Phenoxymethyl derivatives

Abstract

The invention provides novel compounds having the general formula (I)wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

The invention claimed is: 
     
       1. A compound of formula (I): 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein:
 (1) R A  is selected from the group consisting of
 i) C 1 -C 6 -alkyl, 
 ii) cyano-C 1 -C 6 -alkyl, 
 iii) C 3 -C 8 -cycloalkyl, 
 iv) halo-C 1 -C 6 -alkoxy, 
 v) halo-C 1 -C 6 -alkyl, 
 vi) aryl substituted with R G , R G1  and R G2 , 
 vii) heterocycloalkyl substituted with R G , R G1  and R G2 , and 
 viii) heteroaryl substituted with R G , R G1  and R G2 ; and 
 
 R B  is selected from the group consisting of
 i) C 1 -C 6 -alkyl, 
 ii) C 3 -C 8 -cycloalkyl, 
 iii) C 1 -C 6 -alkylsulfonyl, 
 iv) C 3 -C 8 -cycloalkylsulfonyl, 
 v) C 1 -C 6 -alkylsulfonylamino, 
 vi) C 3 -C 8 -cycloalkylsulfonylamino, 
 vii) aminocarbonyl, 
 ix) halogen, 
 x) halo-C 1 -C 6 -alkoxy, 
 xi) halo-C 1 -C 6 -alkyl, 
 xii) heterocycloalkyl, and 
 xiii) heteroaryl substituted with one H, C 1 -C 6 -alkyl, or trialkylsilyl-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl; 
 
 
         or
 (2) R A  is selected from the group consisting of
 i) cyano-C 1 -C 6 -alkyl, 
 ii) C 3 -C 8 -cycloalkyl, 
 iii) halo-C 1 -C 6 -alkoxy, 
 iv) halo-C 1 -C 6 -alkyl, 
 v) aryl substituted with R G , R G1  and R G2 , 
 vi) heterocycloalkyl substituted with R G , R G1  and R G2 , and 
 vii) heteroaryl substituted with R G , R G1  and R G2 ; and 
 
 R B  is cyano; 
 
         and:
 R C  and R C1  are independently selected from the group consisting of
 i) H, 
 ii) C 1 -C 6 -alkyl, 
 iii) C 3 -C 8 -cycloalkyl, 
 iv) halo-C 1 -C 6 -alkoxy, 
 v) halo-C 1 -C 6 -alkyl, and 
 vi) halogen; 
 
 or R B  and R C  together with the carbon atoms to which they are attached form a ring system selected from the group consisting of
 i) C 3 -C 8 -cycloalkyl substituted with one to two substituent independently selected from H, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkyl and C 3 -C 8 -cycloalkyl, 
 ii) heterocycloalkyl substituted with one to two substituent independently selected from H, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkyl and C 3 -C 8 -cycloalkyl, 
 iii) aryl substituted with one to two substituent independently selected from H, halogen, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkyl and C 3 -C 8 -cycloalkyl, and 
 iv) heteroaryl substituted with one to two substituent independently selected from H, halogen, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkyl, and C 3 -C 8 -cycloalkyl; 
 
 W is ring system A: 
 
       
       
         
           
           
               
               
           
         
         
           
             R D1  is selected from the group consisting of 
             i) H, 
             ii) C 1 -C 6 -alkyl, 
             iii) halo-C 1 -C 6 -alkoxy, 
             iv) halo-C 1 -C 6 -alkyl, and 
             v) C 3 -C 8 -cycloalkyl, 
           
