Synthetic peptides reducing or removing bags formed under the lower eye contour and their use in cosmetic or dermopharmaceutical compositions

Abstract

The invention relates to peptides of general formula (I): that can reduce or remove bags formed under the eyes, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or dermopharmaceutically acceptable salts thereof, wherein X is cystenyl, seryl, threonyl or aminobutyryl; R 1 is H or alkyl, aryl, aralkyl or acyl group; and R 2 is amino, hydroxy or thiol, all of them substituted or non-substituted with aliphatic or cyclic groups. The invention also relates to a method of obtaining, cosmetic or dermopharmaceutical compositions containing them and their use for treating skin, preferably for reducing or removing bags formed under the eyes.

The invention claimed is: 
     
       1. A peptide of general formula (I): 
       
         
           
           
               
               
           
         
         its stereoisomers, mixtures thereof, and its cosmetically and dermopharmaceutically acceptable salts, wherein: 
         X is selected from the group formed by cystenyl consisting of cysteinyl, seryl, threonyl and aminobutyryl; 
         R 1  is selected from the group formed by consisting of H or and alkyl, aryl, aralkyl and acyl group groups; 
         and R 2  is selected from the group formed by consisting of amino, hydroxy and thiol, substituted or non-substituted with aliphatic or cyclic groups. 
       
     
     
       2. A peptide according to  claim 1 , wherein R 1  is saturated or unsaturated, branched or cyclic, linear C 2  to C 24 acyl C 24  acyl. 
     
     
       3. A peptide according to  claim 1 , wherein R 2  is amino or hydroxy, substituted or non-substituted with saturated or unsaturated, branched or cyclic, linear C 1  to C 24  aliphatic groups. 
     
     
       4. A peptide according to  claim 1 , wherein X is L-Ser, R 1  is H and R 2  is amino, substituted or non-substituted with methyl or ethyl or dodecyl or hexadecyl groups. 
     
     
       5. A peptide according to  claim 1 , wherein X is L-Ser, R 1  is acetyl and R 2  is amino, substituted or non-substituted with methyl or ethyl or dodecyl or hexadecyl groups. 
     
     
       6. A peptide according to  claim 1 , wherein X is L-Ser, R 1  is palmitoyl and R 2  is amino, substituted or non-substituted with methyl or ethyl or dodecyl or hexadecyl groups. 
     
     
       7. A peptide according to  claim 1 , wherein X is L-Ser, R 1  is H and R 2  is hydroxy, substituted or non-substituted with methyl or ethyl or dodecyl or hexadecyl groups. 
     
     
       8. A peptide according to  claim 1 , wherein X is L-Ser, R 1  is acetyl and R 2  is hydroxy, substituted or non-substituted with methyl or ethyl or dodecyl or hexadecyl groups. 
     
     
       9. A peptide according to  claim 1 , wherein X is L-Ser, R 1  is palmitoyl and R 2  is hydroxy, substituted or non-substituted with methyl or ethyl or dodecyl or hexadecyl groups. 
     
     
       10. A cosmetic or dermopharmaceutical composition comprising a cosmetically or demopharmaceutically dermopharmaceutically acceptable excipient or adjuvant; and
 an effective amount of the peptide of  claim 1 . 
 
     
     
       11. A cosmetic or dermopharmaceutical composition according to  claim 10 , wherein the composition contains at least one peptide of general formula (I) incorporated to a cosmetically or demopharmaceutically dermopharmaceutically acceptable carrier selected from the group formed by consisting of liposomes, millicapsules, microcapsules, nanocapsules, sponges, millispheres, microspheres, nanospheres, milliparticles, microparticles and nanoparticles. 
     
     
       12. A cosmetic or dermopharmaceutical composition according to  claim 10 , wherein it has a formulation selected from the group formed by consisting of oil-in-water emulsions, water-in-oil emulsions, milks, lotions, gels, ointments, balms, foams, body oils, soaps, bars, pencils, sprays, creams, liniments, unguents, serums and mousses. 
     
