USRE41491EExpiredUtility

(20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses

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Assignee: WISCONSIN ALUMNI RES FOUNDPriority: Dec 13, 2001Filed: May 6, 2008Granted: Aug 10, 2010
Est. expiryDec 13, 2021(expired)· nominal 20-yr term from priority
Inventors:Hector F. DelucaLori A. PlumMargaret Clagett-Dame
A61P 19/00C07C 401/00A61K 31/59
90
PatentIndex Score
8
Cited by
28
References
1
Claims

Abstract

This invention discloses (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.

Claims

exact text as granted — not AI-modified
1. (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol having the formula:

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