P
USRE48809EActiveUtilityPatentIndex 62

Organic electroluminescent materials and devices

Assignee: UNIVERSAL DISPLAY CORPPriority: May 15, 2015Filed: Sep 26, 2019Granted: Nov 2, 2021
Est. expiryMay 15, 2035(~8.9 yrs left)· nominal 20-yr term from priority
Inventors:BOUDREAULT PIERRE-LUC TWENDT HARVEYXIA CHUANJUN
H10K 2101/90C09K 2211/185C09K 11/06C07F 15/0033C09K 11/025C07D 495/04C07D 239/70C07D 487/04C07D 491/048H05B 33/14H01L 51/5016H01L 51/0061H01L 51/0052H01L 51/0073H01L 51/0074H01L 51/0055H01L 51/0085H10K 50/11H10K 85/6572H10K 85/6576H10K 85/342H10K 2101/10H10K 85/615H10K 85/636H10K 85/654H10K 85/623H10K 85/6574H10K 85/657H10K 50/12
62
PatentIndex Score
0
Cited by
194
References
20
Claims

Abstract

Novel ligands for metal complexes containing five-membered ring fused on pyridine or pyrimidine ring combined with partially fluorinated side chains exhibiting improved external quantum efficiency and lifetime are disclosed.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A compound comprising a ligand L A  of Formula I: 
       
         
           
           
               
               
           
         
         wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclic ring; 
         wherein R is fused to ring B and has a structure of Formula II: 
       
       
         
           
           
               
               
           
         
         wherein the wave lines indicate bonds to ring B; 
         wherein R 1  represents mono, di, tri, or tetra substitution, or no substitution; 
         wherein R 2  represents mono or di substitution, or no substitution; 
         wherein X 1 , X 2 , X 3 , and X 4  are each independently carbon or nitrogen; 
         wherein at least one of X 1  to X 4  is nitrogen;  
         wherein at least two adjacent of X 1 , X 2 , X 3 , and X 4  are carbon and fuse to R; 
         wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″; 
         wherein R 1 , R 2 , R 3 , R 4 , R′, and R″ are each independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and wherein any two adjacent substituents are optionally joined to form into a ring; 
         wherein at least one of R 3  and R 4  comprises a chemical group selected from the group consisting of alkyl, cycloalkyl, partially fluorinated alkyl, partially fluorinated cycloalkyl, and combinations thereof; 
         wherein the ligand L A  is coordinated to a metal M; 
         wherein the ligand L A  is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate, or hexadentate ligand; and 
         wherein M is optionally coordinated to other ligands. 
       
     
     
       2. The compound of  claim 1 , wherein M is selected from the group consisting of Ir, Rh, Re, Ru, Os, Pt, Au, and Cu. 
     
     
       3. The compound of  claim 1 , wherein the ligand L A  is selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
       4. The compound of  claim 1 , wherein the ligand L A  is: 
       
         
           
           
               
               
           
         
       
     
     
       5. The compound of  claim 1 , wherein at least one of R 3  and R 4  is a chemical group selected from the group consisting of partially fluorinated alkyl, partially fluorinated cycloalkyl, and combinations thereof. 
     
     
       6. The compound of  claim 1 , wherein R 3  and R 4  are not hydrogen. 
     
     
       7. The compound of  claim 1 , wherein at least one of X 1 , X 2 , X 3 , and X 4  is nitrogen. 
     
     
       8. The compound of  claim 1 , wherein at least one of R 3  and R 4  is selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
       9. The compound of  claim 1 , wherein R 3  and R 4  are joined to form a ring structure selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
       10. The compound of  claim 1 , wherein the ligand L A  is selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
     
     
       11. The compound of  claim 8 , wherein the ligand L A  is selected from the group consisting of L A1  through L A750  defined as follows:
 L A1  through L A375  are based on a structure of Formula IV, 
 
       
         
           
           
               
               
           
         
       
       in which R 3 , R 4 , and X are defined as: 
       
         
           
                 
                 
                 
                 
                 
               
                     
                 
                     
                   Ligand 
                   R 3   
                   R 4   
                   X 
                 
                     
                 