           R G  is selected from the group consisting of
 i) H, 
 ii) C 1 -C 6 -alkoxy, 
 iii) C 1 -C 6 -alkoxy-C 1 -C 6 -alkylcarbonylamino-C 1 -C 6 -alkyl, 
 iv) C 1 -C 6 -alkoxy-C 1 -C 6 -alkylcarbonyl(C 1 -C 6 -alkyl)amino-C 1 -C 6 -alkyl, 
 v) C 1 -C 6 -alkoxycarbonyl, 
 vi) C 1 -C 6 -alkyl, 
 vii) C 1 -C 6 -alkylsulfonyl, 
 viii) C 3 -C 8 -cyloalkylsulfonyl, 
 ix) carboxy, 
 x) cyano, 
 xi) C 3 -C 8 -cycloalkyl, 
 xii) C 3 -C 8 -cycloalkoxy, 
 xiii) C 3 -C 8 -cycloalkylcarbonylamino-C 1 -C 6 -alkyl, 
 xiv) C 3 -C 8 -cycloalkylcarbonyl(C 1 -C 6 -alkyl)amino-C 1 -C 6 -alkyl, 
 xv) C 1 -C 6 -alkylcarbonylamino-C 1 -C 6 -alkyl, 
 xvi) C 1 -C 6 -alkylcarbonyl(C 1 -C 6 -alkyl)amino-C 1 -C 6 -alkyl, 
 xvii) halo-C 1 -C 6 -alkyl, 
 xviii) halo-C 1 -C 6 -alkoxy, 
 xix) halogen, 
 xx) hydroxy, 
 xxi) aminocarbonyl substituted on the nitrogen atom with RN and Ro, 
 xxii) aminocarbonyl-C 1 -C 6 -alkoxy substituted on the nitrogen atom with RN and Ro, 
 xxiii) heteroaryl substituted with one H, C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, alkyl, halo-C 1 -C 6 -alkoxy, benzyl or aryl, wherein benzyl and aryl are substituted with one to three substituents independently selected from H, C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, halo-C 1 -C 6 -alkyl and halo-C 1 -C 6 -alkoxy, 
 xxiv) heterocycloalkyl-C 1 -C 6 -alkoxy substituted with one H, C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, halo-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, benzyl or aryl, wherein benzyl and aryl are substituted with one to three substituents independently selected from H, C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, halo-C 1 -C 6 -alkyl and halo-C 1 -C 6 -alkoxy, and 
 xxv) heterocycloalkyl-C 1 -C 6 -alkyl substituted with one H, C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, halo-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, benzyl or aryl, wherein benzyl and aryl are substituted with one to three substituents independently selected from H, C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, halo-C 1 -C 6 -alkyl and halo-C 1 -C 6 -alkoxy; 
 
           R G1  and R G2  are independently selected from the group consisting of
 i) H, 
 ii) halogen, 
 iii) C 1 -C 6 -alkyl, 
 iv) C 3 -C 8 -cycloalkyl, 
 v) halo-C 1 -C 6 -alkoxy, and 
 vi) halo-C 1 -C 6 -alkyl; 
 
           R N  is selected from the group consisting of
 i) H, 
 ii) C 1 -C 6 -alkoxy, 
 iii) C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, 
 iv) C 1 -C 6 -alkoxycarbonyl-C 1 -C 6 -alkyl, 
 v) C 1 -C 6 -alkyl, 
 vi) carboxy-C 1 -C 6 -alkyl, 
 vii) C 3 -C 8 -cycloalkyl, 
 viii) C 3 -C 8 -cycloalkyl-C 1 -C 6 -alkyl, 
 ix) hydroxy-C 1 -C 6 -alkyl, 
 x) phenyl, and 
 xi) heteroaryl-C 1 -C 6 -alkyl; and 
 
           R O  is selected from the group consisting of
 i) H, and 
 ii) C 1 -C 6 -alkyl; 
 
           or R N  and R O  together with the nitrogen atom to which they are attached form a heterocycloalkyl. 
         
       
     
     
       2. The compound of  claim 1 , wherein the compound is:
 3-[(2-tert-butyl-4-chloro-5-methylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(2-tert-butyl-4-chloro-5-fluorophenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(3,3-dimethyl-6-propan-2-yl-1,2-dihydroinden-5-yl)oxymethyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(2-tert-butyl-4-[1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]phenoxy]methyl-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-(1-methylimidazol-2-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-(1,3-oxazol-2-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(2-tert-butyl-4-morpholin-4-ylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-(3-methylimidazol-4-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-2-cyclopropyl-5-methylsulfonylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(2-tert-butyl-4-methylsulfonylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-[3-(2-trimethyl silyl-ethoxymethyl)imidazol-4-yl]phenoxy]-methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-2-cyclopropyl-5-methylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-2-cyclohexyl-5-methylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(oxan-4-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-4-cyclopropyl-5-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 N-[2-chloro-4-cyclopropyl-5-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]methanesulfonamide; 
 4-tert-butyl-3-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzamide; 
 4-methyl-3-[(5-methyl-2-propan-2-ylphenoxy)methyl]-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-5-methyl-2-propan-2-ylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-2-propan-2-ylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(6-cyclopropyl-2-methyl-1,3-benzothiazol-5-yl)oxymethyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-2-cyclobutyl-5-methylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[2-tert-butyl-4-(1H-imidazol-2-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[ [2-tert-butyl-4-(1H-imidazol-5-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-5-methyl-2-phenylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(2-chlorophenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(3-chlorophenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(4-chlorophenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzonitrile; 
 3-[[4-chloro-5-methyl-2-(3-methylsulfonylphenyl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(2-methylsulfonylphenyl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-[3-(piperidine-1-carbonyl)phenyl]phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-cyclohexylbenzamide; 
 3-[[4-chloro-5-methyl-2-[3-(morpholine-4-carbonyl)phenyl]phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N,N-dimethylbenzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-phenylbenzamide; 
 3-chloro-5-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-cyclopropyl-4-fluorobenzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-(2-methoxyethyl)benzamide; 
 3-[[4-chloro-2-(2-chloropyridin-3-yl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(6-chloropyridin-2-yl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 5-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]pyri dine-3-carboxamide; 
 3-[[4-chloro-2-(6-methoxypyridin-2-yl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-5-methyl-2-pyrazin-2-ylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[(4-chloro-5-methyl-2-pyrimidin-2-ylphenoxy)methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(1,2-oxazol-5-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(1,3-oxazol-5-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(3-methylimidazol-4-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(1H-imidazol-5-yl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(1,3-oxazol-2-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-5-methyl-2-(2-methylpyrazol-3-yl)phenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]-5-phenylbenzonitrile; 
 2-chloro-5-(4-fluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[4-chloro-5-cyano-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-methylbenzamide, 
 2-chloro-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]-5-[3-(1H-pyrazol-3-yl)phenyl]benzonitrile; 
 2-chloro-5-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-(2-hydroxyethyl)benzamide; 
 2-chloro-5-[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluoro-N,N-dimethylbenzamide; 
 3-[4-chloro-5-cyano-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N,N-dimethylbenzamide; 
 3-[[4-chloro-2-[2-fluoro-5-(morpholine-4-carbonyl)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]-5-[3-(morpholine-4-carbonyl)phenyl]benzonitrile; 
 methyl 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzoate; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzoic acid; 
 methyl 3-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzoyl]amino]propanoate; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-(2-hydroxyethyl)-N-methylbenzamide; 
 ethyl 2-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzoyl]amino]acetate; 
 3-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzoyl]amino]propanoic acid; 
 2-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]benzoyl]amino]acetic acid; 
 methyl 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-methylbenzoate; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-methylbenzoic acid; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N,N,4-trimethylbenzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-(trifluoromethoxy)benzamide; 
 3-[[4-chloro-2-(2-methoxypyridin-3-yl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-5-(2-methoxypyridin-3-yl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[[4-chloro-2-(5-ethoxy-2-fluorophenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(2-methoxyphenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(2-fluoro-5-propan-2-yloxyphenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-[2-fluoro-5-(2-methylpropoxy)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-[2-methoxy-5-(trifluoromethyl)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[4-chloro-2-(2-methoxy-5-propan-2-ylphenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-5-[2-fluoro-5-(morpholine-4-carbonyl)phenyl-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[[4-chloro-2-[2-fluoro-5-(pyrrolidine-1-carbonyl)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-cyclopropyl-4-fluoro-N-methylbenzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluoro-N-(2-hydroxyethyl)-N-methylbenzamide; 
 4-[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorobenzoyl]-1-methylpiperazin-2-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-cyclopentyl-4-fluoro-N-methylbenzamide; 
 3-[[4-chloro-2-[2-fluoro-5-(oxolan-3-ylmethoxy)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluoro-N-methyl-N-(thiophen-2-ylmethyl)benzamide; 
 3-[[4-chloro-2-[2-fluoro-5-(piperidine-1-carbonyl)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-N-(cyclopropylmethyl)-4-fluoro-N-methylbenzamide; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluoro-N-methyl-N-(pyridin-2-ylmethyl)benzamide; 
 3-[[4-chloro-2-[2-fluoro-5-(oxan-4-ylmethoxy)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluoro-N-(2-methoxyethyl)-N-methylbenzamide; 
 3-[[4-chloro-2-[2-fluoro-5-(oxolan-2-ylmethoxy)phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-[3[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenoxy]-N,N-dimethylacetamide; 
 1-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenyl]methyl]-4-methylpiperazine-2,5-dione; 
 7-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-6-fluoro-3-methyl-1,3-benzoxazol-2-one; 
 N-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenyl]methyl]-2-methoxy-N-methyl acetamide; 
 N-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenyl]methyl]cyclopropanecarboxamide; 
 N-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenyl]methyl]-N-methylcyclopropanecarboxamide; 
 3-[[4-chloro-2-[2-fluoro-5-[(2-oxopyrrolidin-1-yl)methyl]phenyl]-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 3-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenyl]methyl]-1,3-oxazolidin-2-one; 
 N-[[3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-fluorophenyl]methyl]-2-methoxyacetamide; 
 2-chloro-5-(2-fluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 2-chloro-5-(3-fluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[5-chloro-4-methyl-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]phenyl]-4-(trifluoromethoxy)benzonitrile; 
 2-chloro-5-[2-fluoro-5-(oxolan-2-ylmethoxy)phenyl]-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 2-chloro-5-(2-fluoro-3-methoxyphenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 2-chloro-5-(2-fluoro-5-propan-2-yloxyphenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[[4-chloro-2-(2-fluoro-3-methoxyphenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-5-(2,3-difluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 3-[[4-chloro-2-(5-cyclopropyloxy-2-fluorophenyl)-5-methylphenoxy]methyl]-4-methyl-1H-1,2,4-triazol-5-one; 
 2-chloro-5-(5-chloro-2-fluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 2-chloro-5-(2,5-difluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 2-chloro-5-(5-cyclopropyloxy-2-fluorophenyl)-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; or 
 2-chloro-5-[2-fluoro-5-(trifluoromethyl)phenyl]-4-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methoxy]benzonitrile; 
 or a pharmaceutically acceptable salt thereof. 
 
