Furanone derivative

Abstract

To provide a novel furanone derivative, and a medicine including the same. The furanone derivative is represented by the formula (I): wherein A represents —COOR1 or a hydrogen atom; R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocycle; R2 and R3 are the same or different and each independently represent a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted phenyl group, an optionally substituted heterocycle, an optionally substituted heterocyclic fused ring, or an optionally substituted amino group; or alternatively, R2 and R3, taken together with the nitrogen atom to which they are attached, may form an optionally substituted heterocycle or an optionally substituted heterocyclic fused ring; and R4 represents a hydrogen atom or a halogen atom; with the proviso that when A represents —COOR1, R2 and R3 are not optionally substituted amino groups at the same time, and when A represents a hydrogen atom, R3 represents a hydrogen atom.

The invention claimed is: 
     
       1. A furanone derivative or a pharmaceutically acceptable salt thereof, represented by the formula (I):
 [Chemical Formula 1]   
       
         
           
           
               
               
           
         
         wherein A represents —COOR1 or a hydrogen atom; R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocycle; R2 and R3 are the same or different and each independently represent a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted phenyl group, an optionally substituted heterocycle, an optionally substituted heterocyclic fused ring, or an optionally substituted amino group; or alternatively, R2 and R3, taken together with the nitrogen atom to which they are attached, form an optionally substituted heterocycle or an optionally substituted heterocyclic fused ring; and R4 represents a hydrogen atom or a halogen atom; with the proviso that when A represents —COOR1, R2 and R3 are not optionally substituted amino groups at the same time, and when A represents a hydrogen atom, R3 represents a hydrogen atom. 
       
     
     
       2. The furanone derivative or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein A is —COOR1. 
     
     
       3. The furanone derivative or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein A is a hydrogen atom. 
     
     
       4. A furanone derivative or pharmaceutically acceptable salt thereof, represented by the formula (III-Z) or formula (III-E): 
       
         
           
           
               
               
           
         
         wherein 
         A represents —COOR1 or a hydrogen atom; 
         R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocycle; 
         R2 and R3 are the same or different and each independently represent a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted phenyl group, an optionally substituted heterocycle, an optionally substituted heterocyclic fused ring, or an optionally substituted amino group; 
         and R4 represents a hydrogen atom or a halogen atom; 
         with the proviso that when A represents —COOR1, R2 and R3 are not optionally substituted amino groups at the same time, and when A represents a hydrogen atom, R3 represents a hydrogen atom. 
       
     
     
       5. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       6. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       7. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       8. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       9. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       10. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       11. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       12. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       13. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       14. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       15. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       16. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       17. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       18. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       19. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein the furanone derivative is: 
       
         
           
           
               
               
           
         
        
       
     
     
       20. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein A is —COOR1. 
     
     
       21. The furanone derivative or a pharmaceutically acceptable salt thereof according to claim 4, wherein A is a hydrogen atom.