Inventor · disambiguated record
David R. Liu
Also filed as: LIU DAVID · LIU DAVID R · LIU DAVID R-CHEN · LIU DAVID RU-CHEN
159 granted patents·89 pending applications·9,847 citations·filing 1992–2025
99Inventor score
Top patents by PatentIndex Score
248 records- 0199US10508298B2Methods for identifying a target site of a CAS9 nucleaseHARVARD COLLEGE·Filed 2015·Granted Dec 17, 2019·65 cites·31 claims
- 0299US9771574B2Apparatus for continuous directed evolution of proteins and nucleic acidsHARVARD COLLEGE·Filed 2015·Granted Sep 26, 2017·81 cites·21 claims
- 0399US9163284B2Methods for identifying a target site of a Cas9 nucleaseHARVARD COLLEGE·Filed 2014·Granted Oct 20, 2015·119 cites·24 claims
- 0498US12215365B2Cas variants for gene editingHARVARD COLLEGE·Filed 2021·Granted Feb 4, 2025·7 cites·37 claims
- 0598US12043852B2Evolved Cas9 proteins for gene editingHARVARD COLLEGE·Filed 2016·Granted Jul 23, 2024·18 cites·22 claims
- 0698US11999947B2Adenosine nucleobase editors and uses thereofHARVARD COLLEGE·Filed 2023·Granted Jun 4, 2024·18 cites·21 claims
- 0798US11920181B2Nuclease profiling systemHARVARD COLLEGE·Filed 2021·Granted Mar 5, 2024·20 cites·22 claims
- 0898US11820969B2Editing of CCR2 receptor gene to protect against HIV infectionHARVARD COLLEGE·Filed 2020·Granted Nov 21, 2023·21 cites·31 claims
- 0998US11702651B2Adenosine nucleobase editors and uses thereofHARVARD COLLEGE·Filed 2021·Granted Jul 18, 2023·29 cites·61 claims
- 1098US11299755B2Switchable CAS9 nucleases and uses thereofHARVARD COLLEGE·Filed 2020·Granted Apr 12, 2022·35 cites·20 claims
- 1198US11268082B2Nucleobase editors comprising nucleic acid programmable DNA binding proteinsHARVARD COLLEGE·Filed 2018·Granted Mar 8, 2022·46 cites·26 claims
- 1298US11124782B2Cas variants for gene editingHARVARD COLLEGE·Filed 2019·Granted Sep 21, 2021·70 cites·28 claims
- 1398US11053481B2Fusions of Cas9 domains and nucleic acid-editing domainsHARVARD COLLEGE·Filed 2014·Granted Jul 6, 2021·79 cites·15 claims
- 1498US11046948B2Engineered transcription activator-like effector (TALE) domains and uses thereofHARVARD COLLEGE·Filed 2019·Granted Jun 29, 2021·64 cites·19 claims
- 1598US10954548B2Nuclease profiling systemHARVARD COLLEGE·Filed 2014·Granted Mar 23, 2021·59 cites·23 claims
- 1698US10947530B2Adenosine nucleobase editors and uses thereofHARVARD COLLEGE·Filed 2018·Granted Mar 16, 2021·71 cites·23 claims
- 1798US10912833B2Delivery of negatively charged proteins using cationic lipidsHARVARD COLLEGE·Filed 2018·Granted Feb 9, 2021·66 cites·18 claims
- 1898US10745677B2Editing of CCR5 receptor gene to protect against HIV infectionHARVARD COLLEGE·Filed 2017·Granted Aug 18, 2020·68 cites·25 claims
- 1998US10682410B2Delivery system for functional nucleasesHARVARD COLLEGE·Filed 2014·Granted Jun 16, 2020·83 cites·30 claims
- 2098US10597679B2Switchable Cas9 nucleases and uses thereofHARVARD COLLEGE·Filed 2014·Granted Mar 24, 2020·80 cites·20 claims
- 2198US10465176B2Cas variants for gene editingHARVARD COLLEGE·Filed 2014·Granted Nov 5, 2019·76 cites·44 claims
- 2298US10336997B2Continuous directed evolutionHARVARD COLLEGE·Filed 2016·Granted Jul 2, 2019·69 cites·20 claims
- 2398US10179911B2Negative selection and stringency modulation in continuous evolution systemsHARVARD COLLEGE·Filed 2015·Granted Jan 15, 2019·78 cites·21 claims
- 2498US10113163B2Adenosine nucleobase editors and uses thereofHARVARD COLLEGE·Filed 2017·Granted Oct 30, 2018·249 cites·32 claims
- 2598US9840699B2Methods for nucleic acid editingHARVARD COLLEGE·Filed 2014·Granted Dec 12, 2017·193 cites·20 claims
