6  alkenyl,  
 C 2-6  alkynyl,  
 C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-2 R 2 ,  
 C 2-4  alkenyl substituted with 0-2 R 2 , and  
 C 2-4  alkynyl substituted with 0-2 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from 
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloakyl,  
 phenyl substituted with 0-5 R 42 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 41 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is selected independently from 
 H, —OH, —NR 46 R 47 , —CF 3 , C 1-3  alkyl, and C 1-3  alkoxy;  
 
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 0-2 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O) NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 ) NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 ;  
 
 R 8  is selected from 
 —OH, —CN, —NO 2 ,  
 C 2-6  alkenyl, C 2-6  alkynyl, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 1-2 R 11 ,  
 C 2-4  alkenyl substituted with 0-2 R 11 ,  
 C 2-4  alkynyl substituted with 0-1 R 11 ,  
 C 3-10  carbocyclic group substituted wit 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O) NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 ) NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 —CN, —NO 2 ,  
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  alkoxy, C 3-10  cycloalkyl,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O) NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 ) NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , SO(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , and NR 14 S(O) 2 R 12 ;  
 
 R 12 , at each occurrence, is independently selected from 
 C 1-4  alkyl substituted with 0-1 R 12a ,  
 C 1-4  alkenyl substituted with 0-1 R 12a ,  
 C 2-4  alkynyl substituted with 0-1 R 12a ,  
 C 3-6  cycloalkyl substituted with 0-3 R 33 ,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12a , at each occurrence, is independently selected from phenyl substituted with 0-5 R 33 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-3 R 16 ;  
 R 14 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 15 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 R 16 , at each occurrence, is independently selected from  
 H, OH, F, Cl, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 R 31 , at each occurrence, is independently selected from H, OH, halo, CF 3 , SO 2 R 45 , NR 46 R 47 , and C 1-4  alkyl;  
 R 33 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl,  
 C 3-6  cycloalkyl, C 1-4  haloalkyl, C 1-4  haloalkyl-oxy-, C 1-4  alkyloxy-,  
 
 C 1-4  alkylthio-, C 1-4  alkyl-C(═)—, C 1-4  alkyl-C(═O)NH—, C 1-4  alkyl-OC(═)—, C 1-4  alkyl-C(═O)O—, C 3-6  cycloalkyl-oxy-, C 3-6  cycloalkylmethyl-oxy-;  
 C 1-6  alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and  
 C 2-6  alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;  
 R 41 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47  , NO 2 , CN,  
 C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 42 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 42 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 ,  
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ;  
 aryl substituted with 0-3 R 44 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 43  is C 3-6  cycloalkyl or aryl substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , C 1-4  alkyl, and C 1-4  alkoxy;  
 R 45  is C 1-4  alkyl;  
 R 46 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 R 47 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 k is 1 or 2;  
 m is 0 or 1; and  
 n is 1 or 2.  
 
     
     
       3. A compound of  claim 1  wherein:
 X is —S—;  
 R 1  is selected from 
 H,  
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-4  cycloalkyl,  
 C 1-3  alkyl substituted with 0-1 R 2 ,  
 C 2-3  alkenyl substituted with 0-1 R 2 , and  
 C 2-3  alkynyl substituted with 0-1 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from 
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloakyl,  
 phenyl substituted with 0-5 R 42 ;  
 C 3-6  carbocyclic group substituted with 0-3 R 41 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is H, methyl, ethyl, methoxy, —OH, or —CF 3 ;  
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  haloalkyl, C 1-4  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 0-2 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 8  is selected from 
 —OH, —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 1-2 R 11 ,  
 C 2-4  alkenyl substituted with 0-2 R 11 ,  
 C 2-4  alkynyl substituted with 0-1 R 11 ,  
 C 3-10  carbocyclic group substituted wit 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3, heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12 , at each occurrence, is independently selected from 
 C 1-4  alkyl substituted with 0-1 R 12a ,  
 C 2-4  alkenyl substituted with 0-1 R 12a ,  
 C 2-4  alkynyl substituted with 0-1 R 12a ,  
 C 3-6  cycloalkyl substituted with 0-3 R 33 ,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12a , at each occurrence, is independently selected from phenyl substituted with 0-5 R 33 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of one N, two N, three N, one N one O, and one N one S; wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-2 R 16 ;  
 R 14 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 15 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 16 , at each occurrence, is independently selected from H, OH, F, Cl, CN, NO 2 , methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 R 31 , at each occurrence, is independently selected from H, OH, halo, CF 3 , methyl, ethyl, and propyl;  
 R 33 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl,  
 C 3-6  cycloalkyl, C 1-4  haloalkyl, C 1-4  haloalkyl-oxy-, C 1-4  alkyloxy-, C 1-4  alkylthio-, C 1-4  alkyl-C(═)—,  
 C 1-4  alkyl-C(═O)NH—, C 1-4  alkyl-OC(═)—,  
 C 1-4  alkyl-C(═O)O—, C 3-6  cycloalkyl-oxy-,  
 C 3-6  cycloalkylmethyl-oxy-;  
 C 1-6  alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and  
 C 2-6  alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;  
 
 R 41 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47  , NO 2 , CN,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, and C 1-3  alkyl;  
 
 R 42 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, C 3-6  cycloalkyl, and C 1-3  alkyl;  
 
 R 43  is cycloalkyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;  
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;  
 k is 1;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       4. A compound of  claim 1  wherein:
 X is —S—;  
 R 1  is selected from 
 H,  
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-4  cycloalkyl,  
 C 1-3  alkyl substituted with 0-1 R 2 ,  
 C 2-3  alkenyl substituted with 0-1 R 2 , and  
 C 2-3  alkynyl substituted with 0-1 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from C 1-4  alkyl, 
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 phenyl substituted with 0-5 R 42 ;  
 C 3-6  carbocyclic group substituted with 0-3 R 41 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is H, methyl, ethyl, methoxy, —OH, or —CF 3 ;  
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, F, Cl, —CH 3 , —OCH 3 , —CF 3 , —OCF 3 , —CN, and —NO 2 ,  
 
 R 8  is selected from 
 —OH, —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 1-2 R 11 ,  
 C 2-4  alkenyl substituted with 0-2 R 11 ,  
 C 2-4  alkynyl substituted with 0-1 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-6 membered heterocyclic ring system comprising 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, (C 1-4  haloalkyl) oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O , and S substituted with 0-3 R 31 ;  
 
 R 12 , at each occurrence, is independently selected from C 1-4  alkyl substituted with 0-1 R 12a , 
 C 2-4  alkenyl substituted with 0-1 R 12a ,  
 C 2-4  alkynyl substituted with 0-1 R 12a ,  
 C 3-6  cycloalkyl substituted with 0-3 R 33 ,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12a , at each occurrence, is independently selected from phenyl substituted with 0-5 R 33 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 33 ;  
 
 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R 16 ;  
 R 14 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 15 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 16 , at each occurrence, is independently selected from 
 H, OH, F, Cl, CN, NO 2 , methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 
 R 31 , at each occurrence, is independently selected from 
 H, OH, halo, CF 3 , methyl, ethyl, and propyl;  
 
 R 33 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl,  
 C 3-6  cycloalkyl, C 1-4  haloalkyl, C 1-4  haloalkyl-oxy-, C 1-4  alkyloxy;  
 C 1-4  alkylthio-, C 1-4  alkyl-C(═O)—, C 1-4  alkyl-C(═O)NH—, C 1-4  alkyl-OC(═O)—,  
 C 1-4  alkyl-C(═O)O—, C 3-6  cycloalkyl-oxy-, C 3-6  cycloalkylmethyl-oxy-;  
 C 1-6  alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and  
 C 2-6  alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;  
 
 R 41 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, and C 1-3  alkyl;  
 
 R 42 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 , C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, C 3-6  cycloalkyl, and C 1-3  alkyl;  
 
 R 43  is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;  
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;  
 k is 1;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       5. A compound of  claim 1  wherein:
 X is —S—;  
 R 1  is selected from H, 
 C 1-5  alkyl substituted with 0-1 R 2 ,  
 C 2-5  alkenyl substituted with 0-1 R 2 , and  
 C 2-3  alkynyl substituted with 0-1 R 2 ;  
 
 R 2  is C 3-6  cycloalkyl;  
 R 5  is H, methyl, ethyl, or propyl;  
 R 6a  is H, methyl, or ethyl;  
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, F, Cl, —CH 3 , —OCH 3 , —CF 3 , —OCF 3 , —CN, and —NO 2 ,  
 
 R 8  is selected from 
 methyl substituted with R 11 ;  
 ethenyl substituted with R 11 ;  
 OR 12 , SR 12 , NR 12 R 13 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 phenyl-substituted with 0-5 fluoro;  
 2-(H 3 CCH 2 C(═O))-phenyl substituted with R 33 ;  
 2-(H 3 CC(═O))-phenyl-substituted with R 33 ;  
 2-(HC(═O))-phenyl-substituted with R 32 ;  
 2-(H 3 CCH(OH))-phenyl-substituted with R 32 ;  
 2-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 2-(HOCH 2 )-phenyl-substituted with R 33 ;  
 2-(HOCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OMe))-phenyl-substituted with R 33 ;  
 2-(H 3 COC(═O))-phenyl-substituted with R 33 ;  
 2-(HOCH-CH═CH)-phenyl-substituted with R 33 ;  
 2-((MeOC═O)CH═CH)-phenyl-substituted with R 33 ;  
 2-(methyl)-phenyl-substituted with R 33 ;  
 2-(ethyl)-phenyl-substituted with R 33 ;  
 2-(i-propyl)-phenyl-substituted with R 33 ;  
 2-(F 3 C)-phenyl-substituted with R 33 ;  
 2-(NC)-phenyl-substituted with R 33 ;  
 2-(H 3 CO)-phenyl-substituted with R 33 ;  
 2-(fluoro)-phenyl-substituted with R 33 ;  
 2-(chloro)-phenyl-substituted with R 33 ;  
 3-(NC)-phenyl-substituted with R 33 ;  
 3-(H 3 CO)-phenyl-substituted with R 33 ;  
 3-(fluoro)-phenyl-substituted with R 33 ;  
 3-(chloro)-phenyl-substituted with R 33 ;  
 4-(NC)-phenyl-substituted with R 33 ;  
 4-(fluoro)-phenyl-substituted with R 33 ;  
 4-(chloro)-phenyl-substituted with R 32 ;  
 4-(H 3 CS)-phenyl-substituted with R 33 ;  
 4-(H 3 CO)-phenyl-substituted with R 33 ;  
 4-(ethoxy)-phenyl-substituted with R 33 ;  
 4-(i-propoxy)-phenyl-substituted with R 33 ;  
 4-(i-butoxy)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-((H 3 ) 2 CHC(═O))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-(H 3 CC(═O)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-((H 3 C) 2 CHCH(OH)-phenyl-substituted with R 32 ;  
 4-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH(OH))-phenyl-substituted with R 33 ;  
 4-(cyclopropyloxy)-phenyl-substituted with R 33 ;  
 4-(cyclobutyloxy)-phenyl-substituted with R 33 ; and  
 4-(cyclopentyloxy)-phenyl-substituted with R 33 ;  
 
 R 12  is selected from 
 phenyl-substituted with 0-5 fluoro;  
 2-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 2-(H 3 CC(═O))-phenyl-substituted with R 33 ;  
 2-(HC(═O))-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OH))-phenyl substituted with R 33 ;  
 2-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 2-(HOCH 2 )-phenyl-substituted with R 33 ;  
 2-(HOCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OMe))-phenyl-substituted with R 33 ;  
 2-(H 3 COC(═O))-phenyl-substituted with R 33 ;  
 2-(HOCH 2 CH═CH)-phenyl-substituted with R 33 ;  
 2-((MeOC═O)CH═CH)-phenyl-substituted with R 33 ;  
 2-(methyl)-phenyl-substituted with R 33 ;  
 2-(ethyl)-phenyl-substituted with R 33 ;  
 2-(i-propyl)-phenyl-substituted with R 33 ;  
 2-(F 3 C)-phenyl-substituted with R 33 ;  
 2-(NC)-phenyl-substituted with R 33 ;  
 2-(H 3 CO)-phenyl-substituted with R 33 ;  
 2-(fluoro)-phenyl-substituted with R 33 ;  
 2-(chloro)-phenyl-substituted with R 33 ;  
 3-(NC)-phenyl-substituted with R 33 ;  
 3-(H 3 CO)-phenyl-substituted with R 33 ;  
 3-(fluoro)-phenyl-substituted with R 33 ;  
 3-(chloro)-phenyl-substituted with R 33 ;  
 4-(NC)-phenyl-substituted with R 33 ;  
 4-(fluoro)-phenyl-substituted with R 33 ;  
 4-(chloro)-phenyl-substituted with R 33 ;  
 4-(H 3 CS)-phenyl-substituted with R 33 ;  
 4-(H 3 CO)-phenyl-substituted with R 33 ;  
 4-(ethoxy)-phenyl-substituted with R 33 ;  
 4-(i-propoxy)-phenyl-substituted with R 33 ;  
 4-(i-butoxy)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-((H 2 C) 2 CHC(═O) )-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-(H 3 CC(═))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-((H 3 C) 2 CHCH(OH))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH(OH))-phenyl-substituted with R 33 ;  
 4-(cyclopropyloxy)-phenyl-substituted with R 33 ;  
 4-(cyclobutyloxy)-phenyl-substituted with R 33 ; and  
 4-(cyclopentyloxy)-phenyl-substituted with R 33 ;  
 
 R 13  is H, methyl, or ethyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring selected from pyrrolyl, pyrrolidinyl, imidazolyl, piperidinyl, piperizinyl, methylpiperizinyl, and morpholinyl;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing form 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R 16 ;  
 R 15  is H, methyl, ethyl, propyl, or butyl;  
 R 16 , at each occurrence, is independently selected from H, OH, F, Cl, CN, NO 2 , methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 R 33 , at each occurrence, is independently selected from H, F, Cl, —CH 3 , —OCH 3 , —CF 3 , —OCF 3 , —CN, and —NO 2 ;  
 k is 1;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       6. A compound of  claim 1  wherein:
 X is —O—;  
 R 1  is selected from 
 H,  
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-4  cycloalkyl,  
 C 1-3  alkyl substituted with 0-1 R 2 ,  
 C 2-3  alkenyl substituted with 0-1 R 2 , and  
 C 2-3  alkynyl substituted with 0-1 R 2 ,  
 
 R 2 , at each occurrence, is independently selected from C 1-4  alkyl, 
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 phenyl substituted with 0-5 R 42 ;  
 C 3-6  carbocyclic group substituted with 0-3 R 42 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is H, methyl, ethyl, methoxy, —OH, or —CF 3 ;  
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  haloalkyl, C 1-4  alkoxy (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 0-2 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 8  is selected from 
 —OH, —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 1-2 R 11 ,  
 C 2-4  alkenyl substituted with 0-2 R 11 ,  
 C 2-4  alkynyl substituted with 0-1 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 15 , C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, (C 1-4  haloalkyl) oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12 , at each occurrence, is independently selected from 
 C 1-4  alkyl substituted with 0-1 R 12a ,  
 C 2-4  alkenyl substituted with 0-1 R 12a ,  
 C 2-4  alkynyl substituted with 0-1 R 12a ,  
 C 3-6  cycloalkyl substituted with 0-3 R 13 ,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12a , each occurrence, is independently selected from phenyl substituted with 0-5 R 33 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of one N, two N, three N, one N one O, and one N one S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-2 R 16 ;  
 R 14 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 15 , at each occurrence, is independently selected from H, methyl, ethyl propyl, and butyl;  
 R 16 , at each occurrence, is independently selected from H, OH, F, Cl, CN, NO 2 , methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 R 31 , at each occurrence, is independently selected from H, OH, halo, CF 3 , methyl, ethyl, and propyl;  
 R 33 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl,  
 C 3-6  cycloalkyl, C 3-4  haloalkyl, C 1-4  haloalkyl-oxy-, C 1-4  alkyloxy-,  
 C 1-4  alkylthio-, C 1-4  alkyl-C(═O)—, C 1-4  alkyl-C(═O)NH—, C 1-4  alkyl-OC(═O)—,  
 C 1-4  alkyl-C(═O)O—, C 3-6  cycloalkyl-oxy-, C 3-6  cycloalkylmethyl-oxy-;  
 C 1-6  alkyl substituted with OH, methoxy, ethoxy, propoxy, or butyoxy; and  
 C 2-6  alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;  
 