                     
                   L A1   
                   H 
                   R A2   
                   O 
                 
                     
                   L A2   
                   R A2   
                   R A2   
                   O 
                 
                     
                   L A3   
                   R A3   
                   R A2   
                   O 
                 
                     
                   L A4   
                   R A14   
                   R A2   
                   O 
                 
                     
                   L A5   
                   R A22   
                   R A2   
                   O 
                 
                     
                   L A6   
                   R A28   
                   R A2   
                   O 
                 
                     
                   L A7   
                   H 
                   R A3   
                   O 
                 
                     
                   L A8   
                   R A2   
                   R A3   
                   O 
                 
                     
                   L A9   
                   R A3   
                   R A3   
                   O 
                 
                     
                   L A10   
                   R A14   
                   R A3   
                   O 
                 
                     
                   L A11   
                   R A22   
                   R A3   
                   O 
                 
                     
                   L A12   
                   R A28   
                   R A3   
                   O 
                 
                     
                   L A13   
                   H 
                   R A14   
                   O 
                 
                     
                   L A14   
                   R A2   
                   R A14   
                   O 
                 
                     
                   L A15   
                   R A3   
                   R A14   
                   O 
                 
                     
                   L A16   
                   R A14   
                   R A14   
                   O 
                 
                     
                   L A17   
                   R A22   
                   R A14   
                   O 
                 
                     
                   L A18   
                   R A28   
                   R A14   
                   O 
                 
                     
                   L A19   
                   H 
                   R A22   
                   O 
                 
                     
                   L A20   
                   R A2   
                   R A22   
                   O 
                 
                     
                   L A21   
                   R A3   
                   R A22   
                   O 
                 
                     
                   L A22   
                   R A14   
                   R A22   
                   O 
                 
                     
                   L A23   
                   R A22   
                   R A22   
                   O 
                 
                     
                   L A24   
                   R A28   
                   R A22   
                   O 
                 
                     
                   L A25   
                   H 
                   R A28   
                   O 
                 
                     
                   L A26   
                   R A2   
                   R A28   
                   O 
                 
                     
                   L A27   
                   R A3   
                   R A28   
                   O 
                 
                     
                   L A28   
                   R A14   
                   R A28   
                   O 
                 
                     
                   L A29   
                   R A22   
                   R A28   
                   O 
                 
                     
                   L A30   
                   R A28   
                   R A28   
                   O 
                 
                     
                   L A31   
                   R A2   
                   H 
                   O 
                 
                     
                   L A32   
                   R A3   
                   H 
                   O 
                 
                     
                   L A33   
                   R A14   
                   H 
                   O 
                 
                     
                   L A34   
                   R A22   
                   H 
                   O 
                 
                     
                   L A35   
                   R A28   
                   H 
                   O 
                 
                     
                   L A36   
                   R A2   
                   R B1   
                   O 
                 
                     
                   L A37   
                   R A3   
                   R B1   
                   O 
                 
                     
                   L A38   
                   R A14   
                   R B1   
                   O 
                 
                     
                   L A39   
                   R A22   
                   R B1   
                   O 
                 
                     
                   L A40   
                   R A28   
                   R B1   
                   O 
                 
                     
                   L A41   
                   R A2   
                   R B2   
                   O 
                 
                     
                   L A42   
                   R A3   
                   R B2   
                   O 
                 
                     
                   L A43   
                   R A14   
                   R B2   
                   O 
                 
                     
                   L A44   
                   R A22   
                   R B2   
                   O 
                 
                     
                   L A45   
                   R A28   
                   R B2   
                   O 
                 
                     
                   L A46   
                   R A2   
                   R B3   
                   O 
                 
                     
                   L A47   
                   R A3   
                   R B3   
                   O 
                 
                     
                   L A48   
                   R A14   
                   R B3   
                   O 
                 
                     
                   L A49   
                   R A22   
                   R B3   
                   O 
                 
                     
                   L A50   
                   R A28   
                   R B3   
                   O 
                 
                     
                   L A51   
                   R A2   
                   R B4   
                   O 
                 
                     
                   L A52   
                   R A3   
                   R B4   
                   O 
                 
                     
                   L A53   
                   R A14   
                   R B4   
                   O 
                 
                     
                   L A54   
                   R A22   
                   R B4   
                   O 
                 
                     
                   L A55   
                   R A28   
                   R B4   
                   O 
                 
                     
                   L A56   
                   R B1   
                   R A2   
                   O 
                 
                     
                   L A57   
                   R B1   
                   R A3   
                   O 
                 
                     
                   L A58   
                   R B1   
                   R A14   
                   O 
                 
                     
                   L A59   
                   R B1   
                   R A22   
                   O 
                 
                     
                   L A60   
                   R B1   
                   R A28   
                   O 
                 
                     
                   L A61   
                   R B2   
                   R A2   
                   O 
                 
                     
                   L A62   
                   R B2   
                   R A3   
                   O 
                 
                     
                   L A63   
                   R B2   
                   R A14   
                   O 
                 
                     
                   L A64   
                   R B2   
                   R A22   
                   O 
                 
                     
                   L A65   
                   R B2   
                   R A28   
                   O 
                 
                     
                   L A66   
                   R B3   
                   R A2   
                   O 
                 
                     
                   L A67   
                   R B3   
                   R A3   
                   O 
                 
                     
                   L A68   
                   R B3   
                   R A14   
                   O 
                 
                     
                   L A69   
                   R B3   
                   R A22   
                   O 
                 
                     
                   L A70   
                   R B3   
                   R A28   
                   O 
                 
                     
                   L A71   
                   R B4   
                   R A2   
                   O 
                 
                     
                   L A72   
                   R B4   
                   R A3   
                   O 
                 
                     
                   L A73   
                   R B4   
                   R A14   
                   O 
                 
                     
                   L A74   
                   R B4   
                   R A22   
                   O 
                 
                     
                   L A75   
                   R B4   
                   R A28   
                   O 
                 
                     
                   L A76   
                   H 
                   R A2   
                   S 
                 
                     
                   L A77   
                   R A2   
                   R A2   
                   S 
                 
                     
                   L A78   
                   R A3   
                   R A2   
                   S 
                 
                     
                   L A79   
                   R A14   
                   R A2   
                   S 
                 
                     
                   L A80   
                   R A22   
                   R A2   
                   S 
                 
                     
                   L A81   
                   R A28   
                   R A2   
                   S 
                 
                     
                   L A82   
                   H 
                   R A3   
                   S 
                 
                     
                   L A83   
                   R A2   
                   R A3   
                   S 
                 
                     
                   L A84   
                   R A3   
                   R A3   
                   S 
                 
                     
                   L A85   
                   R A14   
                   R A3   
                   S 
                 
                     
                   L A86   
                   R A22   
                   R A3   
                   S 
                 
                     
                   L A87   
                   R A28   
                   R A3   
                   S 
                 
                     
                   L A88   
                   H 
                   R A14   
                   S 
                 
                     
                   L A89   
                   R A2   
                   R A14   
                   S 
                 
                     
                   L A90   
                   R A3   
                   R A14   
                   S 
                 
                     
                   L A91   
                   R A14   
                   R A14   
                   S 
                 
                     
                   L A92   
                   R A22   
                   R A14   
                   S 
                 
                     
                   L A93   
                   R A28   
                   R A14   
                   S 
                 
                     
                   L A94   
                   H 
                   R A22   
                   S 
                 
                     
                   L A95   
                   R A2   
                   R A22   
                   S 
                 
                     
                   L A96   
                   R A3   
                   R A22   
                   S 
                 
                     
                   L A97   
                   R A14   
                   R A22   
                   S 
                 
                     
                   L A98   
                   R A22   
                   R A22   
                   S 
                 
                     
                   L A99   