- 2698US9737604B2Use of cationic lipids to deliver CAS9HARVARD COLLEGE·Filed 2014·Granted Aug 22, 2017·140 cites·25 claims
- 2798US9526784B2Delivery system for functional nucleasesHARVARD COLLEGE·Filed 2014·Granted Dec 27, 2016·123 cites·24 claims
- 2898US9340799B2MRNA-sensing switchable gRNAsHARVARD COLLEGE·Filed 2014·Granted May 17, 2016·121 cites·27 claims
- 2998US9340800B2Extended DNA-sensing GRNASHARVARD COLLEGE·Filed 2014·Granted May 17, 2016·95 cites·30 claims
- 3098US9228207B2Switchable gRNAs comprising aptamersHARVARD COLLEGE·Filed 2014·Granted Jan 5, 2016·106 cites·22 claims
- 3198US9068179B1Methods for correcting presenilin point mutationsHARVARD COLLEGE·Filed 2014·Granted Jun 30, 2015·135 cites·22 claims
- 3298US8030074B2In vivo incorporation of unnatural amino acidsSCRIPPS RESEARCH INST·Filed 2007·Granted Oct 4, 2011·53 cites·6 claims
- 3398US7998904B2Evolving new molecular functionHARVARD COLLEGE·Filed 2005·Granted Aug 16, 2011·75 cites·51 claims
- 3498US7638300B2In vivo incorporation of unnatural amino acidsSCRIPPS RESEARCH INST·Filed 2006·Granted Dec 29, 2009·63 cites·2 claims
- 3598US7557068B2Evolving new molecular functionHARVARD COLLEGE·Filed 2003·Granted Jul 7, 2009·87 cites·11 claims
- 3698US7442160B2Evolving new molecular functionHARVARD COLLEGE·Filed 2005·Granted Oct 28, 2008·83 cites·33 claims
- 3798US7368275B2In vivo incorporation of unnatural amino acidsSCRIPPS RESEARCH INST·Filed 2005·Granted May 6, 2008·76 cites·4 claims
- 3898US7354761B2Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairsSCRIPPS RESEARCH INST·Filed 2005·Granted Apr 8, 2008·77 cites·9 claims
- 3998US7223545B2Evolving new molecular functionHARVARD COLLEGE·Filed 2004·Granted May 29, 2007·93 cites·12 claims
- 4098US7083970B2Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairsUNIV CALIFORNIA·Filed 2002·Granted Aug 1, 2006·385 cites·12 claims
- 4198US7070928B2Evolving new molecular functionHARVARD COLLEGE·Filed 2002·Granted Jul 4, 2006·107 cites·71 claims
- 4298US7045337B2In vivo incorporation of unnatural amino acidsUNIV CALIFORNIA·Filed 2002·Granted May 16, 2006·497 cites·15 claims
- 4398US5356478APlasma cleaning method for removing residues in a plasma treatment chamberLAM RES CORP·Filed 1994·Granted Oct 18, 1994·892 cites·22 claims
- 4497US12281303B2Methods and compositions for prime editing nucleotide sequencesBROAD INST INC·Filed 2023·Granted Apr 22, 2025·5 cites·30 claims
- 4597US12084663B2Incorporation of unnatural amino acids into proteins using base editingHARVARD COLLEGE·Filed 2022·Granted Sep 10, 2024·14 cites·22 claims
- 4697US11898179B2Suppression of pain by gene editingHARVARD COLLEGE·Filed 2018·Granted Feb 13, 2024·21 cites·28 claims
- 4797US11795452B2Methods and compositions for prime editing nucleotide sequencesBROAD INST INC·Filed 2022·Granted Oct 24, 2023·22 cites·30 claims
- 4897US11643652B2Methods and compositions for prime editing nucleotide sequencesBROAD INST INC·Filed 2021·Granted May 9, 2023·34 cites·60 claims
- 4997US11578343B2CAS9 proteins including ligand-dependent inteinsHARVARD COLLEGE·Filed 2020·Granted Feb 14, 2023·30 cites·34 claims
- 5097US11560566B2Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activationHARVARD COLLEGE·Filed 2018·Granted Jan 24, 2023·29 cites·20 claims
Showing the top 50 of 248 patent records by PatentIndex Score.
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Identity basis: PatentsView inventor disambiguation (2025Q4-odp release). How scoring works →