 R 41 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, and C 1-3  alkyl;  
 R 42 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 , C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, C 3-6  cycloalkyl, and C 1-3  al  
 R 43  is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;  
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;  
 k is 1;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       7. A compound of  claim 1  wherein
 X is —O—;  
 R 1  is selected from 
 H,  
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-4  cycloalkyl,  
 C 1-3  alkyl substituted with 0-1 R 2 ,  
 C 2-3  alkenyl substituted with 0-1 R 2 , and  
 C 2-3  alkynyl substituted with 0-1 R 2 ,  
 
 R 2 , at each occurrence, is independently selected from C 1-4  alkyl, 
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 phenyl substituted with 0-5 R 42 ;  
 C 3-6  carbocyclic group substituted with 0-3 R 41 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is H, methyl, ethyl, methoxy, —OH, or —CF 3 ;  
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, F, Cl, —CH 3 , —OCH 3 , —CF 3 , —OCF 3 , —CN, and —NO 2 ,  
 
 R 8  is selected from 
 —OH, —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, (C 1-4  haloalkyl)oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 1-4  alkyl substituted with 1-2 R 11 ,  
 C 2-4  alkenyl substituted with 0-2 R 11 ,  
 C 2-4  alkynyl substituted with 0-1 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 —CN, —NO 2 ,  
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, (C 1-4  haloalkyl) oxy,  
 C 3-10  cycloalkyl substituted with 0-2 R 33 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 , and  
 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12 , at each occurrence, is independently selected from 
 C 1-4  alkyl substituted with 0-1 R 12a ,  
 C 2-4  alkenyl substituted with 0-1 R 12a ,  
 C 2-4  alkynyl substituted with 0-1 R 12a ,  
 C 3-6  cycloalkyl substituted with 0-3 R 33 ,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 12a , each occurrence, is independently selected from phenyl substituted with 0-5 R 33 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 b  5 - 10  membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is benzimidazolyl, benzimidazolinyl, benztriazolyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, and dioxobenzthiazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R 16 ;  
 R 14 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 15 , at each occurrence, is independently selected from H, methyl, ethyl propyl, and butyl;  
 R 16 , at each occurrence, is independently selected from H, OH, F, Cl, CN, NO 2 , methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 R 31 , at each occurrence, is independently selected from H, OH, halo, CF 3 , methyl, ethyl, and propyl;  
 R 33 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 , —C(═O)H,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl,  
 C 3-6  cycloalkyl, C 3-4  haloalkyl, C 1-4  haloalkyl-oxy-, C 1-4  alkyloxy-,  
 C 1-4  alkylthio-, C 1-4  alkyl-C(═O)—, C 1-4  alkyl-C(═O)NH—, C 1-4  alkyl-OC(═O)—,  
 C 1-4  alkyl-C(═O)O—, C 3-6  cycloalkyl-oxy-, C 3-6  cycloalkylmethyl-oxy-;  
 C 1-6  alkyl substituted with OH, methoxy, ethoxy, propoxy, or butyoxy; and  
 C 2-6  alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy;  
 
 R 41 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, and C 1-3  alkyl;  
 R 42 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 , 
 C 2-4  alkenyl, C 2-4  alkynyl, C 1-3  alkoxy, C 1-3  haloalkyl, C 3-6  cycloalkyl, and C 1-3  alkyl;  
 
 R 43  is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;  
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl;  
 k is 1;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       8. A compound of  claim 1  wherein:
 X is —O—;  
 R 1  is selected from H, 
 C 1-5  alkyl substituted with 0-1 R 2 ,  
 C 2-5  alkenyl substituted with 0-1 R 2 , and  
 C 2-3  alkynyl substituted with 0-1 R 2 ;  
 
 R 2  is C 3-6  cycloalkyl;  
 R 5  is H, methyl, ethyl, or propyl;  
 R 6a  is H, methyl, or ethyl;  
 R 6b  is H;  
 R 7  and R 9 , at each occurrence, are independently selected from 
 H, F, Cl, —CH 3 , —OCH 3 , —CF 3 , —OCF 3 , —CN, and —NO 2 ,  
 
 R 8  is selected from 
 methyl substituted with R 11 ;  
 ethenyl substituted with R 11 ;  
 OR 12 , SR 12 , NR 12 R 13 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 phenyl-substituted with 0-5 fluoro;  
 2-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 2-(H 3 CC(═O))-phenyl-substituted with R 33 ;  
 2-(HC(═O))-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OH))-phenyl-substituted with R 33 ;  
 2-(H 3 CCH 2 CH(OH))-phenyl substituted with R 33 ;  
 2-(HOCH 2 )-phenyl-substituted with R 33 ;  
 2-(HOCH 2 )-phenyl-substituted with R 33 ;  
 2-(HOCH 3 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OMe))-phenyl-substituted with R 33 ;  
 2-(H 3 COC(═O))-phenyl-substituted with R 33 ;  
 2-(HOCH 2 CH═CH)-phenyl-substituted with R 33 ;  
 2-((MeOC═O)CH═CH)-phenyl-substituted with R 33 ;  
 2-(methyl)-phenyl-substituted with R 33 ;  
 2-(ethyl)-phenyl-substituted with R 33 ;  
 2-(i-propyl)-phenyl-substituted with R 33 ;  
 2-(F 3 C)-phenyl-substituted with R 33 ;  
 2-(NC)-phenyl-substituted with R 33 ;  
 2-(H 3 CO)-phenyl-substituted with R 33 ;  
 2-(fluoro)-phenyl-substituted with R 33 ;  
 2-(chloro)-phenyl-substituted with R 33 ;  
 3-(NC)-phenyl-substituted with R 33 ;  
 3-(H 3 CO)-phenyl-substituted with R 33 ;  
 3-(fluoro)-phenyl-substituted with R 33 ;  
 3-(chloro)-phenyl-substituted with R 33 ;  
 4-(NC)-phenyl-substituted with R 33 ;  
 4-(fluoro)-phenyl-substituted with R 33 ;  
 4-(chloro)-phenyl-substituted with R 33 ;  
 4-(H 3 CS)-phenyl-substituted with R 33 ;  
 4-(H 3 CO)-phenyl-substituted with R 33 ;  
 4-(ethoxy)-phenyl-substituted with R 33 ;  
 4-(i-propoxy)-phenyl-substituted with R 33 ;  
 4-(i-butoxy)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-((H 3 C) 2 CHC(═O))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-(H 3 CC(═O)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-((H 3 C) 2 CHCH(OH)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH(OH))-phenyl-substituted with R 33 ;  
 4-(cyclopropyloxy)-phenyl-substituted with R 33 ;  
 4-(cyclobutyloxy)-phenyl-substituted with R 33 ; and  
 4-(cyclopentyloxy)-phenyl-substituted with R 33 ;  
 
 R 12  is selected from 
 phenyl-substituted with 0-5 fluoro;  
 2-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 2-(H 3 CC(═O))-phenyl-substituted with R 33 ;  
 2-(HC(═O))-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OH))-phenyl substituted with R 33 ;  
 2-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 2-(HOCH 2 )-phenyl-substituted with R 33 ;  
 2-(HOCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 COCH 2 CH 2 )-phenyl-substituted with R 33 ;  
 2-(H 3 CCH(OMe))-phenyl-substituted with R 33 ;  
 2-(H 3 COC(═O))-phenyl-substituted with R 33 ;  
 2-(HOCH 2 CH═CH)-phenyl-substituted with R 33 ;  
 2-((MeOC═O)CH═CH)-phenyl-substituted with R 33 ;  
 2-(methyl)-phenyl-substituted with R 33 ;  
 2-(ethyl)-phenyl-substituted with R 33 ;  
 2-(i-propyl)-phenyl-substituted with R 33 ;  
 2-(F 3 C)-phenyl-substituted with R 33 ;  
 2-(NC)-phenyl-substituted with R 33 ;  
 2-(H 3 CO)-phenyl-substituted with R 33 ;  
 2-(fluoro)-phenyl-substituted with R 33 ;  
 2-(chloro)-phenyl-substituted with R 33 ;  
 3-(NC)-phenyl-substituted with R 33 ;  
 3-(H 3 CO)-phenyl-substituted with R 33 ;  
 3-(fluoro)-phenyl-substituted with R 33 ;  
 3-(chloro)-phenyl-substituted with R 33 ;  
 4-(NC)-phenyl-substituted with R 33 ;  
 4-(fluoro)-phenyl-substituted with R 33 ;  
 4-(chloro)-phenyl-substituted with R 33 ;  
 4-(H 3 CS)-phenyl-substituted with R 33 ;  
 4-(H 3 CO)-phenyl-substituted with R 33 ;  
 4-(ethoxy)-phenyl-substituted with R 33 ;  
 4-(i-propoxy)-phenyl-substituted with R 33 ;  
 4-(i-butoxy)-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-((H 3 C) 2 CHC(═O) )-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 C(═O))-phenyl-substituted with R 33 ;  
 4-(H 3 CC(═))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-((H 3 C) 2 CHCH(OH))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH 2 CH(OH))-phenyl-substituted with R 33 ;  
 4-(H 3 CCH(OH))-phenyl-substituted with R 33 ;  
 4-(cyclopropyloxy)-phenyl-substituted with R 33 ;  
 4-(cyclobutyloxy)-phenyl-substituted with R 33 ; and  
 4-(cyclopentyloxy)-phenyl-substituted with R 33 ;  
 
 R 13  is H, methyl, or ethyl;  
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring selected from pyrrolyl, pyrrolidinyl, imidazolyl, piperidinyl, piperizinyl, methylpiperizinyl, and morpholinyl;  
 alternatively, R 12  and R 13  when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing form 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, and dioxobenzthiazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R 16 ;  
 R 15  is H, methyl, ethyl, propyl, or butyl;  
 R 16 , at each occurrence, is independently selected from H, OH, F, Cl, CN, NO 2 , methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy;  
 R 33 , at each occurrence, is independently selected from H, F, Cl, —CH 3 , —OCH 3 , —CF 3 , —OCF 3 , —CN, and —NO 2 ;  
 k is 1;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       9. A compound of  claim 2  of Formula 
                 
 
       wherein:
 b is a single bond;  
 X is —S— or —O—;  
 R 1  is selected from 
 hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl,  
 t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 2-methylpentyl, 3-methylbutyl,  
 4-methylpentyl, 2-fluoroethyl, 2,2-difluoroethyl,  
 2,2,2-trifluoroethyl,  
 2-propenyl, 2-methyl-2-propenyl, trans-2-butenyl,  
 3-methyl-butenyl, 3-butenyl, trans-2-pentenyl,  
 cis-2-pentenyl, 4-pentenyl, 4-methyl-3-pentenyl,  
 3,3-dichloro-2-propenyl, trans-3-phenyl-2-propenyl,  
 cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl,  
 
 benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 2,5-dimethylbenzyl, 2,4-dimethylbenzyl, 3,5-dimethylbenzyl, 
 2,4,6-trimethyl-benzyl, 3-methoxy-benzyl, 3,5-dimethoxy-benzyl, pentafluorobenzyl, 2-phenylethyl, 1-phenyl-2-propyl, 4-phenylbutyl, 4-phenylbenzyl, 2-phenylbenzyl,  
 (2,3-dimethoxy-phenyl)C(═O)—, (2,5-dimethoxy-phenyl)C(═O)—,  
 (3,5-dimethoxy-phenyl)C(═O)—, cyclopropyl-C(═O)—,  
 isopropyl-C(═O)—, ethyl-CO 2 —, propyl-CO 2 —, t-butyl-CO 2 —,  
 2,6-dimethoxy-benzyl, 2,4-dimethoxy-benzyl,  
 2,4,6-trimethoxy-benzyl, 2,3-dimethoxy-benzyl,  
 2,4,5-trimethoxy-benzyl, 2,3,4-trimethoxy-benzyl,  
 3,4-dimethoxy-benzyl, 3,4,5-trimethoxy-benzyl,  
 (4-fluoro-phenyl)ethyl,  
 —CH═CH 2 , —CH 2 —CH═CH 2 , —CH═CH—CH 3 , —C═CH, —C═CH—CH 3 , and —CH 2 C═—CH;  
 
 R 8  is selected from 
 cyano, nitro, trifluoromethoxy, phenyl,  
 methylC(═)—, ethylC(═)—, propylC(═O)—, isopropylC(═O)—, butylC(═O)—, phenylC(═O)—,  
 methylCO 2 —, ethylCO 2 —, propylCO 2 —, isopropylCO 2 —, butylCO 2 —, phenylCO 2 —,  
 dimethylamino-S(═O)—, diethylamino-S(═O)—,  
 dipropylamino-S(═O)—, di-isopropylamino-S(═O)—, dibutylamino-S(═O)—, diphenylamino-S(═O)—,  
 dimethylamino-SO 2 —, diethylamino-SO 2 —, dipropylamino-SO 2 —, di-isopropylamino-SO 2 —, dibutylamino-SO 2 —,  
 diphenylamino-SO 2 —, dimethylamino-C(═O)—, diethylamino-C(═O)—,  
 dipropylamino-C(═O)—, di-isopropylamino-C(═O)—, dibutylamino-C(═O)—, diphenylamino-C(═O)—,  
 2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-cyanophenyl, 2-methylphenyl, 2-trifluoromethylphenyl,  
 2-methoxyphenyl, 2-trifluoromethoxyphenyl,  
 3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl,  
 3-cyanophenyl, 3-methylphenyl, 3-ethylpropyl,  
 3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl,  
 3-trifluoromethylphenyl, 3-methoxyphenyl,  
 3-isopropoxyphenyl, 3-trifluoromethoxyphenyl,  
 3-thiomethoxyphenyl,  
 4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl,  
 4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl,  
 4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl,  
 4-trifluoromethylphenyl, 4-methoxyphenyl,  
 4-isopropoxyphenyl, 4-trifluoromethoxyphenyl,  
 4-thiomethoxyphenyl,  
 2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl,  
 2,3-ditrifluoromethylphenyl-2,3-dimethoxyphenyl,  
 2,3-ditrifluoromethoxyphenyl,  
 2,4-dichlorophenyl, 2,4-difluorophenyl, 2,4-dimethylphenyl,  
 2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl,  
 2,4-ditrifluoromethoxyphenyl,  
 2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl,  
 2,5-trifluoromethylphenyl, 2,5-dimethoxyphenyl,  
 2,5-ditrifluoromethoxyphenyl,  
 2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl,  
 2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl,  
 2,6-ditrifluoromethoxyphenyl,  
 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,4-dimethylphenyl,  
 3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl,  
 3,4-ditrifluoromethoxyphenyl,  
 2,4,6-trichlorohenyl, 2,4,6-trifluorophenyl,  
 2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl,  
 2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl,  
 2-chloro-4-CF 3 -phenyl, 2-fluoro-3-chloro-phenyl,  
 2-chloro-4-CF 3 -phenyl, 2-chloro-4-methoxy-phenyl,  
 2-methoxy-4-isopropyl-butyl, 2-CF 3 -4-methoxy-phenyl,  
 2-methyl-4-methoxy-5-fluoro-phenyl,  
 2-methyl-4-methoxy-phenyl, 2-chloro-4-CF 3 O-phenyl,  
 2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl,  
 methyl-C(═O)NH—, ethyl-C(═O)NH—, propyl-C(═O)NH—,  
 isopropyl-C(═O)NH—, butyl-C(═O)NH—, phenyl-C(═O)NH—,  
 4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl,  
 2-thiophenyl, 2-naphthyl;  
 2-Me-4-F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl,  
 2-Me-3-Cl-phenyl, 3-NO 2 -phenyl, 2-NO 2 -phenyl,  
 2-Cl-3-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,  
 2-Cl-6-F-phenyl, 2-Cl-4-(CHF 2 )O-phenyl,  
 2,4-diMeO-6-F-phenyl, 2-CF 3 -6-F-phenyl,  
 2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl,  
 2,3,4-triF-phenyl, 2,6-diF-4-Cl-phenyl,  
 2,3,4,6-tert-F-phenyl, 2,3,4,5,6-pentaF-phenyl,  
 2-CF 3 -4-EtO-phenyl, 2-CF 3 -4-iPrO-phenyl,  
 2-CF 3 -4-Cl-phenyl, 2-CF 3 -4-F-phenyl, 2-Cl-4-EtO-phenyl,  
 2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl,  
 2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl,  
 2-CHO(OMe)Me-4-MeO-phenyl, 2-C(═O)Me-4-MeO-phenyl,  
 2-CH 2 (OH)-4-MeO-phenyl, 2-CH 2 (OMe)-4-MeO-phenyl,  
 2-CH(OH)Et-4-MeO-phenyl, 2-C(═O)Et-4-MeO-phenyl,  
 (Z)-2-CH═CHCO 2 Me-4-MeO-phenyl,  
 2-CH 2 CH 2 CO 2 Me-4-MeO-phenyl,  
 (Z)-2-CH═CHCH 2 (OH)-4-MeO-phenyl,  
 (E)-2-CH═CHCO 2 Me-4-MeO-phenyl,  
 (E)-2-CH═CHCH 2 (OH)-4-MeO-phenyl,  
 2-CH 2 CH 2 OMe-4-MeO-phenyl,  
 2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl,  
 (2-Cl-phenyl)-CH═CH—, (3-Cl-phenyl)-CH═CH—,  
 (2,6-diF-phenyl)-CH═CH—, —CH 2 CH═CH 2 ,  
 phenyl-CH═CH—, (2-Me-4-MeO-phenyl)-CH═CH—,  
 cyclohexyl, cyclopentyl, cyclohexylmethyl,  
 —CH 2 CH 2 CO 2 Et, —(CH 2 ) 3 CO 2 Et, —(CH 2 ) 4 CO 2 Et,  
 benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl,  
 3-MeO-benzyl, 3-OH-benzyl, 2-MeO-benzyl,  
 2-OH-benzyl, 2-CO 2 Me-3-MeO-phenyl,  
 2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF 3 -4-CN-phenyl,  
 3-CHO-phenyl, 3-CH 2 (OH)-phenyl, 3-CH 2 (OMe)-phenyl,  
 3-CH 2 (NMe 2 )-phenyl, 3-CN-4-F-phenyl,  
 3-CONH 2 -4-F-phenyl, 2-CH 2 (NH 2 )-4-MeO-phenyl-,  
 phenyl-NH—, (4-F-phenyl)-NH—, (2,4-diCl-phenyl)-NH—,  
 phenyl-C(═O)NH—, benzyl-NH—, (2,4-Me-4-MeO-phenyl)-NH—,  
 (2-F-4-MeO-phenyl)-NH—, (2-Me-4-F-phenyl)-NH—,  
 phenyl-S—, —NMe 2 , 1-pyrrolidinyl, and  
 -N(tosylate) 2 ,  
 
