Method of Inhibiting Chronification of Pain

Abstract

The use of tapentadol in the treatment of pain and/or pain chronification in a subject suffering from pain chronification and/or in the treatment of pain and inhibition of pain chronification in a subject suffering from pain and at risk of pain chronification, as well as the use of tapentadol for the treatment or inhibition of migraine.

1 . A method of treating pain in a subject suffering from pain chronification or for inhibiting pain chronification in a subject suffering from pain and at risk for pain chronification, said method comprising administering to said subject an effective pain alleviating or pain chronification inhibiting amount of tapentadol. 
     
     
         2 . A method as recited in  claim 1 , wherein said subject is a subject suffering from pain and at risk of pain chronification, and the tapentadol is administered in an effective pain alleviating and pain chronification inhibiting amount. 
     
     
         3 . A method as recited in  claim 1 , wherein said subject is a subject suffering from pain and pain chronification, and the tapentadol is administered in an effective pain alleviating and pain chronification treating amount. 
     
     
         4 . A method as recited in  claim 1 , wherein said subject is a subject suffering from pain, and the tapentadol is administered in an effective pain alleviating amount. 
     
     
         5 . A method as recited in  claim 1 , wherein said subject is a subject suffering from central pain. 
     
     
         6 . A method as recited in  claim 1 , wherein said subject is a subject suffering from peripheral pain. 
     
     
         7 . A method as recited in  claim 1 , wherein said subject is a subject suffering from acute pain. 
     
     
         8 . A method as recited in  claim 7 , wherein said acute pain is selected from the group consisting of mechanical pain, heat pain, cold pain, ischemic pain, and chemical-induced pain. 
     
     
         9 . A method as recited in  claim 1 , wherein said subject is a subject suffering from pain selected from the group consisting of postoperative pain, inflammatory pain, migraine-pain, headache pain, irritable bowel syndrome pain, fibromyalgia pain, arthritic pain, skeletal pain, joint pain, gastrointestinal pain, muscle pain, angina pain, facial pain, pelvic pain, claudication, postoperative pain, post traumatic pain, tension headache pain, obstetric pain, gynecological pain, and chemotherapy-induced pain. 
     
     
         10 . A method as recited in  claim 1 , wherein said subject is a subject suffering from postoperative pain and the tapentadol is administered:
 during N 1  consecutive days of a postoperative phase P 1 ,   during N 2  consecutive days of a phase P 2  following said postoperative phase P 1 ,   but not during N 3  consecutive days of a phase P 3  following said phase P 2 ;   
       wherein N 1 , N 2  and N 3  each independently denote an integer of from 1 to 100, with the proviso that N 1 ≧N 2 . 
     
     
         11 . A method as recited in  claim 10 , wherein N 3 ≧N 1 ≧N 2  or N 3 ≧N 2 ≧N 1 . 
     
     
         12 . A method of treating or inhibiting migraine in a subject suffering therefrom, said method comprising administering to said subject an effective migraine treating or inhibiting amount of tapentadol. 
     
     
         13 . A method as recited in  claim 1 , wherein said subject is a subject suffering from moderate or severe pain. 
     
     
         14 . A method as recited in  claim 1 , wherein the tapentadol is administered orally. 
     
     
         15 . A method as recited in  claim 1 , wherein the tapentadol is administered one daily. 
     
     
         16 . A method as recited in  claim 1 , wherein the tapentadol is administered twice daily. 
     
     
         17 . A method as claimed in  claim 1 , wherein the tapentadol is administered at a daily dose within the range of from 25 to 600 mg.