Device for photodynamical therapy of cancer

Abstract

A method and device for photodynamic therapy for treating cancer. The method includes: providing a photodynamic therapeutic device for treating cancer. The provided device includes a plurality of light emitting diodes that are positionable in proximity of a patient's body and are adapted to provide a light fluence to a lesion area. The method also includes administering an effective dose of a photosensitizer in the lesion area; positioning the device in proximity to the patient's body; and irradiating the patient's body.

What is claimed is: 
     
       1. A method of photodynamic therapy for treating cancer; said method comprising the steps of:
 a. providing a photodynamic therapeutic device for treating cancer;, said device comprises a copper circuit board, a plurality of light emitting diodes on said copper circuit board and positionable in proximity of a patient's body adapted to provide a light fluence to a lesion area and a passage connected to said copper circuit board to withdraw heat and accommodating a coolant circulating within said passage and removing heat generated by said plurality of light emitting diodes;, wherein said passage is connected in fluid communication to a feeding pipe; 
 b. administering an effective dose of a photosensitizer in a lesion area of said patient's body; 
 c. positioning the device in proximity of said lesion area of said patient's body, wherein said lesion area has an effective dose of a photosensitizer administered therein; 
 dc. irradiating said lesion area; 
 ed. transferring heat generated by said plurality of light emitting diodes through said copper circuit board to said passage; and  
 fe. removing said generated heat from said passage by said coolant circulating within said passage; wherein said step of irradiating said lesion area is characterized by power density at a skin surface overlaying the lesion area ranging between 1200 mW/cm 2  and 10,0003500 mW/cm 2  and treatment duration ranging between 150 sec and 3600 sec such that density of total energy incident to said lesion area is in a range between 0.01 J/cm 2  and 100 J/cm 2 , thereat, wherein said step of irradiating said lesion area is performed by said photodynamic therapeutic device having a luminous surface of a total area which is greater than 10from 31.25 cm 2  to 240 cm 2 . 
 
     
     
       2. The method according to  claim 1 , wherein said device is positioned in proximity of said patient's body in a location selected from the group consisting of a breast, an arm, a leg, a neck, an abdomen and any combination thereof. 
     
     
       3. The method according to  claim 1 , wherein a mode of device operation is selected from the group consisting of a continuous mode, a pulse mode, an intermittent mode and any combination thereof. 
     
     
       4. The method according to  claim 1 , wherein said step of positioning the device in proximity of said patient's body lesion area further comprises a step of preliminary positioning a silicon spacer between the device and said patient's body. 
     
     
       5. The method according to  claim 1 , wherein said step of irradiating said lesion area includes irradiating at maximum light intensity at at least one wavelength selected from the group consisting and is performed in coordination with the photosensitizer that is administered within the lesion area and comprises at least one of:
 a wavelength of about 630 nm performed in coordination with said preceding step of administering an effective dose of a with the photosensitizer being 5-aminolaevulinic acid (5-ALA); 
 a wavelength of about 585 to about 740 nm performed in coordination with said preceding step of administering an effective dose of a with the photosensitizer being 5,10,15,20-tetrakis(m-hydroxyphenyl) chlorin (Foscan); 
 a wavelength of about 570 to about 670 nm is performed in coordination with said preceding step of administering an effective dose of a with the photosensitizer being methyl aminolevulinate (Metvix); 
 a wavelength of about 615 to about 800 nm performed in coordination with said preceding step of administering an effective dose of a with the photosensitizer being Pd-bacteriopheophorbide (Tookad); 
 a wavelength of about 600 to about 750 nm performed in coordination with said preceding step of administering an effective dose of a with said photosensitizer being a concentrated distillate of hematoporphyrins (Photofrin); or  
 a wavelength of about 450 to about 600 nm performed in coordination with said preceding step of administering an effective dose of a with said photosensitizer being verteporfin (Visudyne) and any combination thereof. 
 
     
     
       6. The device method according to  claim 1 , wherein said step of irradiating is performed by said plurality of light emitting diodes distributed along an inner surface of an annular structure. 
     
     
       7. The method according to  claim 6 , wherein said step of irradiating is performed by LEDs said plurality of light emitting diodes are grouped in a plurality of cooled units comprising at least two of said plurality of light emitting diodes; said cooled units are distributed along said inner surface of said annular structure. 
     
     
       8. The method according to claim  1  6, wherein said step of positioning said device in proximity of said lesion area of said patient's body comprises positioning said device in proximity of said patient's breast, and wherein positioning said device in proximity of said patient's breast further comprises a step of adjusting a length of said annular structure according to a patient's breast size. 
     
     
       9. The method according to claim  1  8, wherein said step of positioning said device in proximity of said patient's breast further comprises steps of disposing said patient on a bearing surface in a prone position and putting in said patient's breast in said annular structure so that said annular structure embraces thereof and/or positioning the device in proximity of said patient's breast is performed frontally. 
     
     
       10. The method according to  claim 1 , wherein at said step of irradiating, light intensity gradually increases over treatment time, allowing each measure of depth to receive an effective amount of light until that depth is treated. 
     
     
       11. The method according to  claim 1 , wherein said copper circuit board is 0.005″ thick. 
     
     
       12. The method according to  claim 1 , wherein said photodynamic therapeutic device comprises a plurality of segments. 
     
     
       13. The method according to  claim 12 , wherein each segment contains 2 to 40 high power LEDs and would require up to 100 watts of heat removal for each segment. 
     
     
       14. The method according to  claim 12 , wherein said copper circuit board comprises a plurality of said copper circuit boards having a plurality of said plurality of light emitting diodes thereon, and wherein each segment contains one of said copper circuit boards. 
     
     
       15. The method according to  claim 12 , wherein said segments have a clear silicone spacer mat directly in front of the LEDs to protect and to remove the possibility of a lens of the LED directly coming into contact with the skin and causing direct heat transfer. 
     
     
       16. The method according to  claim 15 , wherein said clear silicone spacer mat is 0.3-0.5 cm thick. 
     
     
       17. The method according to  claim 15 , wherein the LEDs are soldered directly to the copper circuit board. 
     
     
       18. The method according to  claim 1 , wherein said coolant is not in direct contact with said light emitting diodes.