US2011158933A1PendingUtilityA1

Liver function and treatment of liver disease

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Assignee: IND TECHNOLOGY RES INST ITRIPriority: Dec 30, 2009Filed: Oct 20, 2010Published: Jun 30, 2011
Est. expiryDec 30, 2029(~3.5 yrs left)· nominal 20-yr term from priority
Inventors:Shau-Feng ChangChun-Hsien MaKuo-Yi YangChien-Tung LinShyh-Horng LinKai-Wen Huang
A61K 31/70A61K 31/765A61K 31/353A61P 1/16
45
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Claims

Abstract

A pharmaceutical preparation containing polymeric compounds as shown in the specification. This preparation can be used to improve liver function and treat liver disease, and promoting liver tissue regeneration.

Claims

exact text as granted — not AI-modified
1 . A method of improving liver function, comprising administering to a subject in need thereof a pharmaceutical composition obtained by mixing a pharmaceutically acceptable carrier and an isolated preparation containing one or more polymeric compounds, each of which includes two or more monomer units having the following formula: 
       
         
           
           
               
               
           
         
         in which each of R 1  and R 2 , independently, is H, alkyl, or acyl; each of R 3 , R 4 , R 5 , R 6 , and R 7 , independently, is H, OH, alkoxyl, or acyl; and R 8  is H or a saccharide moiety; wherein the polymeric compounds constitute 20% or higher of the isolated preparation by weight. 
       
     
     
         2 . The method of  claim 1 , wherein R 1  and R 2 , independently, is H. 
     
     
         3 . The method of  claim 2 , wherein each of R 3  and R 7  is H. 
     
     
         4 . The method of  claim 3 , wherein each of R 4 , R 5 , and R 6  is OH or alkoxyl. 
     
     
         5 . The method of  claim 4 , wherein R 8  is H. 
     
     
         6 . The method of  claim 5 , wherein the polymeric compound includes 2-30 monomer units. 
     
     
         7 . The method of  claim 6 , wherein the monomer units are covalently bonded to each other via C4-C8 bonding, C4-C6 bonding, or C2-O7 bonding. 
     
     
         8 . The method of  claim 1 , wherein the polymeric compound includes 2-30 monomer units. 
     
     
         9 . The method of  claim 8 , wherein the monomer units are covalently bonded to each other via C4-C8 bonding, C4-C6 bonding, or C2-O7 bonding. 
     
     
         10 . The method of  claim 1 , wherein each of R 4 , R 5 , and R 6  is OH or alkoxyl. 
     
     
         11 . A method of treating liver disease, comprising administering to a subject in need thereof a pharmaceutical composition obtained by mixing a pharmaceutically acceptable carrier and an isolated preparation containing one or more polymeric compounds, each of which includes two or more monomer units having the following formula: 
       
         
           
           
               
               
           
         
         in which each of R 1  and R 2 , independently, is H, alkyl, or acyl; each of R 3 , R 4 , R 5 , R 6 , and R 7 , independently, is H, OH, alkoxyl, or acyl; and R 8  is H or a saccharide moiety; wherein the polymeric compounds constitute 20% or higher of the isolated preparation by weight. 
       
     
     
         12 . The method of  claim 11 , wherein R 1  and R 2 , independently, is H. 
     
     
         13 . The method of  claim 12 , wherein each of R 3  and R 7  is H. 
     
     
         14 . The method of  claim 13 , wherein each of R 4 , R 5 , and R 6  is OH or alkoxyl. 
     
     
         15 . The method of  claim 14 , wherein R 8  is H. 
     
     
         16 . The method of  claim 15 , wherein the polymeric compound includes 2-30 monomer units. 
     
     
         17 . The method of  claim 16 , wherein the monomer units are covalently bonded to each other via C4-C8 bonding, C4-C6 bonding, or C2-O7 bonding. 
     
     
         18 . The method of  claim 11 , wherein the polymeric compound includes 2-30 monomer units. 
     
     
         19 . The method of  claim 28 , wherein the monomer units are covalently bonded to each other via C4-C8 bonding, C4-C6 bonding, or C2-O7 bonding. 
     
     
         20 . The method of  claim 11 , wherein each of R 4 , R 5 , and R 6  is OH or alkoxyl. 
     
     
         21 . The method of  claim 20 , wherein the liver disease is liver fibrosis, liver cirrhosis, liver infection, liver inflammation, or liver cancer. 
     
     
         22 . A method of regenerating liver tissues, comprising administering to a subject in need thereof a pharmaceutical composition obtained by mixing a pharmaceutically acceptable carrier and an isolated preparation containing one or more polymeric compounds, each of which includes two or more monomer units having the following formula: 
       
         
           
           
               
               
           
         
         in which each of R 1  and R 2 , independently, is H, alkyl, or acyl; each of R 3 , R 4 , R 5 , R 6 , and R 7 , independently, is H, OH, alkoxyl, or acyl; and R 8  is H or a saccharide moiety; wherein the polymeric compounds constitute 20% or higher of the isolated preparation by weight. 
       
     
     
         23 . The method of  claim 22 , wherein R 1  and R 2 , independently, is H. 
     
     
         24 . The method of  claim 23 , wherein each of R 3  and R 7  is H. 
     
     
         25 . The method of  claim 24 , wherein each of R 4 , R 5 , and R 6  is OH or alkoxyl. 
     
     
         26 . The method of  claim 25 , wherein R 8  is H. 
     
     
         27 . The method of  claim 26 , wherein the polymeric compound includes 2-30 monomer units. 
     
     
         28 . The method of  claim 27 , wherein the monomer units are covalently bonded to each other via C4-C8 bonding, C4-C6 bonding, or C2-O7 bonding. 
     
     
         29 . The method of  claim 22 , wherein the polymeric compound includes 2-30 monomer units. 
     
     
         30 . The method of  claim 29 , wherein the monomer units are covalently bonded to each other via C4-C8 bonding, C4-C6 bonding, or C2-O7 bonding. 
     
     
         31 . The method of  claim 22 , wherein each of R 4 , R 5 , and R 6  is OH or alkoxyl.

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