High-Purity Quinoline Derivative and Method for Manufacturing Same

Abstract

Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

1 .- 13 . (canceled) 
     
     
         14 . A method for producing a compound represented by formula (IV) 
       
         
           
           
               
               
           
         
         or a salt thereof, comprising:
 a step B of allowing a compound represented by formula (I) 
 
       
       
         
           
           
               
               
           
         
         or a salt thereof to react with the compound represented by formula (II-A) 
       
       
         
           
           
               
               
           
         
         wherein R 1  is a C 6-10  aryl group that may have one to three substituents that may be the same or different and are selected from the group consisting of a halogen atom, a methyl group, a methoxy group, and a nitro group; and X is a halogen atom, 
         in the presence of a base and water to thereby obtain a compound represented by formula (III) 
       
       
         
           
           
               
               
           
         
         wherein R 1  is the same group as above, and
 a step C of, after allowing the compound represented by formula (III) obtained in the step B to react without isolation with cyclopropylamine, precipitating and isolating a compound represented by formula (IV) 
 
       
       
         
           
           
               
               
           
         
         or a salt thereof by introducing hydrous acetone to a reaction solution. 
       
     
     
         15 . The method according to  claim 14 , wherein the hydrous acetone is a mixture of water and acetone at a volume ratio ranging from 3:100 to 1:20. 
     
     
         16 . The method according to  claim 14 , wherein the hydrous acetone is a mixture of water and acetone at a volume ratio of 1:20.