Adjunctive therapy

Abstract

A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.

1. A method which comprises administering to an individual  a person an effective  amount effective to temporarily reduce circulating estrogen of a gonadotropin releasing hormone antagonist or mime thereof selected from the group consisting of antide and azaline B and thereafter conducting an invasive procedure to excise a growth or portion thereof before the effect of the analog  antagonist or mime thereof has dissipated. 
     
     
       2. The method of  claim 1  wherein the invasive procedure comprises excising a growth or portion thereof. 
     
     
       3. The method of claim  2    1  wherein the antagonist is administered about one day before the excisement. 
     
     
       4. The method of  claim 3  in which only a single administration of the antagonist is effected. 
     
     
       5. The method of  claim 2  in which only a single administration of the antagonist is effected. 
     
     
       6. The method of  claim 5  in which about 0.001 to 5 mg/kg of body weight of antagonist is administered. 
     
     
       7. The method of  claim 2  in which about 0.5 to 5 mg/kg of body weight of antagonist is administered. 
     
     
       8. The method of claim  2    1  in which the antagonist is antide. 
     
     
       9. The method of claim  2    1  in which the antagonist is azaline B. 
     
     
       10. The method of  claim 1  wherein the antagonist or mime is administered about one day before the invasive procedure. 
     
     
       11. The method of  claim 10  in which only a single administration of the antagonist or mime is effected. 
     
     
       12. The method of  claim 1  in which only a single administration of the antagonist or mime is effected. 
     
     
       13. The method of  claim 1  in which about 0.001 to 5 mg/kg of body weight of antagonist or mime is administrated. 
     
     
       14. The method of  claim 1  in which about 0.5 to 5 mg/kg of body weight of antagonist or mime is administered. 
     
     
       15. The method of  claim 1  wherein the effective amount is that sufficient to adjust the circulating estrogen to a value below about  20  pg/ml.  
     
     
       16. The method of  claim 1  wherein the effective amount is that sufficient to adjust the circulating estrogen to a value below about  10  pg/ml.  
     
     
       17. The method of  claim 1  wherein the length of time of administration of the antagonist or mime thereof is about one week.  
     
     
       18. A method which comprises administering to a female person an effective amount of a gonadotropin releasing hormone antagonist or mime thereof, said antagonist or mime acting by competitive receptor occupancy, in an amount effective to adjust the circulating estrogen to a value below about  20  pg/ml, and thereafter conducting an invasive procedure which excises a tissue growth or portion thereof before the effect of the antagonist or mime thereof has dissipated and the circulating estrogen has a value above about  20  pg/ml.  
     
     
       19. The method of  claim 18  wherein the effective amount is that sufficient to adjust the circulating estrogen to a value below about  10  pg/ml.  
     
     
       20. The method of  claim 18  wherein the length of time of the antagonist or mime thereof administration is about one week.  
     
     
       21. The method of  claim 18  wherein the antagonist is administered about one day before the excisement.  
     
     
       22. The method of  claim 18  in which only a single administration of the antagonist is effected.  
     
     
       23. The method of  claim 18  in which about  0 . 001  to  5  mg/kg of body weight of antagonist is administrated.  
     
     
       24. The method of  claim 23  in which about  0 . 05  to  5  mg/kg of body weight of antagonist is administrated.  
     
     
       25. The method of  claim 18  wherein the tissue growth or portion thereof excised is a tumor, hypertrophied tissue or a cyst.