 R 7  and R 9 , are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, and trifluoromethoxy;  
 m is 1; and  
 n is 1 or 2.  
 
     
     
       10. A compound of  claim 9  of Formula (II) 
                 
 
       wherein:
 b is a single bond, wherein the bridge hydrogens are in a cis position;  
 R 1  is selected from 
 hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl,  
 t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 3-methylpentyl, 3-methylbutyl,  
 4-methylphenyl, 2-fluoroethyl, 2,2-difluoroethyl,  
 2,2,2-trifluoroethyl, 2-propyl, 2-methyl-2-propenyl, trans-2-butenyl, 3-methyl-butenyl, 3-butenyl,  
 trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl,  
 4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl,  
 trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl,  
 —CH═CH 2 , —CH 2 —CH═CH 2 , —CH═CH—CH 3 , —C≡CH, —C≡C—CH 3 ,  
 —CH═CH 2 , —CH 2 —CH═CH 2 , —CH═CH—CH 3 , —C≡—CH, —C≡—C—CH 3 , and —CH 2 —CH≡CH;  
 
 R 7  and R 9 , at each occurrence, are independently selected from hydrogen, fluoro, methyl, trifluoromethyl, and methoxy;  
 R 8  is selected from 
 cyano, nitro, trifluoromethoxy, phenyl,  
 methylC(═O)—, ethylC(═O)—, propylC(═O)—, isopropylC(═O)—, butylC(═O)—, phenylC(═)—,  
 methylCo 2 —, ethylCO 2 —, propylCO 2 —, isopropylCO 2 —, butylCO 2 —, phenylCO 2 —,  
 dimethylamino-S(═O)—, diethylamino-S(═O)—,  
 dipropylamino-S(═O)—, di-isopropylamino-S(═O)—, dibutylamino-S(═O)—, diphenylamino-S(═O)—,  
 dimethylamino-SO 2 —, diethylamino-SO 2 —, dipropylamino-SO 2 —, di-isopropylamino-SO 2 —, dibutylamino-SO 2 —,  
 
 diphenylamino-SO 2 —, 
 dimethylamino-C(═O)—, diethylamino-C(═O)—,  
 dipropylamino-C(═O)—, di-isopropylamino-C(═O)—, dibutylamino-C(═O)—, diphenylamino-C(═O)—,  
 2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-cyanophenyl, 2-methylphenyl, 2-trifluromethylphenyl,  
 2-methoxyphenyl, 2-trifluoromethoxyphenyl,  
 3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl,  
 3-cyanophenyl, 3-methylphenyl, 3-ethylphenyl,  
 3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl,  
 3-trifluoromethyl, 3-methoxyphenyl,  
 3-isopropoxyphenyl, 3-trifluoromethoxyphenyl,  
 3-thiomethoxyphenyl,  
 4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl,  
 4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl,  
 4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl,  
 4-trifluoromethylphenyl, 4-methoxyphenyl,  
 4-isopropoxyphenyl, 4-trifluoromethoxyphenyl,  
 4-thiomethoxyphenyl,  
 2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl,  
 2,3-ditrifluoromethylphenyl, 2,3-dimethoxyphenyl,  
 2,3-ditrifluoromethoxyphenyl,  
 2,4-dichlorophenyl, 2,4-difluorophenyl, 2,4-dimethylphenyl,  
 2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl,  
 2,4-ditrifluoromethoxyphenyl,  
 2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl,  
 2,5-trifluoromethylphenyl, 2,5-dimethoxyphenyl,  
 2,5-ditrifluoromethoxyphenyl,  
 2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl,  
 2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl,  
 2,6-ditrifluoromethoxyphenyl,  
 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,4-dimethylphenyl,  
 3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl,  
 3,4-ditrifluoromethoxyphenyl,  
 2,4,6-trichlorohenyl, 2,4,6-trifluorophenyl,  
 2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl,  
 2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl,  
 2-chloro-4-CF 3 -phenyl, 2-fluoro-3-chloro-phenyl,  
 2-chloro-4-CF 3 -phenyl, 2-chloro-4-methoxy-phenyl,  
 2-methoxy-4-isopropyl-butyl, 2-CF 3 -4-methoxy-phenyl,  
 2-methyl-4-methoxy-5-fluoro-phenyl,  
 2-methyl-4-methoxy-phenyl, 2-chloro-4-CF 3 O-phenyl,  
 2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl,  
 methyl-C(═O)NH—, ethyl-C(═O)NH—, propyl-C(═O)NH—,  
 isopropyl-C(═O)NH—, butyl-C(═O)NH—, phenyl-C(═O)NH—;  
 4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl,  
 2-thiophenyl, 2-naphthyl;  
 2-Me-4-F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl,  
 2-Me-3-Cl-phenyl, 3-NO 2 -phenyl, 2-NO 2 -phenyl,  
 2-Cl-3-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,  
 2-Cl-6-F-phenyl, 2-Cl-4-(CHF 2 )O-phenyl,  
 2,4-diMeO-6-F-phenyl, 2-CF 3 -6-F-phenyl,  
 2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl,  
 2,3,4-triF-phenyl, 2,6-diF-4-Cl-phenyl,  
 2,3,4,6-tert-F-phenyl, 2,3,4,5,6-pentaF-phenyl,  
 2-CF 3 -4-EtO-phenyl, 2-CF 3 -4-iPrO-phenyl,  
 2-CF 3 -4-Cl-phenyl, 2-CF 3 -4-F-phenyl, 2-Cl-4-EtO-phenyl,  
 2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl,  
 2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl,  
 2-CHO(OMe)Me-4-MeO-phenyl, 2-C(═O)Me-4-MeO-phenyl,  
 2-CH 2 (OH)-4-MeO-phenyl, 2-CH 2 (OMe)-4-MeO-phenyl,  
 2-CH(OH)Et-4-MeO-phenyl, 2-C(═O)Et-4-MeO-phenyl,  
 (Z)-2-CH═CHCO 2 Me-4-MeO-phenyl,  
 2-CH 2 CH 2 CO 2 Me-4-MeO-phenyl,  
 (Z)-2-CH═CHCH 2 (OH)-4-MeO-phenyl,  
 (E)-2-CH═CHCO 2 Me-4-MeO-phenyl,  
 (E)-2-CH═CHCH 2 (OH)-4-MeO-phenyl,  
 2-CH 2 CH 2 OMe-4-MeO-phenyl,  
 2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl,  
 (2-Cl-phenyl)-CH═CH—, (3-Cl-phenyl)-CH═CH—,  
 (2,6-diF-phenyl)-CH═CH—, —CH 2 CH═CH 2 ,  
 phenyl-CH═CH—, (2-Me-4-MeO-phenyl)-CH═CH—,  
 cyclohexyl, cyclopentyl, cyclohexylmethyl,  
 —CH 2 CH 2 CO 2 Et, —(CH 2 ) 3 CO 2 Et, —(CH 2 ) 4 CO 2 Et,  
 benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl,  
 3-MeO-benzyl, 3-OH-benzyl, 2-MeO-benzyl,  
 2-OH-benzyl, 2-CO 2 Me-3-MeO-phenyl,  
 2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF 3 -4-CN-phenyl,  
 3-CHO-phenyl, 3-CH 2 (OH)-phenyl, 3-CH 2 (OMe)-phenyl,  
 3-CH 2 (NMe 2 )-phenyl, 3-CN-4-F-phenyl,  
 3-CONH 2 -4-F-phenyl, 2-CH 2 (NH 2 )-4-MeO-phenyl,  
 phenyl-NH—, (4-F-phenyl)-NH—, (2,4-diCl-phenyl)-NH—,  
 phenyl-C(═O)NH—, benzyl-NH—, (2,4-Me-4-MeO-phenyl)-NH—,  
 (2-F-4-MeO-phenyl)-NH—, (2-Me-4-F-phenyl)-NH—,  
 phenyl-S—, —NMe 2 , 1-pyrrolidinyl, and  
 -N(tosylate) 2 ; and  
 
 n is 1 or 2.  
 
     
     
       11. A compound of  claim 9  of Formula (III) 
                 
 
       wherein:
 b is a single bond, wherein the bridge hydrogens are in a cis position;  
 R 1  is selected from 
 hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl,  
 t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 3-methylpentyl, 3-methylbutyl,  
 4-methylphenyl, 2-fluoroethyl, 2,2-difluoroethyl,  
 2,2,2-trifluoroethyl, 2-propyl, 2-methyl-2-propenyl, trans-2-butenyl, 3-methyl-butenyl, 3-butenyl,  
 trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl,  
 4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl,  
 trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl,  
 —CH═CH 2 , —CH 2 —CH═CH 2 , —CH═CH—CH 3 , —C≡CH, —C≡C—CH 3 ,  
 and —CH 2 —CH≡CH;  
 
 R 7  and R 9 , at each occurrence, are independently selected from hydrogen, fluoro, methyl, trifluoromethyl, and methoxy; and  
 R 8  is selected from 
 cyano, nitro, trifluoromethoxy, phenyl,  
 methylC(═O)—, ethylC(═O)—, propylC(═O)—, isopropylC(═O)—, butylC(═O)—, phenylC(═)—,  
 methylCO 2 —, ethylCO 2 —, propylCO 2 —, isopropylCO 2 —, butylCO 2 —, phenylCO 2 —,  
 
 dimethylamino-S(═O)—, diethylamino-S(═O)—, 
 dipropylamino-S(═O)—, di-isopropylamino-S(═O)—, dibutylamino-S(═O)—, diphenylamino-S(═O)—,  
 dimethylamino-SO 2 —, diethylamino-SO 2 —,  
 dipropylamino-SO 2 —, di-isopropylamino-SO 2 —,  
 dibutylamino-SO 2 —, diphenylamino-SO 2 —,  
 dimethylamino-C(═O)—, diethylamino-C(═O)—,  
 dipropylamino-C(═O)—, di-isopropylamino-C(═O)—, dibutylamino-C(═O)—, diphenylamino-C(═O)—,  
 2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl,  
 2-cyanophenyl, 2-methylphenyl, 2- trifluoromethylphenyl,  
 2-methoxyphenyl, 2-trifluoromethoxyphenyl,  
 3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl,  
 3-cyanophenyl, 3-methylphenyl, 3-ethylphenyl,  
 3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl,  
 3-trifluoromethylphenyl, 3-methoxyphenyl,  
 3-isopropoxyphenyl, 3-trifluoromethoxyphenyl,  
 3-thiomethoxyphenyl,  
 4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl,  
 4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl,  
 4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl,  
 4-trifluoromethylphenyl, 4-methoxyphenyl,  
 4-isopropoxyphenyl, 4-trifluoromethoxyphenyl,  
 4-thiomethoxyphenyl,  
 2,3-dichlorophenyl, 2,3-difluorophenyl,  
 2,3-dimethylphenyl, 2,3-ditrifluoromethylphenyl,  
 2,3-dimethoxyphenyl, 2,3-ditrifluoromethoxyphenyl,  
 2,4-dichlorophenyl, 2,4-difluorophenyl,  
 2,4-dimethylphenyl, 2,4-ditrifluoromethylphenyl,  
 2,4-dimethoxyphenyl, 2,4-ditrifluoromethoxyphenyl,  
 2,5-dichlorophenyl, 2,5-difluorophenyl,  
 2,5-dimethylphenyl, 2,5-ditrifluoromethylphenyl,  
 2,5-dimethoxyphenyl, 2,5-ditrifluoromethoxyphenyl,  
 2,6-dichlorophenyl, 2,6-difluorophenyl,  
 2,6-dimethylphenyl, 2,6-ditrifluoromethylphenyl,  
 2,6-dimethoxyphenyl, 2,6-trifluoromethoxyphenyl,  
 3,4-dichlorophenyl, 3,4-difluorophenyl,  
 3,4-dimethylphenyl, 3,4-ditrifluoromethylphenyl,  
 3,4-dimethoxyphenyl, 3,4-ditrifluoromethoxyphenyl,  
 2,4,6-trichlorophenyl, 2,4,6-trifluorophenyl,  
 2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl,  
 2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl,  
 2-chloro-4-CF 3 -phenyl, 2-fluoro-3-chloro-phenyl,  
 2-chloro-4-CF 3 -phenyl, 2-chloro-4-methoxy-phenyl,  
 2-methoxy-4-isopropyl-phenyl, 2-CF 3 -4-methoxy-phenyl,  
 2-methyl-4-methoxy-5-fluoro-phenyl,  
 2-methyl-4-methoxy-phenyl, 2-chloro-4-CF 3 O-phenyl,  
 2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl,  
 methyl-C(═O)NH—, ethyl-C(═O)NH—, propyl-C(═O)NH—,  
 isopropyl-C(═O)NH—, butyl-C(═O)NH—, phenyl-C(═O)NH—,  
 4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl,  
 2-thiophenyl, 2-naphthyl;  
 2-Me-5F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl,  
 2-Me-3-Cl-phenyl, 3-NO 2 -phenyl, 2-NO 2 -phenyl,  
 2-Cl-3-Me-phenyl, 2-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,  
 2-Cl-6-F-phenyl, 2-Cl-4-(CHF 2 )O-phenyl,  
 2,4-diMeO-6-F-phenyl, 2-CF 3 -6-F-phenyl,  
 2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl,  
 2,3,4-triF-phenyl, 2,6-diF-5-Cl-phenyl,  
 2,3,4-tetraF-phenyl, 2,3,4,5,6-pentaF-phenyl,  
 2-CF 3 -4-EtO-phenyl, 2-CF 3 -iPrO-phenyl,  
 2-CF 3 -4-Cl-phenyl, 2-CF 3 -4-F-phenyl, 2-Cl-4-EtO-phenyl,  
 2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl,  
 2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl,  
 2-CH(OMe)Me-4-MeO-phenyl, 2C(═O)Me-4-MeO-phenyl,  
 2-CH 2 (OH)-4-O-phenyl, 2-CH 3 (OMe)-phenyl,  
 2-CH(OH)Et-4-MeO-phenyl, 2-C(═O)Et-4-MeO-phenyl,  
 (Z)-2-CH═CHCO 2 Me-4-MeO-phenyl,  
 2-CH 2 CH 2 CO 2 Me-4-MeO-phenyl,  
 (Z)-2-CH═CHCH 2 (OH)-4-MeO-phenyl,  
 (E)-2-CH═CHCO 2 Me-4-MeO-phenyl,  
 (E)-2-CH═CHCH 2 (OH)-4-MeO-phenyl,  
 2-CH 2 C 2 OMe-4-MeO-phenyl,  
 2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl,  
 (2-Cl-phenyl)-CH═CH—, (3-Cl-phenyl)-CH═CH—,  
 (2,6-diF-phenyl)-CH═CH—, —CH 2 CH═CH 2 ,  
 phenyl-CH═CH—, (2-Me-4-MeO-phenyl)CH═C—,  
 cyclohexyl, cyclopentyl, cyclohexylmethyl,  
 13 CH 2 CH 2 CO 2 Et, —(CH 2 ) 3 CO 2 Et, —(CH 2 ) 4 CO 2 Et,  
 benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl,  
 3-MeO-benyzl, 3-OH-benzyl, 2-MeO-benzyl,  
 2-OH-benzyl, 2-CO 2 Me-3-MeO-phenyl,  
 2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF 3 -4-CN-phenyl,  
 3-CHO-phenyl, 3-CH 2 (OH)-phenyl, 3-CH 2 (OMe)-phenyl,  
 3-CH 2 (NMe 2 )-phenyl, 3-CN-4-F-phenyl,  
 3-CONH 2 -4-F-phenyl, 2-CH 2 (NH 2 )-4-MeO-phenyl-,  
 phenyl-NH—, (4-F-phenyl)-NH—, (2,4-diCl-phenyl)-NH—,  
 phenyl-C(═O)NH—, benzyl-NH—, (2-Me-4-MeO-phenyl)-NH—,  
 (2-F-4-MeO-phenyl)-NH—, (2-Me-4-F-phenyl)-NH—,  
 phenyl-S—, —NM 2 , 1-pyrrolidinyl, and —N(tosylate)2; and  
 n is 1 or 2.  
 
