US11390604B2ActiveUtilityA1
Imidazole-pyrazole derivatives
Est. expiryMar 8, 2039(~12.7 yrs left)· nominal 20-yr term from priority
Inventors:Jean-Baptiste BlancChristian KramerChristian LernerMatthias NettekovenPhilippe PfliegerBernd PuellmannThomas RyckmansSebastien SchmittMin WangSong YangChengang Zhou
C07D 487/10C07D 401/14C07D 409/14C07D 413/14A61P 31/04C07D 403/14C07D 417/14C07D 471/08C07D 487/04C07D 403/04
77
PatentIndex Score
1
Cited by
4
References
31
Claims
Abstract
The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein:Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
Claims
exact text as granted — not AI-modifiedThe invention claimed is:
1. A compound of formula (I)
or a pharmaceutically acceptable salt thereof, wherein:
R A is C 1 -C 6 -alkyl or a group
wherein:
(i) R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a C 2 -C 9 -heterocyclic ring which is optionally substituted with one or more (1-2) R 8 ; or
(ii) R 1 is hydrogen, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl-O—C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl-NH—C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxycarbonyl-C 1 -C 6 -alkyl-NH—C 1 -C 6 -alkyl- or a group
and
R 2 is hydrogen or C 1 -C 6 -alkyl;
R 3 and IC are each independently hydrogen, halogen or C 1 -C 6 -alkyl;
R 4 is halo-C 1 -C 6 -alkyl or C 6 -C 14 -aryl;
R 5 is hydrogen, CF 3 , C 1 -C 6 -alkyl substituted with R 11 and R 12 , C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, amino-C 2 -C 6 -alkynyl-, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 2 -C 6 -alkynyl-, hydroxy-C 2 -C 6 -alkynyl-, or a group
R 6 is C 1 -C 6 -alkyl;
R 8 is C 1 -C 6 -alkoxycarbonyl, amino-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-NH—, amino-C 1 -C 6 -alkyl-C(O)—, amino-C 1 -C 6 -alkyl-NH—C(O)—C 1 -C 6 -alkyl-, amino-C 1 -C 6 -alkyl-CH(OH)—, amino-C 1 -C 6 -alkyl-CH(NH 2 )—C(O)—, (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-, (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-N(C 1 -C 6 -alkyl)-, (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-C(O)—, C 1 -C 6 -alkyl-NH—C 1 -C 6 -alkyl-C(O)—, C 1 -C 6 -alkyl-NH—C 1 -C 6 -alkyl-NH—C(O)—, oxo, amino, halogen, or a group
R 9 and R 10 are each independently hydrogen, hydroxy, amino, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, amino-C 1 -C 6 -alkyl-C(O)—NH—, amino-C 1 -C 6 -alkyl-CH(halo-C 1 -C 6 -alkyl)-NH—C(O)—, amino-C 3 -C 12 -cycloalkyl-C(O)—NH— or a group
R 11 and R 12 are each independently hydrogen, halogen, hydroxy, cyano, CF 3 , carbamoyl, halo-C 1 -C 6 -alkoxy-, (C 1 -C 6 -alkyl) 2 N—C(O)—, C 1 -C 6 -alkyl-NH—C(O)—, C 1 -C 6 -alkoxy-, or C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy;
R 13 , R 14 , and R 15 are each independently hydrogen, oxo, amino, hydroxy, C 1 -C 6 -alkyl-NH—, (C 1 -C 6 -alkyl) 2 N—, halogen, C 3 -C 12 -cycloalkyl, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl or hydroxy-C 1 -C 6 -alkyl;
R 16 , R 17 and R 18 are each independently hydrogen, halogen, amino, hydroxy, amino-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-NH— or C 1 -C 6 -alkyl;
R 19 and R 20 are each independently hydrogen, amino, hydroxy, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl-, or HO—S(O) 2 -C 1 -C 6 -alkyl;
A, B, C, and D are each independently C 6 -C 14 -aryl, C 1 -C 13 -heteroaryl, C 3 -C 12 -cycloalkyl, or C 2 -C 9 -heterocyclyl; and
X 1 , X 2 , X 3 , X 4 , and X 5 are each independently a covalent bond, carbonyl, C 1 -C 6 -alkyl, —C 1 -C 6 -alkyl-C(O)—, —NH—C(O)—, —C(O)—NH—, —NH—C(O)—NH—, —NH—C(O)—NH—C 1 -C 6 -alkyl-, —NH—C(O)—N(C 1 -C 6 -alkyl)-C 1 -C 6 -alkyl-, —C 1 -C 6 -alkyl-NH—C(O)—NH—C 1 -C 6 -alkyl-, —C 1 -C 6 -alkyl-NH—C(O)—, —S—, —SO—, —SO 2 — or a group
2. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is a compound of formula (I-I)
wherein:
(i) R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a C 2 -C 9 -heterocyclic ring which is optionally substituted with R 8 ; or
(ii) R 1 is hydrogen, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl-, amino-C 1 -C 6 -alkyl-O—C 1 -C 6 -alkyl-, or a group
and
R 2 is hydrogen or C 1 -C 6 -alkyl;
R 3 and R 7 are each independently hydrogen, halogen or C 1 -C 6 -alkyl;
R 4 is halo-C 1 -C 6 -alkyl or C 6 -C 14 -aryl;
R 5 is hydrogen, CF 3 , C 1 -C 6 -alkyl substituted with R 11 and R 12 , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, amino-C 2 -C 6 -alkynyl-, C 1 -C 6 -alkoxy-C 2 -C 6 -alkynyl-, hydroxy-C 2 -C 6 -alkynyl-, or a group