                   R A28   
                   R A22   
                   S 
                 
                     
                   L A100   
                   H 
                   R A28   
                   S 
                 
                     
                   L A101   
                   R A2   
                   R A28   
                   S 
                 
                     
                   L A102   
                   R A3   
                   R A28   
                   S 
                 
                     
                   L A103   
                   R A14   
                   R A28   
                   S 
                 
                     
                   L A104   
                   R A22   
                   R A28   
                   S 
                 
                     
                   L A105   
                   R A28   
                   R A28   
                   S 
                 
                     
                   L A106   
                   R A2   
                   H 
                   S 
                 
                     
                   L A107   
                   R A3   
                   H 
                   S 
                 
                     
                   L A108   
                   R A14   
                   H 
                   S 
                 
                     
                   L A109   
                   R A22   
                   H 
                   S 
                 
                     
                   L A110   
                   R A28   
                   H 
                   S 
                 
                     
                   L A111   
                   R A2   
                   R B1   
                   S 
                 
                     
                   L A112   
                   R A3   
                   R B1   
                   S 
                 
                     
                   L A113   
                   R A14   
                   R B1   
                   S 
                 
                     
                   L A114   
                   R A22   
                   R B1   
                   S 
                 
                     
                   L A115   
                   R A28   
                   R B1   
                   S 
                 
                     
                   L A116   
                   R A2   
                   R B2   
                   S 
                 
                     
                   L A117   
                   R A3   
                   R B2   
                   S 
                 
                     
                   L A118   
                   R A14   
                   R B2   
                   S 
                 
                     
                   L A119   
                   R A22   
                   R B2   
                   S 
                 
                     
                   L A120   
                   R A28   
                   R B2   
                   S 
                 
                     
                   L A121   
                   R A2   
                   R B3   
                   S 
                 
                     
                   L A122   
                   R A3   
                   R B3   
                   S 
                 
                     
                   L A123   
                   R A14   
                   R B3   
                   S 
                 
                     
                   L A124   
                   R A22   
                   R B3   
                   S 
                 
                     
                   L A125   
                   R A28   
                   R B3   
                   S 
                 
                     
                   L A126   
                   R A2   
                   R B4   
                   S 
                 
                     
                   L A127   
                   R A3   
                   R B4   
                   S 
                 
                     
                   L A128   
                   R A14   
                   R B4   
                   S 
                 
                     
                   L A129   
                   R A22   
                   R B4   
                   S 
                 
                     
                   L A130   
                   R A28   
                   R B4   
                   S 
                 
                     
                   L A131   
                   R B1   
                   R A2   
                   S 
                 
                     
                   L A132   
                   R B1   
                   R A3   
                   S 
                 
                     
                   L A133   
                   R B1   
                   R A14   
                   S 
                 
                     
                   L A134   
                   R B1   
                   R A22   
                   S 
                 
                     
                   L A135   
                   R B1   
                   R A28   
                   S 
                 
                     
                   L A136   
                   R B2   
                   R A2   
                   S 
                 
                     
                   L A137   
                   R B2   
                   R A3   
                   S 
                 
                     
                   L A138   
                   R B2   
                   R A14   
                   S 
                 
                     
                   L A139   
                   R B2   
                   R A22   
                   S 
                 
                     
                   L A140   
                   R B2   
                   R A28   
                   S 
                 
                     
                   L A141   
                   R B3   
                   R A2   
                   S 
                 
                     
                   L A142   
                   R B3   
                   R A3   
                   S 
                 
                     
                   L A143   
                   R B3   
                   R A14   
                   S 
                 
                     
                   L A144   
                   R B3   
                   R A22   
                   S 
                 
                     
                   L A145   
                   R B3   
                   R A28   
                   S 
                 
                     
                   L A146   
                   R B4   
                   R A2   
                   S 
                 
                     
                   L A147   
                   R B4   
                   R A3   
                   S 
                 
                     
                   L A148   
                   R B4   
                   R A14   
                   S 
                 
                     
                   L A149   
                   R B4   
                   R A22   
                   S 
                 
                     
                   L A150   
                   R B4   
                   R A28   
                   S 
                 
                     
                   L A151   
                   H 
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A152   
                   R A2   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A153   
                   R A3   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A154   
                   R A14   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A155   
                   R A22   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A156   
                   R A28   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A157   
                   H 
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A158   
                   R A2   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A159   
                   R A3   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A160   
                   R A14   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A161   
                   R A22   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A162   
                   R A28   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A163   
                   H 
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A164   
                   R A2   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A165   
                   R A3   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A166   
                   R A14   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A167   
                   R A22   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A168   
                   R A28   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A169   
                   H 
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A170   
                   R A2   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A171   
                   R A3   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A172   
                   R A14   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A173   
                   R A22   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A174   
                   R A28   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A175   
                   H 
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A176   
                   R A2   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A177   
                   R A3   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A178   
                   R A14   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A179   
                   R A22   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A180   
                   R A28   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A181   
                   R A2   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A182   
                   R A3   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A183   
                   R A14   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A184   
                   R A22   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A185   
                   R A28   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A186   
                   R A2   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A187   
                   R A3   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A188   
                   R A14   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A189   
                   R A22   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A190   
                   R A28   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A191   
                   R A2   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A192   
                   R A3   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A193   
                   R A14   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A194   
                   R A22   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A195   
                   R A28   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A196   
                   R A2   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A197   
                   R A3   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A198   
                   R A14   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A199   
                   R A22   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A200   
                   R A28   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A201   
                   R A2   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A202   
                   R A3   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A203   
                   R A14   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A204   
                   R A22   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A205   
                   R A28   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A206   
                   R B1   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A207   
                   R B1   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A208   
                   R B1   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A209   
                   R B1   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A210   
                   R B1   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A211   
                   R B2   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A212   
                   R B2   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A213   
                   R B2   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A214   
                   R B2   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A215   
                   R B2   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A216   
                   R B3   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A217   
                   R B3   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A218   
                   R B3   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A219   
                   R B3   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A220   
                   R B3   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A221   
                   R B4   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A222   
                   R B4   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A223   
                   R B4   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A224   
                   R B4   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A225   
                   R B4   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A226   
                   H 
                   R A2   
                   NCH 3   
                 
