Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection

Abstract

The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials after they are combined and blended into a smooth viscous material containing an emollient package generates active antimicrobial chlorine dioxide and can be immediately contacted with the target animals. The compositions of the invention provide stable visual indication, rapid initial kill, consistent long term kill with chemical and rheological stability.

1. A physically and chemically stable, visibly indicated, mastitis treatment composition that can effectively reduce microbial populations on contact with an animal skin for an extended period, said composition comprising a blended combination comprising:
 (a) an aqueous acidulant part comprising an activator acid, a rheology modifier or a pseudoplastic thickener, a chlorine dioxide stable visual indicator system selected from the group consisting of: 
 (i) about  0 . 05 - 30  wt % of urea and about  0 . 001 - 10  wt % of a colorant, based on the weight of the blended composition; and  
 (ii)  comprising about 0.001-50 wt %, based on the weight of the blended composition  combination, of a dispersed oil phase, wherein said oil phase contains about 0.001-50 wt % of an oil-soluble dye, based on the weight of said oil phase, and said oil phase is uniformly dispersed in a fine particle size in the blended composition  combination and a major proportion of water; and  
 
 (b) a chlorite part substantially free of organic component, consisting essentially of  comprising an alkali metal chlorite salt;  
 
       wherein the composition exhibits a visual indicator for a period of at least 24 hours and the composition comprises a rheology that promotes cling to immobilize the composition on the animal skin surface and provides  thereby providing a barrier to environmental contamination. 
     
     
       2. The composition of  claim 1  wherein the visual indicator system contains, in the blended composition, about  0 . 1  to  5 . 0  wt % of urea and about  0 . 005  to  2 . 0  wt % of a blue dye. 
     
     
       3. The composition of  claim 2  wherein the blue dye comprises FD&C Blue No. 1 . 
     
     
       4. The composition of  claim 1  wherein the blended composition  combination further comprises a first indicator dye having color instability in the presence of chlorite or chlorine dioxide such that the dye substantially loses color within about an hour of blending and a second dye that maintains an effective color for at least 24 hours after blending. 
     
     
       5. The composition of claim  1    4  wherein the indicator stability comprises about one week. 
     
     
       6. The composition of claim  1    4  wherein the indicator stability comprises about two weeks. 
     
     
       7. The composition of  claim 1  wherein the oil phase contains a drying oil. 
     
     
       8. A physically and chemically stable visibly indicated mastitis treatment composition that can effectively reduce microbial populations on contact with an animal surface for an extended period of time comprising a combined aqueous acidulant part and a chlorite part, the mastitis treatment composition can effectively reduce microbial populations on contact with an animal surface for an extended period of time,
 (a) said aqueous acidulant part comprising an activator acid comprising a phosphoric acid, lactic acid, glycolic acid or mixtures thereof, and a chlorine dioxide stable visual indicator system selected from the group consisting of: 
 (i) about  0 . 05 - 30  wt % of urea and about  0 . 001 - 10  wt % of a colorant, based on the weight of the composition; and  
 (ii)  comprising about 0.001-50 wt %, based on the weight of the composition, of a dispersed oil phase, wherein said oil phase contains about 0.001-50 wt % of an oil-soluble dye, based on the weight of said oil phase, and said oil phase is uniformly dispersed in a fine particle size in the composition;  , and stable in the combined mastitis treatment composition; and  
 
 (b) said chlorite part substantially free of organic component, consisting essentially of  comprising an alkali metal chlorite salt;  
 
       wherein the composition exhibits a visual indicator for a period of at least 24 hours and the composition comprises a rheology that promotes cling to immobilize the composition on the animal skin surface and provides  thereby providing a barrier to environmental contamination.  
     
     
       9. The composition of  claim 8  wherein the visual indicator system contains, in the composition, about  0 . 1  to  5 . 0  wt % of urea and about  0 . 005  to  2 . 0  wt % of a blue dye. 
     