R 6 is C 1 -C 6 -alkyl;
R 8 is C 1 -C 6 -alkoxycarbonyl, (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-C(O)—, C 1 -C 6 -alkyl-NH—C 1 -C 6 -alkyl-C(O)—, C 1 -C 6 -alkyl-NH—C 1 -C 6 -alkyl-NH—C(O)—, or a group
R 9 and R 10 are each independently hydrogen, hydroxy, amino, amino-C 1 -C 6 -alkyl-C(O)—NH—, or amino-C 3 -C 12 -cycloalkyl-C(O)—NH—;
R 11 and R 12 are each independently hydrogen, halogen, hydroxy, cyano, CF 3 , carbamoyl, halo-C 1 -C 6 -alkoxy-, (C 1 -C 6 -alkyl) 2 N—C(O)—, C 1 -C 6 -alkyl-NH—C(O)—, C 1 -C 6 -alkoxy-, or C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy;
R 13 , R 14 , and R 15 are each independently hydrogen, oxo, halogen, C 3 -C 12 -cycloalkyl, C 1 -C 6 -alkyl, or hydroxy-C 1 -C 6 -alkyl;
R 16 and R 17 are each independently hydrogen, amino, hydroxy, amino-C 1 -C 6 -alkyl, or C 1 -C 6 -alkyl;
A, B, and C are each independently C 6 -C 14 -aryl, C 1 -C 13 -heteroaryl, C 3 -C 12 -cycloalkyl, or C 2 -C 9 -heterocyclyl; and
X 1 , X 2 , X 3 , and X 4 are each independently a covalent bond, carbonyl, C 1 -C 6 -alkyl, C(O)—, —C(O)—NH—, —C 1 -C 6 -alkyl-NH—C(O)—, or SO 2 .
3. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
(i) R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a piperazinyl or a piperidyl ring which is optionally substituted with one or two R 8 ; or
(ii) R 1 is 2-(2-amino-2-methyl-propoxy)ethyl or a group
and R 2 is hydrogen.
4. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is chloro.
5. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is CF 3 .
6. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is C 1 -C 6 -alkyl substituted with R 11 and R 12 , allyl, vinyl, 2-fluoroallyl, 2-methylallyl, prop-2-ynyl, or a group
wherein said C 1 -C 6 -alkyl is methyl, ethyl, or isopropyl.
7. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is methyl.
8. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is hydrogen.
9. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 8 is C 1 -C 6 -alkoxycarbonyl, amino-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-NH—, amino-C 1 -C 6 -alkyl-C(O)—, amino-C 1 -C 6 -alkyl-CH(OH)—, amino-C 1 -C 6 -alkyl-CH(NH 2 )—C(O)—, (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-, (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-N(C 1 -C 6 -alkyl), (C 1 -C 6 -alkyl) 2 N—C 1 -C 6 -alkyl-C(O)—, C 1 -C 6 -alkyl-NH—C 1 -C 6 -alkyl-NH—C(O)—, oxo, amino, halogen, or a group
10. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 9 is hydrogen, amino, hydroxy, alkyl, alkoxy, amino-C 1 -C 6 -alkyl-C(O)—NH— or a group
11. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 10 is hydrogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy.
12. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 11 is hydrogen, halogen, hydroxy, cyano, CF 3 , carbamoyl, halo-C 1 -C 6 -alkoxy-, (C 1 -C 6 -alkyl) 2 N—C(O)—, C 1 -C 6 -alkyl-NH—C(O)—, or C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy.
13. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 12 is hydrogen or halogen.
14. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 13 is hydrogen, oxo, halogen, C 3 -C 12 -cycloalkyl, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl or hydroxy-C 1 -C 6 -alkyl.
15. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 14 is hydrogen, oxo, halogen, or C 1 -C 6 -alkyl.
16. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 15 is hydrogen or halogen.
17. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 16 is hydrogen, amino, or hydroxy.
18. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 17 is hydrogen, amino or C 1 -C 6 -alkyl.
19. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 18 is hydrogen or amino.
20. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 19 is hydrogen, amino, hydroxy, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl or HO—SO 2 -C 1 -C 6 -alkyl.
21. The compound of formula (I) according claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 20 is hydrogen or hydroxy.
22. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is C 2 -C 9 -heterocyclyl or C 3 -C 12 -cycloalkyl.
23. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is cyclobutyl, cyclopropyl or 3-azabicyclo[3.1.0]hexan-6-yl.
24. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein X 1 is —S—, a covalent bond, carbonyl, SO 2 or a group
25. The compound of formula (I) according to claim 24 , or a pharmaceutically acceptable salt thereof, wherein X 1 is carbonyl.
26. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein X 2 is a covalent bond or C 1 -C 6 -alkyl.
27. The compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is selected from the group consisting of:
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-Chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
5-(1-(3-amino-3-oxopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2-cyanoethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(4-hydroxybut-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-allyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(but-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(but-3-yn-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclobutyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2-fluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazole-2-carboxamide;
N-(3-chloro-4-(4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(cyanomethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(1,1-dioxidothietan-3-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(4-aminobut-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(4-methoxybut-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(pent-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
5-(1-(2-amino-2-oxoethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2-(dimethylamino)-2-oxoethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(1-amino-1-oxopropan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(2-(1H-pyrazol-1-yl)ethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2-(isopropylamino)-2-oxoethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2-(2-methoxyethoxy)ethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(1-cyclopropyl-2-oxopyrrolidin-3-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-isobutyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(2-(methylamino)-2-oxoethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
1-Methyl-N-(3-methyl-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
5-(1-(cyanomethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-N-(3-methyl-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1H-imidazole-2-carboxamide;
(R)—N-(3-Chloro-4-((pyrrolidin-3-ylmethyl)carbamoyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
(S)—N-(3-chloro-4-((pyrrolidin-3-ylmethyl)carbamoyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-chloro-4-((((3 S,4R)-4-hydroxypyrrolidin-3-yl)methyl)carbamoyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
tert-butyl 4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxylate;
N-[3-chloro-4-(piperazine-1-carbonyl)phenyl]-1-methyl-5-[3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-Chloro-4-[4-[(2S,4R)-4-hydroxypyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-[(3 S)-pyrrolidine-3-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-[(2R)-pyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-(3-chloro-4-(4-((3 S,4 S)-3-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-Carbamoyl-3-chlorophenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(dimethylcarbamoyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(methylcarbamoyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-((3-aminopropyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
(R)—N-(4-((2-(2-aminopropoxy)ethyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-((2-(2-amino-2-methylpropoxy)ethyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
(S)—N-(4-((2-(2-aminopropoxy)ethyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-((2-(2-aminoethoxy)ethyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-((6-aminohexyl)carbamoyl)-3-methylphenyl)-1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-((5-aminopentyl)carbamoyl)-3-methylphenyl)-1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(Azetidin-3-yl)-4-(2-chloro-4-(1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
4-(2-chloro-4-(1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)-N-((3-hydroxyazetidin-3-yl)methyl)piperazine-1-carboxamide;
(S)-4-(2-chloro-4-(1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)-N-(pyrrolidin-3-yl)piperazine-1-carboxamide;
N-(3-Chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[3-Chloro-4-[4-[(2S,4R)-4-hydroxypyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-Chloro-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-(4-((2-(2-aminoethoxy)ethyl)carbamoyl)-3-ethylphenyl)-1-methyl-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-Chloro-4-((4-(dimethylglycyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-Chloro-4-((4-((2S,4R)-4-hydroxypyrrolidine-2-carbonyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-[3-Chloro-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-[3-Chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-[4-[4-[(2 S)-2-Aminopropanoyl]piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
rac-N-(4-(4-((1r,3 r)-3-aminocyclobutane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-1-methyl-5-(1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-(4-((1S,3R)-3-aminocyclopentane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-1-methyl-5-(1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-propa-1,2-dienyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-(3-phenyl-1H-pyrazol-4-yl)imidazole-2-carboxamide;
N-[3-chloro-4-(piperazine-1-carbonyl)phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-(piperazine-1-carbonyl)phenyl]-5-[1-(2-fluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-(piperazine-1-carbonyl)phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-[(3 S)-pyrrolidine-3-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[4-[(2 S)-2-aminopropanoyl]piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(3-hydroxypiperidine-3-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(3-aminocyclobutanecarbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(3-aminocyclobutanecarbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-(2-fluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(3-hydroxypiperidine-3-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]-N-[2-(methylamino)ethyl]piperazine-1-carboxamide;
