Isobutylgaba and its derivatives for the treatment of pain

Abstract

The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.

1. A method for treating pain comprising administering a therapeutically effective amount of a compound of Formula I 
                   
       or a pharmaceutically acceptable salt, diastereomer, or enantiomer thereof wherein
 R 1  is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl of from 3 to 6 carbon atoms;  
 R 2  is hydrogen or methyl; and  
 R 3  is hydrogen, methyl, or carboxyl to a mammal in need of said treatment.  
 
     
     
       2. A method according to  claim 1   for treating pain comprising administering a therapeutically effective amount of a compound of Formula I
                 
 
         or a pharmaceutically acceptable salt thereof, wherein the compound administered is a compound of Formula I  wherein R   3  and R 2  are hydrogen, and R 1  is —(CH 2 ) 0-2 —i C 4 H 9 isobutyl as an (R),  (S), or (R,S)  isomer, to a mammal in need of said treatment. 
     
     
       3. A method according to  claim 1  wherein the compound administered is named (S)-3-(aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methylhexanoic acid. 
     
     
       4. A method according to claim  1    2  wherein the pain treated is inflammatory pain. 
     
     
       5. A method according to claim  1    2  wherein the pain treated is neuropathic pain. 
     
     
       6. A method according to claim  1    2  wherein the pain treated is cancer pain. 
     
     
       7. A method according to claim  1    2  wherein the pain treated is postoperative pain. 
     
     
       8. A method according to claim  1    2  wherein the pain treated is phantom limit  limb pain. 
     
     
       9. A method according to claim  1    2  wherein the pain treated is bum  burn pain. 
     
     
       10. A method according to claim  1    2  wherein the pain treated is gout pain. 
     
     
       11. A method according to claim  1    2  wherein the pain treated is osteoarthritic pain. 
     
     
       12. A method according to claim  1    2  wherein the pain treated is trigeminal neuralgia pain. 
     
     
       13. A method according to claim  1    2  wherein the pain treated is acute herpetic and postherpetic pain. 
     
     
       14. A method according to claim  1    2  wherein the pain treated is causalgia pain. 
     
     
       15. A method according to claim  1    2  wherein the pain treated is idiopathic pain. 
     
     
       16. A method for treating pain comprising administering a therapeutically effective amount of ( S )-   3   -( aminomethyl )-   5   - methylhexanoic acid, or a pharmaceutically acceptable salt thereof, to a human in need of said treatment.   
     
     
       17. A method according to  claim 16  wherein the compound administered is ( S )-   3   -( aminomethyl )-   5   - methylhexanoic acid.   
     
     
       18. A method according to  claim 16  wherein the compound administered is a pharmaceutically acceptable salt of ( S )-   3   -( aminomethyl )-   5   - methylhexanoic acid.   
     
     
       19. A method according to  claim 17  wherein the pain treated is chronic pain. 
     
     
       20. A method according to  claim 17  wherein the pain treated is selected from the group consisting of inflammatory pain, neuropathic pain, cancer pain, postoperative pain, and idiopathic pain. 
     
     
       21. A method according to  claim 17  wherein the pain treated is neuropathic pain. 
     
     
       22. A method according to  claim 17  wherein the pain treated is diabetic neuropathic pain. 
     
     
       23. A method according to  claim 17  wherein the pain treated is acute herpetic pain. 
     
     
       24. A method according to  claim 17  wherein the pain treated is postherpetic pain. 
     
     
       25. A method according to  claim 17  wherein the pain treated is fibromyalgia pain.