A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

1 . A pharmaceutical composition for preventing or treating voiding dysfunction, comprising of  Piper longum  L. as an active ingredient. 
     
     
         2 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract of  Piper Longum  L. is extracted from one or more extraction solvents selected from the group consisting of water, alcohol, glycerin, butylene glycol, propylene glycol, methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, chloroform and dichloromethane. 
     
     
         3 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 2 , wherein said alcohol is anhydrous or hydrous lower alcohol with 1 to 4 carbon atoms. 
     
     
         4 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 3 , wherein said anhydrous or hydrous lower alcohol is 30 to 100% by volume of methanol or ethanol. 
     
     
         5 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract of  Piper Longum  L. increases a micturition interval. 
     
     
         6 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract of  Piper Longum  L. decreases a micturition pressure and increases a volume of bladder. 
     
     
         7 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract of  Piper Longum  L. induces inhibition of detrusor contraction and relaxation of detrusor. 
     
     
         8 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract of  Piper Longum  L. extract inhibits a muscarinic M 3  receptor or a muscarinic M 2  receptor. 
     
     
         9 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract of  Piper Longum  L. is an agonist of a β 3 -adrenegic receptor. 
     
     
         10 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said voiding dysfunction is one or more selected from the group consisting of overactive bladder syndromes, urgency incontinence, urgency urine, frequent urination, nocturia and interstitial cystitis. 
     
     
         11 . A health functional food for preventing or improving voiding dysfunction, comprising extract of  Piper longum  L. as an active ingredient 
     
     
         12 . The health functional food for preventing or improving voiding dysfunction according to  claim 11 , wherein said voiding dysfunction is one or more selected from the group consisting of overactive bladder syndromes, urgency incontinence, urgency urine, frequent urination, nocturia and interstitial cystitis. 
     
     
         13 . The pharmaceutical composition for preventing or treating voiding dysfunction according to  claim 1 , wherein said extract  Piper Longum  L. is a polar solvent-soluble extract or non-polar solvent-soluble extract. 
     
     
         14 . The health functional food for preventing or improving voiding dysfunction according to  claim 11 , wherein said extract  Piper Longum  L. is a polar solvent-soluble extract or non-polar solvent-soluble extract.