N-[3-chloro-4-[4-(piperazine-1-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-(3-aminocyclobutyl)-4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-[4-[4-[(3R)-3-aminopyrrolidine-1-carbonyl]piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[4-[(3 S)-3-aminopyrrolidine-1-carbonyl]piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[4-(3-amino-3-methylazetidine-1-carbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[(1S,2R)-2-aminocyclopentyl]-4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-[(1S,3 S)-3-aminocyclopentyl]-4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-[4-[4-(4-aminopiperidine-1-carbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[4-[(3 S)-3-aminopiperidine-1-carbonyl]piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(3,6-diazabicyclo[3.2.0]heptane-3-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]-N-[rac-(1R,5 S)-3-azabicyclo[3.1.0]hexan-6-yl]piperazine-1-carboxamide;
N-[3-chloro-4-[4-[(1S,4 S)-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-(2-azaspiro[3.3]heptan-6-yl)-4-[2-chloro-4-[[1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-[4-[4-[(3aS,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl]piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(1,6-diazaspiro[3.3]heptane-6-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-[rac-(1R,5 S)-3-azabicyclo[3.1.0]hexane-6-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[(3-aminocyclobutyl)carbamoyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[(3-aminocyclobutyl)carbamoyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[[3-[[(2R)-2-aminopropanoyl]amino]cyclobutyl]carbamoyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[[3-[[(1S,3R)-3-aminocyclopentanecarbonyl]amino]cyclobutyl]carbamoyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4[(3-aminocyclobutyl)carbamoyl]-3-chlorophenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[3-(trifluoromethyl)-1-(3,3,3-trifluoropropyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(fluoromethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(1H-pyrazol-5-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
5-[1-[2-(chloromethyl)-3-hydroxy-2-methylpropyl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-propan-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
5-[1-(1-chloro-3-hydroxypropan-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(3-hydroxy-3-methylbutyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
5-[1-[[3-chloro-1-(hydroxymethyl)-3-methylcyclobutyl]methyl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[(3-methylthietan-3-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-spiro[2.3]hexan-5-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[2-(difluoromethoxy)ethyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[(2,2-difluorocyclopropyl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[(3,3-difluorocyclobutyl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(cyclopropylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(cyclobutylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(difluoromethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(1-cyanoethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(3-aminocyclobutanecarbonyl)piperazine-1-carbonyl]-3-fluoro-5-methylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[4-[(1S,3R)-3-aminocyclopentanecarbonyl]piperazine-1-carbonyl]-3-fluoro-5-methylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-fluoro-4-[4-(3-hydroxypiperidine-3-carbonyl)piperazine-1-carbonyl]-5-methylphenyl]-1-methylimidazole-2-carboxamide;
N-[4-[4-[(2 S)-2-aminopropanoyl]piperazine-1-carbonyl]-3-fluoro-5-methylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-fluoro-5-methyl-4-[4-[(3 S)-pyrrolidine-3-carbonyl]piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[4-[(4-aminocyclohexyl)carbamoyl]-3-chlorophenyl]-1-methyl-5-[3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[(3-aminocyclobutyl)carbamoyl]-3-chlorophenyl]-1-methyl-5-[1-[(2-methyl-1,3-thiazol-4-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[4-[(3-aminocyclobutyl)carbamoyl]-3-chlorophenyl]-5-[1-cyclobutyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[(3-aminocyclobutyl)carbamoyl]-3-chlorophenyl]-1-methyl-5-[1-prop-2-enyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-[(3R)-pyrrolidine-3-carbonyl]piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(azetidine-3-carbonyl)piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
4-[4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]-2-ethylbenzoyl]-N-[(3-hydroxyazetidin-3-yl)methyl]piperazine-1-carboxamide;
N-[4-[4-(3-aminopiperidine-1-carbonyl)piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(6-amino-2-azaspiro[3.3]heptane-2-carbonyl)piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(3-methylpiperazine-1-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(4-amino-4-methylpiperidine-1-carbonyl)piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-[rac-(3R,4R)-3-amino-4-methylpiperidine-1-carbonyl]piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[4-[4-[3-(aminomethyl)pyrrolidine-1-carbonyl]piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[4-[2-(aminomethyl)pyrrolidine-1-carbonyl]piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(3-azabicyclo[3.1.0]hexan-6-yl)-4-[4-[[ 5 -[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]-2-ethylbenzoyl]piperazine-1-carboxamide;
5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[4-[4-(2,5-diazabicyclo[2.2.1]heptane-2-carbonyl)piperazine-1-carbonyl]-3-ethylphenyl]-1-methylimidazole-2-carboxamide;
4-[2-chloro-4-[[5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]-N-[(3 S)-pyrrolidin-3-yl]piperazine-1-carboxamide;
4-[2-chloro-4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]-N-[(3 S)-pyrrolidin-3-yl]piperazine-1-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[5-[1-(2-fluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-[4-[4-[4-(aminomethyl)-4,5-dihydro-1,3-oxazol-2-yl]piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-(2-fluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[1-methyl-5-[1-prop-2-enyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-[4-[4-[4-(aminomethyl)-4,5-dihydro-1,3-oxazol-2-yl]piperazine-1-carbonyl]-3-chlorophenyl]-1-methyl-5-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[1-methyl-5-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[5-[1-cyclobutyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
N-[4-[4-(azetidine-3-carbonyl)piperazine-1-carbonyl]-3-ethylphenyl]-5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-ethyl-4 [(3R)-pyrrolidine-3-carbonylbpiperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;
4-[4-[[5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]-2-ethylbenzoyl]-N-[(3-hydroxyazetidin-3-yl)methyl]piperazine-1-carboxamide;
N-[3-ethyl-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-ethyl-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-ethyl-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-[3-ethyl-4-[4-[(3R)-pyrrolidine-3-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
4-[2-ethyl-4-[[1-methyl-5-[1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carbonyl]amino]benzoyl]-N-[(3-hydroxyazetidin-3-yl)methyl]piperazine-1-carboxamide;
N-(3-aminocyclobutyl)-4-(2-chloro-4-(1-methyl-5-(1-(2-methylallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(4-((2-(2-amino-2-methylpropoxy)ethyl)carbamoyl)-3-ethylphenyl)-5-(1-(cyanomethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(azetidin-3-yl)-4-(2-chloro-4-(1-methyl-5-(3-(trifluoromethyl)-1-vinyl-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(3-chloro-4-(((1R,5 S,6s)-3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(((1R,5 S,6s)-3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-cyclobutyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(((1R,5 S,6s)-3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(1R,5 S,6 s)-6-(2-chloro-4-(5-(1-(cyanomethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-(trans-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1R,5 S,6 s)-6-(2-chloro-4-(5-(1-(2-fluoroallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-(trans-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1R,5 S,6s)-N-(cis-3-aminocyclobutyl)-6-(2-chloro-4-(5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(4-(((1-aminocyclopropyl)methyl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-fluoro-4-((3-(trans-4-hydroxypyrrolidin-3-yl)ureido)methyl)piperidine-1-carbonyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[4-(3-hydroxypiperidine-3-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(2-fluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
(1S,5R)-6-[[2-chloro-4-[[5-[1-[(1R)-2,2-difluorocyclopropyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]-N-[(3R,4R)-4-hydroxypyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1S,5R)-6-[[2-chloro-4-[[5-[1-[(1R)-2,2-difluorocyclopropyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]-N-[(3S,4S)-4-hydroxypyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1S,5R)-6-[[2-chloro-4-[[5-[1-[(1S)-2,2-difluorocyclopropyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]-N-[(3R,4R)-4-hydroxypyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1S,5R)-6-[[2-chloro-4-[[5-[1-[(1S)-2,2-difluorocyclopropyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]-N-[(3 S,4S)-4-hydroxypyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(3-chloro-4-(((1R,5 S,6s)-3-(piperazine-1-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-((5-aminopentyl)carbamoyl)-3-chlorophenyl)-5-(1-(2-fluoroallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
cis-N-[(1R,2S)-2-aminocyclopentyl]-6-[[2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]amino]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(4-((6-aminohexyl)carbamoyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(piperazin-1-ylsulfonyl)phenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
6-[[2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]-N-[rac-(3 S)-pyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
6-[[2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]-N-[rac-(3R)-pyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(4-((4-aminobutyl)(methyl)carbamoyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(2-aminoethyl)piperidine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[[cis-3-[(3R)-3-aminopyrrolidine-1-carbonyl]-3-azabicyclo[3.1.0]hexan-6-yl]carbamoyl]-3-chlorophenyl]-5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(4-((6-aminospiro[3.3]heptan-2-yl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(4-((1R,5-azabicyclo[3.1.0]hexane-6-carbonyl)piperazine-1-carbonyl)-3-fluorophenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(R)—N-(4-(3-(aminomethyl)pyrrolidine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(((octahydrocyclopenta[c]pyrrol-5-yl)methyl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(azetidin-3-yl)piperidine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-((4-((2R,4 S)-4-hydroxypyrrolidine-2-carbonyl)piperazin-1-yl)sulfonyl)phenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-((4-aminobutyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(2-methylallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-glycylpiperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(aminomethyl)-4-fluoropiperidine-1-carbonyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-glycylpiperazine-1-carbonyl)phenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-N-(4-(2-oxopyrrolidin-1-yl)phenyl)-1H-imidazole-2-carboxamide;
N-(4-((5-aminopentyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(2-methylallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(4-(4-((1R,3R)-3-aminocyclopentane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(aminomethyl)piperidine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(azetidine-3-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-glycylpiperazine-1-carbonyl)phenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-((1s,3s)-3-aminocyclobutyl)-4-(2-chloro-4-(1-methyl-5-(1-(spiro[2.3]hexan-5-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(4-((4-((1S,3R)-3-aminocyclopentane-1-carbonyl)piperazin-1-yl)sulfonyl)-3-chlorophenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(6-amino-3-azabicyclo[3.1.0]hexane-3-carbonyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(4-((1R,5S,6r)-3-azabicyclo[3.1.0]hexane-6-carbonyl)piperazine-1-carbonyl)-3-fluorophenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(azetidin-3-ylmethyl)-4-(2-chloro-4-(5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
5-(1-allyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-((3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(3-aminoazetidine-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(S)—N-(4-(3-(aminomethyl)pyrrolidine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-((1s,3 s)-3-aminocyclobutyl)-4-(4-(5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)-2-fluorobenzoyl)piperazine-1-carboxamide;
tert-butyl (5-(4-(5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)-2-ethylbenzamido)pentyl)glycinate;