                     
                   L A227   
                   R A2   
                   R A2   
                   NCH 3   
                 
                     
                   L A228   
                   R A3   
                   R A2   
                   NCH 3   
                 
                     
                   L A229   
                   R A14   
                   R A2   
                   NCH 3   
                 
                     
                   L A230   
                   R A22   
                   R A2   
                   NCH 3   
                 
                     
                   L A231   
                   R A28   
                   R A2   
                   NCH 3   
                 
                     
                   L A232   
                   H 
                   R A3   
                   NCH 3   
                 
                     
                   L A233   
                   R A2   
                   R A3   
                   NCH 3   
                 
                     
                   L A234   
                   R A3   
                   R A3   
                   NCH 3   
                 
                     
                   L A235   
                   R A14   
                   R A3   
                   NCH 3   
                 
                     
                   L A236   
                   R A22   
                   R A3   
                   NCH 3   
                 
                     
                   L A237   
                   R A28   
                   R A3   
                   NCH 3   
                 
                     
                   L A238   
                   H 
                   R A14   
                   NCH 3   
                 
                     
                   L A239   
                   R A2   
                   R A14   
                   NCH 3   
                 
                     
                   L A240   
                   R A3   
                   R A14   
                   NCH 3   
                 
                     
                   L A241   
                   R A14   
                   R A14   
                   NCH 3   
                 
                     
                   L A242   
                   R A22   
                   R A14   
                   NCH 3   
                 
                     
                   L A243   
                   R A28   
                   R A14   
                   NCH 3   
                 
                     
                   L A244   
                   H 
                   R A22   
                   NCH 3   
                 
                     
                   L A245   
                   R A2   
                   R A22   
                   NCH 3   
                 
                     
                   L A246   
                   R A3   
                   R A22   
                   NCH 3   
                 
                     
                   L A247   
                   R A14   
                   R A22   
                   NCH 3   
                 
                     
                   L A248   
                   R A22   
                   R A22   
                   NCH 3   
                 
                     
                   L A249   
                   R A28   
                   R A22   
                   NCH 3   
                 
                     
                   L A250   
                   H 
                   R A28   
                   NCH 3   
                 
                     
                   L A251   
                   R A2   
                   R A28   
                   NCH 3   
                 
                     
                   L A252   
                   R A3   
                   R A28   
                   NCH 3   
                 
                     
                   L A253   
                   R A14   
                   R A28   
                   NCH 3   
                 
                     
                   L A254   
                   R A22   
                   R A28   
                   NCH 3   
                 
                     
                   L A255   
                   R A28   
                   R A28   
                   NCH 3   
                 
                     
                   L A256   
                   R A2   
                   H 
                   NCH 3   
                 
                     
                   L A257   
                   R A3   
                   H 
                   NCH 3   
                 
                     
                   L A258   
                   R A14   
                   H 
                   NCH 3   
                 
                     
                   L A259   
                   R A22   
                   H 
                   NCH 3   
                 
                     
                   L A260   
                   R A28   
                   H 
                   NCH 3   
                 
                     
                   L A261   
                   R A2   
                   R B1   
                   NCH 3   
                 
                     
                   L A262   
                   R A3   
                   R B1   
                   NCH 3   
                 
                     
                   L A263   
                   R A14   
                   R B1   
                   NCH 3   
                 
                     
                   L A264   
                   R A22   
                   R B1   
                   NCH 3   
                 
                     
                   L A265   
                   R A28   
                   R B1   
                   NCH 3   
                 
                     
                   L A266   
                   R A2   
                   R B2   
                   NCH 3   
                 
                     
                   L A267   
                   R A3   
                   R B2   
                   NCH 3   
                 
                     
                   L A268   
                   R A14   
                   R B2   
                   NCH 3   
                 
                     
                   L A269   
                   R A22   
                   R B2   
                   NCH 3   
                 
                     
                   L A270   
                   R A28   
                   R B2   
                   NCH 3   
                 
                     
                   L A271   
                   R A2   
                   R B3   
                   NCH 3   
                 
                     
                   L A272   
                   R A3   
                   R B3   
                   NCH 3   
                 
                     
                   L A273   
                   R A14   
                   R B3   
                   NCH 3   
                 
                     
                   L A274   
                   R A22   
                   R B3   
                   NCH 3   
                 
                     
                   L A275   
                   R A28   
                   R B3   
                   NCH 3   
                 
                     
                   L A276   
                   R A2   
                   R B4   
                   NCH 3   
                 
                     
                   L A277   
                   R A3   
                   R B4   
                   NCH 3   
                 
                     
                   L A278   
                   R A14   
                   R B4   
                   NCH 3   
                 
                     
                   L A279   
                   R A22   
                   R B4   
                   NCH 3   
                 
                     
                   L A280   
                   R A28   
                   R B4   
                   NCH 3   
                 
                     
                   L A281   
                   R A2   
                   R B1   
                   NCH 3   
                 
                     
                   L A282   
                   R A3   
                   R B1   
                   NCH 3   
                 
                     
                   L A283   
                   R A14   
                   R B1   
                   NCH 3   
                 
                     
                   L A284   
                   R A22   
                   R B1   
                   NCH 3   
                 
                     
                   L A285   
                   R A28   
                   R B1   
                   NCH 3   
                 
                     
                   L A286   
                   R A2   
                   R B2   
                   NCH 3   
                 
                     
                   L A287   
                   R A3   
                   R B2   
                   NCH 3   
                 
                     
                   L A288   
                   R A14   
                   R B2   
                   NCH 3   
                 
                     
                   L A289   
                   R A22   
                   R B2   
                   NCH 3   
                 
                     
                   L A290   
                   R A28   
                   R B2   
                   NCH 3   
                 
                     
                   L A291   
                   R A2   
                   R B3   
                   NCH 3   
                 
                     
                   L A292   
                   R A3   
                   R B3   
                   NCH 3   
                 
                     
                   L A293   
                   R A14   
                   R B3   
                   NCH 3   
                 
                     
                   L A294   
                   R A22   
                   R B3   
                   NCH 3   
                 
                     
                   L A295   
                   R A28   
                   R B3   
                   NCH 3   
                 
                     
                   L A296   
                   R A2   
                   R B4   
                   NCH 3   
                 
                     
                   L A297   
                   R A3   
                   R B4   
                   NCH 3   
                 
                     
                   L A298   
                   R A14   
                   R B4   
                   NCH 3   
                 
                     
                   L A299   
                   R A22   
                   R B4   
                   NCH 3   
                 
                     
                   L A300   
                   R A28   
                   R B4   
                   NCH 3   
                 
                     
                   L A301   
                   H 
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A302   
                   R A2   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A303   
                   R A3   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A304   
                   R A14   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A305   
                   R A22   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A306   
                   R A28   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A307   
                   H 
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A308   
                   R A2   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A309   
                   R A3   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A310   
                   R A14   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A311   
                   R A22   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A312   
                   R A28   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A313   
                   H 
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A314   
                   R A2   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A315   
                   R A3   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A316   
                   R A14   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A317   
                   R A22   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A318   
                   R A28   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A319   
                   H 
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A320   
                   R A2   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A321   
                   R A3   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A322   
                   R A14   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A323   
                   R A22   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A324   
                   R A28   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A325   
                   H 
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A326   
                   R A2   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A327   
                   R A3   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A328   
                   R A14   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A329   
                   R A22   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A330   
                   R A28   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A331   
                   R A2   
                   H 
                   N(isobutyl) 
                 
                     
                   L A332   
                   R A3   
                   H 
                   N(isobutyl) 
                 
                     
                   L A333   
                   R A14   
                   H 
                   N(isobutyl) 
                 
                     
                   L A334   
                   R A22   
                   H 
                   N(isobutyl) 
                 
                     
                   L A335   
                   R A28   
                   H 
                   N(isobutyl) 
                 
                     
                   L A336   
                   R A2   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A337   
                   R A3   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A338   
                   R A14   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A339   
                   R A22   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A340   
                   R A28   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A341   
                   R A2   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A342   
                   R A3   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A343   
                   R A14   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A344   
                   R A22   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A345   
                   R A28   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A346   
                   R A2   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A347   
                   R A3   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A348   
                   R A14   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A349   
                   R A22   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A350   
                   R A28   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A351   
                   R A2   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A352   
                   R A3   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A353   
                   R A14   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A354   
                   R A22   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A355   
                   R A28   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A356   
                   R B1   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A357   
                   R B1   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A358   
                   R B1   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A359   
                   R B1   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A360   
                   R B1   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A361   
                   R B2   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A362   
                   R B2   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A363   
                   R B2   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A364   
                   R B2   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A365   
                   R B2   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A366   
                   R B3   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A367   
                   R B3   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A368   
                   R B3   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A369   
                   R B3   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A370   
                   R B3   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A371   
                   R B4   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A372   
                   R B4   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A373   
                   R B4   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A374   
                   R B4   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A375   
                   R B4   
                   R A28   
                   N(isobutyl) 
                 
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
         and L A376  through L A750  are based on a structure of Formula V, 
       
       
         
           
           
               
               
           
         
       
       in which R 3 , R 4 , and X are defined as: 
       
         
           
                 
                 
                 
                 
                 
               
                     
                 
                     
                   Ligand 
                   R 3   
                   R 4   
                   X 
                 
                     
                 