     
       13. A cosmetic or dermopharmaceutical composition according to  claim 10 , wherein it contains at least one peptide of general formula (I) incorporated to solid supports selected from the group formed by consisting of towelletes, hydrogels, patches and face masks. 
     
     
       14. A cosmetic or dermopharmaceutical composition according to  claim 10 , wherein it contains at least one peptide of general formula (I) incorporated to make-up line products selected from the group formed by consisting of concealers, make-up foundations, lotions, and make-up removal lotions. 
     
     
       15. A method of treating facial skin in need skin, comprising administering to the skin an effective amount of a peptide of  claim 1  for reducing bags formed under the lower eye contour. 
     
     
       16. The method of  claim 15 , wherein a cosmetic or dermopharmaceutical composition comprises the peptide of general formula (I). 
     
     
       17. A peptide of general formula (I): 
       
         
           
           
               
               
           
         
         its stereoisomers, mixtures thereof, and its cosmetically and dermopharmaceutically acceptable salts, wherein: 
         X is selected from the group formed by cystenyl consisting of cysteinyl, seryl, threonyl and aminobutyryl; 
         R 1  is selected from the group formed by consisting of H or and saturated or unsaturated, branched or cyclic, linear C 2  to C 24 acyl; 
         and R 2  is selected from the group formed by consisting of amino, hydroxy and thiol, substituted or non-substituted with aliphatic or cyclic groups. 
       
     
     
       18. A cosmetic or dermopharmaceutical composition, comprising a cosmetically or demopharmaceutically acceptable excipient or adjuvant; and
 an effective amount of the peptide of  claim 17 . 
 
     
     
       19. A method of treating facial skin in need skin, comprising administering to the skin an effective amount of the peptide of  claim 17  for reducing bags formed under the lower eye contour. 
     
     
       20. A peptide according to claim 1, wherein R 1  is acetyl.  
     
     
       21. A peptide according to claim 1, wherein R 1  is palmitoyl.  
     
     
       22. A peptide according to claim 1, wherein R 1  is —H.  
     
     
       23. A peptide according to claim 1, wherein R 2  is —OH.  
     
     
       24. A peptide according to claim 1, wherein R 2  is —NH 2 .  
     
     
       25. A peptide according to claim 1, wherein R 2  is —NH—(CH 2 ) 9 —CH 3 .  
     
     
       26. A peptide according to claim 1, X is seryl.  
     
     
       27. A peptide according to claim 1, wherein X is aminobutyryl.  
     
     
       28. A peptide according to claim 1, wherein X is cysteinyl.  
     
     
       29. A peptide according to claim 7, wherein X is L-Ser, R 1  is H, and R 2  is hydroxy.  
     
     
       30. A peptide according to claim 8, wherein X is L-Ser, R 1  is acetyl, and R 2  is hydroxy.  
     
     
       31. A peptide according to claim 1, wherein X is L-Ser, R 1  is palmitoyl and R 2  is hydroxy.  
     
     
       32. A cosmetic or dermopharmaceutical composition according to claim 10, wherein said excipient or adjuvant is selected from the group consisting of emulsion agents, emollients, organic solvents, skin conditioners, gelling polymers, thickeners, softeners, anti-wrinkle agents, whitening agents, compounds capturing free radicals, anti-oxidizing compounds, compounds stimulating collagen synthesis, compounds stimulating elastin synthesis, compounds inhibiting collagen degradation, compounds stimulating fibroblast proliferation, compounds stimulating keratinocyte proliferation, compounds stimulating keratinocyte differentiation, skin relaxing compounds, compounds stimulating glycosaminoglycan synthesis, firming compounds, compounds acting on capillary circulation, compounds acting on cell metabolism, compounds stimulating melanin synthesis, preservatives, perfumes, chelating agents, plant extracts, essential oils, marine extracts, cell extracts, and sunscreens.