Methods and compositions for wound treatment

Abstract

The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.

What is claimed is: 
     
       1. A method for treatment of an open wound in a subject,
 comprising administering to the open wound a composition comprising a carrier containing a hemostatic active agent, and a wound targeting moiety comprising an antibody specific for actin, 
 wherein the carrier is conjugated to the antibody, and 
 wherein the antibody facilitates local delivery of the hemostatic active agent to wound tissue by binding to an exposed actin protein, wherein the exposed actin protein is exposed upon wounding of the subject. 
 
     
     
       2. The method of  claim 1 , wherein the antibody binds to an exposed intracellular actin protein. 
     
     
       3. A method for treatment of an internal wound in a subject, comprising administering to the subject a composition comprising a carrier containing a hemostatic active agent and displaying a wound targeting moiety comprising an antibody specific for actin, wherein the antibody facilitates local delivery of the hemostatic active agent to injured tissue by binding to an intracellular actin protein that is exposed by displacement from its natural location. 
     
     
       4. The method of  claim 3 , wherein the intracellular actin protein is exposed by cell lysis or rupture. 
     
     
       5. The method of claim 1, wherein the administering is performed by irrigating the wound with the composition.  
     
     
       6. The method of claim 3, wherein the administering is performed by intravenous delivery of the composition.  
     
     
       7. The method of claim 3, wherein the administering is performed by oral delivery of the composition.  
     
     
       8. The method of claim 3, wherein the administering is performed by inhalation of the composition.