Compound containing an oxygen-15, preparation and use thereof, and composition comprising thereof

Abstract

The present disclosure relates to a compound comprising an oxygen-15 and a process for preparation thereof. It also relates to the use of the compound in positron and/or other nuclide imaging and use of the compound in obtaining a perfusion and/or metabolic image in an animal and/or human body. A process for preparing the compound comprises irradiating a compound comprising oxygen via irradiation energy in the range of 10 MeV to 430 MeV. The oxygen atom in the compound may then be allowed to be converted to an oxygen-15 positron nuclide through a photonuclear reaction. Provided that the molecular structure of the irradiated compound is not disrupted, a compound comprising an oxygen-15 is prepared.

1 . A process, comprising:
 utilizing irradiation energy in the range of 10 MeV to 430 MeV generated by at least one of a high energy electron accelerator, a proton treatment device, a heavy ion treatment device, or a neutron treatment device to irradiate a compound comprising an oxygen atom; and   allowing the oxygen atom to convert to an oxygen-15 positron nuclide through a photonuclear reaction, the molecular structure of the irradiated compound not disrupted, thereby preparing a compound comprising an oxygen-15.   
     
     
         2 . The process of  claim 1 , comprising using the compound comprising the oxygen-15 in nuclide imaging. 
     
     
         3 . The process of  claim 1 , comprising using the compound comprising the oxygen-15 to obtain at least one of a perfusion image or a metabolic image of at least one of an animal or a human body. 
     
     
         4 . The process of  claim 1 , comprising using the compound comprising the oxygen-15 in preparing a tracer used before nuclide imaging. 
     
     
         5 . The process of  claim 1 , comprising using the compound comprising the oxygen-15 in at least one of PET, PET-CT, PET-MRI, and PET-MRI-CT. 
     
     
         6 . A compound comprising an oxygen-15 positron isotope prepared by irradiating an oxygen atom of a compound utilizing irradiation energy in the range of 10 MeV to 430 MeV and allowing the oxygen atom to convert to an oxygen-15 positron nuclide through a photonuclear reaction. 
     
     
         7 . A composition comprising a compound comprising an oxygen-15 positron isotope prepared by irradiating an oxygen atom of a compound utilizing irradiation energy in the range of 10 MeV to 430 MeV and allowing the oxygen atom to convert to an oxygen-15 positron nuclide through a photonuclear reaction. 
     
     
         8 . The composition of  claim 7 , comprising at least one of a pharmaceutically acceptable carrier or a pharmaceutically acceptable excipient.