                     
                   L A376   
                   H 
                   R A2   
                   O 
                 
                     
                   L A377   
                   R A2   
                   R A2   
                   O 
                 
                     
                   L A378   
                   R A3   
                   R A2   
                   O 
                 
                     
                   L A379   
                   R A14   
                   R A2   
                   O 
                 
                     
                   L A380   
                   R A22   
                   R A2   
                   O 
                 
                     
                   L A381   
                   R A28   
                   R A2   
                   O 
                 
                     
                   L A382   
                   H 
                   R A3   
                   O 
                 
                     
                   L A383   
                   R A2   
                   R A3   
                   O 
                 
                     
                   L A384   
                   R A3   
                   R A3   
                   O 
                 
                     
                   L A385   
                   R A14   
                   R A3   
                   O 
                 
                     
                   L A386   
                   R A22   
                   R A3   
                   O 
                 
                     
                   L A387   
                   R A28   
                   R A3   
                   O 
                 
                     
                   L A388   
                   H 
                   R A14   
                   O 
                 
                     
                   L A389   
                   R A2   
                   R A14   
                   O 
                 
                     
                   L A390   
                   R A3   
                   R A14   
                   O 
                 
                     
                   L A391   
                   R A14   
                   R A14   
                   O 
                 
                     
                   L A392   
                   R A22   
                   R A14   
                   O 
                 
                     
                   L A393   
                   R A28   
                   R A14   
                   O 
                 
                     
                   L A394   
                   H 
                   R A22   
                   O 
                 
                     
                   L A395   
                   R A2   
                   R A22   
                   O 
                 
                     
                   L A396   
                   R A3   
                   R A22   
                   O 
                 
                     
                   L A397   
                   R A14   
                   R A22   
                   O 
                 
                     
                   L A398   
                   R A22   
                   R A22   
                   O 
                 
                     
                   L A399   
                   R A28   
                   R A22   
                   O 
                 
                     
                   L A400   
                   H 
                   R A28   
                   O 
                 
                     
                   L A401   
                   R A2   
                   R A28   
                   O 
                 
                     
                   L A402   
                   R A3   
                   R A28   
                   O 
                 
                     
                   L A403   
                   R A14   
                   R A28   
                   O 
                 
                     
                   L A404   
                   R A22   
                   R A28   
                   O 
                 
                     
                   L A405   
                   R A28   
                   R A28   
                   O 
                 
                     
                   L A406   
                   R A2   
                   H 
                   O 
                 
                     
                   L A407   
                   R A3   
                   H 
                   O 
                 
                     
                   L A408   
                   R A14   
                   H 
                   O 
                 
                     
                   L A409   
                   R A22   
                   H 
                   O 
                 
                     
                   L A410   
                   R A28   
                   H 
                   O 
                 
                     
                   L A411   
                   R A2   
                   R B1   
                   O 
                 
                     
                   L A412   
                   R A3   
                   R B1   
                   O 
                 
                     
                   L A413   
                   R A14   
                   R B1   
                   O 
                 
                     
                   L A414   
                   R A22   
                   R B1   
                   O 
                 
                     
                   L A415   
                   R A28   
                   R B1   
                   O 
                 
                     
                   L A416   
                   R A2   
                   R B2   
                   O 
                 
                     
                   L A417   
                   R A3   
                   R B2   
                   O 
                 
                     
                   L A418   
                   R A14   
                   R B2   
                   O 
                 
                     
                   L A419   
                   R A22   
                   R B2   
                   O 
                 
                     
                   L A420   
                   R A28   
                   R B2   
                   O 
                 
                     
                   L A421   
                   R A2   
                   R B3   
                   O 
                 
                     
                   L A422   
                   R A3   
                   R B3   
                   O 
                 
                     
                   L A423   
                   R A14   
                   R B3   
                   O 
                 
                     
                   L A424   
                   R A22   
                   R B3   
                   O 
                 
                     
                   L A425   
                   R A28   
                   R B3   
                   O 
                 
                     
                   L A426   
                   R A2   
                   R B4   
                   O 
                 
                     
                   L A427   
                   R A3   
                   R B4   
                   O 
                 
                     
                   L A428   
                   R A14   
                   R B4   
                   O 
                 
                     
                   L A429   
                   R A22   
                   R B4   
                   O 
                 
                     
                   L A430   
                   R A28   
                   R B4   
                   O 
                 
                     
                   L A431   
                   R B1   
                   R A2   
                   O 
                 
                     
                   L A432   
                   R B1   
                   R A3   
                   O 
                 
                     
                   L A433   
                   R B1   
                   R A14   
                   O 
                 
                     
                   L A434   
                   R B1   
                   R A22   
                   O 
                 
                     
                   L A435   
                   R B1   
                   R A28   
                   O 
                 
                     
                   L A436   
                   R B2   
                   R A2   
                   O 
                 
                     
                   L A437   
                   R B2   
                   R A3   
                   O 
                 
                     
                   L A438   
                   R B2   
                   R A14   
                   O 
                 
                     
                   L A439   
                   R B2   
                   R A22   
                   O 
                 
                     
                   L A440   
                   R B2   
                   R A28   
                   O 
                 
                     
                   L A441   
                   R B3   
                   R A2   
                   O 
                 
                     
                   L A442   
                   R B3   
                   R A3   
                   O 
                 
                     
                   L A443   
                   R B3   
                   R A14   
                   O 
                 
                     
                   L A444   
                   R B3   
                   R A22   
                   O 
                 
                     
                   L A445   
                   R B3   
                   R A28   
                   O 
                 
                     
                   L A446   
                   R B4   
                   R A2   
                   O 
                 
                     
                   L A447   
                   R B4   
                   R A3   
                   O 
                 
                     
                   L A448   
                   R B4   
                   R A14   
                   O 
                 
                     
                   L A449   
                   R B4   
                   R A22   
                   O 
                 
                     
                   L A450   
                   R B4   
                   R A28   
                   O 
                 
                     
                   L A451   
                   H 
                   R A2   
                   S 
                 
                     
                   L A452   
                   R A2   
                   R A2   
                   S 
                 
                     
                   L A453   
                   R A3   
                   R A2   
                   S 
                 
                     
                   L A454   
                   R A14   
                   R A2   
                   S 
                 
                     
                   L A455   
                   R A22   
                   R A2   
                   S 
                 
                     
                   L A456   
                   R A28   
                   R A2   
                   S 
                 
                     
                   L A457   
                   H 
                   R A3   
                   S 
                 
                     
                   L A458   
                   R A2   
                   R A3   
                   S 
                 
                     
                   L A459   
                   R A3   
                   R A3   
                   S 
                 
                     
                   L A460   
                   R A14   
                   R A3   
                   S 
                 
                     
                   L A461   
                   R A22   
                   R A3   
                   S 
                 
                     
                   L A462   
                   R A28   
                   R A3   
                   S 
                 
                     
                   L A463   
                   H 
                   R A14   
                   S 
                 
                     
                   L A464   
                   R A2   
                   R A14   
                   S 
                 
                     
                   L A465   
                   R A3   
                   R A14   
                   S 
                 
                     
                   L A466   
                   R A14   
                   R A14   
                   S 
                 
                     
                   L A467   
                   R A22   
                   R A14   
                   S 
                 
                     
                   L A468   
                   R A28   
                   R A14   
                   S 
                 
                     
                   L A469   
                   H 
                   R A22   
                   S 
                 
                     
                   L A470   
                   R A2   
                   R A22   
                   S 
                 
                     
                   L A471   
                   R A3   
                   R A22   
                   S 
                 
                     
                   L A472   
                   R A14   
                   R A22   
                   S 
                 
                     
                   L A473   
                   R A22   
                   R A22   
