Vesicle composition

Abstract

The present invention is to provide a vesicle composition comprising the following components (A), (B) and (C): (A) 0.0001 to 20 mass % of an organic acid represented by general formula (1): wherein R 1 represents a natural sterin having a single hydroxy group or a hydrogenated product thereof or a residue which remains after a hydrogen atom is removed from the hydroxy group of bile acid, R 2 represents a divalent hydrocarbon group having 1 to 24 carbon atoms, M represents a hydrogen atom, an alkali metal, an alkali earth metal, ammonium, an alkanolammonium having 2 to 9 carbon atoms in total, an alkylammonium or alkenylammonium having 1 to 22 carbon atoms in total, pyridinium substituted with an alkyl group or alkenyl group having 1 to 18 carbon atoms or a basic amino acid, (B) 0.0001 to 10 mass % of a sphingosine, and (C) water, and having a pH of 2 to 11.

1 - 9 . (canceled) 
     
     
         10 . A method, comprising:
 mixing an oil phase comprising a component (A) and a component (B) with heating;   dissolving a component (G) or a component (H) in part of a component (C) to form a first solution,   adding the first solution to said oil phase and mixing the first solution and the oil phase to form a second solution;   cooling said second solution; and   mixing a water phase comprising the remaining part of said component (C) to said second solution to form a vesicle composition and stirring the vesicle composition,   thereby producing a vesicle composition comprising components (A), (B), (C) and at least one of component (G) and component (H):
 (A) 0.0001 to 20 mass % of an organic acid represented by formula (1): 
   
       
         
           
           
               
               
           
         
         
           where R 1  represents a natural sterin having a single hydroxy group or a hydrogenated product thereof or a residue which remains after a hydrogen atom is removed from the hydroxy group of bile acid, R 2  represents a divalent hydrocarbon group having 1 to 24 carbon atoms, M represents a hydrogen atom, an alkali metal, an alkali earth metal, ammonium, an alkanolammonium having 2 to 9 carbon atoms in total, an alkylammonium or alkenylammonium having 1 to 22 carbon atoms in total, pyridinium substituted with an alkyl group or alkenyl group having 1 to 18 carbon atoms or a basic amino acid, 
           (B) 0.0001 to 10 mass % of a sphingosine, 
           (C) water, and 
           at least one of: (G) a base other than component (B), and (H) an acid other than component (A), 
           wherein said vesicle composition has a pH of from 2 to 11. 
         
       
     
     
         11 . The method according to  claim 10 , wherein said second solution obtained by adding the first solution which is obtained by dissolving component (G) in part of component (C) to said oil phase and mixing them has a pH of greater than 5.5, and, after said mixing, the method further comprises dissolving component (H) in a part of component (C) to form said vesicle composition, thereby controlling the pH of the vesicle composition to a value of from 2 to 11. 
     
     
         12 . The method according to  claim 10 , wherein said second solution obtained by adding the first solution which is obtained by dissolving component (H) in part of component (C) to said oil phase and mixing them a pH 5.5 or less, and, after said mixing, the method further comprises dissolving component (G) in a part of component (C) to form said vesicle composition, thereby controlling the pH of the vesicle composition to a value of from 2 to 11. 
     
     
         13 . A vesicle composition, comprising components (A), (B) and (C):
 (A) 0.0001 to 20 mass % of an organic acid represented by formula (1):   
       
         
           
           
               
               
           
         
         where R 1  represents a natural sterin having a single hydroxy group or a hydrogenated product thereof or a residue which remains after a hydrogen atom is removed from the hydroxy group of bile acid, R 2  represents a divalent hydrocarbon group having 1 to 24 carbon atoms, M represents a hydrogen atom, an alkali metal, an alkali earth metal, ammonium, an alkanolammonium having 2 to 9 carbon atoms in total, an alkylammonium or alkenylammonium having 1 to 22 carbon atoms in total, pyridinium substituted with an alkyl group or alkenyl group having 1 to 18 carbon atoms or a basic amino acid, 
         (B) 0.0001 to 10 mass % of a sphingosine, and 
         (C) water, wherein 
       
       said vesicle composition has a pH of 2 to 11. 
     