 
     
     
       12. A compound of formula (I): 
                 
 
       or steroisomers or pharmaceutically acceptable salt forms thereof, wherein:
 b is a single bond;  
 X is —O—, —S—, —S(═O)—, or —S(═O) 2 —,  
 R 1  is selected from 
 C 1-6  alkyl substituted with Z,  
 C 2-6  alkenyl substituted with Z,  
 C 2-6  alkynyl substituted with Z,  
 C 3-6  cycloalkyl substituted with Z,  
 aryl substituted with Z,  
 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z,  
 C 1-6  alkyl substituted with 1-2 R 2 , but R 2  cannot be alkyl;  
 C 2-6  alkenyl substituted with 0-2 R 2 ,  
 C 2-6  alkynyl substituted with 0-2 R 2 ,  
 aryl substituted with 0-2 R 2 , and  
 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R 2 ,  
 
 Z is selected from 
 —CH(OH) 2 ,  
 —C(ethylenedioxy)R 2 ,  
 —OR 2 ,  
 —SR 2 ,  
 —NR 2 R 3 ,  
 —C(O)R 2 ,  
 —C(O)N 2 R 3 ,  
 —NR 3 C(O)R 2 ,  
 —C(O)OR 2 ,  
 —OC(O)R 2 ,  
 —CH(═NR 4 )NR 2 R 3 ,  
 —NHC(═NR 4 )NR 2 R 3 ,  
 —S(O)R 2 ,  
 —S(O) 2 R 2 ,  
 —S(O) 2 NR 2 R 3 , and —NR 3 S(O) 2 R 2 ,  
 
 R 2 , at each occurrence, is independently selected from 
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 aryl substituted with 0-5 R 42 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 41 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 3 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, and 
 C 3-4  alkoxy;  
 alternatively, R 2  and R 3  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 4 )—;  
 
 R 4 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 5  is H, methyl, ethyl, propyl, or butyl;  
 R 6a  is selected from 
 H, —OH, —NR 46 R 47 , —CF 3 ,  
 C 1-4  alkyl, C 2-4  alkenyl, C 1-4  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl, and  
 aryl substituted with 0-3 R 44 ;  
 
 R 6b  is H;  
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  haloalkyl, C 1-8  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 1-4  alkyl substituted with 0-2 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O)NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 , OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 )NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 H, halo, —CF 3 , —CN, —NO 2 ,  
 C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  haloalkyl, C 1-8  alkoxy, C 3-10  cycloalkyl,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O)NR 12 R 13 , NR 14 C(O)R 12 , (O)OR 12 ,  
 OC(O)R 12 , OC(O)OR 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 )NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O)NR 12 R 13 , S(O) 2 NR 12 R 13 , NR 14 S(O)R 12 , and NR 14 S(O) 2 R 12 ,  
 
 R 12 , at each occurrence, is independently selected from 
 C 1-4  alkyl,  
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ; p1 R 13 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 R 14 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 R 31 , at each occurrence, is independently selected from 
 H, OH, halo, CF 3 SO 2 R 45 , NR 46 R 47 , methyl, ethyl, and propyl;  
 
 R 33 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , SO 2 R 45 , NR 46 R 47 ,  
 C 1-3  alkyl, C 2-3  alkenyl, C 2-3  alkynyl, C 3-5  cycloalkyl, C 1-3  haloalkyl, C 1-3  haloalkyl-oxy-, C 1-3  alkyloxy-, C 1-3  alkylthio, C 1-3  alkyl-C(═O)—, and C 1-3  alkyl- C(═O)NH—;  
 
 R 41 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, ═O,  
 C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 42 , and  
 5-10 membered heterocycle ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 42 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , SR 45 , NR 46 R 47 , OR 48 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 , 
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 45 ,  
 aryl substituted with 0-3 R 44 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 43  is C 3-6  cycloalkyl or aryl substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , C 1-4  alkyl, and C 1-4  alkoxy;  
 R 45  is C 1-4  alkyl;  
 R 46 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 R 47 , at each occurrence, is independently selected from H, C 1-4  alkyl, —C(═O)NHC(C 1-4  alkyl), —SO 2 (C 1-4  alkyl), —SO 2 (phenyl), —C(═O)O(C 1-4  alkyl), —C(═O)(C 1-4  alkyl), and —C(═O)H;  
 R 48 , at each occurrence, is independently selected from H, C 1-4  alkyl, —C(═O)NH(C 1-4  alkyl), —C(═O)O(C 1-4  alkyl), —C(═O)(C 1-4 alkyl), and —C(═O)H;  
 k is 1 or 2;  
 m is 0, 1, or 2; and  
 n is 1 or 2;  
 provided when m is 0 or 1 then k is 1 or 2;  
 provided when m is 2 then l is 1;  
 provided that when b is a single bond; n is 1 or 2; m is 1; k is 1; X is O or S; and R 1  is C 1-4  alkyl or cyclopropyl, then R 8  is a substituent other than H.  
 
     
     
       13. A compound of  claim 12  wherein:
 X is —O— or —S—;  
 R 1  is selected from 
 C 2-5  alkyl substituted with Z,  
 C 2-5  alkenyl substituted with Z,  
 C 2-5  alkynyl substituted with Z,  
 C 3-6  cycloalkyl substituted with Z,  
 aryl substituted with Z,  
 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z;  
 C 1-5  alkyl substituted with 1-2 R 2 , but R 2  cannot be alkyl;  
 C 2-5  alkenyl substituted with 0-2 R 2 , and  
 C 2-5  alkynyl substituted with 0-2 R 2 ;  
 
 Z is selected from 
 —CH(OH)R 2 ,  
 —C(ethylenedioxy)R 2 ,  
 —OR 2 ,  
 —SR 2 ,  
 —NR 2 R 3 ,  
 —C(O)R 2 ,  
 —C(O)NR 2 R 3 ,  
 —NR 3 C(O)R 2 ,  
 —C(O)OR 2 ,  
 —OC(O)R 2 ,  
 CH(═NR 4 )NR 2 R 3 ,  
 —NHC(═NR 4 )NR 2 R 3 ,  
 —S(O)R 2 ,  
 —S(O)R 2 R 2 ,  
 —S(O) 2 NR 2 R 3 , and —NR 3 S(O) 2 R 2 ;  
 
 R 3 , at each occurrence, is independently selected from C 1-4  alkyl, 
 C 2-4  alkenyl,  
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 aryl substituted with 0-5 R 42 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 43 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 3 , at each occurrence, is independently selected from H, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, and C 1-4  alkoxy;  
 alternatively, R 2  and R 3  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 6 )—;  
 R 4 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 5  is H, methyl, or ethyl;  
 R 6a  is selected from 
 H, —OH, —NR 46 R 47 , —CF 3 ,  
 C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, and C 3-6  cycloalkyl;  
 
 R 6b  is H;  
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —OCH 3 , —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-4  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, C 1-6  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 1-4  alkyl substituted with 0-2 R 11 ,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 OR 12 , SR 12 , NR 12 R 13 , C(O)H, C(O)R 12 , C(O)NR 12 R 13 , NR 14 C(O)R 12 , C(O)OR 12 OC(O)R 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 )NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O) 2 NR 12 R 13 , NR 14 S(O) 2 R 12 , NR 14 S(O)R 12 , NR 14 S(O) 2 R 12 , NR 12 C(O)R 15 , NR 12 C(O)OR 15 , NR 12 S(O) 2 R 15 , and NR 12 C(O)NHR 15 ;  
 
 R 11  is selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —OCH 3 , —CN, —NO 2 , —NR 46 R 47 ,  
 C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, C 1-6  alkoxy, (C 1-4  haloalkyl)oxy,  
 C 3-10  carbocyclic group substituted with 0-3 R 33 ,  
 aryl substituted with 0-5 R 33 ,  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the groups consisting of N, O, and S substituted with 0-3 R 31 ,  
 OR 12 , SR 12 NR 12 R 13 , C(O)H, C(O)R 12 , C(O)NR 12 R 13 , NR 14 C(O)R 12 , C(O)R 12 , OC(O)R 12 , CH(═NR 14 )NR 12 R 13 , NHC(═NR 14 )NR 12 R 13 , S(O)R 12 , S(O) 2 R 12 , S(O) 2 NR 12 R 13 , and NR 14 S(O) 2 R 12 ;  
 
 R 12 , at each occurrence, is independently selected from C 1-4  alkyl,  
 C 2-4  alkenyl, 
 C 2-4  alkynyl,  
 C 3-6  cycloalkyl,  
 phenyl substituted with 0-5 R 33 ;  
 C 3-10  carbocyclic group substituted with 0-3 R 33 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 31 ;  
 
 R 13 , at each occurrence, is independently selected from 
 H, C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl;  
 
 alternatively, R 12  and R 13  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 14 )—;  
 R 14 , at each occurrence, is independently selected from H and C 1-4  alkyl;  
 R 33 , at each occurrence, is independently selected from H, OH, halo, CF 3 , methyl, and ethyl;  
 R 13 , at each occurrence, is independently selected from 
 H, OH, halo, CN, NO 2 , CF 3 , methyl, and ethyl;  
 
 R 41 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2   2 R 45 , NR 46 R 47 , NO 2 , CN, ═O,  
 C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 42 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 42 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , SR 45 , NR 46 R 47 , OR 48 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 , 
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 44 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 43  is C 3-6  cycloalkyl or aryl substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , C 1-4  alkyl, and C 1-4  alkoxy;  
 R 45  is C 1-4  alkyl;  
 R 46 , at each occurrence, is independently selected from H, and C 1-3  alkyl;  
 R 47 , at each occurrence, is independently selected from H, 
 C 1-4  alkyl, —C(═O)NH(C 1-4  alkyl),  
 —SO 2 (C 1-4  alkyl),  
 —SO 2 (phenyl), —C(═O)O(C 1-4  alkyl), —C(═O) (C 1-4  alkyl), and —C(═O)H;  
 
 R 48 , at each occurrence, is independently selected from H, 
 C 1-4  alkyl, —C(═O)NH(C 1-4  alkyl),  
 —C(═O)O(C 1-4  alkyl),  
 —C(═O)(C 1-4  alkyl), and —C(═O)H;  
 k is 1 or 2;  
 
 m is 0, 1, 2; and  
 n is 1 or 2.  
 
     
     
       14. A compound of  claim 12  wherein:
 X —O—;  
 R 1  is selected from 
 C 2-4  alkyl substituted with Z,  
 C 2-4  alkenyl substituted with Z,  
 C 2-4  alkynyl substituted with Z,  
 C 3-6  cycloalkyl substituted with Z,  
 aryl substituted with Z,  
 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z;  
 
 C 2-4  alkyl substituted with 1-2 R 2 , but R 2  is other than alkyl; and 
 C 2-4  alkenyl substituted with 0-2 R 2 ;  
 
 Z is selected from 
 —CH(OH)R 2 , —C(ethylenedioxy)R 2 ,  
 —OR 2 ,  
 —SR 2 ,  
 —NR 2 R 3 ,  
 —C(O)R 2 ,  
 —C(O)NR 2 R 3 ,  
 —NR 3 C(O)R 2 , ——C(O)OR 2 ,  
 —S(O)R 2 ,  
 —S(O) 2 R 2 ,  
 —S(O) 2 NR 2 R 3 , and —NR 3 S(O) 2 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from phenyl substituted with 0-5 R 42 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 41 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 3 , at each occurrence, is independently selected from 
 H, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, and  
 C 1-4  alkoxy;  
 
 alternatively, R 2  and R 3  join to form a 5- or 6-membered ring optionally substituted with —O— or —N(R 4 )—;  
 R 4 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl,  
 R 5  is H;  
 R 6a  is selected from H, —OH, —CF 3 , methyl, ethyl, propyl, butyl, methoxy, and ethoxy;  
 R 6b  is H;  
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —OCH 3 , —CN, —NO 2 ,  
 C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, (C 1-3  haloalkyl) oxy, and  
 C 1-4  alkyl substituted with 0-2 R 11 ;  
 
 R 11  is selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —OCH 3 , —CN, —NO 2 ,  
 C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, and (C 1-3  haloalkyl)oxy;  
 
 R 33 , at each occurrence, is independently selected from H, OH, halo, CF 3 , and methyl;  
 R 41 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, ═O, 
 C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 42 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 42 , at each occurrence, is independently selected from 
 H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , SR 45 , NR 46 R 47 , OR 48 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 ,  
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 44 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 43  is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;  
 R 43  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, —C(═O)NH(methyl), —C(═O)NH(ethyl), —SO 2 (methyl), —SO 2 (ethyl), —SO 2 (phenyl), —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl), 
 —C(═O)(ethyl), and —C(═O)H;  
 
 R 48 , at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, —C(═O)NH(methyl), —C(═O)NH(ethyl), —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl), —C(═O)(ethyl), and —C(═O)H;  
 k is 1;  
 m is 0, 1, or 2; and  
 n is 1 or 2.  
 
     
     
       15. A compound of  claim 12  wherein:
 X is —O—;  
 R 1  is selected from 
 ethyl substituted with Z,  
 propyl substituted with Z,  
 butyl substituted with Z,  
 propenyl substituted with Z,  
 butenyl substituted with Z,  
 ethyl substituted with R 2 ,  
 propyl substituted with R 2 ,  
 butyl substituted with R 2 ,  
 propenyl substituted with R 2 , and  
 butenyl substituted with R 2 ; provided that with respect to ethyl, propyl and butyl, R 2  is other than alkyl;  
 Z is selected from  
 —CH(OH)R 2 ,  
 —OR 2 ,  
 —SR 2 ,  
 —NR 2 R 3 ,  
 —C(O)R 2 ,  
 —C(O)NR 2 R 3 ,  
 —NR 3 C(O)R 2 ,  
 C(O)OR 2 ,  
 —S(O)R 2 ,  
 —S(O) 2 R 2 ,  
 —S(O) 2 NR 2 R 3 , and —NR 3 S(O) 2 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from phenyl substituted with 0-3 R 42 ; 
 naphthyl substituted with 0-3 R 42 ;  
 cyclopropyl substituted with 0-3 R 41 ;  
 cyclobutyl substituted with 0-3 R 41 ;  
 cyclopentyl substituted with 0-3 R 41 ;  
 cyclohexyl substituted with 0-3 R 41 ;  
 pyridyl substituted with 0-3 R 41 ;  
 indolyl substituted with 0-3 R 41 ;  
 indolinyl substituted with 0-3 R 41 ;  
 benzimidazolyl substituted with 0-3 R 41 ;  
 benzotriazolyl substituted with 0-3 R 41 ;  
 benzothienyl substituted with 0-3 R 41 ;  
 benzofuranyl substituted with 0-3 R 41 ;  
 phthalimid-1-yl substituted with 0-3 R 41 ;  
 inden-2-yl substituted with 0-3 R 41 ;  
 
 2,3-dihydro-1H-inden-2-yl substituted 0-3 R 41 ; 
 indazolyl substituted with 0-3 R 41 ;  
 tetrahydroquinolinyl substituted with 0-3 R 41 ; and  
 tetrahydro-isoquinolinyl substituted with 0-3 R 41 ;  
 
 R 3 , at each occurrence, is independently selected from H, methyl, and ethyl;  
 R 3  is H;  
 R 6a  is selected from H, —OH, methyl, and methoxy;  
 R 6b  is H;  
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from H, F, Cl, methyl, ethyl, 
 methoxy, —CF 3 ,  
 and —OCF 3 ;  
 
 R 41 , at each occurrence, is independently selected from H, F, Cl, Br, OH, CF 3 , NO 2 , CN, ═O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;  
 R 42 , at each occurrence, is independently selected from 
 H, F, Cl, Br, OH, CF 3 , SO 2 R 45 , SR 45 , NR 46 R 47 , OR 48 , NO 2 , CN, ═O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;  
 
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from 
 H, methyl, ethyl, n-propyl, i-propyl, n-butyl,  
 i-butyl, —C(═O)NH(methyl), —C(═O)NH(ethyl),  
 —SO 2 (methyl), —SO 2 (ethyl), —SO 2 (phenyl),  
 —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl),  
 —C(═O)(ethyl), and —C(═O)H;  
 
 R 48 , at each occurrence, is independently selected from 
 H, methyl, ethyl, n-propyl, i-propyl, —C(═O)NH(methyl), —C(═O)NH(ethyl), —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl), —C(═O)(ethyl), and —C(═O)H;  
 
 k is 1;  
 m is 0, 1, or 2; and  
 n is 1 or 2.  
 
     
     
       16. A compound of  claim 12  wherein:
 X is —S—;  
 R 1  is selected from 
 C 2-4  alkyl substituted with Z,  
 C 2-4  alkenyl substituted with Z,  
 C 2-4  alkynyl substituted with Z,  
 C 3-6  cycloalkyl substituted with Z,  
 aryl substituted with Z,  
 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z;  
 C 2-4  alkyl substituted with 1-2 R 2 , where R 2  is other than alkyl; and  
 C 2-4  alkenyl substituted with 0-2 R 2 ;  
 
 Z is selected from 
 —CH(OH)R 2 ,  
 —C(ethylenedioxy)R 2 ,  
 —OR 2 ,  
 —SR 2 ,  
 —NR 2 R 3 ,  
 —C(O)R 2 ,  
 —S(O)R 2 ,  
 —S(O)R 2 ,  
 —S(O) 2 NR 2 R 3 , and —NR 3 S(O) 2 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from phenyl substituted with 0-5 R 42 ; 
 C 3-10  carbocyclic group substituted with 0-3 R 41 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 41 ;  
 
 R 3 , at each occurrence, is independently selected from 
 H, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, and  
 C 1-4  alkoxy;  
 
 alternatively, R 2  and R 3  join to form a 5- or 6-membered ring optionally substituted with —O— or N(R 4)—;    
 R 4 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 5  is H;  
 R 6a  is selected from H, —OH, —CF 3 , methyl, ethyl, propyl, butyl, methoxy, and ethoxy;  
 R 6b  is H;  
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —OCH 3 , —CN, —NO 2 ,  
 C 1-4  alkyl, C 3-4  haloalkyl, C 1-4  alkoxy, (C 1-3  haloalkyl) oxy, and  
 C 1-4  alkyl substituted with 0-2 R 11 ;  
 
 R 11  is selected from 
 H, halo, —CF 3 , —OCF 3 , —OH, —OCH 3 , —CN: —NO 2 ,  
 C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, and (C 1-3  haloalkyl)oxy;  
 
 R 33 , at each occurrence, is independently selected from H, OH, halo, CF 3 , and methyl; 
 R 42 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , NR 46 R 47 , NO 2 , CN, ═O,  
 C 2-8  alkenyl, C 2-8  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 42 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 42 , at each occurrence, is independently selected from H, CF 3 , halo, OH, CO 2 H, SO 2 R 45 , SR 45 , NR 46 R 47 , OR 48 , NO 2 , CN, CH(═NH)NH 2 , NHC(═NH)NH 2 , 
 C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 3-6  cycloalkyl,  
 C 1-4  alkyl substituted with 0-1 R 43 ,  
 aryl substituted with 0-3 R 44 , and  
 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R 44 ;  
 
 R 43  is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R 44 ;  
 R 44 , at each occurrence, is independently selected from H, halo, —OH, NR 46 R 47 , CO 2 H, SO 2 R 45 , —CF 3 , —OCF 3 , —CN, —NO 2 , methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy;  
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl,  
 R 47 , at each occurrence, is independently selected from 
 H, methyl, ethyl, n-propyl, i-propyl, n-butyl,  
 i-butyl, —C(═O)NH(methyl), —C(═O)NH(ethyl),  
 —SO 2 (methyl), —SO 2 (ethyl), —SO 2 (phenyl),  
 —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl),  
 
 —C(═O)(ethyl), and —C(═O)H;  
 R 49 , at each occurrence, is independently selected from 
 H, methyl, ethyl, n-propyl, —C(═O)NH(methyl),  
 —C(═O)NH(ethyl), —C(═O)O(methyl),— 
 C(═O)O(ethyl), —C(═O)O(methyl),  
 —C(═O)(ethyl), and —C(═)H;  
 
 k is 1;  
 m is 0, 1 or 2; and  
 n is 1 or 2.  
 
     
     
       17. A compound of  claim 12  wherein:
 X is —O—;  
 R 1  is selected from 
 ethyl substituted with Z;  
 propyl substituted with Z;  
 butyl substituted with Z;  
 propenyl substituted with Z;  
 butenyl substituted with Z;  
 ethyl substituted with R 2 ;  
 propyl substituted with R 2 ;  
 butyl substituted with R 2 ; provided that with respect to ethyl, propyl and butyl, R 2  is other than alkyl;  
 propenyl substituted with R 2 ; and  
 butenyl substituted with R 2 ;  
 
 Z is selected from 
 —CH(OH)R 2 ,  
 —OR 2 ,  
 —SR 2 ,  
 —NR 2 R 3 ,  
 —C(O)R 2 ,  
 —(O)NR 2 R 3 ,  
 —NR 3 C(O)R 2 ,  
 —C(O)OR 2 ,  
 —S(O)R 2 ,  
 —S(O) 2 R 2 ,  
 —S(O) 2 NR 2 R 3 , and —NR 3 S(O) 2 R 2 ;  
 
 R 2 , at each occurrence, is independently selected from 
 phenyl substituted with 0-3 R 42 ,  
 naphthyl substituted with 0-3 R 42 ;  
 cyclopropyl substituted with 0-3 R 41 ;  
 cyclobutyl substituted with 0-3 R 41 ;  
 cyclopentyl substituted with 0-3 R 41 ;  
 cyclohexyl substituted with 0-3 R 41 ;  
 pyridyl substituted with 0-3 R 41 ;  
 indolyl substituted with 0-3 R 41 ;  
 indolinyl substituted with 0-3 R 41 ;  
 benzimidazolyl substituted with 0-3 R 41 ;  
 benzotriazolyl substituted with 0-3 R 41 ;  
 benzothienyl substituted with 0-3 R 41 ;  
 benzofuranyl substituted with 0-3 R 41 ;  
 phthalimid-1-yl substituted with 0-3 R 41 ;  
 inden-2-yl substituted with 0-3 R 41 ;  
 
 2,3-dihydro-1H-inden-2-yl substituted 0-3 R 41 ; 
 indazolyl substituted with 0-3 R 41 ;  
 tetrahydroquinolinyl substituted with 0-3 R 41 ; and  
 tetrahydro-isoquinolinyl substituted with 0-3 R 41 ;  
 
 R 3 , at each occurrence, is independently selected from H, methyl, and ethyl;  
 R 5  is H;  
 R 6a  is selected from H, —OH, methyl, and methoxy;  
 R 6b  is H;  
 R 7 , R 8 , and R 9 , at each occurrence, are independently 
 selected from H, F, Cl, methyl, ethyl,  
 methoxy, —CF 3 ,  
 and —OCF 3 ,  
 
 R 41 , at each occurrence, is independently selected from H, F, Cl, Br, OH, CF 3 , NO 2 , CN, ═O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy;  
 R 42 , at each occurrence, is independently selected from 
 H, F, Cl, Br, OH, CF 3 , SO 2 R 45 , SR 45 , NR 46 R 47 , OR 48 ,  
 NO 2 , CN, ═O, methyl, ethyl, propyl, butyl,  
 methoxy, and ethoxy;  
 
 R 45  is methyl, ethyl, propyl, or butyl;  
 R 46 , at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl;  
 R 47 , at each occurrence, is independently selected from 
 H, methyl, ethyl, n-propyl, i-propyl, n-butyl,  
 i-butyl, —(C═O)NH(methyl), —C(═O)NH(ethyl),  
 —SO 2 (methyl), —SO 2 (ethyl), —SO 2 (phenyl),  
 —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl),  
 —C(═O)(ethyl), and —C(═O)H;  
 
 R 48 , at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, —C(═O)NH (methyl), —C(═O)H(ethyl), —C(═O)O(methyl), —C(═O)O(ethyl), —C(═O)(methyl), —C(═O)(ethyl), and —C(═O)H;  
 k is 1;  
 m is 0, 1, or 2; and  
 n is 1 or 2.  
 
     
     
       18. A compound of  claim 12  of Formula (I-a) 
                 
 
       wherein:
 b is a single bond;  
 X is —S— or —O—;  
 R 1  is selected from 
 —C(CH 2 ) 3 C(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(4-bromo-phenyl),  
 —(CH 2 ) 3 C(═O)(4-methyl-phenyl),  
 —(CH 2 ) 3 C(═O)(4-methoxy-phenyl),  
 —(CH 2 ) 3 C(═O)(4-(3,4-dichloro-phenyl)phenyl),  
 —(CH 2 ) 3 C(═O)(3-methyl-4-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(2,3-dimethoxy-phenyl),  
 —(CH 2 ) 3 C(═O)(phenyl),  
 —(CH 2 ) 3 C(═O)(4-chloro-phenyl),  
 —(CH 2 ) 3 C(═O)(3-methyl-phenyl),  
 —(CH 2 ) 3 C(═O)(4-t-butyl-phenyl),  
 —(CH 2 ) 3 C(═O)(3,4-difluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(2-methoxy-5-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(4-fluoro-1-naphthyl),  
 —(CH 2 ) 3 C(═O)(benzyl),  
 —(CH 2 ) 3 C(═O)(4-pyridyl),  
 —(CH 2 ) 3 C(═O)(3-pyridyl),  
 —(CH 2 ) 3 CH(OH)(4-fluoro-phenyl),  
 —(CH 2 ) 3 CH(OH)(4-pyridyl),  
 —(CH 2 ) 3 CH(OH)(2,3-dimethoxy-phenyl),  
 —(CH 2 ) 3 S(3-fluoro-phenyl),  
 —(CH 2 ) 3 S(4-fluoro-phenyl),  
 —(CH 2 ) 3 S(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 3 SO 2 (3-fluoro-phenyl),  
 —(CH 2 ) 3 SO 2 (4-fluoro-phenyl),  
 —(CH 2 ) 3 O(4-fluoro-phenyl),  
 —(CH 2 ) 3 O(phenyl),  
 —(CH 2 ) 3 O(3-pyridyl),  
 —(CH 2 ) 3 O(4-pyridyl),  
 —(CH 2 ) 3 O(2-NH 2 -phenyl),  
 —(CH 2 ) 2 O(2-NH 2 -5-F-phenyl),  
 —(CH 2 ) 3 O(2-NH 2 -4-F-phenyl),  
 —(CH 2 ) 3 O(2-NH 2 -3-F-phenyl),  
 —(CH 2 ) 3 O(2-NH 2 -4-Cl-phenyl),  
 —(CH 2 ) 3 O(2-NH 2 -4-OH-phenyl),  
 —(CH 2 ) 3 O(2-NH 2 -4-Br-phenyl),  
 —(CH 2 ) 3 O(2-NHC(═O)Me-4-phenyl),  
 —(CH 2 ) 3 O(2-NHC(═O)Me-phenyl),  
 —(CH 2 ) 3 NH(4-fluoro-phenyl),  
 —(CH 2 ) 3 N(methyl)(4-fluoro-phenyl),  
 —(CH 2 ) 3 CO 2 (ethyl),  
 —(CH 2 ) 3 C(═O)N(methyl)(methoxy),  
 —(CH 2 ) 3 C(═O)NH(4-fluoro-phenyl),  
 —(CH 2 ) 3 NHC(═O)(phenyl),  
 —(CH 2 ) 2 (NMeC(═O)(phenyl),  
 —(CH 2 ) 2 NHC(═O)(2-fluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(2-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(2,4-difluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(2,4-difluoro-phenyl),  
 —(CH 2 ) 3 (3-indolyl),  
 —(CH 2 ) 3 (1-methyl-3-indolyl),  
 —(CH 2 ) 3 (1-indolyl),  
 —(CH 2 ) 3 (1-indolinyl),  
 —(CH 2 ) 3 (1-benzimidazolyl),  
 —(CH 2 ) 3 (1H-1,2,3-benzotriazol-1-yl),  
 —(CH 2 ) 3 (1H-1,2,3-benzotriazol-2-yl),  
 —(CH 2 ) 2 (1H-1,2,3-benzotriazol-1-yl),  
 —(CH 2 ) 2 (1H-1,2,3-benzotriazol-2-yl),  
 —(CH 2 ) 3 (3,4 dihydro-1(2H)-quinolinyl),  
 —(CH 2 ) 2 C(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 C(═O)NH(4-fluoro-phenyl),  
 —CH 2 CH 2 (3-indolyl),  
 —CH 2 CH 2 (1-phthalimidyl),  
 —(CH 2 ) 4 C(═O)N(methyl)(methoxy),  
 —(CH 2 ) 4 CO 2 (ethyl),  
 —(CH 2 ) 4 C(═O)(phenyl),  
 —(CH 2 ) 3 CH(phenyl) 2 ,  
 —CH 2 CH 2 CH═C(phenyl) 2 ,  
 —CH 2 CH 2 CH═CMe(4-F-phenyl),  
 —(CH 2 ) 3 CH(4-fluoro-phenyl) 2 ,  
 —CH 2 CH 2 CH═C(4-fluoro-phenyl) 2 ,  
 —(CH 2 ) 2 (2,3-dihydro-1H-inden-2-yl), —(CH 2 ) 3 C(═O)(2-NH 2 -phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -5-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 4 -4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -3-F-phenyl),  
 —(CH 2 ) 3 C(═O((2-NH 2 -4-Cl-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-OH-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-Br-phenyl),  
 —(CH 2 ) 3 (1H-indazol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 (7-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 (6-Cl-1H-indazol-3-yl),  
 —(CH 2 ) 3 (6-Br-1H-indazol-3-yl),  
 —(CH 2 ) 3 C(═O)(2-NHMe-phenyl),  
 —(CH 2 ) 3 (1-benzothien-3-yl),  
 —(CH 2 ) 3 (6-F-1H-indazol-1-yl),  
 —(CH 2 ) 3 (5-F-1H-indazol-1-yl),  
 —(CH 2 ) 3 (6-F-2,3-dihydro-1H-indol-1-yl),  
 —(CH 2 ) 3 (5-F-2,3-dihydro-1H-indol-1-yl),  
 —(CH 2 ) 3 (6-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (9H-purin-9-yl),  
 —(CH 2 ) 3 (7H-purin-7-yl),  
 —(CH 2 ) 3 (6-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)Me-4-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)Me-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHCO 2 Et-4-F-phenyl),  
 —(CH 2 ) 3 C(═O) (2-NHC(═O)NHEt-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHCHO-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-OH-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-MeS-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)CO 2 Me,  
 —(CH 2 ) 2 C(Me)CH(OH)(4-F-phenyl) 2 ,  
 —(CH 2 ) 2 C(Me)C(OH)(4-Cl-phenyl) 2 ,  
 —(CH 2 ) 2 C(Me)C(═O)(4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(2-MeO-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(3-Me-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(2-Me-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)phenyl, 
                 
 
 
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from 
 hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluromethyl, methoxy, ethoxy, isopropoxy, trifluoromethoxy, phenyl, benzyl,  
 HC(═O)—, methylC(═O)—, ethylC(═O)—, propylC(═O)—, isopropylC(═O)—, n-butylC(═O)—, isobutylC(═O)—, secbutylC(═O)—, tertbutylC(═O)—, phenylC(═O)—,  
 methylC(═O)NH—, ethylC(═O)NH—, propylC(═O)NH—, isopropylC(═O)NH—, n-butylC(═O)NH—, isobutylC(═O)NH—, secbutylC(═O)NH—, tertbutylC(═O)NH—, phenylC(═O)NH—,  
 methylamino-, ethylamino-, propylamino-, isopropylamino-, n-butylamino-, isobutylamino-, secbutylamino-, tertbutylamino-, phenylamino-, p2 provided that two of substituents R 7 , R 8 , and R 9 , are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, and trifluoromethoxy;  
 
 k is 1 or 2;  
 m is 1 or 2; and  
 n is 1 or 2.  
 
