Blood component sampling cassette, blood sampling circuit set, and blood component sampling system

Abstract

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette ( 22 ) includes a cassette main body ( 23 ) made of a soft material to which heat sterilization is applicable. The cassette main body ( 23 ) is provided with a retransfusion line ( 44 ). The retransfusion line ( 44 ) is provided with a reservoir ( 47 ) configured to temporarily store a blood component to be returned to a blood donor. The reservoir ( 47 ) is pressed by a retransfusion pump ( 49 ) to discharge the blood component from the reservoir ( 47 ).

The invention claimed is: 
     
         1 . A biological component sampling cassette, comprising:
 a cassette main body provided with a plurality of flow paths that are blow molded or fusion bonded, wherein the cassette main body is configured to be attachable to a separation device that separates a biological component from liquid containing at least one biological component,   wherein the cassette main body comprises a first sheet of a soft resin to which heat sterilization is applicable and a second sheet of said soft resin, said first and second sheets being bonded to each other to form said plurality of flow paths,   wherein the plurality of flow paths includes:
 an introduction line configured to introduce the liquid, 
 a biological component transfer line configured to transfer, to a sampling container, the biological component obtained by separation processing of the liquid, and 
 a return line configured to transfer return liquid including liquid other than the biological component obtained by separation processing with the separation device, 
   wherein the return line is provided with a reservoir configured to temporarily store the return liquidto be returned,   wherein the cassette main body includes a sensor pressing section that presses a reservoir pressure sensor to thereby detect an inner pressure of the reservoir, wherein the sensor pressing section is located in a portion of the return line that is connected between the reservoir and first and second port members of the cassette main body that connect to respective external tubes,   wherein the first port member and the second port member are at an edge of the cassette main body and adjacent to one another in a first direction that is perpendicular to a second direction,   wherein the sensor pressing section is between the edge of the cassette main body and the reservoir along the second direction, and   wherein the reservoir is configured to be expandable and contractable, and is pressed by a return pump provided at the separation device to discharge the return liquid from the reservoir.   
     
     
         2 . The biological component sampling cassette according to  claim 1 , wherein the first port member and the second port member are immediately adjacent to one another. 
     
     
         3 . The biological component sampling cassette according to  claim 2 , wherein the first port member is connected to a first flow path of the plurality of flow paths and the second port member is connected to a second flow path of the plurality of flow paths, wherein the first flow path and the second flow path branch from a third flow path connected to the sensor pressing section. 
     
     
         4 . The biological component sampling cassette according to  claim 1 , wherein the reservoir is expanded in an unpressed state. 
     
     
         5 . The biological component sampling cassette according to  claim 1 , wherein red blood cells flow to the reservoir through the first port member, and wherein plasma flows to the reservoir through the second port member. 
     
     
         6 . The biological component sampling cassette according to  claim 1 , wherein said cassette main body further comprises a filter member between said first and second sheets, said filter member being in fluid communication with and downstream from said reservoir. 
     
     
         7 . The biological component sampling cassette according to  claim 1 , wherein said flow paths are open when positive pressure is not applied. 
     
     
         8 . The biological component sampling cassette according to  claim 1 , wherein said flow paths are closed when positive pressure is not applied. 
     
     
         9 . The biological component sampling cassette according to  claim 1 , wherein the reservoir is defined by part of the first sheet and part of the second sheet, and wherein the part of the first sheet and the part of the second sheet both flex when pressed by the return pump to discharge the return liquid from the reservoir. 
     
     
         10 . A biological component sampling circuit set comprising:
 a biological component sampling cassette including a cassette main body provided with a plurality of flow paths that are blow molded or fusion bonded, wherein the cassette main body is configured to be attachable to a separation device that separates a biological component from liquid containing at least one biological component;   a separation processing section connected to the biological component sampling cassette through a first tube and having a processing chamber configured to separate the liquid into multiple biological components by actuation of the separation device; and   a bag connected to the biological component sampling cassette through a second tube,   wherein the cassette main body comprises a first sheet of a soft resin to which heat sterilization is applicable and a second sheet of said soft resin, said first and second sheets being bonded to each other to form said plurality of flow paths,   wherein the plurality of flow paths includes:
 an introduction line configured to introduce the liquid; 
 a biological component transfer line configured to transfer, to a sampling container, the biological component obtained by separation processing of the liquid; and 
 a return line configured to transfer return liquid including liquid other than the biological component obtained by separation processing with the separation device, wherein 
 the return line is provided with a reservoir configured to temporarily store the return liquidto be returned, 
   wherein the cassette main body includes a sensor pressing section that presses a reservoir pressure sensor to thereby detect an inner pressure of the reservoir, wherein the sensor pressing section is located in a portion of the return line that is connected between the reservoir and first and second port members of the cassette main body that connect to respective external tubes,   wherein the first port member and the second port member are at an edge of the cassette main body and adjacent to one another in a first direction that is perpendicular to a second direction,   wherein the sensor pressing section is between the edge of the cassette main body and the reservoir along the second direction, and   wherein the reservoir is configured to selectively expand or contract, and is pressed by a return pump provided at the separation device to discharge the return liquid from the reservoir.   
     
     
         11 . The biological component sampling circuit set according to  claim 10 , wherein the first port member is connected to a first flow path of the plurality of flow paths and the second port member is connected to a second flow path of the plurality of flow paths, wherein the first flow path and the second flow path branch from a third flow path connected to the sensor pressing section. 
     
     
         12 . The biological component sampling circuit set according to  claim 10 , wherein the reservoir is defined by part of the first sheet and part of the second sheet, and wherein the part of the first sheet and the part of the second sheet both flex when pressed by the return pump to discharge the return liquid from the reservoir. 
     
     
         13 . A biological component sampling system comprising:
 a separation device configured to separate a biological component from liquid containing at least one biological component; and   a biological component sampling cassette configured to be attachable to the separation device,   wherein the biological component sampling cassette includes a cassette main body provided with a plurality of flow paths that are blow molded or fusion bonded,   wherein the cassette main body comprises a first sheet of a soft resin to which heat sterilization is applicable and a second sheet of said soft resin, said first and second sheets being bonded to each other to form said plurality of flow paths,   wherein the plurality of flow paths includes:
 an introduction line configured to introduce the liquid; 
 a biological component transfer line configured to transfer, to a sampling container, the biological component obtained by separation processing of the liquid; and 
 a return line configured to transfer return liquid including liquid other than the biological component obtained by separation processing with the separation device, wherein 
   wherein the return line is provided with a reservoir configured to temporarily store the return liquidto be returned,   wherein the cassette main body includes a sensor pressing section that presses a reservoir pressure detection mechanism to thereby detect an inner pressure of the reservoir, wherein the sensor pressing section is located in a portion of the return line that is connected between the reservoir and first and second port members of the cassette main body that connect to respective external tubes,   wherein the first port member and the second port member are at an edge of the cassette main body and adjacent to one another in a first direction that is perpendicular to a second direction,   wherein the sensor pressing section is between the edge of the cassette main body and the reservoir along the second direction, and   wherein the reservoir is configured to selectively expand or contract, and is pressed by a return pump provided at the separation device to discharge the return liquid from the reservoir.   
     
     
         14 . The biological component sampling system according to  claim 13 , wherein the return pump equipped at the separation device has a pressing plate configured to press the reservoir in a thickness direction. 
     
     
         15 . The biological component sampling system according to  claim 14 , wherein the separation device includes:
 the reservoir pressure detection mechanism configured to detect the inner pressure of the reservoir; and   a control section configured to control the return pump based on the inner pressure detected by the reservoir pressure detection mechanism.   
     
     
         16 . The biological component sampling system according to  claim 15 , wherein
 the control section controls the return pump such that the inner pressure of the reservoir reaches a predetermined target pressure.   
     
     
         17 . The biological component sampling system according to  claim 15 , wherein the first port member and the second port member are immediately adjacent to one another, wherein the first port member is connected to a first flow path of the plurality of flow paths and the second port member is connected to a second flow path of the plurality of flow paths, and wherein the first flow path and the second flow path branch from a third flow path connected to the sensor pressing section. 
     
     
         18 . The biological component sampling system according to  claim 13 , further comprising a cover body coupled to said separation device and configured to close over said cassette main body, said cover body having a holding section configured to engage a peripheral edge of said cassette main body. 
     
     
         19 . The biological component sampling system according to  claim 13 , wherein the reservoir is defined by part of the first sheet and part of the second sheet, and wherein the part of the first sheet and the part of the second sheet both flex when pressed by the return pump to discharge the return liquid from the reservoir. 
     
     
         20 . The biological component sampling system according to  claim 18 , wherein said holding section comprises a peripheral edge of said cover body configured to sandwich said peripheral edge of said cassette main body against said separation device.