Anti-inflammatory lipopeptide and preparing method and application thereof

Abstract

Disclosed is an anti-inflammatory lipopeptide, which comprises peptide chains and aliphatic chains, the peptide chain being linked to the aliphatic chain through a peptide bond, and an aliphatic acid being linked to the N-terminus of the peptide chain. The lipopeptide suppresses inflammatory response induced by poly(I:C), so as to prevent inflammation after skin injury and alleviate inflammatory response of skin inflammation such as allergic dermatitis. Also disclosed is a preparing method of the lipopeptide.

What is claimed is: 
     
       1. An anti-inflammatory lipopeptide comprising a peptide chain and an aliphatic chain; the peptide chain being linked to the aliphatic chain through a peptide bond, and the aliphatic chain being linked to the N-terminus of the peptide chain; said lipopeptide having the structure as the Formula (1); 
       
         
           
           
               
               
           
         
       
     
     
       2. A method of suppressing inflammatory response induced by poly(I:C), which comprises administering the anti-inflammatory lipopeptide according to  claim 1 . 
     
     
       3. A method of suppressing inflammatory responses induced by dinitrofluorobenzene (DNFB), which comprises administering the anti-inflammatory lipopeptide according to  claim 1 . 
     
     
       4. A composition for inhibiting inflammation in wounds which comprises the anti-inflammatory lipopeptide according to  claim 1 . 
     
     
       5. A composition for treating atopic dermatitis, which comprises anti-inflammatory lipopeptide according to  claim 1 . 
     
     
       6. A method of inhibiting an inflammatory response, which comprises administering to patient in need thereof an effective amount of the anti-inflammatory lipopeptide according to  claim 1 , wherein, the lipopeptide binds to TLR2, induces β-catenin translocation into nucleus, and then β-catenin competes with p65 for interaction with PPARγ, thus inhibiting inflammatory response.