Method for evaluation of drug efficacy of a medicine having a therapeutic or preventive effect against a disease related to el activity and a method for screening an inhibitor of el activity

Abstract

The present invention is related to a method for evaluation of drug efficacy of a medicine having a therapeutic or preventive effect against a disease related to EL activity wherein phosphatidylinositol or lysophosphatidylinositol is used as an indicator. The present invention is also related to a method for screening an inhibitor of EL activity using phosphatidylinositol and a kit for use in the method.

1 . A method for measurement of EL activity, wherein phosphatidylinositol or lysophosphatidylinositol is used as an indicator. 
     
     
         2 . A method for evaluation of drug efficacy of a medicine having a therapeutic or preventive effect against a disease related to EL activity, comprising
 (1) a step for comparing a concentration of phosphatidylinositol or lysophosphatidylinositol in a sample obtained from a mammal after the administration of a test substance with a concentration of phosphatidylinositol or lysophosphatidylinositol in a sample obtained from the mammal before the administration of the test substance, and   (2) a step for evaluating the test substance as a medicine having a therapeutic or preventive effect against a disease related to EL activity when the concentration of phosphatidylinositol or lysophosphatidylinositol in the sample obtained from the mammal after the administration of the test substance is altered relative to the concentration of phosphatidylinositol or lysophosphatidylinositol in the sample obtained from the mammal before the administration of the test substance.   
     
     
         3 . The method described in  claim 2 , wherein the sample is blood, serum or plasma.