     
         14 . The vesicle composition according to  claim 13 , further comprising (D) a ceramide. 
     
     
         15 . The vesicle composition according to  claim 13 , further comprising (E) cholesterol or a derivative thereof. 
     
     
         16 . The vesicle composition according to  claim 13 , further comprising (F) a fatty acid. 
     
     
         17 . The vesicle composition according to  claim 13 , further comprising at least one of a component (G), which is a base other than component (B), and a component (H), which is an acid other than component (A). 
     
     
         18 . The vesicle composition according to  claim 13 , wherein the mass ratio of component (A) and component (B), (A)/(B), is 0.001 or more and 50 or less. 
     
     
         19 . The vesicle composition according to  claim 14 , wherein the mass ratio of component (B) and component (D), (B)/(D), is 0.01 to 15. 
     
     
         20 . The vesicle composition according to  claim 13 , wherein component (A) comprises a residue which remains after a hydrogen atom is removed from the hydroxy group of the compound in which R 1  in the formula (1) is cholesterol. 
     
     
         21 . The vesicle composition according to  claim 13 , wherein component (B) comprises at least one member selected from the group consisting of natural sphingosine, dihydrosphingosine, phytosphingosine, sphingadienine, dehydrosphingosine, dehydrophytosphingosine, and a pseudo sphingosine represented by one of formula (i) to (iv): 
       
         
           
           
               
               
           
         
       
     
     
         22 . The vesicle compound according to  claim 14 , wherein component (D) comprises at least one member selected from the group consisting of a natural-type ceramide represented by formula (5) 
       
         
           
           
               
               
           
         
         wherein R 11  represents a linear, branched or cyclic, and saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms, which is optionally substituted with a hydroxyl group; Z 1  represents a methylene group or a methine group; X 11 , X 12  and X 13  each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group; X 14  represents a hydrogen atom or forms an oxo group together with the adjacent oxygen atom, with the proviso that when Z 1  is a methine group, either X 11  or X 12  is a hydrogen atom and the other is not present, and when X 14  forms an oxo group, X 13  is not present; R 12  represents a hydroxymethyl group or an acetoxymethyl group; R 13  represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 14  represents a linear, branched or cyclic, and saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms, which is optionally substituted with a hydroxyl group, or represents a substituent in which a linear or branched, and saturated or unsaturated fatty acid having 8 to 22 carbon atoms which is optionally substituted with a hydroxyl group is ester-bonded to the ω terminal of the alkyl group; and the broken line indicates that the bond may be an unsaturated bond; 
         and 
         a pseudo ceramide represented by formula (6): 
       
       
         
           
           
               
               
           
         
         wherein R 15  represents a linear, branched or cyclic, and saturated or unsaturated hydrocarbon group having 10 to 22 carbon atoms, which is optionally substituted with a hydroxyl group or represents a hydrogen atom; X 15  represents a hydrogen atom, an acetyl group or a glyceryl group; R 16  represents a linear, branched or cyclic, and saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms, which is optionally substituted with a hydroxyl group or an amino group, or represents a substituent in which a linear or branched, and saturated or unsaturated fatty acid having 8 to 22 carbon atoms which is optionally substituted with a hydroxyl group is ester-bonded to the ω terminal of the hydrocarbon group; and R 17  represents a hydrogen atom or represents an alkyl group having 1 to 30 carbon atoms in total, which is optionally substituted with a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an acetoxy group. 
       
     
     
         23 . The vesicle composition according to  claim 15 , wherein component (E) comprises at least one member selected from the group consisting of cholesteryl laurate, cholesteryl palmitate, cholesteryl myristate, cholesteryl oleate, cholesteryl isostearate and cholesteryl linoleate. 
     
     
         24 . The vesicle composition according to  claim 16 , wherein component (F) comprises at least one member selected from the group consisting of isostearic acid, oleic acid, myristic acid, palmitic acid, stearic acid, arachic acid, behenic acid, lignoceric acid, cerotic acid, montanic acid and melissic acid. 
     
     
         25 . The vesicle composition according to  claim 13 , which is a cosmetic product. 
     
     
         26 . A method for using the vesicle composition according to  claim 25 , comprising applying the composition to the skin.