     
     
       19. A compound of  claim 18  of Formula (II-a) 
                 
 
       wherein:
 b is a single bond, wherein the bridge hydrogens are in a cis position;  
 R 1  is selected from 
 —(CH 2 ) 3 C(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(4-bromo-phenyl),  
 —(CH 2 ) 3 C(═O)(4-methyl-phenyl),  
 —(CH 2 ) 3 C(═O)(4-methoxy-phenyl),  
 —(CH 2 ) 3 C(═O)(4-(4-dichloro-phenyl)phenyl),  
 —(CH 2 ) 3 C(═O)(3-methyl-4-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(2,3-dimethoxy-phenyl),  
 —(CH 2 ) 3 C(═O)(phenyl),  
 —(CH 2 ) 3 C(═O)(4-chloro-phenyl),  
 —(CH 2 ) 3 C(═O)(3-methyl-phenyl),  
 —(CH 2 ) 3 C(═O)(4-t-butyl-phenyl),  
 —(CH 2 ) 3 C(═O)(3,4-difluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(2-methoxy-5-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(4-fluoro-1-naphthyl),  
 —(CH 2 ) 3 C(═O)(benzyl),  
 —(CH 2 ) 3 C(═O)(4-pyridyl),  
 —(CH 2 ) 3 C(═O)(3-pyridyl),  
 —(CH 2 ) 3 CH(OH)(4-fluoro-phenyl),  
 —(CH 2 ) 3 CH(OH)(4-pyridyl),  
 —(CH 2 ) 3 CH(OH)(2,3-dimethoxy-phenyl),  
 —(CH 2 ) 3 S(3-fluoro-phenyl),  
 —(CH 2 ) 3 S(4-fluoro-phenyl),  
 —(CH 2 ) 3 S(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 3 SO 2 (3-fluoro-phenyl),  
 —(CH 2 ) 3 SO 2 (4-fluoro-phenyl),  
 —(CH 2 ) 3 O(4-fluoro-phenyl),  
 —(CH 2 ) 3 O(phenyl),  
 —(CH 2 ) 3 NH(4-pyridyl),  
 —(CH 2 ) 3 N(methyl)(4-fluoro-phenyl),  
 —(CH 2 ) 3 CO 2 (ethyl),  
 —(CH 2 ) 3 C(═O)N(methyl)(methoxy),  
 —(CH 2 ) 3 C(═O)NH(4-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(phenyl),  
 —(CH 2 ) 2 NMeC(═O)(phenyl),  
 —(CH 2 ) 2 NHC(═O)(2-fluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(2-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)4-fluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(2,4-difluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(2,4-difluoro-phenyl),  
 —(CH 2 ) 3 (3-indolyl),  
 —(CH 2 ) 3 (1-methyl-3-indolyl),  
 —(CH 2 ) 3 (1-indolyl),  
 —(CH 2 ) 3 (1-indolinyl),  
 —(CH 2 ) 3 (1-benzimidazolyl),  
 —(CH 2 ) 3 (1H-1,2,3-benzotriazol-1-yl),  
 —(CH 2 ) 3 (1H-1,2,3-benzotriazol-2-yl),  
 —(CH 2 ) 2 (1H-1,2,3-benzotriazol-1-yl),  
 —(CH 2 ) 2 (1H-1,2,3-benzotriazol-2-yl),  
 —(CH 2 ) 3 (3,4 dihydro-1(2H)-quinolinyl),  
 —(CH 2 ) 2 C(═)(4-fluoro-phenyl),  
 —(CH 2 ) 2 C(═O)NH(4-fluoro-phenyl),  
 —CH 2 CH 2 (3-indolyl),  
 —CH 2 CH 2 (1-phthalimidyl),  
 —(CH 2 ) 4 C(═O)N(methyl)(methoxy),  
 —(CH 2 ) 4 CO 2 (ethyl),  
 —(CH 2 ) 4 C(═O)(phenyl),  
 —(CH 2 ) 3 CH(phenyl) 2 ,  
 —CH 2 CH 2 CH═C(phenyl) 2 ,  
 —CH 2 CH 2 CH═CMe(4-F-phenyl),  
 —(CH 2 ) 3 CH(4-fluoro-phenyl) 2 ,  
 —CH 2 CH 2 CH═C(4-fluoro-phenyl) 2 ,  
 —(CH 2 ) 2 (2,3-dihydro-1H-inden-2-yl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -5-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -3-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-Cl-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-OH-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-Br-phenyl),  
 —(CH 2 ) 3 (1H-indazol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 (7-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 (6-Cl-1H-indazol-3-yl),  
 —(CH 2 ) 3 (6-Br-1H-indazol-3-yl),  
 —(CH 2 ) 3 C(═O)(2-NHMe-phenyl),  
 —(CH 2 ) 3 (1-benzothien-3-yl),  
 —(CH 2 ) 3 (6-F-1H-indol-1-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-1-yl),  
 —(CH 2 ) 3 (6-F-2,3-dihydro-1H-indol-1-yl),  
 —(CH 2 ) 3 (5-F-2,3-dihydro-1H-indol-1-yl),  
 —(CH 2 ) 3 (6-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (9H-purin-9-yl),  
 —(CH 2 ) 3 (7H-purin-7-yl),  
 —(CH 2 ) 3 (6-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHCO 2 Et-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)NHEt-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHCHO-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-OH-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-MeS-4-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)CO 2 Me,  
 —(CH 2 ) 2 C(Me)CH(OH)(4-F-phenyl) 2 ,  
 —(CH 2 ) 2 C(ME)CH(OH)(4-Cl-phenyl) 2 ,  
 —(CH 2 ) 2 C(Me)C(═O)(4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(2-MeO-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(3-Me-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(2-Me-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)phenyl, 
                 
 
 
 R 7 , R 8 , and R 9 , at each occurrence, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropyoxy, trifluoromethoxy, methylC(═O)—, ethylC(═O)—, propylC(═O)—, isopropylC(═O)—, methylC(═O)NH—, ethylC(═O)NH—, propylC(═O)NH—, isopropylC(═O)NH, methylamino-, ethylamino-, propylamino-, and isopropylamino-, provided that two of substituents R 7 , R 8 , and R 9 , are independently selected from hydrogen, fluoro, chloro, methyl, trifluoromethyl, methoxy, and trifluoromethoxy;  
 m is 1 or 2; and  
 n is 1 or 2.  
 
     
     
       20. A compound of  claim 18  of Formula (III-a) 
                 
 
       wherein:
 b is a single bond, wherein the bridge hydrogens are in a cis position;  
 R 1  is selected from 
 —(CH 2 ) 3 C(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(4-bromo-phenyl),  
 —(CH 2 ) 3 C(═O)(4-methyl-phenyl),  
 —(CH 2 ) 3 C(═O)(4-methoxy-phenyl),  
 —(CH 2 ) 3 C(═O)(4-(3,4-dichloro-phenyl)phenyl),  
 —(CH 2 ) 3 C(═O)(3-methyl-4-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(2,3-dimethoxy-phenyl),  
 —(CH 2 ) 3 C(═O)(phenyl),  
 —(CH 2 ) 3 C(═O)(4-chloro-phenyl),  
 —(CH 2 ) 3 C(═O)(3-methyl-phenyl),  
 —(CH 2 ) 3 C(═O)(4-t-butyl-phenyl),  
 —(CH 2 ) 3 C(═O)(3,4-difluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(2-methoxy-5-fluoro-phenyl),  
 —(CH 2 ) 3 C(═O)(4-fluoro-1-naphthyl),  
 —(CH 2 ) 3 C(═O)(benzyl),  
 —(CH 2 ) 3 C(═O)(pyridyl),  
 —(CH 2 ) 3 C(═O)(3-pyridyl),  
 —(CH 2 ) 3 CH(OH)(4-fluoro-phenyl),  
 —(CH 2 ) 3 CH(OH)(4-pyridyl),  
 —(CH 2 ) 3 CH(OH)(2,3-dimethoxy-phenyl),  
 —(CH 2 ) 3 S(3-fluoro-phenyl),  
 —(CH 2 ) 3 S(4-fluoro-phenyl),  
 —(CH 2 ) 3 S(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 3 SO 2 (3-fluoro-phenyl),  
 —(CH 2 ) 3 SO 2 (4-fluoro-phenyl),  
 —(CH 2 ) 3 O(4-fluoro-phenyl),  
 —(CH 2 ) 3 O(phenyl),  
 —(CH 2 ) 3 NH(4-fluoro-phenyl),  
 —(CH 2 ) 3 N(methyl)(4-fluoro-phenyl),  
 —(CH 2 ) 3 CO 2 (ethyl),  
 —(CH 2 ) 3 C(═O)N(methyl)(methoxy),  
 —(CH 2 ) 3 C(═O)NH(4-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(phenyl),  
 —(CH 2 ) 2 NMeC(═O)(phenyl),  
 —(CH 2 ) 2 NHC(═O)(2-fluorophenyl),  
 —(CH 2 ) 2 NMeC(═O)(2-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 NHC(═O)(2,4-difluoro-phenyl),  
 —(CH 2 ) 2 NMeC(═O)(2,4-difluoro-phenyl),  
 —(CH 2 ) 3 (3-incolyl),  
 —(CH 2 ) 3 (1-methyl-3-indolyl),  
 —(CH 2 ) 3 (1-indolyl),  
 —(CH 2 ) 3 (1-indolinyl),  
 —(CH 2 ) 3 (1-benzimidazolyl),  
 —(CH 2 ) 3 (1H-1,2,3-benzotriazol-1-yl),  
 —(CH 2 ) 3 (1H-1,2,3-benzotriazol-2-yl),  
 —(CH 2 ) 2 (1H-1,2,3-benzotriazol-1-yl),  
 —(CH 2 ) 2 (1H-1,2,3-benzotriazol-2-yl),  
 —(CH 2 ) 3 (3,4-dihydro-1(2H)-quinolinyl),  
 -(CH 2 ) 2 C(═O)(4-fluoro-phenyl),  
 —(CH 2 ) 2 C(═O)NH(4-fluoro-phenyl),  
 —CH 2 CH 2 (3-indolyl),  
 —CH 2 CH 2 (1-phthalimidyl),  
 —(CH 2 ) 4 C(═O)N(methyl)(methoxy),  
 —(CH 2 ) 4 CO 2 (ethyl),  
 —(CH 2 ) 4 C(═O)(phenyl),  
 —(CH 2 ) 3 CH(phenyl) 2 ,  
 —CH 2 CH 2 CH═C(phenyl) 2 ,  
 —CH 2 CH 2 CH═CMe(4-F-phenyl),  
 —(CH 2 ) 3 CH(4-fluoro-phenyl) 2 ,  
 —CH 2 CH 2 CH═C(4-fluoro-phenyl) 2 ,  
 —(CH 2 ) 2 (2,3-dihydro-1H-inden-2-yl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -5-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -3-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-Cl-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-OH-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NH 2 -4-Br-phenyl),  
 —(CH 2 ) 3 (1H-indazol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 (7-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 (6-Cl-1H-indazol-3-yl),  
 —(CH 2 ) 3 (6-Br-1H-indazol-3-yl),  
 —(CH 2 ) 3 C(═O)(2-NHMe-phenyl),  
 —(CH 2 ) 3 (1-benzothien-3-yl),  
 —(CH 2 ) 3 (6-F-1H-indol-1-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-1-yl),  
 —(CH 2 ) 3 (6-F-2,3-dihydro-1H-indol-1-yl),  
 —(CH 2 ) 3 (5-F-2,3-dihydro-1H-indol-1-yl),  
 —(CH 2 ) 3 (6-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (5-F-1H-indol-3-yl),  
 —(CH 2 ) 3 (9H-purin-9-yl),  
 —(CH 2 ) 3 (7H-purin-7-yl),  
 —(CH 2 ) 3 (6-F-1H-indazol-3-yl),  
 —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)Me-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHCO 2 -Et-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHC(═O)NHEt-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHCHO-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-OH-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-MeS-4-F-phenyl),  
 —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)CO 2 Me,  
 —(CH 2 ) 2 C(Me)CH(OH)(4-F-phenyl) 2 ,  
 —(CH 2 ) 2 C(Me)CH(OH)(4-Cl-phenyl) 2 ,  
 —(CH 2 ) 2 C(Me)C(═O)(4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(2-MeO-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(3-Me-4-F-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)(2-Me-phenyl),  
 —(CH 2 ) 2 C(Me)C(═O)phenyl, 
                 
 
 
 R 7 , R 8 , R 9 , at each occurrence, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, trifluoromethoxy, methylC(═O)—, ethylC(═O)—, propylC(═O)—, isopropylC(═O)—, methylC(═O)NH—, ethylC(═O)NH—, propylC(═O)NH—, isopropyl-C(═O)NH, methylamino-, ethylamino-, propylamino-, and isopropylamino-,  
 provided that two of substituents R 7 , R 8 , and R 9 , are independently selected from hydrogen, fluoro, chloro, methyl, trifluoromethyl, methoxy, and trifluoromethoxy;  
 m is 1 or 2; and  
 n is 1 or 2.  
 
     
     
       21. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claims  1 - 20  or a pharmaceutically acceptable salt thereof. 
     
     
       22. A method for treating a human suffering from a disorder associated with 5HT2C receptor modulation selected from obesity, anorexia, bulemia, depression, anxiety, psychosis, schizophrenia, migraine, addictive behavior, obsessive-compulsive disorder, and sexual disorders; comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims  1 - 11  or a pharmaceutically acceptable salt thereof. 
     
     
       23. A method for treating a human suffering from a disorder associated with 5HT2A receptor modulation selected from depression, psychosis, schizophrenia, migraine, attention deficit disorder, attention deficit hyperactivity disorder, obsessive-compulsive disorder, and sleep disorders; comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims  12 - 20 , or a pharmaceutically acceptable salt thereof. 
     
     
       24. A method for treating obesity comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims  1 - 11 , or a pharmaceutically acceptable salt thereof. 
     
     
       25. A method for treating schizophrenia comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims  12 - 20  or a pharmaceutically acceptable salt thereof. 
     
     
       26. A method for treating depression comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claims  12 - 20  or a pharmaceutically acceptable salt thereof. 
     
