Prolyl hydroxylase inhibitors and methods of use

Abstract

The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

What is claimed is: 
     
       1. A compound having the formula: 
       
         
           
           
               
               
           
         
       
     
     
       2. A pharmaceutical composition comprising:
 A) the compound according to  claim 1 ; and 
 B) one or more pharmaceutically acceptable excipients. 
 
     
     
       3. A compound having the formula: 
       
         
           
           
               
               
           
         
       
     
     
       4. A pharmaceutical composition comprising:
 A) the compound according to  claim 3 ; and 
 B) one or more pharmaceutically acceptable excipients. 
 
     
     
       5. A compound having the formula: 
       
         
           
           
               
               
           
         
         wherein: 
         R 6  is hydrogen, methyl, or ethyl; 
         R 7a  and R 7b  are each independently: 
         i) hydrogen; or 
         ii) methyl. 
       
     
     
       6. The compound according to  claim 5 , wherein the compound is:
 {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester; 
 {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester; 
 5-(3-Chlorophenyl)-N-(2-amino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide; 
 5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide; and 
 5-(3-Chlorophenyl)-N-(2-dimethylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide. 
 
     
     
       7. A pharmaceutical composition comprising:
 A) one or more compounds according to  claim 6 ; and 
 B) one or more pharmaceutically acceptable excipients. 
 
     
     
       8. The composition according to  claim 7 , wherein the compound is:
 {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester; or 
 {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester.