US2015353559A1PendingUtilityA1
New bicyclic derivatives
Est. expirySep 25, 2032(~6.2 yrs left)· nominal 20-yr term from priority
C07D 471/04C07D 487/04C07D 403/12A61P 37/06C07D 413/12A61P 25/00C07D 519/00A61P 13/12A61P 1/16
57
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
The invention provides novel compounds having the general formula (I) wherein R 1 , Y, A, W, R 2 , m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
Claims
exact text as granted — not AI-modified1 . A Compounds of formula (I)
wherein
R 1 is alkyl, haloalkyl, substituted cycloalkyl, substituted cycloalkylalkyl, substituted piperazinyl, substituted piperidinyl, substituted indanyloxyalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted phenylalkynyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, substituted pyridinylalkynyl substituted thiophenyl, substituted thiophenylalkyl, substituted thiophenylalkenyl, substituted thiophenylalkynyl, naphtyl, substituted naphthyl, quinolyl, substituted quinolinyl, isoquinolyl, substituted isoquinolinyl, substituted 2,3-dihydro-1H-isoindol-2-yl, substituted 1H-indol-2-yl or substituted benzofuran-2-yl wherein substituted cycloalkyl, substituted cycloalkylalkyl, substituted piperazinyl, substituted piperidinyl, substituted indanyloxyalkyl, substituted phenyl, substituted phenylalkyl, substituted phenylalkynyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, substituted pyridinylalkynyl, substituted thiophenyl, substituted thiophenylalkyl, substituted thiophenylalkenyl, substituted thiophenylalkynyl, substituted naphthyl, substituted quinolinyl, substituted isoquinolinyl, substituted 2,3-dihydro-1H-isoindol-2-yl, substituted 1H-indol-2-yl and substituted benzofuran-2-yl are substituted with R 8 , R 9 and R 10 ;
Y is —OC(O)—, —NR 7 C(O)—, —C(O)—, —S(O) 2 —,
A is —N— or CR 5 —;
W is —O—, —S—, —NR 6 —, —C(O)—, —S(O) 2 —, —C(O)—NR 6 — or —CR 3 R 4 —;
R 3 and R 4 are independently selected from H, halogen, alkyl and cycloalkyl;
R 5 , R 6 and R 7 are independently selected from H, alkyl and cycloalkyl;
R 8 , R 9 and R 10 are independently selected from H, alkyl, hydroxyalkyl, haloalkyl, hydroxyhaloalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkoxy, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy, alkoxyhaloalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, phenyl, substituted phenyl, pyridinyl, substituted pyridinyl, pyrrolyl, substituted pyrrolyl, pyrrolydinyl, substituted pyrrolydinyl, tetrahydrofuranyl, substituted tetrahydrofuranyl, halogen, hydroxy, cyano, alkylsulfanyl, haloalkylsulfanyl, cycloalkylsulfanyl, alkylsulfinyl, haloalkylsulfinyl, cycloalkylsulfinyl, alkylcarbonyl, haloalkylcarbonyl, cycloalkylcarbonyl, alkylsulfonyl, haloalkylsulfonyl, cycloalkylsulfonyl, substituted aminosulfonyl, substituted amino and substituted aminoalkyl, wherein substituted aminosulfonyl, substituted amino and substituted aminoalkyl are substituted on the nitrogen atom with one to two substituents independently selected from H, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl and cycloalkylcarbonyl, and wherein substituted phenyl, substituted pyrrolyl, substituted pyrrolydinyl, substituted tetrahydrofuranyl, and substituted pyridinyl are substituted with one to three substituents independently selected from alkyl, halogen, haloalkyl, alkoxy and haloalkoxy;
m, n, p and q are independently selected from 1 or 2;
R 11 is H, alkyl, haloalkyl or cycloalkyl;
R 12 is alkyl, halogen, haloalkyl and alkoxy;
R 2 is selected from the ring systems B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, X, Z, AA, AB, AC, AD, AE, AF, AG, AH, AI and AJ;
and pharmaceutically acceptable salts thereof.
