Fibrosis inhibitor

Abstract

[Object] The main object of the present invention is to provide a fibrosis inhibitor. [Solving Means] The present invention relates to a fibrosis inhibitor containing the heterocyclic derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient; In the formula (1), R 1 and R 2 are the same or different and each represents an optionally substituted aryl; R 3 and R 4 are the same or different and each represents hydrogen atom or alkyl; R 5 represents hydrogen atom, alkyl or halogen atom; Y represents N or N→O; A represents NR 6 , and R 6 represents hydrogen atom, alkyl, etc.; D represents alkylene or alkenylene which is optionally substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, etc.; and Q represents carboxy, alkoxycarbonyl, etc.

The invention claimed is: 
     
       1. A method for treating interstitial pneumonia comprising administering a fibrosis inhibitor containing 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid, 2-{4[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide or a pharmaceutically acceptable salt thereof as an active ingredient to a patient in need of such treatment. 
     
     
       2. The method according to claim 1, wherein the active ingredient is 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid or a pharmaceutically acceptable salt thereof. 
     
     
       3. The method according to claim 2, wherein what is treated is pulmonary fibrosis. 
     
     
       4. The method according to claim 1, wherein the active ingredient is 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide or a pharmaceutically acceptable salt thereof. 
     
     
       5. The method according to claim 4, wherein what is treated is pulmonary fibrosis.