Method and compositions for increasing the anaerobic working capacity in tissues

Abstract

A method for increasing the synthesis and accumulation of beta-alanylhistidine dipeptides, with a simultaneous increase in the accumulation of creatine, in bodily tissues of humans and animals is described. This is accomplished by causing an increase in the blood plasma concentrations of beta-alanine and creatine, or the blood plasma concentrations of beta-alanine, L-histidine and creatine, by the ingestion or infusion of a composition including beta-alanine, beta-alanine and creatine, or beta-alanine, L-histidine and creatine, or active derivatives thereof.

What is claimed is: 
     
       1. A composition comprising a mixture of a creatine and a composition comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine. 
     
     
       2. The composition of  claim 1 , further comprising an L-histidine. 
     
     
       3. The composition of  claim 1 , wherein the beta-alanine further comprises a dipeptide, an oligopeptide, or a polypeptide. 
     
     
       4. The composition of  claim 1 , wherein the creatine is a creatine monohydrate. 
     
     
       5. A dietary supplement comprising a mixture of a creatine and a composition comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine. 
     
     
       6. The dietary supplement of  claim 5  in a unit dosage form. 
     
     
       7. The dietary supplement of  claim 6 , wherein one dose comprises up to 99% by weight of beta-alanine. 
     
     
       8. The dietary supplement of  claim 6 , wherein one dose comprises up to 98% by weight of L-histidine. 
     
     
       9. The dietary supplement of  claim 5  in an injectable formulation. 
     
     
       10. A composition comprising a mixture of a carbohydrate and a composition comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine. 
     
     
       11. The composition of  claim 10 , further comprising an L-histidine. 
     
     
       12. The composition of  claim 10 , wherein the beta-alanine further comprises a dipeptide, an oligopeptide, or a polypeptide. 
     
     
       13. The composition of  claim 10 , wherein the carbohydrate is a simple carbohydrate. 
     
     
       14. The composition of  claim 13 , wherein the simple carbohydrate is a glucose. 
     
     
       15. The composition of  claim 10 , further comprising creatine. 
     
     
       16. The composition of  claim 11 , further comprising creatine. 
     
     
       17. A dietary supplement comprising a mixture of a carbohydrate and a composition comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine. 
     
     
       18. The dietary supplement of  claim 17  in a unit dosage form. 
     
     
       19. The dietary supplement of  claim 17 , wherein one dose comprises up to 99% by weight of beta-alanine. 
     
     
       20. The dietary supplement of  claim 17 , wherein one dose comprises up to 99% by weight of a carbohydrate. 
     
     
       21. The dietary supplement of  claim 17  in an injectable formulation. 
     
     
       22. A composition comprising a mixture of insulin and a composition comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine. 
     
     
       23. The composition of  claim 22 , further comprising an L-histidine. 
     
     
       24. The composition of  claim 22 , wherein the beta-alanine further comprises a dipeptide, an oligopeptide, or a polypeptide. 
     
     
       25. The composition of  claim 22 , further comprising creatine. 
     
     
       26. The composition of  claim 22 , further comprising creatine. 
     
     
       27. A dietary supplement comprising a mixture of insulin and a composition comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine. 
     
     
       28. The dietary supplement of  claim 27  in a unit dosage form. 
     
     
       29. The dietary supplement of  claim 28 , wherein one dose comprises up to 99% by weight of beta-alanine. 
     
     
       30. The dietary supplement of  claim 28 , wherein one dose comprises up to 99% by weight of a carbohydrate. 
     
     
       31. The dietary supplement of  claim 27  in an injectable formulation. 
     
     
       32. A human dietary supplement comprising beta-alanine and L-histidine. 
     
     
       33. A human dietary supplement comprising an amino acid or an active derivative thereof selected from the group consisting of a beta-alanine, an ester of a beta-alanine and an amide of a beta-alanine and L-histidine. 
     
     
       34. A human dietary supplement for increasing human muscle tissue strength comprising a mixture of creatine, a carbohydrate and free amino acid beta-alanine that is not part of a dipeptide, polypeptide or an oligopeptide, wherein the human dietary supplement does not contain a free amino acid L-histidine, wherein the free amino acid beta-alanine is in an amount that is from 0.4 g to 16.0 g per daily dose, wherein the amount increases the muscle tissue strength in the human, and wherein the human dietary supplement is formulated for one or more doses per day for at least 14 days. 
     
     
       35. A human dietary supplement for increasing human muscle tissue strength comprising a mixture of creatine monohydrate, a carbohydrate and free amino acid beta-alanine that is not part of a dipeptide, polypeptide or an oligopeptide, wherein the human dietary supplement does not contain a free amino acid L-histidine, wherein the free amino acid beta-alanine is in an amount that is from 0.4 g to 16.0 g per daily dose, wherein the amount increases the muscle tissue strength in the human, and wherein the human dietary supplement is formulated for one or more doses per day for at least 14 days.