Inventor

RASMUSSON GARY H

US38 patents

Patents

38 patents

US4760071AJul 26, 1988

17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors

MERCK & CO INC240 citations98

US4377584AMar 22, 1983

Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors

MERCK & CO INC77 citations94

US5910497AJun 8, 1999

16-pyrazinyl-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors

MERCK & CO INC18 citations92

US5777134AJul 7, 1998

4-oxa and 4-thia steriods

MERCK & CO INC24 citations92

US5719158AFeb 17, 1998

16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors

MERCK & CO INC22 citations92

US5710275AJan 20, 1998

7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors

MERCK & CO INC22 citations92

US5693809ADec 2, 1997

Substituted 4-aza-5α-androstan-ones as 5α-reductase inhibitors

MERCK & CO INC37 citations92

US5525608AJun 11, 1996

17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors

MERCK & CO INC20 citations92

US5278159AJan 11, 1994

Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors

MERCK & CO INC20 citations92

US5237064AAug 17, 1993

Process for producing 7β-substituted-aza-5αandrostan-3-ones

MERCK & CO INC42 citations92

US5151429ASep 29, 1992

17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors

MERCK & CO INC22 citations92

US5120742AJun 9, 1992

17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors

MERCK & CO INC22 citations92

US5098908AMar 24, 1992

17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors

MERCK & CO INC24 citations92

US5049562ASep 17, 1991

17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors

MERCK & CO INC43 citations92

US4845104AJul 4, 1989

Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones

MERCK & CO INC38 citations88

US5739137AApr 14, 1998

16-substituted-4-aza-3-oxo-androstane as 5-alpha-reductase isozyme 1 inhibitors

MERCK & CO INC14 citations82

US5571817ANov 5, 1996

Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]

MERCK & CO INC18 citations81

US5380728AJan 10, 1995

Aldehyde metabolite of 17β-N-monosubstituted-carbamoyl-4-aza-5α-a

MERCK & CO INC7 citations74

US4407802AOct 4, 1983

6-Amidino-9-substituted benzyl purines

MERCK & CO INC13 citations74

US4361699ANov 30, 1982

Novel process for the preparation of N6 -alkyl-arprinocid

MERCK & CO INC17 citations74

US5998464ADec 7, 1999

4-Oxa and 4-thia steroids

MERCK & CO INC11 citations73

US5693810ADec 2, 1997

17 β-carboxanilides of 4-aza-5α-androstan-3-ones as 5α-reductase inhibitors

MERCK & CO INC8 citations73

US5567708AOct 22, 1996

Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]

MERCK & CO INC11 citations73

US5438061AAug 1, 1995

7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors

MERCK & CO INC9 citations73

US5196411AMar 23, 1993

17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors

MERCK & CO INC12 citations73

US5138063AAug 11, 1992

17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones

MERCK & CO INC13 citations73

US5091380AFeb 25, 1992

N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors

MERCK & CO INC12 citations73

US5075450ADec 24, 1991

Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes

MERCK & CO INC8 citations73

US5061802AOct 29, 1991

17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents

MERCK & CO INC13 citations73

US5578726ANov 26, 1996

Process for producing 7 β-substituted-4-aza-5 α-androstan-3-ones

MERCK & CO INC4 citations63

US5527807AJun 18, 1996

7β-substituted-4-aza-5α-cholestan-3-ones as 5α reductase inhibitors useful in the prevention and treatment of hyperandrogenetic disorders

MERCK & CO INC6 citations62

US5162332ANov 10, 1992

Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors

MERCK & CO INC4 citations62

US5151430ASep 29, 1992

Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents

MERCK & CO INC5 citations62

US6204273B1Mar 20, 2001

16-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors

MERCK & CO INC0 citations52

RASMUSSON GARY H

Patents

17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors

4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors

Ester derivatives of 4-aza-steroids

17-Ethers and thioethers of 4-aza-steroids

17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors

Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors

16-pyrazinyl-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors

4-oxa and 4-thia steriods

16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors

7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors

Substituted 4-aza-5α-androstan-ones as 5α-reductase inhibitors

17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors

Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors

Process for producing 7β-substituted-aza-5αandrostan-3-ones

17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors

17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors

17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors

17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors

Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones

16-substituted-4-aza-3-oxo-androstane as 5-alpha-reductase isozyme 1 inhibitors

Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]

Aldehyde metabolite of 17β-N-monosubstituted-carbamoyl-4-aza-5α-a

6-Amidino-9-substituted benzyl purines

Novel process for the preparation of N6 -alkyl-arprinocid

4-Oxa and 4-thia steroids

17 β-carboxanilides of 4-aza-5α-androstan-3-ones as 5α-reductase inhibitors

Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]

7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors

17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors

17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones

N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors

Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes

17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents

Process for producing 7 β-substituted-4-aza-5 α-androstan-3-ones

7β-substituted-4-aza-5α-cholestan-3-ones as 5α reductase inhibitors useful in the prevention and treatment of hyperandrogenetic disorders

Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors

Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents

16-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors