Method of treating a systemic disease

Abstract

A method of treating a systemic disease in a patient in need of such treatment is disclosed. The method comprising maintaining the inspiratory flow rate and volume of the patient to a certain value and then administering a medicament aerosol formulation to such patient.

1. A method of treating a systemic disease in a patient in need thereof, which consists essentially of:
 (a) maintaining the inspiratory flow rate in the patient in a range of about 0.05 to about 2 liters per second and the inspiratory volume of the patient in the range of about 0.1 to about 5 liters; and  
 (b) administering to the patient a medicinal aerosol formulation comprising 
 (a′) a medicament present in an effective amount; and ,  
 (b′) a fluid propellant carrier for carrying said transporting said medicament to the patient at a suitable dosing time of about 200 to about 2000 milliseconds for a suitable dosing period and  
 
 ( c′ )  a stabilizer selected from the group consisting of an amino acid, a derivative thereof, a water addition stabilizer and a mixture of any of the foregoing .  
 
     
     
       2. The method as defined in  claim 1  wherein said suitable dosing time comprises about 200 to about 2000 milliseconds. 
     
     
       3. The method as defined in  claim 1  or  claim 2   wherein said suitable dosing period comprises about 1 to about 4 sprays of the aerosol formulation every 3 to 4 hours. 
     
     
       4. The method as defined in  claim 3  wherein said effective amount of medicament comprises from about 0.00001 parts by weight to about 5 parts by weight based on 100 parts by weight of said carrier. 
     
     
       5. A method of treating a systemic disease in a patient in need thereof which comprises:
 (a) administering to the patient a medicinal aerosol formulation comprising (a′) a medicament present in an effective amount; (b′) a fluid propellent carrier for carrying and transporting said medicament at a suitable dosing time for a suitable dosing period; and (c′) a stabilizer selected from the group consisting of (1) an amino acid (2) a derivative thereof; (3) a water addition stabilizer and (4) a mixture of any of the foregoing stabilizers; and  
 (b) maintaining the inspiratory flow rate in the patient in a range of about 0.05 to about 2 liters per second and the inspiratory volume of the patient in the range of about 0.1 to about 5 liters.  
 
     
     
       6. The method as defined in  claim 4  wherein said medicament is a particulate medicament having a diameter ranging from about 1 to about 7 micrometers. 
     
     
       7. The method as defined in  claim 4  wherein said medicament comprises a protein or a peptide medicament having a molecular size ranging from about 0.5 K Dalton to about 150 K Daltons. 
     
     
       8. The method as defined in  claim 5  wherein said stabilizer comprises said water addition stabilizer.