                   S 
                 
                     
                   L A474   
                   R A28   
                   R A22   
                   S 
                 
                     
                   L A475   
                   H 
                   R A28   
                   S 
                 
                     
                   L A476   
                   R A2   
                   R A28   
                   S 
                 
                     
                   L A477   
                   R A3   
                   R A28   
                   S 
                 
                     
                   L A478   
                   R A14   
                   R A28   
                   S 
                 
                     
                   L A479   
                   R A22   
                   R A28   
                   S 
                 
                     
                   L A480   
                   R A28   
                   R A28   
                   S 
                 
                     
                   L A481   
                   R A2   
                   H 
                   S 
                 
                     
                   L A482   
                   R A3   
                   H 
                   S 
                 
                     
                   L A483   
                   R A14   
                   H 
                   S 
                 
                     
                   L A484   
                   R A22   
                   H 
                   S 
                 
                     
                   L A485   
                   R A28   
                   H 
                   S 
                 
                     
                   L A486   
                   R A2   
                   R B1   
                   S 
                 
                     
                   L A487   
                   R A3   
                   R B1   
                   S 
                 
                     
                   L A488   
                   R A14   
                   R B1   
                   S 
                 
                     
                   L A489   
                   R A22   
                   R B1   
                   S 
                 
                     
                   L A490   
                   R A28   
                   R B1   
                   S 
                 
                     
                   L A491   
                   R A2   
                   R B2   
                   S 
                 
                     
                   L A492   
                   R A3   
                   R B2   
                   S 
                 
                     
                   L A493   
                   R A14   
                   R B2   
                   S 
                 
                     
                   L A494   
                   R A22   
                   R B2   
                   S 
                 
                     
                   L A495   
                   R A28   
                   R B2   
                   S 
                 
                     
                   L A496   
                   R A2   
                   R B3   
                   S 
                 
                     
                   L A497   
                   R A3   
                   R B3   
                   S 
                 
                     
                   L A498   
                   R A14   
                   R B3   
                   S 
                 
                     
                   L A499   
                   R A22   
                   R B3   
                   S 
                 
                     
                   L A500   
                   R A28   
                   R B3   
                   S 
                 
                     
                   L A501   
                   R A2   
                   R B4   
                   S 
                 
                     
                   L A502   
                   R A3   
                   R B4   
                   S 
                 
                     
                   L A503   
                   R A14   
                   R B4   
                   S 
                 
                     
                   L A504   
                   R A22   
                   R B4   
                   S 
                 
                     
                   L A505   
                   R A28   
                   R B4   
                   S 
                 
                     
                   L A506   
                   R B1   
                   R A2   
                   S 
                 
                     
                   L A507   
                   R B1   
                   R A3   
                   S 
                 
                     
                   L A508   
                   R B1   
                   R A14   
                   S 
                 
                     
                   L A509   
                   R B1   
                   R A22   
                   S 
                 
                     
                   L A510   
                   R B1   
                   R A28   
                   S 
                 
                     
                   L A511   
                   R B2   
                   R A2   
                   S 
                 
                     
                   L A512   
                   R B2   
                   R A3   
                   S 
                 
                     
                   L A513   
                   R B2   
                   R A14   
                   S 
                 
                     
                   L A514   
                   R B2   
                   R A22   
                   S 
                 
                     
                   L A515   
                   R B2   
                   R A28   
                   S 
                 
                     
                   L A516   
                   R B3   
                   R A2   
                   S 
                 
                     
                   L A517   
                   R B3   
                   R A3   
                   S 
                 
                     
                   L A518   
                   R B3   
                   R A14   
                   S 
                 
                     
                   L A519   
                   R B3   
                   R A22   
                   S 
                 
                     
                   L A520   
                   R B3   
                   R A28   
                   S 
                 
                     
                   L A521   
                   R B4   
                   R A2   
                   S 
                 
                     
                   L A522   
                   R B4   
                   R A3   
                   S 
                 
                     
                   L A523   
                   R B4   
                   R A14   
                   S 
                 
                     
                   L A524   
                   R B4   
                   R A22   
                   S 
                 
                     
                   L A525   
                   R B4   
                   R A28   
                   S 
                 
                     
                   L A526   
                   H 
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A527   
                   R A2   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A528   
                   R A3   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A529   
                   R A14   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A530   
                   R A22   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A531   
                   R A28   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A532   
                   H 
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A533   
                   R A2   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A534   
                   R A3   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A535   
                   R A14   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A536   
                   R A22   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A537   
                   R A28   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A538   
                   H 
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A539   
                   R A2   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A540   
                   R A3   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A541   
                   R A14   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A542   
                   R A22   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A543   
                   R A28   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A544   
                   H 
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A545   
                   R A2   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A546   
                   R A3   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A547   
                   R A14   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A548   
                   R A22   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A549   
                   R A28   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A550   
                   H 
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A551   
                   R A2   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A552   
                   R A3   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A553   
                   R A14   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A554   
                   R A22   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A555   
                   R A28   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A556   
                   R A2   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A557   
                   R A3   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A558   
                   R A14   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A559   
                   R A22   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A560   
                   R A28   
                   H 
                   C(CH 3 ) 2   
                 
                     
                   L A561   
                   R A2   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A562   
                   R A3   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A563   
                   R A14   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A564   
                   R A22   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A565   
                   R A28   
                   R B1   
                   C(CH 3 ) 2   
                 
                     
                   L A566   
                   R A2   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A567   
                   R A3   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A568   
                   R A14   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A569   
                   R A22   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A570   
                   R A28   
                   R B2   
                   C(CH 3 ) 2   
                 
                     
                   L A571   
                   R A2   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A572   
                   R A3   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A573   
                   R A14   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A574   
                   R A22   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A575   
                   R A28   
                   R B3   
                   C(CH 3 ) 2   
                 
                     
                   L A576   
                   R A2   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A577   
                   R A3   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A578   
                   R A14   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A579   
                   R A22   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A580   
                   R A28   
                   R B4   
                   C(CH 3 ) 2   
                 
                     
                   L A581   
                   R B1   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A582   
                   R B1   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A583   
                   R B1   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A584   
                   R B1   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A585   
                   R B1   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A586   
                   R B2   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A587   
                   R B2   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A588   
                   R B2   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A589   
                   R B2   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A590   
                   R B2   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A591   
                   R B3   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A592   
                   R B3   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A593   
                   R B3   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A594   
                   R B3   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A595   
                   R B3   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A596   
                   R B4   
                   R A2   
                   C(CH 3 ) 2   
                 