     
       27. A compound of  claim 12  selected from the compounds disclosed in Table 1:
             TABLE 1                                                             Ex #   R 7     R 8     R 9     b   R 1                                       25   H   H   H   sgl   —C(═O)(3,4-diMeO-phenyl)     26   H   H   H   sgl   —C(═O)(2,5-diMeO-phenyl)     27   H   H   H   sgl   —C(═O)(3,5-diMeO-phenyl)     28   H   H   H   sgl   2,6-diMeO-benzyl     29   H   H   H   sgl   2,4-diMeO-benzyl     30   H   H   H   sgl   2,4,6-triMeO-benzyl     31   H   H   H   sgl   2,3-diMeO-benzyl     32   H   H   H   sgl   2,4,5-triMeO-benzyl     33   H   H   H   sgl   cyclohexylmethyl     34   H   H   H   sgl   2,3,4-triMeO-benzyl     35   H   H   H   sgl   3,4-diMeO-benzyl     36   H   H   H   sgl   3,4,5-triMeO-benzyl     39   H   H   H   sgl   —CO 2 Et     40   H   —C(═O)CH 3     H   sgl   —CO 2 Et     41   H   —NHC(═O)CH 3     H   sgl   —CO 2 Et     42   H   H   H   sgl   —CH 2 CH 2 (4-F-phenyl)     46   H   H   H   sgl   pentyl     47   H   H   H   sgl   hexyl     50   H   H   H   sgl   2-pentyl     51   H   H   H   sgl   2-hexyl     53   H   H   H   sgl   2-Me-butyl     54   H   H   H   sgl   2-Me-pentyl     55   H   H   H   sgl   2-Et-butyl     56   H   H   H   sgl   3-Me-pentyl     57   H   H   H   sgl   3-Me-butyl     58   H   H   H   sgl   4-Me-pentyl     59   H   H   H   sgl   cyclopropylmethyl     60   H   H   H   sgl   cyclobutylmethyl     61   H   H   H   sgl   cyclohexylmethyl     62   H   H   H   sgl   2-propenyl     63   H   H   H   sgl   2-Me-2-propenyl     64   H   H   H   sgl   trans-2-butenyl     65   H   H   H   sgl   3-Me-butenyl     66   H   H   H   sgl   3-butenyl     67   H   H   H   sgl   trans-2-pentenyl     68   H   H   H   sgl   cis-2-pentenyl     69   H   H   H   sgl   4-pentenyl     70   H   H   H   sgl   4-Me-3-pentenyl     71   H   H   H   sgl   3,3-diCl-2-propenyl     72   H   H   H   sgl   benzyl     73   H   H   H   sgl   2-Me-benzyl     74   H   H   H   sgl   3-Me-benzyl     75   H   H   H   sgl   4-Me-benzyl     76   H   H   H   sgl   2,5-diMe-benzyl     77   H   H   H   sgl   2,4-diMe-benzyl     78   H   H   H   sgl   3,5-diMe-benzyl     79   H   H   H   sgl   2,4,6-triMe-benzyl     80   H   H   H   sgl   3-MeO-benzyl     81   H   H   H   sgl   3,5-diMeO-benzyl     82   H   H   H   sgl   pentafluorobenzyl     83   H   H   H   sgl   2-phenylethyl     84   H   H   H   sgl   1-phenyl-2-propyl     85   H   H   H   sgl   trans-3-phenyl-2-propenyl     86   H   H   H   sgl   4-phenylbutyl     87   H   H   H   sgl   4-phenylbenzyl     88   H   H   H   sgl   2-phenylbenzyl     178   Cl   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     179   Me   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     180   H   H   H   sgl   —(CH 2 ) 3 S(3-F-phenyl)     181   H   H   H   sgl   —(CH 2 ) 3 CH(OH)(4-F-phenyl)     186   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     187   H   MeO   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     192   H   H   H   sgl   —(CH 2 ) 3 (═O)(4-Br-phenyl)     193   H   H   H   sgl   —(CH 2 ) 3 SO 2 (3-F-phenyl)     194   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-(3,4-diCl-phenyl)phenyl)     197   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-Me-phenyl)     198   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     199   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-MeO-phenyl)     200   H   H   H   sgl   —(CH 2 ) 2 C(═O)(4-F-phenyl)     201   H   H   H   sgl   —(CH 2 ) 3 SO 2 (4-F-phenyl)     202   H   H   H   sgl   —(CH 2 ) 3 S(═O)(4-F-phenyl)     203   H   H   H   sgl   —(CH 2 ) 3 O(4-F-phenyl)     204   H   H   H   sgl   —(CH 2 ) 3 O(phenyl)     205   H   H   H   sgl   —(CH 2 ) 3 S(4-F-phenyl)     206   H   H   H   sgl   —(CH 2 ) 3 NH(4-F-phenyl)     207   H   H   H   sgl   —(CH 2 ) 3 N(CH 3 )(4-F-phenyl)     208   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-pyridyl)     209   H   H   H   sgl   —(CH 2 ) 3 C(═O)(3-pyridyl)     214   H   H   H   sgl                           215   H   H   H   sgl                           219   H   H   H   sgl   —(CH 2 ) 3 CO 2 Et     220   H   H   H   sgl   —(CH 2 ) 4 CO 2 Et     221   H   H   H   sgl   —(CH 2 ) 3 C(═O)N(CH 3 )(OCH 3 )     222   H   H   H   sgl   —(CH 2 ) 4 C(═O)N(CH 3 )(OCH 3 )     223   H   H   H   sgl   —(CH 2 ) 3 C(═O)(3-Me-4-F-phenyl)     224   H   H   H   sgl   —(CH 2 ) 3 C(═O)(phenyl)     225   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-Cl-phenyl)     226   H   H   H   sgl   —(CH 2 ) 3 C(═O)(3-Me-phenyl)     227   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-tBu-phenyl)     228   H   H   H   sgl   —(CH 2 ) 3 C(═O)(3,4-diF-phenyl)     229   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-MeO-5-F-phenyl)     230   H   H   H   sgl   —(CH 2 ) 4 C(═O)(phenyl)     231   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-1-naphthyl)     232   H   H   H   sgl   —(CH 2 ) 3 C(═O)(benzyl)     233   H   H   H   sgl   —(CH 2 ) 2 C(═O)NH(4-F-phenyl)     234   H   H   H   sgl   —(CH 2 ) 3 C(═O)NH(4-F-phenyl)     235   H   H   H   sgl   —(CH 2 ) 3 CH(OH)(4-F-phenyl)     236   H   H   H   sgl   —(CH 2 ) 3 CH(OH)(4-pyridyl)     237   H   H   H   sgl   —(CH 2 ) 3 CH(OH)(2,3-diMeO-phenyl)     238   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2,3-diMeO-phenyl)     239   H   H   H   sgl   —(CH 2 ) 4 (cyclohexyl)     240   H   H   H   sgl   —(CH 2 ) 3 CH(phenyl) 2       241   H   H   H   sgl   —CH 2 CH 2 CH═C(phenyl) 2       242   H   H   H   sgl   —(CH 2 ) 3 CH(4-F-phenyl) 2       243   H   H   H   sgl   —CH 2 CH 2 CH═C(4-F-phenyl) 2       244   H   H   H   sgl   —(CH 2 ) 2 NHC(═O)(phenyl)     245   H   H   H   sgl   —(CH 2 ) 2 NHC(═O)(2-F-phenyl)     246   H   H   H   sgl   —(CH 2 ) 2 NHC(═O)(4-F-phenyl)     247   H   H   H   sgl   —(CH 2 ) 3 (3-indolyl)     248   H   H   H   sgl   —(CH 2 ) 3 (1-Me-3-indolyl)     249   H   H   H   sgl   —CH 2 CH 2 (3-indolyl)     250   H   H   H   sgl   —(CH 2 ) 3 (1-indolyl)     251   H   H   H   sgl   —(CH 2 ) 3 (1-indolinyl)     252   H   H   H   sgl   —(CH 2 ) 3 (1-benzimidazolyl)     253   H   H   H   sgl                           254   H   H   H   sgl                           268   H   F   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     286   H   H   H   sgl   —(CH 2 ) 2 NHO(═O)(2,4-diF-phenyl)     287   H   H   H   sgl   —(CH 2 ) 2 NMeO(═O)-phenyl     288   H   H   H   sgl   —(CH 2 ) 2 NMeO(═O)(2-F-phenyl)     289   H   H   H   sgl   —(CH 2 ) 2 NMeO(═O)(2,4-diF-phenyl)     290   H   H   H   sgl   —(CH 2 ) 2 NMeO(═O)(4-F-phenyl)     291   H   H   H   sgl   —(CH 2 ) 3 (1H-1,2,3-benzotriazol-1-yl)     292   H   H   H   sgl   —(CH 2 ) 3 (1H-1,2,3-benzotriazol-2-yl)     293   H   H   H   sgl                           294   H   H   H   sgl                           295   H   H   H   sgl                           296   H   H   H   sgl                           297   H   H   H   sgl   —(CH 2 ) 2 (1H-1,2,3-benzotriazol-1-yl)     298   H   H   H   sgl   —(CH 2 ) 2 (1H-1,2,3-benzotriazol-2-yl)     299   H   H   H   sgl   —(CH 2 ) 3 (3,4-dihydro-1(2H)-quinolyl)     300   H   H   H   sgl   —CH 2 CH 2 CH═CMe(4-F-phenyl)     301   H   H   H   sgl   —(CH 2 ) 2 (2,3-dihydro-1H-inden-2-yl)     302   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -phenyl)     303   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -phenyl)     304   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -5-F-phenyl)     305   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -3-F-phenyl)     306   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-Cl-phenyl)     307   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-OH-phenyl)     308   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-Br-phenyl)     309   H   H   H   sgl   —(CH 2 ) 3 (1H-indazol-3-yl)     310   H   H   H   sgl   —(CH 2 ) 3 (5-F-1H-indazol-3-yl)     311   H   H   H   sgl   —(CH 2 ) 3 (7-F-1H-indazol-3-yl)     312   H   H   H   sgl   —(CH 2 ) 3 (6-Cl-1H-indazol-3-yl)     313   H   H   H   sgl   —(CH 2 ) 3 (6-Br-1H-indazol-3-yl)     314   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHMe-phenyl)     315   H   H   H   sgl   —(CH 2 ) 3 (1-benzothien-3-yl)     355   H   H   H   sgl                           356   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-indol-1-yl)     357   H   H   H   sgl   —(CH 2 ) 3 (5-F-1H-indol-1-yl)     358   H   H   H   sgl   —(CH 2 ) 3 (6-F-2,3-dihydro-1H-indol-1-yl)     359   H   H   H   sgl   —(CH 2 ) 3 (5-F-2,3-dihydro-1H-indol-1-yl)     360   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-indol-3-yl)     361   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-indol-3-yl)     362   H   H   H   sgl   —(CH 2 ) 3 (5-F-1H-indol-3-yl)     363   H   H   H   sgl   —(CH 2 ) 3 (5-F-1H-indol-3-yl)     364   H   H   H   sgl   —(CH 2 ) 3 (9H-purin-9-yl)     365   H   H   H   sgl   —(CH 2 ) 3 (7H-purin-7-yl)     366   H   H   H   sgl                           367   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-indazol-3-yl)     368   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-indazol-3-yl)     369   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-indazol-3-yl)     370   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-F-phenyl)     371   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-F-phenyl)     372   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl)     373   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHO(═O)Me-4-F-phenyl)     374   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHO(═O)Me-4-F-phenyl)     375   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHCO 2 Et-4-F-phenyl)     376   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHO(═O)NHEt-4-F-phenyl)     377   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHCHO-4-F-phenyl)     378   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-OH-4-F-phenyl)     379   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-MeS-4-F-phenyl)     442   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NHSO 2 Me-4-F-phenyl)     485   H   H   H   sgl   —(CH 2 ) 2 C(Me)CO 2 Me     486   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(OH)(4-F-phenyl) 2       487   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(OH)(4-Cl-phenyl) 2       489   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(═O)(4-F-phenyl)     490   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(═O)(2-MeO-4-F-phenyl)     491   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(═O)(3-Me-4-F-phenyl)     492   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(═O)(2-Me-phenyl)     493   H   H   H   sgl   —(CH 2 ) 2 C(Me)C(═O)phenyl     591   Cl   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-phenyl                                                                                                                                                                                                                              
 
       or pharmaceutically acceptable salt forms thereof. 
     
     
       28. A compound of  claim 12  selected from the compounds closed in Table 2:
             TABLE 2                                                                         Ex #   n   k   m   R 7     R 8     R 9     b   R 1             472   2   2   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     473   2   2   1   H   H   H   sgl   —(CH 2 ) 3 O(4-F-phenyl)     474   2   2   1   H   H   H   sgl   —(CH 2 ) 3 (6-F-benzisoxazol-                                     3-yl)     475   2   2   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-pyridyl)     483   2   2   1   H   Br   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     484   2   2   1   H   Br   H   sgl   —(CH 2 ) 3 O(4-F-phenyl)     488   1   2   1   H   Br   H   sgl   —CO 2 —tBu                                           
 
       or pharmaceutically acceptable salt forms thereof. 
     
     
       29. A compound of  claim 12  selected from the compounds closed in Table 3:
             TABLE 3                                                                         Ex #   n   k   m   R7   R8   R9   b   R1           182   1   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-                                     phenyl)     266   1   1   1   H   H   Me   sgl   —(CH 2 ) 3 C(═O)(4-F-                                     phenyl)     270   1   1   1   H   H   H   sgl   —(CH 2 ) 3 O(4-F-                                     phenyl)     272   1   1   1   H   H   H   sgl   H     494   1   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -                                     phenyl)     495   1   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -                                     phenyl)     496   1   1   1   H   H   H   sgl   —(CH 2 ) 3 (1H-indazol-3-yl)     528   1   1   1   H   H   H   sgl   —(CH 2 ) 3 (6-F-1H-                                     indazol-3-yl)     529   1   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -                                     4-F-phenyl)     530   1   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -                                     4-F-phenyl)     531   1   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-OH-                                     4-F-phenyl)     539   1   2   1   H   H   H   sgl   —(CH 2 ) 3 O(4-F-phenyl)     540   1   2   1   H   H   H   sgl   —(CH 2 ) 3 (6-F-1,2-                                     benzisoxazol-3-yl)     544   2   1   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-                                     phenyl)     546   1   2   1   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-                                     phenyl                                                              
 
       or pharmaceutically acceptable salt forms thereof. 
     
     
       30. A compound of  claim 12  selected from the compounds closed in Table 4:
             TABLE 4                                                             Ex #   R 7     R 8     R 9     b   R 1             185   H   H   CF 3     sgl   —(CH 2 ) 4 (4-F-phenyl)     188   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     213   H   CH 3     H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     438   H   H   H   sgl   —(CH 2 ) 3 C(═O)((2-NH 2 -phenyl)     439   H   H   H   sgl   —(CH 2 ) 3 C(═O)((2-NH 2 -phenyl)     440   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-F-phenyl)     441   H   H   H   sgl   —(CH 2 ) 3 C(═O)(2-NH 2 -4-F-phenyl)     456   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)     457   H   H   H   sgl   —(CH 2 ) 3 C(═O)(4-F-phenyl)                                            
 
       or pharmaceutically acceptable salt forms thereof. 
     
