Topic leaderboard
Combinatorial chemistry & libraries
Ranked by the PatentIndex Score — a 1–99 percentile within C40B · public-visibility date · generated 2026
top 25 per window · public-visibility date
Rising· last 2 yrs
Inventors whose newest C40B patents became public in the last 2 years — the current frontier
- 199Mark S. Chee109 patents · 14,937 citations
- 296Shohei Koide14 patents · 1,319 citations
- 392George M. Church30 patents · 1,201 citations
- 488David A. Weitz19 patents · 681 citations
- 583Morten Sommer16 patents · 640 citations
- 679Amy Rowat12 patents · 614 citations
- 775Gautam Dantas12 patents · 614 citations
- 871Jeremy Agresti18 patents · 614 citations
- 967Jin Woong Kim12 patents · 614 citations
- 1063Liang-Yin Chu12 patents · 614 citations
- 1158Kevin L. Gunderson21 patents · 2,389 citations
- 1254Darren Roy Link39 patents · 650 citations
- 1350Alexander B. Rosenberg28 patents · 273 citations
- 1446Georg Seelig28 patents · 273 citations
- 1542Richard Muscat25 patents · 170 citations
- 1638Michael L. Samuels24 patents · 377 citations
- 1733Anthony Makarewicz10 patents · 381 citations
- 1829Bill Kengli Lin10 patents · 381 citations
- 1925Rajiv Bharadwaj10 patents · 381 citations
- 2021Michael Weiner29 patents · 302 citations
- 2117Bandele Jeffrey-Coker11 patents · 291 citations
- 2213Jack Coleman25 patents · 156 citations
- 238John M. Beierle12 patents · 291 citations
- 244Michael Graige14 patents · 73 citations
- 251Michael Schnall-Levin9 patents · 148 citations
Active· last 5 yrs
Sustained C40B output across the last 5 years
- 199Mark S. Chee109 patents · 14,937 citations
- 296Richard P. Rava28 patents · 4,955 citations
- 392Earl Hubbell23 patents · 4,805 citations
- 488George M. Whitesides23 patents · 5,905 citations
- 583Marvin H. Caruthers13 patents · 5,984 citations
- 679Milan Mrksich12 patents · 2,489 citations
- 775Shohei Koide14 patents · 1,319 citations
- 871Andreas Plückthun13 patents · 1,550 citations
- 967George M. Church30 patents · 1,201 citations
- 1063David A. Weitz19 patents · 681 citations
- 1158Morten Sommer16 patents · 640 citations
- 1254Amy Rowat12 patents · 614 citations
- 1350Gautam Dantas12 patents · 614 citations
- 1446Jeremy Agresti18 patents · 614 citations
- 1542Jin Woong Kim12 patents · 614 citations
- 1638Liang-Yin Chu12 patents · 614 citations
- 1733Kevin L. Gunderson21 patents · 2,389 citations
- 1829Bill James Peck23 patents · 996 citations
- 1925Siyuan Chen23 patents · 814 citations
- 2021Radoje Drmanac14 patents · 814 citations
- 2117Douglas J. Dellinger11 patents · 849 citations
- 2213Ryan T. Gill36 patents · 571 citations
- 238Shujun Luo11 patents · 563 citations
- 244Kevin Ness24 patents · 462 citations
- 251Dasa Lipovsek16 patents · 898 citations
All-time canon
Career PatentIndex Score in C40B
- 199Stephen P. A. Fodor85 patents · 41,312 citations
- 296Lubert Stryer43 patents · 22,153 citations
- 392Michael C. Pirrung32 patents · 19,804 citations
- 488J. Leighton Read29 patents · 18,080 citations
- 583Robert Charles Ladner44 patents · 15,182 citations
- 679Arthur C. Ley13 patents · 14,902 citations
- 775Rachel Kent13 patents · 14,902 citations
- 871Gregory Paul Winter34 patents · 13,946 citations
- 967Sonia Guterman12 patents · 14,307 citations
- 1063William Markland11 patents · 13,633 citations
- 1158Andrew David Griffiths32 patents · 9,812 citations
- 1254James D. Marks17 patents · 8,367 citations
- 1350John Mccafferty18 patents · 7,574 citations
- 1446William J. Dower40 patents · 16,948 citations
- 1542Hendricus Renerus Jacobus Mattheus Hoogenboom25 patents · 9,757 citations
- 1638Larry J. Kricka22 patents · 13,355 citations
- 1733Peter Wilding22 patents · 13,355 citations
- 1829Geoffrey Walter Grigg7 patents · 4,880 citations
- 1925Willem P. C. Stemmer48 patents · 13,985 citations
- 2021Andreas Crameri10 patents · 4,877 citations
- 2117Sydney Brenner30 patents · 11,388 citations
- 2213Peter John Zanzucchi19 patents · 8,570 citations
