USRE46639EActiveUtility
4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
Est. expiryMar 20, 2027(~0.7 yrs left)· nominal 20-yr term from priority
A61P 9/10A61P 43/00A61P 37/00A61P 7/06A61P 7/00A61P 7/08A61P 37/04A61P 9/00A61P 37/02A61P 31/18A61P 25/00A61P 27/02A61P 31/00A61P 29/00A61P 33/00A61P 25/20A61P 25/28A61P 31/04A61P 25/04A61P 35/00A61P 17/00A61P 11/00A61K 45/06C07D 409/14A61K 38/00A61K 31/454C07D 401/04A61K 31/4709C07D 405/14C07D 403/04C07D 401/14A61K 31/4525A61K 31/4035A61K 39/0011
68
PatentIndex Score
0
Cited by
27
References
25
Claims
Abstract
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is aryl, optionally substituted with one, two or three groups selected from alkyl, halo, alkoxy, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy, alkylaminocarboxy, and alkylsulfonyl; and
n 1 is 0-5 1-5.
2. The compound of claim 1 , wherein Y is CH 2 .
3. The compound of claim 1 , wherein Y is C═O.
4. The compound of claim 1 , wherein the aryl is phenyl.
5. The compound of claim 1 , wherein the aryl is naphthyl.
6. The compound of claim 4 , wherein the phenyl is substituted with halo.
7. The compound of claim 5 , wherein the naphthyl is substituted with halo.
8. The compound of claim 4 , wherein the phenyl is substituted with alkyl or alkoxy.
9. The compound of claim 5 , wherein the naphthyl is substituted with alkyl or alkoxy.
10. The compound of claim 1 , which is:
11. The compound of claim 1 , which is:
12. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is aryl, optionally substituted with one, two or three groups selected from alkyl, halo, alkoxy, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy, alkylaminocarboxy, and alkylsulfonyl; and
n 1 is 0.
13. The compound of claim 12, wherein Y is CH 2 .
14. The compound of claim 12, wherein Y is C═O.
15. The compound of claim 12, wherein the aryl is phenyl.
16. The compound of claim 12, wherein the aryl is naphthyl.
17. The compound of claim 15, wherein the phenyl is substituted with halo.
18. The compound of claim 16, wherein the naphthyl is substituted with halo.
19. The compound of claim 15, wherein the phenyl is substituted with alkyl or alkoxy.
20. The compound of claim 16, wherein the naphthyl is substituted with alkyl or alkoxy.
21. The compound of claim 12, which is:
22. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is naphthyl; and
n 1 is 1-5.
23. The compound of claim 22, wherein Y is CH 2 .
24. The compound of claim 22, wherein Y is C═O.
25. The compound of claim 22, which is:Cited by (0)
No later patents cite this yet.
References (0)
No backward citations on record.