Granular water dispersible agent and production process

Abstract

A water dispersible granule formulation prepared by pulverized a part of active ingredients into fine particles under wet milling and pulverized another part of the active ingredients into coarse particles under dry milling, then kneading the both active ingredients for the granulation, and a process for producing the water dispersible granule formulation are disclosed. The water dispersible granule formulation according to the present invention is applicable for production of a water dispersible granule formulation comprising an active ingredient which is easily decomposed owing to environmental conditions and allows to provide the water dispersible granule formulation provided with enhanced initial and residual biological activities.

1. A process for producing a water dispersible granule formulation comprising the steps of:
 wet milling a combined mixture of a first active ingredient, a wetting and dispersing agent, and water, 
 pulverizing a combined mixture of a second active ingredient, a mineral carrier, and a wetting and dispersing agent under dry milling, 
 admixing the mixture obtained in the wet milling step and the mixture obtained in the dry milling step, and then 
 drying the admixed mixture to form a homogeneous granule formulation, 
 wherein: 
 the first active ingredient is pulverized to an average particle size value from about 0.5 μm to about 5 μm in the step of wet milling the combined mixture, 
 the second active ingredient is pulverized to an average particle size value from about 3 μm to about 30 μm in the step of pulverizing the combined mixture under dry milling, 
 the first active ingredient is a compound which is a solid at an ambient temperature and has a solubility in water of 1,000 ppm or less, 
 the first and second active ingredients are the same active ingredient that is an agricultural chemical selected from the group consisting of an insecticide, a fungicide, and a herbicide, 
 each of the first and second active ingredients have two different average particle sizes, and 
 the second active ingredient has coarser particles than the first active ingredient. 
 
     
     
       2. The process according to  claim 1 , wherein the active ingredient is selected from the group consisting of triflumizole, thiuram, fluazinam, anilazine, captan, hexythiazox, benzoximate, tebufenpyrad, ziram, thiophanate methyl, mepanipyrim, clethoxim methyl, triazine, N′-cyclopropylmethyloxy-N-phenylacetyl-2,3-difluoro-6-trifluoromethylbenz- amidine, and combinations thereof. 
     
     
       3. A process for producing a water dispersible granule formulation comprising the steps of:
 wet milling a combined mixture of a first active ingredient, a wetting and dispersing agent, and water, 
 pulverizing a combined mixture of a second active ingredient, a mineral carrier and a wetting and dispersing agent under dry milling, 
 admixing the mixture obtained in the wet milling step and the mixture obtained in the dry milling step, and then 
 drying the admixed mixture to form a homogeneous granule formulation, 
 wherein: 
 the first active ingredient is pulverized to an average particle size value from about 0.5 μm to about 5 μm in the step of wet milling the combined mixture, 
 the second active ingredient is pulverized to an average particle size value from about 3 μm to about 30 μm in the step of pulverizing the combined mixture under dry milling, 
 the first active ingredient is a compound which is a solid at an ambient temperature and has a solubility in water of 1,000 ppm or less, 
 the first and second active ingredients are the same active ingredient selected from the group consisting of triflumizole, thiuram, fluazinam, anilazine, captan, hexythiazox, benzoximate, tebufenpyrad, ziram, thiophanate methyl, mepanipyrim, clethoxim methyl, triazine, N′-cyclopropylmethyloxy-N-phenylacetyl-2,3-difluoro-6-trifluoromethylbenz- amidine, and combinations thereof, 
 each of the first and second active ingredients have two different average particle sizes, and 
 the second active ingredient has coarser particles than the first active ingredient.