- 238Satyam Choudary Cherukuri18 patents · 7,840 citations
- 244Sterling Edward Mcbride16 patents · 7,133 citations
- 251Dennis W. Solas18 patents · 8,429 citations
Rising· last 2 yrs
The top-scoring C40B patents made public in the last 2 years
- 199US12234505B2✦ AISpatially encoded biological assays21 cites · 202462% earned
- 296US12169198B2✦ AISystems and methods for sample analysis15 cites · 202483% earned
- 392US11987838B2✦ AIMethods and kits for labeling cellular molecules13 cites · 202461% earned
- 488US12188940B2Determination of protein information by recoding amino acid polymers into DNA polymers5 cites · 202472% earned
- 583US12019078B2Macromolecule analysis employing nucleic acid encoding5 cites · 202461% earned
- 679US12296025B2AAV capsid variants and uses thereof3 cites · 202467% earned
- 775US12061188B2Ligand discovery and gene delivery via retroviral surface display4 cites · 202462% earned
- 871US12275914B2Electronic inhalation device1 cites · 202534% earned
- 967US12292440B2Sandwich assays in droplets1 cites · 202440% earned
- 1063US12162948B2Methods of engineering transferrin receptor binding polypeptides1 cites · 202440% earned
- 1158US12092635B2Methods and systems for characterizing analytes from individual cells or cell populations1 cites · 202446% earned
- 1254US12415835B2Peptide-compound cyclization method1 cites · 202446% earned
- 1350US12116698B1Protein surface recognition via chemically enhanced phage display2 cites · 202476% earned
- 1446US12410245B1Compositions and methods for detecting and regulating fibronectin-integrin interaction and1 cites · 202550% earned
- 1542US12201983B2Droplet forming devices and system with differential surface properties0 cites · 20240% earned
- 1638US12331287B1Assays and other reactions involving droplets0 cites · 20250% earned
- 1733US12522869B2Sequencing methods and compositions for prenatal diagnoses0 cites · 20240% earned
- 1829US12351945B2Antibody libraries with maximized antibody developability characteristics0 cites · 20240% earned
- 1925US12043919B2Immune profiling by primer extension target enrichment0 cites · 20240% earned
- 2021US12360130B2Integrated consumable data management system and platform0 cites · 20240% earned
- 2117US12292446B2Kits for analysis using nucleic acid encoding and/or label0 cites · 20240% earned
- 2213US12454696B2Cutibacterium acnes recombinant phages encoding a human protein0 cites · 20240% earned
- 238US12553074B2Processes and systems for preparation of nucleic acid sequencing libraries and libraries p0 cites · 20240% earned
- 244US12595509B2Synthetic nucleic acid spike-ins0 cites · 20240% earned
- 251USRE49975EMethods and compositions for the selection and optimization of oligonucleotide tag sequenc0 cites · 20240% earned
Active· last 5 yrs
The top-scoring C40B patents of the last 5 years
- 199US11067567B2✦ AISpatially encoded biological assays119 cites · 202176% earned
- 296US11008607B2✦ AISpatially encoded biological assays124 cites · 202172% earned
- 392US11467153B2✦ AIMethods for processing nucleic acid molecules62 cites · 202188% earned
- 488US11168355B2Methods and kits for labeling cellular molecules27 cites · 202166% earned
- 583US12169198B2Systems and methods for sample analysis15 cites · 202483% earned
- 679US11441180B2Compositions and methods for accurately identifying mutations29 cites · 202168% earned
- 775US11782062B2Kits for analysis using nucleic acid encoding and/or label9 cites · 202370% earned
- 871US11187702B2Enzyme quantification17 cites · 202174% earned
- 967US12188940B2Determination of protein information by recoding amino acid polymers into DNA polymers5 cites · 202472% earned
- 1063US11891457B2Peptide-compound cyclization method12 cites · 202176% earned
- 1158US11312765B2Immunoglobulin variable domains9 cites · 202266% earned
- 1254US11459558B2Methods for using transcription-dependent directed evolution of AAV capsids9 cites · 202172% earned
- 1350US11946162B2Directed evolution of synthetic gene cluster9 cites · 202177% earned
