Method for administration

Abstract

There is provided a new dosage regimen for Compound A which maximizes anti-tumor activity while maintaining acceptable toxicity levels.

1 . A method of treating a patient suffering from cancer, comprising administering to said patient a pharmaceutical composition containing as an active ingredient Compound A in an amount from about 800 mg/day to about 3000 mg/day, daily 7 days, followed by a rest period of 21 days, said administration starting on the first day of a 28 day treatment cycle; and wherein Compound A is administered twice daily in equal doses. 
     
     
         2 . A method of treating a patient suffering from cancer, comprising administering to said patient a pharmaceutical composition containing as an active ingredient Compound A in an amount from about 800 mg/day to about 3000 mg/day, daily, for 5 days, followed by a rest period of 23 days, said administration starting on the first day of a 28 day treatment cycle; and wherein Compound A is administered twice daily in equal doses. 
     
     
         3 . The method of  claim 2  wherein Compound A is administered in an amount from about 1000 mg/day to about 2500 mg/day. 
     
     
         4 . The method of  claim 3  wherein Compound A is administered in an amount of from about 1250 mg/day to about 1800 mg/day. 
     
     
         5 . The method of  claim 1  wherein the treatment cycle repeated every 28 days for up to about 12 cycles. 
     
     
         6 . The method of  claim 1  wherein Compound A is administered twice daily in equal doses. 
     
     
         7 . The method of  claim 1  wherein the cancer is colorectal cancer. 
     
     
         8 . The method of  claim 1  wherein the cancer is prostrate cancer. 
     
     
         9 . The method of  claim 1  wherein the cancer is lung cancer. 
     
     
         10 . The method of  claim 1  wherein the cancer is kidney cancer. 
     
     
         11 . The method of  claim 1  wherein the cancer is breast cancer.