                     
                   L A597   
                   R B4   
                   R A3   
                   C(CH 3 ) 2   
                 
                     
                   L A598   
                   R B4   
                   R A14   
                   C(CH 3 ) 2   
                 
                     
                   L A599   
                   R B4   
                   R A22   
                   C(CH 3 ) 2   
                 
                     
                   L A600   
                   R B4   
                   R A28   
                   C(CH 3 ) 2   
                 
                     
                   L A601   
                   H 
                   R A2   
                   NCH 3   
                 
                     
                   L A602   
                   R A2   
                   R A2   
                   NCH 3   
                 
                     
                   L A603   
                   R A3   
                   R A2   
                   NCH 3   
                 
                     
                   L A604   
                   R A14   
                   R A2   
                   NCH 3   
                 
                     
                   L A605   
                   R A22   
                   R A2   
                   NCH 3   
                 
                     
                   L A606   
                   R A28   
                   R A2   
                   NCH 3   
                 
                     
                   L A607   
                   H 
                   R A3   
                   NCH 3   
                 
                     
                   L A608   
                   R A2   
                   R A3   
                   NCH 3   
                 
                     
                   L A609   
                   R A3   
                   R A3   
                   NCH 3   
                 
                     
                   L A610   
                   R A14   
                   R A3   
                   NCH 3   
                 
                     
                   L A611   
                   R A22   
                   R A3   
                   NCH 3   
                 
                     
                   L A612   
                   R A28   
                   R A3   
                   NCH 3   
                 
                     
                   L A613   
                   H 
                   R A14   
                   NCH 3   
                 
                     
                   L A614   
                   R A2   
                   R A14   
                   NCH 3   
                 
                     
                   L A615   
                   R A3   
                   R A14   
                   NCH 3   
                 
                     
                   L A616   
                   R A14   
                   R A14   
                   NCH 3   
                 
                     
                   L A617   
                   R A22   
                   R A14   
                   NCH 3   
                 
                     
                   L A618   
                   R A28   
                   R A14   
                   NCH 3   
                 
                     
                   L A619   
                   H 
                   R A22   
                   NCH 3   
                 
                     
                   L A620   
                   R A2   
                   R A22   
                   NCH 3   
                 
                     
                   L A621   
                   R A3   
                   R A22   
                   NCH 3   
                 
                     
                   L A622   
                   R A14   
                   R A22   
                   NCH 3   
                 
                     
                   L A623   
                   R A22   
                   R A22   
                   NCH 3   
                 
                     
                   L A624   
                   R A28   
                   R A22   
                   NCH 3   
                 
                     
                   L A625   
                   H 
                   R A28   
                   NCH 3   
                 
                     
                   L A626   
                   R A2   
                   R A28   
                   NCH 3   
                 
                     
                   L A627   
                   R A3   
                   R A28   
                   NCH 3   
                 
                     
                   L A628   
                   R A14   
                   R A28   
                   NCH 3   
                 
                     
                   L A629   
                   R A22   
                   R A28   
                   NCH 3   
                 
                     
                   L A630   
                   R A28   
                   R A28   
                   NCH 3   
                 
                     
                   L A631   
                   R A2   
                   H 
                   NCH 3   
                 
                     
                   L A632   
                   R A3   
                   H 
                   NCH 3   
                 
                     
                   L A633   
                   R A14   
                   H 
                   NCH 3   
                 
                     
                   L A634   
                   R A22   
                   H 
                   NCH 3   
                 
                     
                   L A635   
                   R A28   
                   H 
                   NCH 3   
                 
                     
                   L A636   
                   R A2   
                   R B1   
                   NCH 3   
                 
                     
                   L A637   
                   R A3   
                   R B1   
                   NCH 3   
                 
                     
                   L A638   
                   R A14   
                   R B1   
                   NCH 3   
                 
                     
                   L A639   
                   R A22   
                   R B1   
                   NCH 3   
                 
                     
                   L A640   
                   R A28   
                   R B1   
                   NCH 3   
                 
                     
                   L A641   
                   R A2   
                   R B2   
                   NCH 3   
                 
                     
                   L A642   
                   R A3   
                   R B2   
                   NCH 3   
                 
                     
                   L A643   
                   R A14   
                   R B2   
                   NCH 3   
                 
                     
                   L A644   
                   R A22   
                   R B2   
                   NCH 3   
                 
                     
                   L A645   
                   R A28   
                   R B2   
                   NCH 3   
                 
                     
                   L A646   
                   R A2   
                   R B3   
                   NCH 3   
                 
                     
                   L A647   
                   R A3   
                   R B3   
                   NCH 3   
                 
                     
                   L A648   
                   R A14   
                   R B3   
                   NCH 3   
                 
                     
                   L A649   
                   R A22   
                   R B3   
                   NCH 3   
                 
                     
                   L A650   
                   R A28   
                   R B3   
                   NCH 3   
                 
                     
                   L A651   
                   R A2   
                   R B4   
                   NCH 3   
                 
                     
                   L A652   
                   R A3   
                   R B4   
                   NCH 3   
                 
                     
                   L A653   
                   R A14   
                   R B4   
                   NCH 3   
                 
                     
                   L A654   
                   R A22   
                   R B4   
                   NCH 3   
                 
                     
                   L A655   
                   R A28   
                   R B4   
                   NCH 3   
                 
                     
                   L A656   
                   R A2   
                   R B1   
                   NCH 3   
                 
                     
                   L A657   
                   R A3   
                   R B1   
                   NCH 3   
                 
                     
                   L A658   
                   R A14   
                   R B1   
                   NCH 3   
                 
                     
                   L A659   
                   R A22   
                   R B1   
                   NCH 3   
                 
                     
                   L A660   
                   R A28   
                   R B1   
                   NCH 3   
                 
                     
                   L A661   
                   R A2   
                   R B2   
                   NCH 3   
                 
                     
                   L A662   
                   R A3   
                   R B2   
                   NCH 3   
                 
                     
                   L A663   
                   R A14   
                   R B2   
                   NCH 3   
                 
                     
                   L A664   
                   R A22   
                   R B2   
                   NCH 3   
                 
                     
                   L A665   
                   R A28   
                   R B2   
                   NCH 3   
                 
                     
                   L A666   
                   R A2   
                   R B3   
                   NCH 3   
                 
                     
                   L A667   
                   R A3   
                   R B3   
                   NCH 3   
                 
                     
                   L A668   
                   R A14   
                   R B3   
                   NCH 3   
                 
                     
                   L A669   
                   R A22   
                   R B3   
                   NCH 3   
                 
                     
                   L A670   
                   R A28   
                   R B3   
                   NCH 3   
                 
                     
                   L A671   
                   R A2   
                   R B4   
                   NCH 3   
                 
                     
                   L A672   
                   R A3   
                   R B4   
                   NCH 3   
                 
                     
                   L A673   
                   R A14   
                   R B4   
                   NCH 3   
                 
                     
                   L A674   
                   R A22   
                   R B4   
                   NCH 3   
                 
                     
                   L A675   
                   R A28   
                   R B4   
                   NCH 3   
                 
                     
                   L A676   
                   H 
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A677   
                   R A2   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A678   
                   R A3   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A679   
                   R A14   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A680   
                   R A22   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A681   
                   R A28   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A682   
                   H 
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A683   
                   R A2   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A684   
                   R A3   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A685   
                   R A14   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A686   
                   R A22   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A687   
                   R A28   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A688   
                   H 
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A689   
                   R A2   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A690   
                   R A3   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A691   
                   R A14   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A692   
                   R A22   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A693   
                   R A28   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A694   
                   H 
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A695   
                   R A2   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A696   
                   R A3   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A697   
                   R A14   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A698   
                   R A22   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A699   
                   R A28   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A700   
                   H 
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A701   
                   R A2   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A702   
                   R A3   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A703   
                   R A14   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A704   
                   R A22   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A705   
                   R A28   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A706   
                   R A2   
                   H 
                   N(isobutyl) 
                 