- 1446US11639928B2Methods and systems for characterizing analytes from individual cells or cell populations7 cites · 202272% earned
- 1542US11578320B2High density sequencing and multiplexed priming7 cites · 202275% earned
- 1638US12365935B2Methods for increasing resolution of spatial analysis7 cites · 202379% earned
- 1733US12019078B2Macromolecule analysis employing nucleic acid encoding5 cites · 202461% earned
- 1829US10894958B1Automated cell processing methods, modules, instruments, and systems9 cites · 202160% earned
- 1925US11001831B2Simultaneous multiplex genome editing in yeast9 cites · 202174% earned
- 2021US12296025B2AAV capsid variants and uses thereof3 cites · 202467% earned
- 2117US11755922B2On-chip nanoscale storage system using chimeric DNA10 cites · 202181% earned
- 2213US11293021B1Automated cell processing methods, modules, instruments, and systems7 cites · 202286% earned
- 238US11644460B2Identifying new therapeutic agents8 cites · 202269% earned
- 244US12222347B2Ligand discovery and gene delivery via retroviral surface display4 cites · 202462% earned
- 251US11066661B2Methods of gene assembly and their use in DNA data storage8 cites · 202176% earned
All-time canon
The defining C40B patents of the whole record
- 199US4683202A✦ AIProcess for amplifying nucleic acid sequences13,211 cites · 198796% earned
- 296US5223409A✦ AIDirected evolution of novel binding proteins6,875 cites · 199389% earned
- 392US5565332A✦ AIProduction of chimeric antibodies - a combinatorial approach3,895 cites · 199696% earned
- 488US5143854ALarge scale photolithographic solid phase synthesis of polypeptides and receptor binding s3,709 cites · 199285% earned
- 583US5445934AArray of oligonucleotides on a solid substrate3,129 cites · 199584% earned
- 679US5744305AArrays of materials attached to a substrate3,038 cites · 199887% earned
- 775US4458066AProcess for preparing polynucleotides2,902 cites · 198496% earned
- 871US5403484AViruses expressing chimeric binding proteins2,866 cites · 199588% earned
- 967US5571698ADirected evolution of novel binding proteins2,681 cites · 199688% earned
- 1063US5969108AMethods for producing members of specific binding pairs2,337 cites · 199988% earned
- 1158US5580717ARecombinant library screening methods2,200 cites · 199693% earned
- 1254US5605793AMethods for in vitro recombination2,091 cites · 199785% earned
- 1350US5837458AMethods and compositions for cellular and metabolic engineering2,016 cites · 199893% earned
- 1446US5427908ARecombinant library screening methods2,002 cites · 199593% earned
- 1542US5807522AMethods for fabricating microarrays of biological samples1,949 cites · 199893% earned
- 1638US5750373AEnrichment method for variant proteins having altered binding properties, M13 phagemids, a1,868 cites · 199888% earned
- 1733US5474796AMethod and apparatus for conducting an array of chemical reactions on a support surface1,844 cites · 199592% earned
- 1829US5512131AFormation of microstamped patterns on surfaces and derivative articles1,825 cites · 199696% earned
- 1925US5800992AMethod of detecting nucleic acids1,804 cites · 199888% earned
- 2021US5700637AApparatus and method for analyzing polynucleotide sequences and method of generating oligo1,792 cites · 199796% earned
- 2117US5424186AVery large scale immobilized polymer synthesis1,758 cites · 199593% earned
- 2213US5270163AMethods for identifying nucleic acid ligands1,688 cites · 199396% earned
- 238US5830721ADNA mutagenesis by random fragmentation and reassembly1,678 cites · 199885% earned
- 244US5811238AMethods for generating polynucleotides having desired characteristics by iterative selecti1,665 cites · 199885% earned
- 251US5885793AProduction of anti-self antibodies from antibody segment repertoires and displayed on phag1,630 cites · 199986% earned
Rising· last 2 yrs
Assignees whose newest C40B patents became public in the last 2 years — the current frontier
- 199HARVARD COLLEGE80 patents · 7,309 citations
