METHOD FOR PRODUCING Ac-225 SOLUTION AND METHOD FOR PRODUCING MEDICINE USING Ac-225 SOLUTION

Abstract

A method for producing an 225 Ac solution includes a step (I) of irradiating a 226 Ra target with particles to generate two or more actinium radioisotopes (Ac) including at least 225 Ac, a step (II) of dissolving the 226 Ra target after the aforementioned step to obtain a solution (1), a step (III) of separating 226 Ra and Ac contained in the solution (1) to obtain a solution (2), a step (IV) of allowing Ac contained in the solution (2) other than 225 Ac to decay to obtain a solution (3), and a step (V) of separating Ra and Ac contained in the solution (3) to obtain a solution (4). The solution (4) is used to produce a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex with 225 Ac, and a targeting agent.

1 . A method for producing an  225 Ac solution, the method comprising:
 a step (I) of irradiating a  226 Ra target with at least one type of particles selected from protons, deuterons, neutrons, and photons to generate two or more actinium radioisotopes (Ac) including at least  225 Ac;   a step (II) of dissolving the  226 Ra target after the step (I) to obtain a Ra—Ac solution (1) that contains  226 Ra and Ac;   a step (III) of separating  226 Ra and Ac originating from the  226 Ra target and contained in the Ra—Ac solution (1) to obtain an Ac solution (2) that has a higher Ac concentration than the Ra—Ac solution (1);   a step (IV) of allowing the actinium radioisotopes contained in the Ac solution (2) other than  225 Ac to decay to obtain a Ra—Ac solution (3) containing radium isotopes (Ra) resulting from decay; and   a step (V) of separating Ra and Ac contained in the Ra—Ac solution (3) to obtain an Ac solution (4) that has a higher  225 Ac concentration than the Ra—Ac solution (3),   wherein the Ac solution (4) is used for producing a medicine indicated in (a) or (b) below:   (a) a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex with  225 Ac, and an Nd2 antibody   (b) a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex with  225 Ac, and a targeting agent (excluding the Nd2 antibody).   
     
     
         2 . The method for producing an  225 Ac solution according to  claim 1 , wherein:
 when a time from completion of the step (I) to start of the step (III) is represented by T1, and   a time from completion of the step (III) to start of the step (V) is represented by T2,   T1 and T2 satisfy a relationship of T2>T1.   
     
     
         3 . The method for producing an  225 Ac solution according to  claim 1 , wherein a ratio ( 140 La content/ 225 Ac content) of a  140 La content to an  225 Ac content in the Ac solution (4) is 1×10 −5  or less at seven days after completion of the step (V). 
     
     
         4 . The method for producing an  225 Ac solution according to  claim 2 , wherein the time T1 is shorter than seven days. 
     
     
         5 . The method for producing an  225 Ac solution according to  claim 1 , wherein, in the step (III) or (V), a solid-phase extraction agent that captures Ra is used or Ac is colloidized. 
     
     
         6 . The method for producing an  225 Ac solution according to  claim 5 , wherein the solid-phase extraction agent is at least one selected from a cation-exchange resin, a solid-phase extraction agent (a) containing a compound represented by the following formula (A), a solid-phase extraction agent (b) containing a compound represented by the following formula (B), and a solid-phase extraction agent (c) containing a compound represented by the following formula (C): 
       
         
           
           
               
               
           
         
         wherein, in formula (A), m and n each independently represent 0 or 1, and R 1  to R 4  each independently represent an alkyl group having 8 to 12 carbon atoms, 
       
       
         
           
           
               
               
           
         
         wherein, in formula (B), R 5  and R 6  each independently represent an alkyl group having 8 carbon atoms or an alkoxy group having 8 carbon atoms. 
       
       
         
           
           
               
               
           
         
         wherein, in formula (C), R8 to R9 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. 
       
     
     
         7 . A method for producing a medicine, the method comprising a step (VIa) of allowing the chelating agent to form a complex with  225 Ac by using an  225 Ac solution obtained by the method according to  claim 1 .