     
       10. The composition of  claim 9  wherein the blue dye comprises FD&C Blue No.  1 . 
     
     
       11. The composition of  claim 8  wherein the composition further comprises a first indicator dye having color instability in the presence of chlorite or chlorine dioxide such that the dye substantially loses color within about an hour of blending and a second dye that maintains an effective color for at least 24 hours after blending. 
     
     
       12. The composition of claim  8    11  wherein the indicator stability comprises about one week. 
     
     
       13. The composition of claim  8    11  wherein the indicator stability comprises about two weeks. 
     
     
       14. The composition of  claim 8  wherein the oil phase contains a drying oil. 
     
     
       15. A physically and chemically stable visually indicated mastitis treating composition in an acidulant part and a chlorite part, that can effectively reduce microbial populations, on contact with a teat surface and for an extended period, said composition comprising:
 (a)(A) an aqueous acidulant part comprising: 
 (i) about 0.1 to 15 parts by weight of an organic or inorganic acid, or salts thereof, or mixtures thereof, the acid selected from the group consisting of a phosphoric acid, lactic acid, glycolic acid, a C 7-11  carboxylic acid, a C 6-12  alkyl benzene sulfonic acid, and mixtures thereof;    (ii) a rheology modifier comprising about 0.01 to 10 parts by weight of a pseudoplastic thickener;    (iii) a visual indicator system selected from the group consisting of: 
 (a) about  0 . 05 - 30  wt % of urea and about  0 . 001 - 10  wt % of a colorant, based on the weight of the composition; and  
 (b)  comprising about 0.001-50 wt %, based on the weight of the composition, of a dispersed oil phase, wherein said oil phase contains about 0.001-50 wt % of an oil-soluble dye, based on the weight of said oil phase, and said oil phase is uniformly dispersed in a fine particle size in the composition that can retain color stability for at least 24 hours in the presence of chlorite or chlorine dioxide;  
   (iv) about 0.1 to 15 parts of an emollient;    (v) a major proportion of water; and    
 (b)(B) a chlorite part consisting essentially ofcomprising an alkali metal chlorite salt;  
 
       wherein the composition exhibits rheology that promotes cling to immobilize the composition on the teat surface and provides  thereby providing a barrier to environmental contamination. 
     
     
       16. The composition of  claim 15  wherein the alkali metal chlorite salt is sodium chlorite and the organic acid is lactic acid. 
     
     
       17. The composition of  claim 15  additionally comprising about 0.01 to 8 parts of a polymeric film-forming agent. 
     
     
       18. The composition of  claim 15  wherein the visual indicator contains about  0 . 01  to  2  wt % urea. 
     
     
       19. The composition of  claim 15  wherein the visual indicator system comprises, in the composition, about  0 . 05  to  0 . 001  wt % of urea and about  0 . 001  to  10  wt % of a blue dye. 
     
     
       20. The composition of  claim 19  wherein the visual indicator system contains FD&C Blue No.  1 . 
     
     
       21. The composition of  claim 15  wherein the composition further comprises a first indicator dye having color instability in the presence of chlorite or chlorine dioxide such that the dye substantially loses color within about an hour of blending and a second dye that maintains an effective color for at least 24 hours after blending. 
     
     
       22. The composition of claim  15    21  wherein the indicator stability comprises about one week. 
     
     
       23. The composition of claim  15    21  wherein the indicator stability comprises about two weeks. 
     
     
       24. The composition of  claim 21  wherein the oil phase contains a drying oil. 
     
     
       25. The composition of  claim 15  wherein the organic acid is a C 7-11  carboxylic acid, a C 6-12  alkyl benzene sulfonic acid or mixtures thereof. 
     
     
       26. The composition of  claim 15  wherein the composition further comprises a mixture of about 0.05 to 2 parts by eight  weight of a xanthan thickener and about 0.1 to 5 parts by weight of a film-forming agent selected from the group consisting of a polyvinyl alcohol, a polyvinyl acetate and mixtures thereof. 
     
     
       27. The composition of  claim 15  wherein the pH of the composition comprising the acidulant part and the chlorine part, is about 2.5 to 4.5. 
     
     
       28. The composition of  claim 15  wherein the pH of the composition comprising the acidulant part and the chlorite part is about 2.5 to 3.5.