Syringe and method of preparing syringe

Abstract

A syringe ( 18 ) has a longitudinal body ( 28 ) with an interior ( 228 ) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body ( 228 ) and a rigid needle shield ( 38 ) encasing the needle. The rigid needle shield ( 38 ) is essentially water vapour tight. The syringe ( 18 ) according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.

1 . A syringe comprising:
 a longitudinal body with an interior in which a pharmaceutical substance is arranged;   a needle connected to one longitudinal end of the body, and   a rigid needle shield encasing the needle, wherein the rigid needle shield is water vapour tight.   
     
     
         2 . The syringe according to  claim 1 , wherein a needle neighboring part of the rigid needle shield being adjacent to the needle has a low leaching capacity. 
     
     
         3 . The syringe according to  claim 2 , wherein the low leaching capacity is a low Zinc leaching capacity. 
     
     
         4 . The syringe according to  claim 1 , wherein the rigid needle shield comprises a water vapour tight coat. 
     
     
         5 . The syringe according to  claim 4 , wherein the coat comprises wax. 
     
     
         6 . The syringe according to  claim 4 , wherein the coat comprises a water vapour tight pouch filled with an aqueous fluid. 
     
     
         7 . The syringe according to  claim 1 , wherein the rigid needle shield comprises a needle neighboring part being adjacent to the needle which is made of a water vapour tight material. 
     
     
         8 . The syringe according to  claim 7 , wherein the water vapour tight material is ethylene propylene diene methylene based thermoplastic elastomer. 
     
     
         9 . The syringe according to  claim 7 , wherein the water vapour tight material is styrene-butadiene rubber compound free from 2 mercaptobenzothiazole. 
     
     
         10 . The syringe according to  claim 1 , wherein the interior of the body is sealed at a side opposite to the needle by a plunger. 
     
     
         11 . The syringe according to  claim 1 , wherein the needle is integral with the body. 
     
     
         12 . The syringe according to  claim 1 , wherein the pharmaceutical substance is a biopharmaceutical substance. 
     
     
         13 . The syringe according to the  claim 12 , wherein the biopharmaceutical substance comprises a protein. 
     
     
         14 . The syringe according to  claim 13 , wherein the biopharmaceutical substance comprises the protein at a concentration in a range of about 50 mg/ml to about 250 mg/ml. 
     
     
         15 . A method of preparing a syringe having a longitudinal body with an interior and a needle connected to one longitudinal end of the body, comprising:
 filling a pharmaceutical substance inside the interior of the body of the syringe;   sealing the interior of the body of the syringe by pushing a plunger through an opening at a longitudinal end of the body opposite to the needled; and   encasing the needle with a water vapour tight rigid needle shield.   
     
     
         16 . The method according to  claim 15 , wherein encasing the needle with the rigid needle shield comprises putting a needle cap on the needle and covering the needle cap with a water vapour tight coat.