     
     
       3. A pharmaceutical composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier. 
     
     
       4. A pharmaceutical composition comprising a compound of  claim 2 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier. 
     
     
       5. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is manufactured by the process comprising the reaction of a compound of formula (II) in the presence of a compound of formula (III): 
       
         
           
           
               
               
           
         
         wherein X is halogen, mesylate or tosylate; 
         and R A , R B , R C  and W are as defined in formula (I). 
       
     
     
       6. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R A  is selected from the group consisting of:
 C 1 -C 6 -alkyl; 
 cyano-C 1 -C 6 -alkyl; 
 C 3 -C 8 -cycloalkyl; 
 aryl substituted with R G , R G1 , and R G2 ; 
 heterocycloalkyl substituted with R G , R G1 , and R G2 ; and 
 heteroaryl substituted with R G , R G 1, and R G2 . 
 
     
     
       7. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R A  is selected from the group consisting of:
 C 1 -C 6 -alkyl; 
 cyano-C 1 -C 6 alkyl; 
 C 3 -C 8 -cycloalkyl; 
 phenyl substituted with R G , R G1 , and R G2 ; 
 tetrahydropyranyl substituted with R G , R G1 , and R G2 ; and 
 heteroaryl substituted with R G , R G1 , and R G2 , wherein heteroaryl is selected from benzoxazolonyl, imidazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridinyl, and pyrimidinyl. 
 
     
     
       8. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R A  is phenyl substituted with R G , R G1 , and R G2 . 
     
     
       9. The compound of  claim 1 , wherein the compound is of formula (Ib): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein:
 R A  is C 1 -C 6 -alkyl and R B is halogen; or    
 R A  is phenyl substituted with R G , R G1 , and R G2  and R B  is cyano or halogen; and 
 
       R C  is selected from the group consisting of H, C 1 -C 6 -alkyl, and halogen; 
       R D1  is C 1 -C 6 -alkyl, 
       R G  is selected from the group consisting of H; C 1 -C 6 -alkoxy; C 1 -C 6 -alkoxy-C 1 -C 6 -alkylcarbonyl(C 1 -C 6 -alkyl)amino-C 1 -C 6 -alkyl; halogen; aminocarbonyl substituted on the nitrogen atom with R N  and R O ; aminocarbonyl-C 1 -C 6 -alkoxy substituted on the nitrogen atom with R N  and R O ; heteroaryl substituted with one H or C 1 -C 6 -alkyl wherein the heteroaryl is isoxazolyl, oxazolyl, or pyrazolyl; and heterocycloalkyl-C 1 -C 6 -alkoxy substituted with one H or C 1 -C 6 -alkyl, wherein the heterocycloalkyl-C 1 -C 6 -alkoxy is tetrahydropyranylmethoxy or tetrahydrofuranylmethoxy; 
       R G2  is H and R G1  is H or halogen; 
       R N  is C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl and C 1 -C 6 -alkyl; and 
       R O  is C 1 -C 6 -alkyl; 
       or R N  and R O  together with the nitrogen atom to which they are attached form morpholinyl, pyrrolidinyl, or methylpiperazinonyl. 
     
     
       10. A pharmaceutical composition comprising a compound of  claim 9 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.