Production Of Inorganic-Organic Composite Materials By Reactive Spray-Drying

Abstract

A composite material comprising at least one amorphous hydrophobic active ingredient in an amorphous salt matrix with a solubility in the neutral aqueous medium of less than 0.02 mol/l, obtained by a reactive spray-drying process, where a liquid phase A, which comprises inorganic cations, and a liquid phase B, which comprises anions which, with the inorganic cations, form a salt that is insoluble in the mixture of the liquid phases are sprayed together using at least one multi-substance nozzle, and where at least one hydrophobic active ingredient is present in dissolved form in at least one liquid spraying phase, and where the salt formed from the cations of phase A and the anions of phase B has a solubility of less than 0.02 mol/l in the neutral aqueous medium.

What is claimed is: 
     
         1 . A composite material comprising at least one amorphous hydrophobic active ingredient in an amorphous salt matrix with a solubility in the neutral aqueous medium of less than 0.02 mol/l, obtained by a reactive spray-drying process, where a liquid phase A, which comprises inorganic cations, and a liquid phase B, which comprises anions which, with the inorganic cations, form a salt that is insoluble in the mixture of the liquid phases are sprayed together using at least one multi-substance nozzle, and where at least one hydrophobic active ingredient is present in dissolved form in at least one liquid spraying phase, and where the salt formed from the cations of phase A and the anions of phase B has a solubility of less than 0.02 mol/l in the neutral aqueous medium. 
     
     
         2 . The composite material of  claim 1 , comprising at least one amorphous hydrophobic active ingredient in an amorphous salt matrix of at least one salt selected from the group of calcium, magnesium and zinc salts. 
     
     
         3 . The composite material of  claim 1 , comprising at least one amorphous hydrophobic active ingredient in an amorphous salt matrix of calcium carbonate. 
     
     
         4 . The composite material of  claim 1 , further comprising a surfactant. 
     
     
         5 . The composite material of  claim 4 , comprising a surfactant selected from the group of polyoxyethylenated esters of castor oil or hydrogenated castor oil. 
     
     
         6 . The composite material of  claim 4 , comprising sodium laurylsulfate as surfactant. 
     
     
         7 . The composite material of  claim 1 , wherein the inorganic cations of phase A are selected from the group consisting of magnesium ions, calcium ions and zinc ions. 
     
     
         8 . The composite material of  claim 7 , wherein the inorganic cations of phase A used are calcium ions. 
     
     
         9 . The composite material of  claim 1 , wherein the liquid phase A is a solution of salts of the inorganic cations and the salts are selected from the group consisting of calcium chloride, calcium nitrate, calcium acetate, magnesium chloride, magnesium nitrate, magnesium acetate, magnesium citrate, magnesium lactate, zinc chloride, zinc nitrate and zinc acetate. 
     
     
         10 . The composite material of  claim 1 , wherein the liquid phase B used is a solution of salts selected from the group consisting of ammonium, alkali metal or magnesium salts of carbonates, hydrogencarbonates, sulfates, phosphates and hydrogenphosphates. 
     
     
         11 . The composite material of  claim 10 , wherein the liquid phase B used is a solution of salts selected from the group consisting of ammonium, alkali metal or magnesium salts of citric acid, lactic acid and oxalic acid. 
     
     
         12 . The composite material of  claim 1 , wherein the salt formed from the cations of phase A and the anions of phase B that is used is a calcium salt selected from the group consisting of carbonates, phosphates, sulfates, hydroxylapatites, citrates, lactates and oxalates. 
     
     
         13 . The composite material of  claim 1 , wherein the hydrophobic active ingredient is used in the form of an ethanolic or aqueous-ethanolic solution. 
     
     
         14 . The composite material of  claim 4 , wherein the surfactant is present in amounts of from 2 to 50% by weight, based on the amount of active ingredient. 
     
     
         15 . The composite material of  claim 4 , wherein the surfactant is selected from the group consisting of polyoxyalkylated fatty acid esters and polyoxyalkylated fatty alcohol ethers.