2 . The compound according to claim 1 , wherein
R 1 is alkyl, haloalkyl, substituted cycloalkyl, substituted cycloalkylalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted phenylalkynyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, substituted pyridinylalkynyl, substituted thiophenyl, substituted thiophenylalkyl, substituted thiophenylalkenyl, substituted thiophenylalkynyl, substituted 2,3-dihydro-1H-isoindol-2-yl, substituted 1H-indol-2-yl or substituted benzofuran-2-yl wherein substituted cycloalkyl, substituted cycloalkylalkyl, substituted phenyl, substituted phenylalkyl, substituted phenylalkynyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, substituted pyridinylalkynyl, substituted thiophenyl, substituted thiophenylalkyl, substituted thiophenylalkenyl, substituted thiophenylalkynyl, substituted 2,3-dihydro-1H-isoindol-2-yl, substituted 1H-indol-2-yl and substituted benzofuran-2-yl are substituted with R 8 , R 9 and R 10 ; Y is —OC(O)—, —NR 7 C(O)—, —C(O)—, —S(O) 2 —,
A is —N— or CR 5 —;
W is —O—, —S—, —NR 6 —, —C(O)—, —S(O) 2 —, —C(O)—NR 6 — or —CR 3 R 4 —;
R 3 and R 4 are independently selected from H, halogen, alkyl and cycloalkyl;
R 5 , R 6 and R 7 are independently selected from H, alkyl and cycloalkyl;
R 8 , R 9 and R 10 are independently selected from H, alkyl, hydroxyalkyl, haloalkyl, hydroxyhaloalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkoxy, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy, alkoxyhaloalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, phenyl, substituted phenyl, pyridinyl, substituted pyridinyl, halogen, hydroxy, cyano, alkylsulfanyl, haloalkylsulfanyl, cycloalkylsulfanyl, alkylsulfinyl, haloalkylsulfinyl, cycloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, cycloalkylsulfonyl, substituted aminosulfonyl, substituted amino and substituted aminoalkyl, wherein substituted aminosulfonyl, substituted amino and substituted aminoalkyl are substituted on the nitrogen atom with one to two substituents independently selected from H, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl and cycloalkylcarbonyl, and wherein substituted phenyl and substituted pyridinyl are optionally substituted with one to three substituents independently selected from alkyl, halogen, haloalkyl, alkoxy and haloalkoxy;
m, n, p and q are independently selected from 1 or 2;
R 11 is H, alkyl, haloalkyl or cycloalkyl;
R 2 is selected from the ring systems B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, X, Z, AA, AB, AC, AD and AE;
and pharmaceutically acceptable salts.
3 . The compound according to claim 1 , wherein R 1 is substituted cycloalkylalkyl, substituted piperazinyl, substituted piperidinyl, substituted indanyloxyalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, naphtyl, substituted naphthyl, substituted quinolinyl, substituted isoquinolinyl, or substituted 1H-indol-2-yl, wherein substituted cycloalkylalkyl, substituted piperazinyl, substituted piperidinyl, substituted indanyloxyalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, substituted naphthyl, substituted quinolinyl, substituted isoquinolinyl and substituted 1H-indol-2-yl are substituted with R 8 , R 9 and R 10 .
4 . The compound according to claim 1 , wherein R 1 is substituted cycloalkylalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted pyridinylalkyl, substituted pyridinylalkenyl or substituted 1H-indol-2-yl, wherein substituted cycloalkylalkyl, substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted phenylcycloalkyl, substituted phenylalkenyl, substituted pyridinylalkyl, substituted pyridinylalkenyl, and substituted 1H-indol-2-yl are substituted with R 8 , R 9 and R 10 .
5 . The compound according to claim 1 , wherein R 1 is substituted phenylalkyl or substituted phenylalkenyl, wherein substituted phenylalkyl and substituted phenylalkenyl are substituted with R 8 , R 9 and R 10 .
6 . The compound according to claim 1 , wherein R 1 is phenylalkyl substituted with R 8 , R 9 and R 10 .
7 . The compound according to claim 1 , wherein Y is —OC(O)—, —C(O)—, —S(O) 2 — or
8 . The compound according to claim 1 , wherein Y is —OC(O)— or —C(O)—.
9 . The compound according to claim 1 , wherein Y is —OC(O)—.
10 . The compound according to claim 1 , wherein Y is —C(O)—.
11 . The compound according to claim 1 , wherein A is —N—.
12 . The compound according to claim 1 , wherein W is —O—, —NR 6 —, —C(O)—, —S(O) 2 —, —C(O)—NR 6 — or —CR 3 R 4 —.
13 . The compound according to claim 1 , wherein W is —C(O)—, —C(O)—NR 6 — or —CR 3 R 4 —.
14 . The compound according to claim 1 , wherein W is —C(O)—.
15 . The compound according to claim 1 , wherein R 2 is selected from the ring systems B, C, D, E, G, H, M, O, P, R, S, T, U, V, X, Z, AA, AB, AC, AD, AE, AF, AG, AH and AI.
16 . The compound according to claim 1 , wherein R 2 is selected from the ring systems B, C, D, E, G, H, M, O, P, R, S, T, U, V, X, Z, AA, AB, AC, AD and AE.
17 . The compound according to claim 1 , wherein R 2 is selected from the ring systems B, D, H, M, O, R and AJ.
18 . The compound according to claim 1 , wherein R 2 is selected from the ring systems B, D, H, O and R.
19 . The compound according to claim 1 , wherein R 2 is selected from the ring systems B and D.
20 . The compound according to claim 1 , wherein R 2 is the ring system D.
21 . The compound according to claim 1 , wherein R 3 and R 4 are H.
22 . The compound according to claim 1 , wherein R 5 is H.
23 . The compound according to claim 1 , wherein R 6 is H or alkyl.