- 296ILLUMINA INC78 patents · 6,132 citations
- 392MASSACHUSETTS INST TECHNOLOGY40 patents · 5,386 citations
- 488PROGNOSYS BIOSCIENCES INC44 patents · 3,279 citations
- 58310X GENOMICS INC38 patents · 928 citations
- 679UNIV WASHINGTON48 patents · 1,134 citations
- 775TWIST BIOSCIENCE CORP38 patents · 877 citations
- 871UNIV DUKE13 patents · 797 citations
- 967UNIV CHICAGO18 patents · 980 citations
- 1063UNIV COLORADO REGENTS19 patents · 240 citations
- 1158MESO SCALE TECHNOLOGIES LLC12 patents · 271 citations
- 1254CHUGAI PHARMACEUTICAL CO LTD17 patents · 197 citations
- 1350ENZO BIOCHEM INC10 patents · 126 citations
- 1446ENCODIA INC13 patents · 48 citations
- 1542VERINATA HEALTH INC8 patents · 72 citations
- 1638BIO RAD LABORATORIES INC19 patents · 20 citations
- 1733KARIUS INC7 patents · 29 citations
- 1829GEN PROBE INC9 patents · 13 citations
- 1925CATALOG TECH INC5 patents · 32 citations
- 2021BROAD INST INC12 patents · 12 citations
- 2117SINGULAR GENOMICS SYSTEMS INC5 patents · 13 citations
- 2213ROCHE SEQUENCING SOLUTIONS INC18 patents · 3 citations
- 238ST JUDE CHILDRENS RES HOSPITAL INC6 patents · 7 citations
- 244DENALI THERAPEUTICS INC3 patents · 5 citations
- 251VOYAGER THERAPEUTICS INC4 patents · 8 citations
Active· last 5 yrs
Sustained C40B output across the last 5 years
- 199AFFYMETRIX INC175 patents · 34,199 citations
- 296HARVARD COLLEGE80 patents · 7,309 citations
- 392ILLUMINA INC78 patents · 6,132 citations
- 488UNIV CALIFORNIA79 patents · 4,788 citations
- 583MASSACHUSETTS INST TECHNOLOGY40 patents · 5,386 citations
- 679GENENTECH INC32 patents · 5,439 citations
- 775UNIV LELAND STANFORD JUNIOR55 patents · 4,763 citations
- 871UNIV COLUMBIA45 patents · 3,154 citations
- 967SCRIPPS RESEARCH INST35 patents · 4,276 citations
- 1063PROGNOSYS BIOSCIENCES INC44 patents · 3,279 citations
- 1158UNIV BOSTON15 patents · 2,950 citations
- 1254AGILENT TECHNOLOGIES INC120 patents · 9,580 citations
- 1350MORPHOSYS AG18 patents · 1,481 citations
- 144610X GENOMICS INC38 patents · 928 citations
- 1542UNIV ILLINOIS23 patents · 1,400 citations
- 1638UNIV TEXAS26 patents · 1,415 citations
- 1733UNIV WASHINGTON48 patents · 1,134 citations
- 1829TWIST BIOSCIENCE CORP38 patents · 877 citations
- 1925CALIFORNIA INST OF TECHN28 patents · 1,428 citations
- 2021UNIV DUKE13 patents · 797 citations
- 2117BRISTOL MYERS SQUIBB CO30 patents · 737 citations
- 2213US NAVY15 patents · 1,076 citations
- 238UNIV CHICAGO18 patents · 980 citations
- 244ILLUMINA CAMBRIDGE LTD32 patents · 766 citations
- 251INSCRIPTA INC43 patents · 426 citations
All-time canon
All-time PatentIndex Score in C40B
- 199AFFYMAX TECH NV47 patents · 37,008 citations
- 296MEDICAL RES COUNCIL22 patents · 14,042 citations
- 392PROTEIN ENG CORP5 patents · 13,691 citations
- 488AFFYMETRIX INC175 patents · 34,199 citations
- 583UNIV PENNSYLVANIA26 patents · 13,427 citations
- 679MAXYGEN INC45 patents · 13,607 citations
- 775LYNX THERAPEUTICS INC17 patents · 7,625 citations
- 871SARNOFF DAVID RES CENTER10 patents · 5,064 citations
- 967NANOGEN INC46 patents · 8,029 citations
- 1063CALIPER TECHN CORP11 patents · 3,730 citations
- 1158HARVARD COLLEGE80 patents · 7,309 citations
- 1254ILLUMINA INC78 patents · 6,132 citations
- 1350UNIV CALIFORNIA79 patents · 4,788 citations
- 1446MASSACHUSETTS INST TECHNOLOGY40 patents · 5,386 citations
- 1542GENENTECH INC32 patents · 5,439 citations
- 1638UNIV LELAND STANFORD JUNIOR55 patents · 4,763 citations
- 1733ZYOMYX INC14 patents · 2,587 citations
- 1829SARNOFF CORP19 patents · 4,712 citations
- 1925UNIV COLUMBIA45 patents · 3,154 citations
- 2021SYMYX TECHNOLOGIES INC157 patents · 12,882 citations
- 2117TUFTS COLLEGE10 patents · 3,039 citations
- 2213SCRIPPS RESEARCH INST35 patents · 4,276 citations
- 238UNIV RESEARCH CORP6 patents · 4,065 citations
- 244SEQUENOM INC21 patents · 4,139 citations
- 251NEXSTAR PHARMACEUTICALS INC78 patents · 11,316 citations
90–99 field-defining50–89 strong<50 emergingearned by citationsfrom family breadth