N-(3-chloro-4-((3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-((2,2-difluorocyclopropyl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-((5-aminopentyl)carbamoyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[2-(2-amino-2-methyl-propoxy)ethylcarbamoyl]-3-ethyl-phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
(R)—N-(3-chloro-4-(4-(piperidine-3-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(azetidine-3-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-aminocyclobutyl)-4-[2-chloro-4-[[5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
rac-3-((2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)methyl)-N-((3S,4 S)-4-hydroxypyrrolidin-3-yl)piperidine-1-carboxamide;
N-(3-chloro-4-((3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(2-aminoethyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(R)—N-(3-chloro-4-(4-(pyrrolidine-3-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-((1R,3R)-3-aminocyclopentane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[4-(4-aminocyclohexanecarbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-((1R,3R)-3-aminocyclopentyl)-4-(2-chloro-4-(5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
rac-N-(4-(((1s,3 s)-3-aminocyclobutyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(2-methylallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-(3-chloro-4-((3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
4-[2-chloro-4-[[5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]-N-pyrrolidin-3-ylpiperazine-1-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)piperidine-1-carboxamide;
N-(3-amino-3-methylcyclobutyl)-4-[2-chloro-4-[[5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(4-(4-(2-aminoethyl)piperidine-1-carbonyl)-3-chlorophenyl)-5-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
5-(1-benzyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[2-(2-aminoethoxy)ethyl carbamoyl]-3-ethyl-phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
N-(4-(4-((1R,2 S)-2-aminocyclopentane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-N-(4-(piperazin-1-ylsulfonyl)phenyl)-1H-imidazole-2-carboxamide;
N-(3-chloro-4-((3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
(R)—N-(3-chloro-4-(4-(2-(pyrrolidin-3-yl)acetyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-((5-aminopentyl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
cis-N-(1-amino-3-chloropropan-2-yl)-6-[[2-chloro-4-[[ 5 -[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]amino]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(3-chloro-4-(3,9-diazaspiro[5.5]undecane-3-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(R)—N-(3-chloro-4-(4-prolylpiperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(azetidin-3-yl)-4-[2-chloro-4-[[5-[1-(2-chloroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(4-(4-(3-aminopropanoyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[[3-[[(3R)-pyrrolidine-3-carbonyl]amino]cyclobutyl]carbamoyl]phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
rac-N-((1s,3s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-((2,2-difluorocyclopropyl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(4-((3-aminopropyl)carbamoyl)-3-chlorophenyl)-1-methyl-5-(1-(2-methylallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
rac-4-(2-chloro-4-(5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)-N-((1s,3 s)-3-(methylamino)cyclobutyl)piperazine-1-carboxamide;
rac-N-(4-(4-((1R,5-azabicyclo[3.1.0]hexane-6-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-1-methyl-5-(1-(2-methylallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
(S)—N-(3-chloro-4-(4-(2-methylpyrrolidine-2-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(((exo)-3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-(3-fluorocyclobut-2-en-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(3-fluoro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
N-[4-[6-[(3-aminocyclobutyl)carbamoyl amino]hexylcarbamoyl]-3-chlorophenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[3-bromo-4-[4-[rac-(1R,5 S)-3-azabicyclo[3.1.0]hexane-6-carbonyl]piperazine-1-carbonyl]phenyl]-5-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(4-(((1R,5 S,6s)-3-(4-(3-aminopropyl)piperazine-1-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
cis-N-(3-aminocyclobutyl)-6-[[2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]amino]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-[(1R,3 S)-3-amino-2,2-dimethylcyclobutyl]-4-[2-chloro-4-[[5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[[3-[(3-aminocyclobutanecarbonyl)amino]cyclobutyl]carbamoyl]-3-chloro-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-[4-[4-(3-amino-2-hydroxypropanoyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
rac-N-(3-chloro-4-((3aR,6aS)-octahydropyrrolo[3,4-c]pyrrole-2-carbonyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(4-(5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)-2-fluorobenzoyl)piperazine-1-carboxamide;
(R)—N-(3-chloro-4-(4-(piperidine-2-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopentyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[[3-[[(1R,3 S)-3-aminocyclopentyl]carbamoylamino]cyclobutyl]carbamoyl]-3-chloro-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
rac-N-(4-(4-((1 r,3 r)-3-aminocyclobutane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[3-(aminomethyl)piperidine-1-carbonyl]-3-chlorophenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(4-(4-(L-alanyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-4-((4-(5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)phenyl)sulfonyl)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)piperazine-1-carboxamide;
N-(3-chloro-4-((trans-4-methoxypyrrolidin-3-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(azetidine-2-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(4-((4-glycylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(((1R,3 s,5 S)-8-azabicyclo[3.2.1]octan-3-yl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(((6-aminohexyl)carbamoyl)-3-bromophenyl)-5-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(S)—N-(3-chloro-4-(4-(2,5-diaminopentanoyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[4-(5-hydroxypiperidine-3-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(4-(4-((1R,3R)-3-aminocyclohexane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-(3aR,6aS)-5-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxamide;