24 . The compound according to claim 1 , wherein R 8 , R 9 and R 10 are independently selected from H, alkyl, haloalkyl, hydroxyhaloalkyl, alkoxy, haloalkoxy, alkoxyhaloalkyl, phenyl, pyridinyl, halogen, cyano, haloalkylsulfanyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, pyrrolyl substituted with one alkyl, pyrrolydinyl, tetrahydrofuranyl, alkylcarbonyl, and aminosulfonyl substituted on the nitrogen atom with one to two substituents independently selected from H, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl and cycloalkylcarbonyl.
25 . The compound according to claim 1 , wherein R 8 , R 9 and R 10 are independently selected from H, alkyl, haloalkyl, hydroxyhaloalkyl, alkoxy, haloalkoxy, alkoxyhaloalkyl, phenyl, pyridinyl, halogen, cyano, haloalkylsulfanyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl and aminosulfonyl substituted on the nitrogen atom with one to two substituents independently selected from H, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl and cycloalkylcarbonyl.
26 . The compound according to claim 1 , wherein R 8 , R 9 and R 10 are independently selected from H, alkyl, haloalkyl, hydroxyhaloalkyl, alkoxy, haloalkoxy, alkoxyhaloalkyl, phenyl, pyridinyl, halogen, cyano, haloalkylsulfanyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl and aminosulfonyl substituted on the nitrogen atom with two alkyl.
27 . The compound according to claim 1 , wherein R 8 , R 9 and R 10 are independently selected from H, alkyl, haloalkyl, haloalkoxy, halogen and alkylsulfonyl.
28 . The compound according to claim 1 , wherein R 8 is H, alkyl, haloalkyl, hydroxyhaloalkyl, alkoxy, haloalkoxy, alkoxyhaloalkyl, phenyl, pyridinyl, halogen, cyano, haloalkylsulfanyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, pyrrolyl substituted with one alkyl, pyrrolydinyl, tetrahydrofuranyl, alkylcarbonyl, or aminosulfonyl substituted on the nitrogen atom with two alkyl.
29 . The compound according to claim 1 , wherein R 8 is haloalkyl, haloalkoxy, halogen or alkylsulfonyl.
30 . The compound according to claim 1 , wherein R 8 is haloalkoxy or halogen.
31 . The compound according to claim 1 , wherein R 8 is halogen.
32 . The compound according to claim 1 , wherein R 9 is H, alkyl, haloalkyl, cycloalkyl, cycloalkoxy, alkoxy, haloalkoxy, alkoxyalkoxy, cyano or halogen.
33 . The compound according to claim 1 , wherein R 9 is H, alkyl, haloalkyl, alkoxy or halogen.
34 . The compound according to claim 1 , wherein R 9 is H, alkyl or halogen.
35 . The compound according to claim 1 , wherein R 8 and R 9 are halogen.
36 . The compound according to claim 1 , wherein R 10 is H, alkyl, alkoxy or halogen.
37 . The compound according to claim 1 , wherein R 10 is H or alkyl.
38 . The compound according to claim 1 , wherein R 10 is H.
39 . The compound according to claim 1 , wherein R 11 is haloalkyl.
40 . The compound according to claim 1 , wherein m is 1.
41 . The compound according to claim 1 , wherein n is 1.
42 . The compound according to claim 1 , wherein m and n are 1.
43 . The compound according to claim 1 , wherein p and q are 1.
44 . The compound according to claim 1 , wherein m, n, p and q are 1.
45 . The compound according to claim 1 , selected from
(E)-1-[(3aS,8aR)-2-(4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; 1-((3aR,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(3,5-dichlorophenyl)propan-1-one; 6-((3aR,6aS)-5-(3-(3,5-dichlorophenyl)propanoyl)octahydropyrrolo[3,4-c]pyrrole-2-carbonyl)benzo[d]oxazol-2(3H)-one; (3aR,6aS)-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(9H-pyrido[3,4-b]indole-3-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(1H-indole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(9H-carbazole-3-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(1H-indazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(1H-benzo[d]imidazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; trans-3,5-dichlorobenzyl 2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; cis-3,5-dichlorobenzyl 2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; (3aR,8aS)-3,5-dichlorobenzyl 2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepine-6(7H)-carboxylate; (1H-benzotriazol-5-yl)-{(3aS,6aR)-5-[2-(3-chloro-phenyl)-ethanesulfonyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone; (3aR,6aS)-3,5-dichlorobenzyl 5-(4,5,6,7-tetrahydro-1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-chlorophenyl)-2,2-dimethylpropan-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)prop-2-en-1-one; (3aSR,6SR,7aSR)-6-{(3aS,8aR)-6-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-octahydro-pyrrolo[3,4-d]azepine-2-carbonyl}-hexahydro-benzooxazol-2-one; (E)-1-[(3aS,8aR)-2-(benzo[c][1,2,5]oxadiazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2-methyl-4-(trifluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-fluoro-4-methoxyphenyl)prop-2-en-1-one; (E)-1-[(3aS,8aR)-2-((S)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one (E)-1-[(3aS,8aR)-2-((R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one (E)-1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(2-isopropyl-phenyl)-prop-2-ene-1-one; trans-3,5-dichlorobenzyl 2-(2-oxo-2,3-dihydrobenzo[d]oxazole-6-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(2-oxo-2,3-dihydrobenzo[d]oxazole-6-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 6-{(3aS,8aR)-6-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-octahydro-pyrrolo[3,4-d]azepine-2-carbonyl}-3H-benzooxazol-2-one; (3aR,5s,6aS)-3,5-dichlorobenzyl 5-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yloxy)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; (3aR,5r,6aS)-3,5-dichlorobenzyl 5-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yloxy)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; (3aS,6aS)-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid 3-methanesulfonyl-5-trifluoromethyl-benzyl ester; (3aR,6aR)-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; (3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepine-6-carboxylic acid 