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ABBVIE INC
US482 patents
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US10597400B2Mar 24, 2020
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carb oxamide and solid state forms thereof
ABBVIE INC36 citations99
US10344036B2Jul 9, 2019
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-#a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-#carboxamide and solid state forms thereof
ABBVIE INC35 citations99
US10202394B2Feb 12, 2019
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC37 citations99
US10202393B2Feb 12, 2019
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC37 citations99
US9963459B1May 8, 2018
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-alpla]pyrrolo[2,3-e]-pyrazin-8-YL)-N-(2,2,2-Trifluoroethyl)pyrrol and solid state forms thereof
ABBVIE INC42 citations99
US11535624B2Dec 27, 2022
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC19 citations98
US10730883B2Aug 4, 2020
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC35 citations98
US10519164B2Dec 31, 2019
Processes for the preparation of (3S,4R)-3,ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC35 citations98
US10017517B2Jul 10, 2018
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluorethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC41 citations98
US9951080B2Apr 24, 2018
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-alpha]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC41 citations98
US9174982B2Nov 3, 2015
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
ABBVIE INC38 citations98
US11198697B1Dec 14, 2021
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC29 citations97
US11186584B2Nov 30, 2021
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC28 citations97
US10995095B2May 4, 2021
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carb oxamide and solid state forms thereof
ABBVIE INC28 citations97
US10981923B2Apr 20, 2021
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[l,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC32 citations97
US10550126B2Feb 4, 2020
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC37 citations97
USRE47221EFeb 5, 2019
Tricyclic compounds
ABBVIE INC42 citations97
US9359434B2Jun 7, 2016
Cell culture methods to reduce acidic species
ABBVIE INC35 citations97
US9334319B2May 10, 2016
Low acidic species compositions
ABBVIE INC29 citations97
US9163017B2Oct 20, 2015
Anti-viral compounds
ABBVIE INC64 citations97
US9150645B2Oct 6, 2015
Cell culture methods to reduce acidic species
ABBVIE INC40 citations97
US9085618B2Jul 21, 2015
Low acidic species compositions and methods for producing and using the same
ABBVIE INC38 citations97
US8883146B2Nov 11, 2014
Protein formulations and methods of making same
ABBVIE INC102 citations97
US10981924B2Apr 20, 2021
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC33 citations96
US9365579B2Jun 14, 2016
Tricyclic compounds
ABBVIE INC50 citations96
US9284371B2Mar 15, 2016
Methods of producing adalimumab
ABBVIE INC29 citations96
US9067990B2Jun 30, 2015
Protein purification using displacement chromatography
ABBVIE INC49 citations96
US9017687B1Apr 28, 2015
Low acidic species compositions and methods for producing and using the same using displacement chromatography
ABBVIE INC46 citations96
US8911964B2Dec 16, 2014
Fed-batch method of making human anti-TNF-alpha antibody
ABBVIE INC45 citations96
US8906646B2Dec 9, 2014
Fed-batch method of making human anti-TNF-alpha antibody
ABBVIE INC44 citations96
US9879018B2Jan 30, 2018
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl and solid state forms thereof
ABBVIE INC42 citations95
US9181572B2Nov 10, 2015
Methods to modulate lysine variant distribution
ABBVIE INC41 citations95
US11787815B1Oct 17, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC8 citations94
US11780847B1Oct 10, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
ABBVIE INC7 citations94
US11524964B2Dec 13, 2022
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC21 citations94
US9879019B2Jan 30, 2018
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC42 citations94
US9447184B2Sep 20, 2016
IL-1 binding proteins
ABBVIE INC27 citations94
US8383778B2Feb 26, 2013
IL-1 binding proteins
ABBVIE INC42 citations94
US11795175B2Oct 24, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC8 citations93
US11773105B2Oct 3, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]- pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC7 citations93
US11718627B2Aug 8, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC9 citations93
US11680069B2Jun 20, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC6 citations93
US11661425B2May 30, 2023
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC9 citations93
US11535626B2Dec 27, 2022
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1 carboxamide and solid state forms thereof
ABBVIE INC18 citations93
US11535625B2Dec 27, 2022
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC19 citations93
US11512092B2Nov 29, 2022
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
ABBVIE INC21 citations93
US9943649B2Apr 17, 2018
Automatic injection device
ABBVIE INC21 citations93
US9346879B2May 24, 2016
Protein purification methods to reduce acidic species
ABBVIE INC28 citations93
US9266949B2Feb 23, 2016
Low acidic species compositions and methods for producing and using the same
ABBVIE INC25 citations93
US9241873B2Jan 26, 2016
Medicine container, method of assembling the container, and method of dispensing the medicine from the container
ABBVIE INC32 citations93
Showing the top 50 of 482 patents by PatentIndex Score.