rac-N-(4-((((1r,4r)-4-aminocyclohexyl)methyl)carbamoyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(2-aminoethyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[N-(3-aminopropyl)-S-methyl-sulfonimidoyl]-3-methyl-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-isobutyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-((3,3-difluorocyclobutyl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)-N-methylbenzamido)piperidine-1-carboxamide;
rac-N-(4-(4-((1s,3 s)-3-aminocyclobutane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-aminocyclobutyl)-4-[2-chloro-4-[[5-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]piperazine-1-carboxamide;
N-(3-chloro-4-(4-(4-methylpiperazine-1-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[4-(3-aminocyclobutanecarbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-(2-fluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
(S)—N-(3-chloro-4-(4-(pyrrolidine-3-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(3-chloro-4-(6-(3-((3R,4R)-4-hydroxypyrrolidin-3-yl)ureido)-3-azabicyclo[3.1.0]hexane-3-carbonyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-fluoro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(4-aminobutanoyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
4-[2-chloro-4-[[5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]-N-[(3-hydroxyazetidin-3-yl)methyl]piperazine-1-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(cyclopentylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(1-methyl-5-(1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(3-chloro-4-((exo-3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(((1s,3 s)-3-aminocyclobutyl)carbamoyl)-3-chlorophenyl)-5-(1-(3,3-difluoroallyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-N-(3-methyl-4-methyl sulfanyl-phenyl)imidazole-2-carboxamide;
N-(3-chloro-4-(4-(2-(piperidin-4-yl)acetyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-5-((2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)methyl)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide;
N-[3-chloro-4-[4-(4-hydroxypiperidine-3-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
(E)-5-(1-(but-2-en-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-((2R,4 S)-4-hydroxypyrrolidine-2-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
tert-butyl (4-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)butyl)carbamate;
N-[3-chloro-4-[[3-[[(3R)-pyrrolidine-3-carbonyl]amino]cyclobutyl]carbamoyl]phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-[4-[[3-[[(3R)-3-aminopyrrolidine-1-carbonyl]amino]cyclobutyl]carbamoyl]-3-chloro-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-(4-((6-aminospiro[3.3]heptan-2-yl)carbamoyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[3-chloro-4-[4-(3-hydroxypyrrolidine-3-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(4-((3-azabicyclo[3.2.0]heptan-6-yl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
4-(2-chloro-4-(5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)-N-((4-hydroxypiperidin-4-yl)methyl)piperazine-1-carboxamide;
N-(3-chloro-4-(4-((2S,4R)-4-hydroxypyrrolidine-2-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-((exo-3-((R)-3-aminopyrrolidine-1-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamoyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-([4,4′-bipiperidine]-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[[4-[[(2S)-2-aminopropanoyl]amino]cyclohexyl]carbamoyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-bromo-4-(5-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
3-amino-N-[3-[[2-chloro-4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]cyclobutyl]piperidine-1-carboxamide;
N-(4-(4-((1S,3R)-3-aminocyclopentane-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[3-[[2-chloro-4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]cyclobutyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide;
rac-N-(3-chloro-4-((3aR,6aR)-octahydropyrrolo[3,4-c]pyrrole-2-carbonyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[4-(2-aminoacetyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
rac-N-(3-chloro-4-((4-(3-((3 S,4 S)-4-hydroxypyrrolidin-3-yl)-1-methylureido)butyl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(1-(2-(trifluoromethoxy)ethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
rac-N-((1s,3 s)-3-aminocyclobutyl)-4-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-4-methylpiperidine-1-carboxamide;
exo-N-((1R,2 S)-2-aminocyclopentyl)-6-(2-chloro-4-(5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(3-chloro-4-(4-((2S,4R)-4-hydroxypyrrolidine-2-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(piperazine-1-carbonyl)phenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
4-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-(trans-4-hydroxypyrrolidin-3-yl)piperidine-1-carboxamide;
N-(3-chloro-4-(4-(piperazin-1-ylsulfonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-aminocyclobutyl)-1-[2-chloro-4-[[5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]piperidine-4-carboxamide;
N-[4-[4-(3-aminocyclobutanecarbonyl)piperazine-1-carbonyl]-3-ethyl-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-(3-chloro-4-((4-hydroxypyrrolidin-3-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[N-(3-aminopropyl)-S-methyl-sulfonimidoyl]-3-methyl-phenyl]-1-methyl-5-[1-prop-2-ynyl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;
4-[2-chloro-4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]-N-[(3-hydroxyazetidin-3-yl)methyl]piperazine-1-carboxamide;
N-(3-chloro-4-((4-methylpiperidin-4-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-((4-aminobutyl)carbamoyl)-3-chlorophenyl)-5-(1-(cyanomethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(((1R,3r,5 S)-8-azabicyclo[3.2.1]octan-3-yl)carbamoyl)-3-chlorophenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-6-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-((3 S,4S)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.2.0]heptane-3-carboxamide;
(R)—N-(4-(4-(azetidine-2-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
(R)—N-(4-(4-(3-aminopyrrolidine-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(3-chloro-4-((trans-1-(((3R,4R)-4-hydroxypyrrolidin-3-yl)carbamoyl)-4-methoxypyrrolidin-3-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[(4-aminocyclohexyl)carbamoyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-(2-cyclopropyl ethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[N-(3-aminopropyl)-S-methyl-sulfonimidoyl]-3-methyl-phenyl]-5-[1-(2,2-difluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-[3-[[2-chloro-4-[[5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]amino]cyclobutyl]-3-methyl-piperazine-1-carboxamide;