3-methanesulfonyl-5-trifluoromethyl-benzyl ester; (3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepine-6-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-methanesulfonyl-5-trifluoromethyl-benzyl ester; cis-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate; (3aS,7aR)-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; trans-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate; (3aR,8aS)-3,5-dichlorobenzyl 6-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepine-2(1H)-carboxylate; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 1-(3-chloro-phenyl)-cyclopropyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid bicyclo[4.1.0]hept-7-ylmethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid adamantan-2-ylmethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 1-fluoro-cyclohexylmethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 2-adamantan-2-yl-ethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 2-adamantan-1-yl-ethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid adamantan-1-ylmethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid cyclohexylmethyl ester; cis-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-(2,2,2-trifluoro-1-methoxy-ethyl)-benzyl ester; cis-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-(2,2,2-trifluoro-1-hydroxy-ethyl)-benzyl ester; (3aR,6aS)-2-cyclohexylethyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-fluoro-5-trifluoromethoxy-benzyl ester; (3aR,6aS)-3-chloro-5-cyanobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-trifluoromethoxy-benzyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-fluoro-5-trifluoromethyl-benzyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-trifluoromethoxy-benzyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-fluoro-3-trifluoromethoxy-benzyl ester; (3aR,6aS)-3-cyano-5-fluorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3-chloro-5-methoxybenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid (1S,4R)-3-methyl-bicyclo[2.2.1]hept-2-ylmethyl ester; (3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid (1R,4S)-1-bicyclo[2.2.1]hept-2-ylmethyl ester; (3aR,5S,6aS)-5-[(3H-[1,2,3]triazol-4-ylmethyl)-carbamoyl]-hexahydrocyclopenta[c]pyrrole-2-carboxylic acid 3,5-dichloro-benzyl ester; (3aS,6aS)-5-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; (3aS,6aR)-5-[(1H-[1,2,3]triazol-4-ylmethyl)-carbamoyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3,5-dichloro-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aR,5r,6aS)-3,5-dichlorobenzyl 5-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-ylamino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-((1H-benzo[d]imidazol-5-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1-((3aR,6aS)-5-((1H-benzo[d][1,2,3]triazol-5-yl)methyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(3,5-dichlorophenyl)propan-1-one; (3aR,6aS)-3,5-dichlorobenzyl 5-((1H-indazol-5-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-((2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 6-(((3aR,6aS)-5-(3-(3,5-dichlorophenyl)propanoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methyl)benzo[d]oxazol-2(3H)-one; 4-{(E)-3-[(3aS,8aR)-2-(1H-benzotriazol-5-ylmethyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-oxo-propenyl}-benzonitrile; (E)-1-[(3aS,8aR)-2-(1H-benzotriazol-5-ylmethyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (3aR,6aS)-3,5-dichlorobenzyl 5-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-ylsulfonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (3aR,6aS)-3,5-dichlorobenzyl 5-(4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; (E)-1-[(3aS,8aR)-2-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-[(3aS,8aR)-2-(1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; cis-5-((3aR,8aS)-6-((E)-3-(4-(trifluoromethoxy)phenyl)acryloyl)decahydropyrrolo[3,4-d]azepine-2-carbonyl)hexahydrooxazolo[5,4-c]pyridin-2(1H)-one; 6-{(3aS,8aR)-6-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-octahydro-pyrrolo[3,4-d]azepine-2-carbonyl}-5,6,7,8-tetrahydro-1H-[1,6]naphthyridin-2-one; (3aR,7aR)-5-{(3 aS,8aR)-6-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-octahydro-pyrrolo[3,4-d]azepine-2-carbonyl}-hexahydro-oxazolo[5,4-c]pyridin-2-one; (E)-1-[(3aS,8aR)-2-(7,8-Dihydro-5H-[1,6]naphthyridine-6-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-3-(4-trifluoromethoxy-phenyl)-1-[(3 aS,8aR)-2-(2-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-prop-2-ene-1-one; (3aS,8aR)-6-[(E)-3-(3-trifluoromethoxy-phenyl)-acryloyl]-octahydro-pyrrolo[3,4-d]azepine-2-carboxylic acid (1H-[1,2,3]triazol-4-ylmethyl)-amide; (3aR,8aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-6-((E)-3-(4-(trifluoromethoxy)phenyl)acryloyl)octahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; (3aS,6aR)-5-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid (1H-[1,2,3]triazol-4-ylmethyl)-amide; (3aR,8aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-6-((E)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)acryloyl)octahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; (3aS,8aR)-6-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-octahydro-pyrrolo[3,4-d]azepine-2-carboxylic acid (4H-[1,2,4]triazol-3-ylmethyl)-amide; (E)-1-[(3aS,8aR)-2-(6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-[(3 aS,8aR)-2-(1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (3aR,8aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-N-methyl-6-((E)-3-(4-(trifluoromethoxy)phenyl)acryloyl)octahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; (3aS,8aR)-6-[3-(3-chloro-phenyl)-2,2-dimethyl-propionyl]-octahydro-pyrrolo[3,4-d]azepine-2-carboxylic acid (3H-[1,2,3]triazol-4-ylmethyl)-amide; (3aR,8aS)—N-(2-(1H-1,2,3-triazol-5-yl)ethyl)-6-((E)-3-(4-(trifluoromethoxy)phenyl)acryloyl)octahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; (3aR,7aS)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 3,5-dichloro-benzyl ester; (3aS,7aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 3,5-dichloro-benzyl ester; (+)-trans-3,5-dichlorobenzyl 