     
       31. A compound of  claim 1  selected from the compounds disclosed in Table 1A:
             TABLE 1A                                                             Ex #   R 7     R 8     R 9     b   R 1             125   H   H   Br   sgl   —CO 2 —tBu     126   H   H   2,6-diF-phenyl   sgl   —CO 2 —tBu     128   H   2,4-diCl-phenyl   H   sgl   H     129   H   phenyl   H   sgl   H     130   H   4-F-phenyl   H   sgl   H     131   H   4-Cl-phenyl   H   sgl   H     132   H   2-Cl-phenyl   H   sgl   H     133   H   2-MeO-phenyl   H   sgl   H     134   H   2-Cl-4-CF 3 -phenyl   H   sgl   H     135   H   2,4-diMe-phenyl   H   sgl   H     136   H   2-Cl-4-MeO-phenyl   H   sgl   H     137   H   4-iPr-phenyl   H   sgl   H     138   H   4-Bu-phenyl   H   sgl   H     139   H   2-Me-4-MeO-5-F-phenyl   H   sgl   H     140   H   2-Me-4-MeO-phenyl   H   sgl   H     141   H   2-Cl-4-CF 3 O-phenyl   H   sgl   H     142   H   2,4,5-triMe-phenyl   H   sgl   H     143   H   3-Cl-phenyl   H   sgl   H     144   H   4-Me-phenyl   H   sgl   H     145   H   2-Me-4-Cl-phenyl   H   sgl   H     146   H   2,5-diCl-phenyl   H   sgl   H     147   H   2-MeO-4-iPr-phenyl   H   sgl   H     148   H   2,6-diCl-phenyl   H   sgl   H     149   H   2,6-diF-phenyl   H   sgl   H     150   H   2-CF 3 -4-MeO-phenyl   H   sgl   H     151   H   2-CF 3 -phenyl   H   sgl   H     152   H   4-pyridyl   H   sgl   H     153   H   2-furanyl   H   sgl   H     154   H   2-thiophenyl   H   sgl   H     155   H   4-F-phenyl   H   sgl   H     156   H   2,3-diCl-phenyl   H   sgl   H     157   H   4-Et-phenyl   H   sgl   H     158   H   2,4-diMeO-phenyl   H   sgl   H     159   H   2-F-3-Cl-phenyl   H   sgl   H     160   H   4-MeO-phenyl   H   sgl   H     161   H   4-MeS-phenyl   H   sgl   H     162   H   4-CN-phenyl   H   sgl   H     163   H   3-CF 3 -phenyl   H   sgl   H     164   H   2-MeO-phenyl   H   sgl   H     165   H   2-naphthyl   H   sgl   H     166   H   4-acetylphenyl   H   sgl   H     167   H   3-acetamidophenyl   H   sgl   H     168   H   2,4-diCl-phenyl   H   sgl   Me     316   H   2,3-diMe-phenyl   H   sgl   H     317   H   2-Me-5-F-phenyl   H   sgl   H     318   H   2-F-5-Me-phenyl   H   sgl   H     319   H   2-MeO-5-F-phenyl   H   sgl   H     320   H   2-Me-3-Cl-phenyl   H   sgl   H     321   H   3-NO 2 -phenyl   H   sgl   H     322   H   2-NO 2 -phenyl   H   sgl   H     323   H   2-Cl-3-Me-phenyl   H   sgl   H     324   H   2-MeO-phenyl   H   sgl   H     325   H   2,3-diCl-phenyl   H   sgl   H     326   H   2-Cl-4-CF 3 -phenyl   H   sgl   H     327   H   2-Me-4-EtO-phenyl   H   sgl   H     328   H   2-Me-4-F-phenyl   H   sgl   H     329   H   4-Bu-phenyl   H   sgl   H     330   H   2-CF 3 -phenyl   H   sgl   H     331   H   2-Cl-6-F-phenyl   H   sgl   H     332   H   2-Cl-4-(CHF 3 )O-phenyl   H   sgl   H     333   H   4-CF 3 -phenyl   H   sgl   H     334   H   4-Me-phenyl   H   sgl   H     335   H   4-CF 3 O-phenyl   H   sgl   H     336   H   2,4-diMeO-6-F-phenyl   H   sgl   H     337   H   2-Me-phenyl   H   sgl   H     338   H   2-CF 3 -6-F-phenyl   H   sgl   H     339   H   2-MeS-phenyl   H   sgl   H     340   H   2,4,6-triF-phenyl   H   sgl   H     341   H   2,4,6-triCl-phenyl   H   sgl   H     342   H   2,6-diCl-4-MeO-phenyl   H   sgl   H     343   H   2,3,4-triF-phenyl   H   sgl   H     344   H   2,6-diF-4-Cl-phenyl   H   sgl   H     345   H   2,3,4,6-tetraF-phenyl   H   sgl   H     346   H   2,3,4,5,6-pentaF-phenyl   H   sgl   H     347   H   2,6-diCF 3 -phenyl   H   sgl   H     348   H   2-CF 3 O-phenyl   H   sgl   H     349   H   2-CF 3 -4-EtO-phenyl   H   sgl   H     350   H   2-CF 3 -4-iPrO-phenyl   H   sgl   H     351   H   2-naphtyl   H   sgl   H     352   H   2-CF 3 -4-Cl-phenyl   H   sgl   H     353   H   2-CF 3 -4-F-phenyl   H   sgl   H     354   H   2,4-diF-phenyl   H   sgl   Me     380   H   2-Cl-4-EtO-phenyl   H   sgl   H     381   H   2-Cl-4-iPrO-phenyl   H   sgl   H     382   H   2-Et-4-MeO-phenyl   H   sgl   H     383   H   2-CHO-4-MeO-phenyl   H   sgl   H     384   H   2-CH(OH)Me-4-MeO-phenyl   H   sgl   H     385   H   2-CH(OMe)Me-4-MeO-phenyl   H   sgl   H     386   H   2-C(═O)Me-4-MeO-phenyl   H   sgl   H     387   H   2-CH 2 (OH)Me-4-MeO-phenyl   H   sgl   H     388   H   2-CH 2 (OMe)Me-4-MeO-phenyl   H   sgl   H     389   H   2-CH(OH)Et-4-MeO-phenyl   H   sgl   H     390   H   2-C(═O)Et-4-MeO-phenyl   H   sgl   H     391   H   (Z)-2-CH═CHCO 2 Me-4-MeO-phenyl   H   sgl   H     392   H   2-CH 2 CH 2 CO 2 Me-4-MeO-phenyl   H   sgl   H     393   H   (Z)-2-CH═CHCH 2 (OH)-4-MeO-phenyl   H   sgl   H     394   H   (E)-2-CH═CHCO 2 Me-4-MeO-phenyl   H   sgl   H     395   H   (E)-2-CH═CHCH 2 (OH)-4-MeO-phenyl   H   sgl   H     396   H   2-CH 2 CH 2 OMe-4-MeO-phenyl   H   sgl   H     397   H   2-F-4-MeO-phenyl   H   sgl   H     403   H   2-Cl-4-phenyl   H   sgl   H     405   H   (2-Cl-phenyl)-CH═CH—   H   sgl   H     406   H   (3-Cl-phenyl)-CH═CH—   H   sgl   H     407   H   (2,6-diF-phenyl)-CH═CH—   H   sgl   H     410   H   cyclohexyl   H   sgl   H     411   H   cyclopentyl   H   sgl   H     412   H   cyclohexylmethyl   H   sgl   H     413   H   —CH 2 CH 2 CO 2 Et   H   sgl   H     414   H   —(CH 2 ) 3 CO 2 Et   H   sgl   H     415   H   —(CH 2 ) 4 CO 2 Et   H   sgl   H     416   H   —CH 2 CH═CH 2     H   sgl   H     417   H   Pr   H   sgl   H     418   H   benzyl   H   sgl   H     419   H   2-F-benzyl   H   sgl   H     420   H   3-F-benzyl   H   sgl   H     421   H   4-F-benzyl   H   sgl   H     422   H   3-MeO-benzyl   H   sgl   H     423   H   3-OH-benzyl   H   sgl   H     424   H   2-MeO-benzyl   H   sgl   H     425   H   2-OH-benzyl   H   sgl   H     426   H   2-CO 2 Me-3-MeO-phenyl   H   sgl   H     427   H   2,6-diF-phenyl   H   sgl   H     428   H   phenyl-CH═CH—   H   sgl   H     429   H   (2-Me-4-MeO-phenyl)-CH═CH—   H   sgl   H     430   H   —NMe 2     H   sgl   H     431   H   1-pyrrolidinyl   H   sgl   H     432   H   —NTa 2     H   sgl   H     433   H   MeO   H   sgl   H     445   H   2-Me-4-MeO-phenyl   Me   sgl   H     446   H   2-CF 3 -4-MeO-phenyl   Me   sgl   H     458   Me   2-CF 3 -4-MeO-phenyl   H   sgl   H     459   Me   2,4-diCl-phenyl   H   sgl   H     460   H   3-CN-phenyl   H   sgl   H     461   H   2-Me-4-CN-phenyl   H   sgl   H     462   H   2-Me-3-CN-phenyl   H   sgl   H     463   H   2-CN-phenyl   H   sgl   H     464   H   2-CF 3 -4-CN-phenyl   Me   sgl   H     465   H   3-CHO-phenyl   Me   sgl   H     466   H   3-CH 2 (OH)-phenyl   Me   sgl   H     467   H   3-CH 2 (OMe)-phenyl   Me   sgl   H     468   H   3-CH 2 (NMe 2 )-phenyl   Me   sgl   H     469   H   3-CN-4-F-phenyl   Me   sgl   H     470   H   3-CONH 2 -4-F-phenyl   Me   sgl   H     581   H   phenyl-NH—   H   sgl   H     583   H   (4-F-phenyl)-NH—   H   sgl   H     584   H   (2,4-diCl-phenyl)-NH—   H   sgl   H     585   H   phenyl-C(═O)NH—   H   sgl   H     586   H   benzyl-NH—   H   sgl   H     587   H   phenyl-S—   H   sgl   H     589   H   2-CH 2 (NH 2 )4-MeO-phenyl-   H   sgl   H     590   H   2-Me-4-MeO-phenyl-   H   sgl   H     592   H   (2-Me-4-MeO-phenyl)-NH—   H   sgl   H     593   H   (2-F-4-MeO-phenyl)-NH—   H   sgl   H     595   H   (2-Me-4-F-phenyl)-NH—   H   sgl   H     596   H   2-CH(OH)Me-4-F-phenyl   H   sgl   H                                                                                                                                                                                              
 
       or pharmaceutically acceptable salt forms thereof. 
     
     
       32. A compound of  claim 1  selected from the compounds closed in Table 2A:
             TABLE 2A                                                                         Ex #   n   k   m   R7   R8   R9   b   R1           479   2   2   1   H   2,4-diCl-phenyl   H   sgl   H     480   2   2   1   H   2-Cl-4-MeO-phenyl   H   sgl   H     481   2   2   1   H   2-Me-4-MeO-phenyl   H   sgl   H     482   2   2   1   H   Br   H   sgl   H     497   1   1   1   H   2-Cl-phenyl   H   sgl   H     498   1   1   1   H   3-Cl-phenyl   H   sgl   H     499   1   1   1   H   3-F-phenyl   H   sgl   H     500   1   1   1   H   4-Cl-phenyl   H   sgl   H     501   1   1   1   H   4-F-phenyl   H   sgl   H     502   1   1   1   H   2,3-diCl-phenyl   H   sgl   H     503   1   1   1   H   2,4-diF-phenyl   H   sgl   H     504   1   1   1   H   3,5-diCl-phenyl   H   sgl   H     505   1   1   1   H   3,5-diF-phenyl   H   sgl   H     506   1   1   1   H   3,4-diCl-phenyl   H   sgl   H     507   1   1   1   H   3,4-diF-phenyl   H   sgl   H     508   1   1   1   H   3-Cl-4-F-phenyl   H   sgl   H     509   1   1   1   H   2-F-4-Cl-phenyl   H   sgl   H                                                    
 
       or pharmaceutically acceptable salt forms thereof. 
     
     
       33. A compound of  claim 1  selected from the compounds disclosed in Table 3A:
             TABLE 3A                                                                         Ex #   n   k   m   R 7     R 8     R 9     b   R 1             173   1   1   1   H   2,4-diCl-phenyl   H   sgl   H     174   1   1   1   H   2-Cl-4-MeO-phenyl   H   sgl   H     436   1   1   1   H   2-Cl-phenyl   H   sgl   H     497   1   1   1   H   2-Cl-phenyl   H   sgl   H     498   1   1   1   H   3-Cl-phenyl   H   sgl   H     499   1   1   1   H   3-F-phenyl   H   sgl   H     500   1   1   1   H   4-Cl-phenyl   H   sgl   H     501   1   1   1   H   4-F-phenyl   H   sgl   H     502   1   1   1   H   2,3-diCl-phenyl   H   sgl   H     503   1   1   1   H   2,3-diF-phenyl   H   sgl   H     504   1   1   1   H   3,5-diCl-phenyl   H   sgl   H     505   1   1   1   H   3,5-diF-phenyl   H   sgl   H     506   1   1   1   H   3,4-diCl-phenyl   H   sgl   H     507   1   1   1   H   3,4-diF-phenyl   H   sgl   H     508   1   1   1   H   3-Cl-4-F-phenyl   H   sgl   H     509   1   1   1   H   2-F-4-Cl-phenyl   H   sgl   H     510   1   1   1   H   2-Cl-4-F-phenyl   H   sgl   H     511   1   1   1   H   2,5-diCl-phenyl   H   sgl   H     512   1   1   1   H   2,6-diCl-phenyl   H   sgl   H     513   1   1   1   H   2-CF 3 -phenyl   H   sgl   H     514   1   1   1   H   4-CF 3 -phenyl   H   sgl   H     515   1   1   1   H   2,4-diCF 3 -phenyl   H   sgl   H     516   1   1   1   H   2-Cl-4-CF 3 -phenyl   H   sgl   H     517   1   1   1   H   2-MeO-phenyl   H   sgl   H     518   1   1   1   H   2,4-diMeO-phenyl   H   sgl   H     519   1   1   1   H   2-MeO-5-iPr-phenyl   H   sgl   H     520   1   1   1   H   3-NO 2 -phenyl   H   sgl   H     521   1   1   1   H   2-CHO-phenyl   H   sgl   H     522   1   1   1   H   2-CH(Me)(OH)-phenyl   H   sgl   H     523   1   1   1   H   2-CH 2 (OH)-phenyl   H   sgl   H     524   1   1   1   H   2-CHO-4-MeO-phenyl   H   sgl   H     525   1   1   1   H   2-OH-phenyl   H   sgl   H     526   1   1   1   H   2-CF 3 -4-EtO-phenyl   H   sgl   H     527   1   1   1   H   2-CF 3 -4-iPrO-phenyl   H   sgl   H     532   1   1   1   H   2-Me-4-MeO-phenyl   H   sgl   H     533   1   1   1   H   2-CF 3 -4-MeO-phenyl   H   sgl   H     534   1   2   1   H   3,4,5-triMeo-phenyl   H   sgl   H     535   1   2   1   H   1-naphthyl   H   sgl   H     536   1   2   1   H   3-MeO-phenyl   H   sgl   H     537   1   2   1   H   2,4-diCl-phenyl   H   sgl   H     543   2   1   1   H   2,6-diF-phenyl   H   sgl   H     547   2   1   1   H   2-CF 3 -4-MeO-phenyl   H   sgl   H     548   2   1   1   H   2-Me-4-MeO-phenyl   H   sgl   H     549   2   1   1   H   2-Cl-4-CF 3 -phenyl   H   sgl   H     550   2   1   1   H   2,3-diCl-phenyl   H   sgl   H     551   2   1   1   H   2,4-diMeO-phenyl   H   sgl   H     552   2   1   1   H   3,4-diMeO-phenyl   H   sgl   H     553   2   1   1   H   2,4-diCl-phenyl   H   sgl   H     554   2   1   1   H   3,4-diCl-phenyl   H   sgl   H     555   2   1   1   H   2,5-diCl-phenyl   H   sgl   H     556   2   1   1   H   2-CF 3 -phenyl   H   sgl   H     557   2   1   1   H   2-Me-phenyl   H   sgl   H     558   2   1   1   H   2-Cl-phenyl   H   sgl   H     559   2   1   1   H   3-F-phenyl   H   sgl   H     560   2   1   1   H   phenyl   H   sgl   H     561   2   1   1   H   2-CF 3 -4-EtO-phenyl   H   sgl   H     562   2   1   1   H   2-CF 3 -4-iPrO-phenyl   H   sgl   H     563   2   1   1   H   2-MeO-4-iPr-phenyl   H   sgl   H     564   2   1   1   H   2-F-4-Cl-phenyl   H   sgl   H     565   2   1   1   H   2-Cl-4-MeO-phenyl   H   sgl   H     566   2   1   1   H   2-CHO-phenyl   H   sgl   H     567   2   1   1   H   2-CHO-4-MeO-phenyl   H   sgl   H     568   2   1   1   H   2-CH 2 (OH)-4-MeO-   H   sgl   H                         phenyl     569   2   1   1   H   2-CH 2 (OH)-phenyl   H   sgl   H     570   2   1   1   H   2-CF 3 -4-NHMe-   H   sgl   H                         phenyl     571   2   1   1   H   2-CF 3 -4-NH 2 -phenyl   H   sgl   H     572   2   1   1   H   2-C(═O)Me-phenyl   H   sgl   H     573   2   1   1   H   2-C(═O)Me-4-MeO-   H   sgl   H                         phenyl     574   2   1   1   H   2-CH(Me)(OH)-phenyl   H   sgl   H     575   2   1   1   H   2-CH(Me)(OH)-4-   H   sgl   H                         MeO-phenyl     576   2   1   1   H   2-CF 3 -4-OH-phenyl   H   sgl   H     577   2   1   1   H   2-CF 3 -4-O(C═O)Me-   H   sgl   H                         phenyl                                                                                                                
 
       or pharmaceutically acceptable salt forms thereof.