N-[4-[4-(3-aminocyclobutanecarbonyl)piperazine-1-carbonyl]-3-chlorophenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(4-((5-aminopentyl)carbamoyl)-3-ethylphenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-((2-(dimethylamino)ethyl)(methyl)amino)piperidine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(4-((1R,5 S)-3-azabicyclo[3.1.0]hexane-6-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[[3-[[3-(aminomethyl)pyrrolidine-1-carbonyl]amino]cyclobutyl]carbamoyl]-3-chloro-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-(3-chloro-4-(4-(3-(dimethylamino)-3-methylbutyl)piperidine-1-carbonyl)phenyl)-5-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-[4-[[3-[[2-(aminomethyl)pyrrolidine-1-carbonyl]amino]cyclobutyl]carbamoyl]-3-chloro-phenyl]-5-[1-(cyanomethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;
N-(4-(4-(4-aminopiperidine-1-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(6-(piperidine-4-carbonyl)-1,6-diazaspiro[3.3]heptane-1-carbonyl)phenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-((1R,5-azabicyclo[3.1.0]hexane-6-carbonyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(2,2-difluoroethyl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-6-((2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)methyl)-N-((3S,4 S)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-(3-chloro-4-(4-(methylamino)piperidine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(4-((2S,4 S)-4-fluoropyrrolidine-2-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(methyl(piperidin-4-yl)carbamoyl)phenyl)-5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-((1R,3R)-3-aminocyclopentyl)-4-(2-chloro-4-(5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzoyl)piperazine-1-carboxamide;
N-(3-chloro-4-(4-hydroxy-[1,4′-bipiperidine]-1′-carbonyl)phenyl)-5-(1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-chloro-4-(piperazine-1-carbonyl)phenyl)-5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(((1S,4s)-4-((1 r, 3R)-3-aminocyclobutane-1-carboxamido)cyclohexyl)carbamoyl)-3-chlorophenyl)-5-(1-(cyanomethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-N-(4-(((1-(((1s,3 s)-3-aminocyclobutyl)carbamoyl)azetidin-3-yl)methyl)carbamoyl)-3-chlorophenyl)-5-(1-(cyclopropylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(3-bromo-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-5-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
N-(4-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)piperazine-1-carbonyl)-3-chlorophenyl)-5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamide;
rac-(1 S, 5R)-8-[2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carbonyl]amino]benzoyl]-N-[rac-(3 S,4 S)-4-hydroxypyrrolidin-3-yl]-3,8-diazabicyclo[3.2.1]octane-3-carboxamide;
N-[4-[6-(azetidin-3-ylmethyl carbamoyl amino)hexyl carbamoyl]-3-chlorophenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
N-(3-chloro-4-(4-(piperidine-4-carbonyl)piperazine-1-carbonyl)phenyl)-1-methyl-5-(3-(trifluoromethyl)-1-(2-(trifluoromethyl)cyclopropyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide;
(1R,5 S,6R)-6-(2-chloro-4-(5-(1-((R)-2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-((3 S,4 S)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
exo-6-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-((3 S,4 S)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
exo-6-[[2-chloro-4-[[5-[1-(2,2-difluorocyclopropyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carbonyl]amino]benzoyl]amino]-N-[trans-4-hydroxypyrrolidin-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxamide;
N-[3-chloro-4-[4-[rac-(1R,5S)-3-azabicyclo[3.1.0]hexane-6-carbonyl]piperazine-1-carbonyl]phenyl]-5-[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;
(1R,5 S,6s)-6-(2-chloro-4-(1-methyl-5-(1-(prop-2-yn-1-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamido)benzamido)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
rac-(1R,5S,6s)-6-(2-chloro-4-(5-(1-(2,2-difluorocyclopropyl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-((3S,4S)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1R,5S,6s)-6-(2-chloro-4-(5-(1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;
(1R,5S,6s)-6-(4-(5-(1-allyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)-2-chlorobenzamido)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide; and
(1R,5S,6s)-6-(2-chloro-4-(5-(1-(cyclobutylmethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-methyl-1H-imidazole-2-carboxamido)benzamido)-N-((3R,4R)-4-hydroxypyrrolidin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide.
28. A pharmaceutical composition comprising a compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.
29. A process of manufacturing the compounds of formula (I) according to claim 1 , the process comprising:
(i) reacting a heteroaryl bromide 5 or 15, wherein R 1 to R 3 , R 6 and R 7 are as defined herein,
with a boronate, such as heteroaryl boronic acid 6b, wherein R 4 and R 5 are as defined herein,
in the presence of a transition metal catalyst to afford said compound of formula (I); or
(ii) reacting a carboxylic acid 12a, wherein R 3 to R 7 are as defined herein,
with an amine 1, wherein R 1 and R 2 are as defined herein,
in the presence of a coupling reagent and a base to afford said compound of formula (I); or
(iii) reacting an amine 7
with an alkylating reagent 8, wherein X is a leaving group,
to afford said compound of formula (I); and
(iv) optionally converting said compound of formula (I) to a pharmaceutically acceptable salt thereof.
30. The process according to claim 27 , wherein:
the transition metal catalyst is a 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex;
the coupling reagent is HATU or TBTU;
the base is DIPEA or triethyl amine; and
the leaving group is a halide or a sulfonate.
31. A method for the treatment of infections and resulting diseases caused by Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species or E. coli , or a combination thereof, the method comprising administering a compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, to a mammal in need thereof.Cited by (0)
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