2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; (−)-trans-3,5-dichlorobenzyl 2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; (−)-trans-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate; (+)-trans-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate; (E)-1-[trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-3-(3,5-dichloro-phenyl)-prop-2-en-1-one; (1H-benzotriazol-5-yl)-{trans-2-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-octahydro-pyrrolo[3,4-c]pyridin-5-yl}-methanone; (E)-1-((3aR,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; (1H-benzotriazol-5-yl)-[(3aR,6aS)-5-(5-chloro-1H-indole-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; (E)-1-[(3aR,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-fluoro-5-trifluoromethyl-phenyl)-prop-2-ene-1-one; 1-[(3aR,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-fluoro-5-trifluoromethyl-phenyl)-propan-1-one; (1H-benzotriazol-5-yl)-[(3aR,6aS)-5-(6-chloro-1H-indole-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-(trifluoromethylsulfonyl)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-chlorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-p-tolylprop-2-en-1-one; 4-((E)-3-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-oxoprop-1-enyl)-N,N-dimethylbenzenesulfonamide; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-methoxyphenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-6-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; 4-((E)-3-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-oxoprop-1-enyl)benzonitrile; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; 1-((3aR,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)propan-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-fluorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-phenylprop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(pyridin-2-yl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(pyridin-3-yl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-chlorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-6-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-2(1H)-yl)-3-(4-chlorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-6-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-2(1H)-yl)-3-(3-(trifluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-(difluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(3-(trifluoromethoxy)phenyl)prop-2-en-1-one; 4-((E)-3-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-oxoprop-1-enyl)benzonitrile; (E)-1-((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; (−)-(E)-1-[trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (+)-(E)-1-[trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3,5-dichlorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(pyridin-4-yl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2,4-difluorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2,4-dichlorophenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3,4-dichlorophenyl)prop-2-en-1-one; (E)-1-[(3aS,7aS)-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(4-difluoromethoxy-phenyl)-prop-2-ene-1-one; 4-{(E)-3-[(3aS,7aS)-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-oxo-propenyl}-benzonitrile; 4-((E)-3-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-oxoprop-1-enyl)-3-fluorobenzonitrile; 4-((E)-3-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-oxoprop-1-enyl)-3-fluorobenzonitrile; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(difluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-[cis-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; 3-((E)-3-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-oxoprop-1-enyl)benzonitrile; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2-fluoro-4-(trifluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(2-fluoro-4-(trifluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-chloro-2-fluorophenyl)prop-2-en-1-one; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(3,5-dichlorophenyl)prop-2-en-1-one; (E)-1-((3aR,6aS)-5-(4,5,6,7-tetrahydro-1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; (E)-1-[(3aS,6aR)-5-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-chloro-5-methanesulfonyl-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3,5-dimethoxy-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-chloro-5-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-chloro-5-methoxy-phenyl)-prop-2-ene-1-one; 3-{(E)-3-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-oxo-propenyl}-5-chloro-benzonitrile; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-methoxy-5-trifluoromethoxy-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-ene-1-one; 1-[(3aR,6aR)-5-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; (3aR,7aR)-5-{(3aR,6aR)-5-[(E)-3-(4-trifluoromethoxy-phenyl)-acryloyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-hexahydro-oxazolo[5,4-c]pyridin-2-one; (3aR,7aR)-5-{(3aR,6aR)-5-[3-(4-trifluoromethoxy-phenyl)-propionyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-hexahydro-oxazolo[5,4-c]pyridin-2-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-phenyl-prop-2-ene-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-phenyl-propan-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethyl-phenyl)-prop-2-ene-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethyl-phenyl)-propan-1-one; (3aR,6aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-N-methyl-5-(3-(4-(trifluoromethoxy)phenyl)propanoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxamide; (3aR,8aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-6-((E)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)acryloyl)-N-methyloctahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(6-trifluoromethyl-pyridin-3-yl)-propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-trifluoromethoxy-phenoxy)-ethanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-isopropyl-5-methyl-phenoxy)-ethanone; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-biphenyl-4-yl-propan-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-fluoro-2-(trifluoromethyl)phenyl)prop-2-en-1-one; 1-[(3aS,6aR)-5-(1H-Benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-isopropyl-5-methyl-phenoxy)-ethanone; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-(trifluoromethylthio)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; 1-((3aR,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(3-(trifluoromethoxy)phenoxy)ethanone; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-(trifluoromethoxy)phenyl)prop-2-en-1-one; (E)-1-[trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(3-trifluoromethoxy-phenyl)-prop-2-en-1-one; (E)-1-[trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(4-trifluoromethoxy-phenyl)-prop-2-en-1-one; (E)-1-[trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(3-chloro-5-trifluoromethoxy-phenyl)-prop-2-en-1-one; (E)-1-[trans-5-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-2-yl]-3-(3,5-dichloro-phenyl)-prop-2-en-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(6-phenyl-pyridin-3-yl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(5-trifluoromethyl-pyridin-2-yl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-4-yl-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-3-yl-phenyl)-prop-2-ene-1-one; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-2-yl-phenyl)-prop-2-ene-1-one; 1-[(3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-3-methyl-phenoxy)-ethanone; 1-[(3aS,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-methyl-phenoxy)-ethanone; (E)-1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(5-phenyl-pyridin-2-yl)-prop-2-ene-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-(trifluoromethylsulfinyl)phenyl)prop-2-en-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)propan-1-one; (3aR,8aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-N-methyl-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)octahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; (3aR,8aS)—N-((1H-1,2,3-triazol-5-yl)methyl)-6-(3-(3-fluoro-4-(trifluoromethoxy)phenyl)propanoyl)-N-methyloctahydropyrrolo[3,4-d]azepine-2(1H)-carboxamide; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-difluoromethoxy-phenyl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(2-fluoro-4-trifluoromethoxy-phenyl)-propan-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-fluoro-2-(trifluoromethyl)phenyl)propan-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2-methyl-4-(trifluoromethoxy)phenyl)propan-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-fluoro-4-methoxyphenyl)propan-1-one; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-3-(2-isopropyl-phenyl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(5-trifluoromethyl-pyridin-2-yl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(5-phenyl-pyridin-2-yl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-4-yl-phenyl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-3-yl-phenyl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-2-yl-phenyl)-propan-1-one; (3aS,8aR)-6-[3-(4-trifluoromethoxy-phenyl)-propionyl]-octahydro-pyrrolo[3,4-d]azepine-2-carboxylic acid [2-(3H-[1,2,3]triazol-4-yl)-ethyl]-amide; (E)-3-[4-(trifluoro-methoxy)-phenyl]-1-[(3 aS,8aR)-2-((S)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-prop-2-ene-1-one hydrochloride; and pharmaceutically acceptable salts thereof.
46 . The compound according to claim 1 , selected from
trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 4-trifluoromethoxy-benzyl ester; 1-[trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-2-(4-trifluoromethoxy-phenoxy)-ethanone; (E)-1-[trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-3-(4-trifluoromethoxy-phenyl)-propenone; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-chloro-5-(trifluoromethyl)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-methoxy-2-(trifluoromethyl)phenyl)prop-2-en-1-one; (E)-1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2-cyclopropylphenyl)prop-2-en-1-one; trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 4-fluoro-2-trifluoromethyl-benzyl ester; trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 2-cyclopropyl-4-trifluoromethyl-benzyl ester; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-2-(2-trifluoromethoxy-phenoxy)-ethanone; trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridine-5-carboxylic acid 2-methoxy-4-trifluoromethoxy-benzyl ester; 4-{2-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-2-oxo-ethoxy}-3-trifluoromethyl-benzonitrile; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-2-(4-chloro-2-isopropyl-5-methyl-phenoxy)-ethanone; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-2-[4-methyl-2-(1-methyl-pyrrolidin-3-yl)-phenoxy]-ethanone; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepin-6-yl]-2-(2-chloro-4-fluoro-phenoxy)-ethanone; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-2-(2-chloro-4-(trifluoromethyl)phenoxy)ethanone; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-2-(6-isopropyl-3,3-dimethyl-2,3-dihydro-1H-inden-5-yloxy)ethanone; (3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepine-6-carboxylic acid 2-fluoro-4-trifluoromethoxy-benzyl ester; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-2-(5-chloro-2-(trifluoromethyl)phenoxy)ethanone; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-(2-tert-butyl-4-methoxyphenoxy)ethanone; 4-[2-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-oxoethoxy]-3-propan-2-ylbenzonitrile; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[3-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]propan-1-one; 1-[(3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]propan-1-one; (3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepine-6-carboxylic acid 3-fluoro-4-(2,2,2-trifluoro-ethoxy)-benzyl ester; (3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepine-6-carboxylic acid 2-fluoro-4-(2,2,2-trifluoro-ethoxy)-benzyl ester; (3aS,8aR)-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-d]azepine-6-carboxylic acid 4-(2,2,2-trifluoro-ethoxy)-benzyl