USRE50550EActiveUtility

IL-2 muteins and uses thereof

69
Assignee: PANDION OPERATIONS INCPriority: Dec 6, 2017Filed: Jul 28, 2022Granted: Aug 26, 2025
Est. expiryDec 6, 2037(~11.4 yrs left)· nominal 20-yr term from priority
Inventors:Nathan Higginson-ScottJoanne L. VineyJyothsna VisweswaraiahErik Robert SampsonKevin Lewis Otipoby
C07K 14/55C07K 2319/30A61K 38/2013A61K 39/39533A61K 47/6813
69
PatentIndex Score
0
Cited by
466
References
27
Claims

Abstract

The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method of increasing I regulatory cell proliferation in a subject, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a peptide comprising the amino acid sequence of SEQ ID NO: 26 wherein the I regulatory cell proliferation is increased in the subject. 
     
     
       2. The method of  claim 1 , wherein the peptide further comprises a N-terminal leader peptide having the amino acid sequence of SEQ. ID. No: 7. 
     
     
       3. The method of  claim 1 , wherein the peptide further comprises a linker peptide at the C-terminus. 
     
     
       4. The method of  claim 3 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4. 
     
     
       5. The method of  claim 1 , wherein the peptide further comprises a Fc peptide. 
     
     
       6. The method of  claim 5 , wherein the Fc peptide comprises the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 15. 
     
     
       7. The method of  claim 5 , wherein the peptide further comprises a leader peptide having the sequence of SEQ. ID. No: 7 at the N-terminus of the peptide. 
     
     
       8. The method of  claim 5 , wherein the Fc peptide is at the C-terminus of the peptide. 
     
     
       9. The method of  claim 5 , wherein the Fc peptide is at the N-terminus of the peptide. 
     
     
       10. The method of  claim 5 , wherein the peptide further comprises a linker peptide that links the peptide of SEQ ID NO: 26 and the Fc peptide. 
     
     
       11. The method of  claim 10 , wherein the peptide further comprises a N-terminal leader peptide having the amino acid sequence of SEQ. ID. No: 7 at the N terminus. 
     
     
       12. The method of  claim 10 , wherein the linker peptide comprises the sequence of is (GGGGS) n , wherein n is 1, 2, 3, or 4. 
     
     
       13. The method of  claim 10 , wherein the Fc peptide comprises the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 15. 
     
     
       14. The method of  claim 10 , wherein the Fc peptide is at the C-terminus of the peptide. 
     
     
       15. The method of  claim 10 , wherein the Fc peptide is at the N-terminus of the peptide. 
     
     
       16. The method of  claim 10 , wherein the peptide comprises the amino acid sequence of SEQ ID NO: 40 39. 
     
     
       17. The method of  claim 1  wherein the method further comprises activating the T regulatory cells. 
     
     
       18. A method of activating T regulatory cells in a subject, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a peptide comprising the amino acid sequence of SEQ ID NO: 26, wherein the I regulatory cells are activated in the subject. 
     
     
       19. The method of  claim 2 , wherein the peptide further comprises a Fc peptide. 
     
     
       20. The method of  claim 19 , wherein the Fc peptide is at the C-terminus or the N-terminus of the peptide. 
     
     
       21. The method of  claim 19 , wherein the peptide comprises the amino acid sequence of SEQ ID NO: 40 39. 
     
     
       22. The method of  claim 1 , wherein the peptide further comprises a linker peptide at the N-terminus. 
     
     
       23. The method of  claim 14 , wherein the peptide linker links the N-terminus of the Fc peptide to the C-terminus of the peptide. 
     
     
       24. The method of  claim 15 , wherein the peptide linker links the C-terminus of the Fc peptide to the N-terminus of the peptide. 
     
     
       25. The method of  claim 22 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4. 
     
     
       26. The method of  claim 23 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4. 
     
     
       27. The method of  claim 24 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4.

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