                     
                   L A707   
                   R A3   
                   H 
                   N(isobutyl) 
                 
                     
                   L A708   
                   R A14   
                   H 
                   N(isobutyl) 
                 
                     
                   L A709   
                   R A22   
                   H 
                   N(isobutyl) 
                 
                     
                   L A710   
                   R A28   
                   H 
                   N(isobutyl) 
                 
                     
                   L A711   
                   R A2   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A712   
                   R A3   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A713   
                   R A14   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A714   
                   R A22   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A715   
                   R A28   
                   R B1   
                   N(isobutyl) 
                 
                     
                   L A716   
                   R A2   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A717   
                   R A3   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A718   
                   R A14   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A719   
                   R A22   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A720   
                   R A28   
                   R B2   
                   N(isobutyl) 
                 
                     
                   L A721   
                   R A2   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A722   
                   R A3   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A723   
                   R A14   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A724   
                   R A22   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A725   
                   R A28   
                   R B3   
                   N(isobutyl) 
                 
                     
                   L A726   
                   R A2   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A727   
                   R A3   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A728   
                   R A14   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A729   
                   R A22   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A730   
                   R A28   
                   R B4   
                   N(isobutyl) 
                 
                     
                   L A731   
                   R B1   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A732   
                   R B1   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A733   
                   R B1   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A734   
                   R B1   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A735   
                   R B1   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A736   
                   R B2   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A737   
                   R B2   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A738   
                   R B2   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A739   
                   R B2   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A740   
                   R B2   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A741   
                   R B3   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A742   
                   R B3   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A743   
                   R B3   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A744   
                   R B3   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A745   
                   R B3   
                   R A28   
                   N(isobutyl) 
                 
                     
                   L A746   
                   R B4   
                   R A2   
                   N(isobutyl) 
                 
                     
                   L A747   
                   R B4   
                   R A3   
                   N(isobutyl) 
                 
                     
                   L A748   
                   R B4   
                   R A14   
                   N(isobutyl) 
                 
                     
                   L A749   
                   R B4   
                   R A22   
                   N(isobutyl) 
                 
                     
                   L A750   
                   R B4   
                   R A28   
                   N(isobutyl) 
                 
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
         wherein R B1  to R B4  have the following structures: 
       
       
         
           
           
               
               
           
         
       
     
     
       12. The compound of  claim 1 , wherein the compound has a structure of Formula III, (L A ) n Ir(L B ) 3-n , wherein L B  is a bidentate ligand and n is 1, 2, or 3. 
     
     
       13. The compound of  claim 12 , wherein the ligand L B  is selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
       14. The compound of  claim 11 , wherein the compound is selected from the group consisting of Compound 1 through Compound 12,750;
 wherein each Compound x has the formula Ir(L Ak ) 2 (L Bj ); 
 wherein x=750j+k−750, k is an integer from 1 to 750, and j is an integer from 1 to 17; and 
 
       wherein ligands L B1  through L B17  are defined as follows: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
       15. A first device comprising a first organic light emitting device, the first organic light emitting device comprising:
 an anode; 
 a cathode; and 
 an organic layer, disposed between the anode and the cathode, comprising a compound comprising a ligand L A  of Formula I: 
 
       
         
           
           
               
               
           
         
         wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclic ring; 
         wherein R is fused to ring B and has a structure of Formula II: 
       
       
         
           
           
               
               
           
         
         wherein the wave lines indicate bonds to ring B; 
         wherein R 1  represents mono, di, tri, or tetra substitution, or no substitution; 
         wherein R 2  represents mono or di substitution, or no substitution; 
         wherein X 1 , X 2 , X 3 , and X 4  are each independently carbon or nitrogen; 
         wherein at least one of X 1  to X 4  is nitrogen;  
         wherein at least two adjacent of X 1 , X 2 , X 3 , and X 4  are carbon and fuse to R; 
         wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″; 
         wherein R 1 , R 2 , R 3 , R 4 , R′, and R″ are each independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and wherein any two adjacent substituents are optionally joined to form into a ring; 
         wherein at least one of R 3  and R 4  comprises a chemical group selected from the group consisting of alkyl, cycloalkyl, partially fluorinated alkyl, partially fluorinated cycloalkyl, and combinations thereof; 
         wherein L A  is coordinated to a metal M; 
         wherein L A  is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate, or hexadentate ligand; and 
         wherein M is optionally coordinated to other ligands. 
       
     
     
       16. The first device of  claim 15 , wherein the first device is selected from the group consisting of a consumer product, an electronic component module, an organic light-emitting device, and a lighting panel. 
     
     
       17. The first device of  claim 15 , wherein the organic layer is an emissive layer and the compound is an emissive dopant or a non-emissive dopant. 
     
     
       18. The first device of  claim 15 , wherein the organic layer further comprises a host, wherein host comprises at least one chemical group selected from the group consisting of carbazole, dibenzothiophene, dibenzofuran, dibenzoselenophene, azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene. 
     
     
       19. The first device of  claim 15 , wherein the organic layer further comprises a host, wherein the host is selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       and combinations thereof. 
     
     
       20. A formulation comprising a compound comprising a ligand L A  of Formula I: 
       
         
           
           
               
               
           
         
         wherein ring A is a 5-membered or 6-membered carbocyclic or heterocyclic ring; 
         wherein R is fused to ring B and has a structure of Formula II: 
       
       
         
           
           
               
               
           
         
         wherein the wave lines indicate bonds to ring B; 
         wherein R 1  represents mono, di, tri, or tetra substitution, or no substitution; 
         wherein R 2  represents mono or di substitution, or no substitution; 
         wherein X 1 , X 2 , X 3 , and X 4  are each independently carbon or nitrogen; 
         wherein at least one of X 1  to X 4  is nitrogen;  
         wherein at least two adjacent of X 1 , X 2 , X 3 , and X 4  are carbon and fuse to R; 
         wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″; 
         wherein R 1 , R 2 , R 3 , R 4 , R′, and R″ are each independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and wherein any two adjacent substituents are optionally joined to form into a ring; 
         wherein at least one of R 3  and R 4  comprises a chemical group selected from the group consisting of alkyl, cycloalkyl, partially fluorinated alkyl, partially fluorinated cycloalkyl, and combinations thereof; 
         wherein the ligand L A  is coordinated to a metal M; 
         wherein the ligand L A  is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate, or hexadentate ligand; and 
         wherein M is optionally coordinated to other ligands.

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