ester; (3aS,6aS)-5-(3H-[1,2,3]triazolo[4,5-b]pyridine-6-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; 1-[(3aR,6aR)-5-(1H-triazolo[4,5-b]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one; (3aS,6aS)-5-(3H-[1,2,3]triazolo[4,5-c]pyridine-6-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(4-fluoro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(7-fluoro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(6-fluoro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(4-chloro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(6-trifluoromethyl-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(4-methyl-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(6-methyl-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; 1-[(3aR,6aR)-5-(4-fluoro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; (4-ethoxyquinolin-2-yl)((3aS,6aS)-5-((R)-4,5,6,7-tetrahydro-1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone; (4-ethoxyquinolin-2-yl)((3aS,6aS)-5-(4-fluoro-1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone; 6-[(3aR,6aR)-2-[3-[4-(trifluoromethoxy)phenyl]propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-3H-1,3-benzoxazol-2-one; (3aS,6aS)-5-(2-oxo-2,3-dihydro-benzooxazole-6-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-(1,1,2,2-tetrafluoro-ethoxy)-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-difluoromethoxy-3-fluoro-benzyl ester; (3aS,6aS)-5-(1H-[1,2,3]triazolo[4,5-b]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-fluoro-4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-difluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-[1,2,3]triazolo[4,5-b]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-fluoro-4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-(2,2,2-trifluoro-ethoxy)-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 5-trifluoromethoxy-pyridin-2-ylmethyl ester; (3aS,6aS)-5-((R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-isopropyl-benzyl ester; (3aS,6aS)-5-((R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-isopropyl-5-methyl-benzyl ester; (3aS,6aS)-5-((R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 2-fluoro-4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 2-fluoro-4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-ethoxy-benzyl ester; (3aS,6aS)-5-((R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-fluoro-4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-isopropyl-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-isopropyl-5-methyl-benzyl ester; (3aS,6aS)-5-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 2-fluoro-4-trifluoromethyl-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethyl-benzyl ester; (3aS,6aS)-5-((R)-4,5,6,7-Tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-((R)-4,5,6,7-Tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethyl-benzyl ester; (3aS,6aS)-5-((R)-4,5,6,7-Tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-methanesulfonyl-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-ethoxy-5-fluoro-benzyl ester; (3aS,6aS)-5-(4-methoxy-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-cyclobutoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-isopropoxy-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-chloro-2-ethoxy-5-fluoro-benzyl ester; (E)-1-[trans-2-(1H-benzotriazol-5-ylmethyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-3-(4-trifluoromethoxy-phenyl)-propenone; (3aS,6aS)-5-(4-sulfamoyl-piperidine-1-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(6-phenyl-pyridin-3-yl)-propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-isopropyl-phenoxy)-ethanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-trifluoromethyl-phenoxy)-ethanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(biphenyl-2-yloxy)-ethanone; (E)-1-[(3aS,6aS)-5-((R)-4,5,6,7-Tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propenone; 1-((3aR,6aR)-5-((R)-4,5,6,7-tetrahydro-1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-chloro-4-trifluoromethoxy-phenoxy)-ethanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-pyrrol-1-yl-phenoxy)-ethanone; 4-{2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-oxo-ethoxy}-3-methoxy-benzonitrile; 4-{2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-oxo-ethoxy}-benzonitrile; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-phenoxy-ethanone; 2-{2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-oxo-ethoxy}-5-trifluoromethoxy-benzonitrile; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-2-(2-isopropyl-5-methylphenoxy)ethanone; (1H-benzotriazol-5-yl)-[(3aS,6aS)-5-(6-trifluoromethoxy-1H-indole-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; (1H-benzotriazol-5-yl)-[(3aS,6aS)-5-(5-trifluoromethoxy-1H-indole-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; 1-[trans-2-(1H-benzotriazole-5-carbonyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; 1-[trans-2-(1H-benzotriazol-5-ylmethyl)-octahydro-pyrrolo[3,4-c]pyridin-5-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-chloro-5-(trifluoromethyl)phenyl)propan-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(4-methoxy-2-(trifluoromethyl)phenyl)propan-1-one; 1-((3aR,8aS)-2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(2-cyclopropylphenyl)propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-methoxy-5-(trifluoromethoxy)phenyl]propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-isopropyl-5-methyl-phenoxy)-ethanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-bromo-4-trifluoromethoxy-phenoxy)-ethanone; (1H-benzotriazol-5-yl)-[(3aR,6aR)-5-(4′-chloro-biphenyl-4-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; 4-{2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-oxo-ethoxy}-3-isopropylbenzonitrile; 2-(2-Acetyl-phenoxy)-1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethanone; 4-{2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-oxo-ethoxy}-5-isopropyl-2-methylbenzonitrile; (1H-benzotriazol-5-yl)-[(3aR,6aR)-5-(naphthalene-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; (1H-benzotriazol-5-yl)-[(3aS,6aS)-5-(4-methoxy-naphthalene-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; 4-{2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-oxo-ethoxy}-3-ethoxy-benzonitrile; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-fluoro-4-trifluoromethoxy-phenyl)-propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-isopropyl-phenoxy)-ethanone; [(3aS,6aS)-5-(4′-Chloro-biphenyl-4-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(R)-4,5,6,7-tetrahydro-1H-benzotriazol-5-yl-methanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; (1H-benzotriazol-5-yl)-[(3aS,6aS)-5-(4′-chloro-biphenyl-4-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-[2-(tetrahydro-furan-2-yl)-phenoxy]-ethanone; (1H-benzotriazol-5-yl)-[(3aR,6aR)-5-(4-methoxy-naphthalene-2-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(2-tert-butyl-phenoxy)-ethanone; [(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-[trans-4-(4-chloro-phenyl)-cyclohexyl]-methanone; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(3-fluoro-4-trifluoromethyl-phenyl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(2-fluoro-4-trifluoromethyl-phenyl)-propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-pyridin-3-ylphenoxy)ethanone; 4-[3-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxopropyl]-2-methyl-5-propan-2-ylbenzonitrile; 4-[3-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxopropyl]-3-propan-2-ylbenzonitrile; [(3aR,6aR)-5-[1-(4-chlorophenyl)piperidine-4-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(1H-benzotriazol-5-yl)methanone; [(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(4-propan-2-yloxynaphthalen-2-yl)methanone; [(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(4-propan-2-yloxyquinolin-2-yl)methanone; 1-[(3aR,6aR)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[2-fluoro-4-(trifluoromethoxy)phenyl]propan-1-one; 4-[2-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-2-methyl-5-propan-2-ylbenzonitrile; [(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[1-(2,2,2-trifluoroethoxy)isoquinolin-3-yl]methanone; 1-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-bromo-2-tert-butylphenoxy)ethanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-bromo-2-tert-butylphenoxy)ethanone; 4-[2-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-tert-butylbenzonitrile; 4-[2-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-tert-butylbenzonitrile; [(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[1-methyl-5-(trifluoromethoxy)indol-2-yl]methanone; 1-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[4-(trifluoromethoxy)phenoxy]ethanone; [(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(1-ethoxyisoquinolin-3-yl)methanone; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-tert-butyl-4-methoxyphenoxy)ethanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-ethoxyquinolin-2-yl)methanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-(2,2,2-trifluoroethoxy)quinolin-2-yl)methanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(6-cyclobutoxy-5-(trifluoromethyl)pyridin-3-yl)methanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(5-bromo-6-(2-methoxyethoxyl)pyridin-3-yl)methanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(5-bromo-6-(cyclopropylmethoxy)pyridin-3-yl)methanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(5-cyclopropyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanone; ((3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(6-(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyridin-3-yl)methanone; (1H-benzotriazol-5-yl)-{(3aS,6aS)-5-[4-(4-chloro-phenyl)-piperidine-1-carbonyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone; (1H-benzotriazol-5-yl)-{(3aS,6aS)-5-[4-(4-chloro-phenyl)-piperazine-1-carbonyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanonea; and pharmaceutically acceptable salts thereof.
47 . The compound according to claim 1 , selected from
trans-3,5-dichlorobenzyl 2-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; trans-3,5-dichlorobenzyl 2-(2-oxo-2,3-dihydrobenzo[d]oxazole-6-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester; (3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester; (E)-1-((3aR,6aR)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one; 1-((3aR,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-(4-(trifluoromethoxy)phenyl)propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one; 1-[(3aR,6aR)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethyl-phenyl)-propan-1-one; 1-[(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-isopropyl-5-methyl-phenoxy)-ethanone; and pharmaceutically acceptable salts thereof.
48 . The compound according to claim 1 selected from
(3aS,6aS)-5-(4-fluoro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester;
1-[(3aR,6aR)-5-(4-fluoro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-3-(4-trifluoromethoxy-phenyl)-propan-1-one;
(3aS,6aS)-5-(1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-difluoromethoxy-3-fluoro-benzyl ester;
(3aS,6aS)-5-(1,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester;
(3aS,6aS)-5-((R)-4,5,6,7-Tetrahydro-1H-benzotriazole-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 4-trifluoromethoxy-benzyl ester;
and pharmaceutically acceptable salts thereof.
49 . The compound according to claim 1 comprising the reaction of a compound of formula (II) in the presence of a compound of formula (III), wherein R 1 , R 2 , A, W, m, n, p and q are as defined above, Y is —OC(O)—.
50 . (canceled)
51 . A pharmaceutical composition comprising a compound according to claim 1 and a therapeutically inert carrier.
52 . (canceled)
53 . (canceled)
54 . (canceled)
55 . A method for the treatment or prophylaxis a renal condition selected from the group consisting of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, fibrotic diseases and acute and chronic organ transplant rejection, which method comprises administering an effective amount of a compound according to claim 1 .
56 . (canceled)
57 . (canceled)Join the waitlist — get patent alerts
Track US2015353559A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.