Medical device for stimulating and sensing bioactivity

Abstract

In an approach, using a biomedical device, a processor stimulates a cell sample. A processor senses, based on feedback from at least two chemical sensors of the biomedical device, the presence of at least two types of biomolecules released by the cell sample. A processor records, using a computer chip of the device, data collected by the at least two chemical sensors. A processor sends, using an antenna of the biomedical device, the recorded data to a remote server.

What is claimed is: 
     
         1 . A method comprising:
 stimulating, by a device, a cell sample;   sensing, by at least two chemical sensors of the device, the presence of at least two types of biomolecules released by the cell sample;   recording, by a computer chip of the device, data collected by the at least two chemical sensors; and   sending, by an antenna of the device, the recorded data to a remote server.   
     
     
         2 . The method of  claim 1 , wherein the device comprises:
 the computer chip;   at least one electrode, wherein the at least one electrode is coupled with a top side of the computer chip;   the at least two chemical sensors, wherein the at least two chemical sensors are coupled with the top side of the computer chip;   the microfluidic structure, wherein the microfluidic structure is an inert elastomeric polymer that encases all but the top side of the computer chip; and   an antenna configured to send data collected onto the computer chip to a remote server.   
     
     
         3 . The method of  claim 2 , wherein stimulating the cell sample is done by the at least one electrode. 
     
     
         4 . The method of  claim 2 , wherein stimulating the cell sample is done by biomolecules released from the microfluidic structure. 
     
     
         5 . The method of  claim 2 , wherein stimulating the cell sample is done by biomolecules released from the microfluidic structure and by the at least one electrode. 
     
     
         6 . The method of  claim 2 , further comprising:
 sensing, by the at least one electrode, a voltage differential across a cell membrane of the cell sample;   recording, by the computer chip, the voltage differential; and   sending, by the antenna, the voltage differential to the remote server.   
     
     
         7 . The method of  claim 1 , wherein sensing the presence of the at least two types of biomolecules released by the cell sample further comprises:
 sensing, by an amperometric chemical sensor of the at least two chemical sensors, the electrical current arising from an interaction between a bioenzyme coated on the amperometric chemical sensor and a first biomolecule of the at least two types of biomolecules released by the cell sample; and   sensing, by a resistivity chemical sensor of the at least two chemical sensors, the resistivity arising from the interaction between a second biomolecule of the two types of biomolecules and the resistivity chemical sensor.   
     
     
         8 . The method of  claim 7 , wherein recording the data collected by the at least two chemical sensors further comprises;
 recording, by the computer chip, the electrical current arising from the interaction between the amperometric chemical sensor and the first biomolecule; and   recording, by the computer chip, the resistivity arising from the interaction between the resistivity chemical sensor and the second biomolecule.   
     
     
         9 . The method of  claim 1 , further comprising:
 wherein stimulating the cell sample is done by a first electrode;   sensing, by a second electrode, a voltage differential across a cell membrane of the cell sample;   recording, by the computer chip, the voltage differential; and   sending, by the antenna, the voltage differential to the remote server.   
     
     
         10 . A computer system comprising:
 one or more computer processors;   one or more computer readable storage media;   program instructions stored on the computer readable storage media for execution by at least one of the one or more processors, the program instructions comprising:   program instructions to stimulate a cell sample;   program instructions to sense, by at least two chemical sensors of a biomedical device, the presence of at least two types of biomolecules released by the cell sample;   program instructions to record, by a computer chip of the biomedical device, data collected by the at least two chemical sensors; and   program instructions to send, by an antenna of the biomedical device, the recorded data to a remote server.   
     
     
         11 . The computer system of  claim 10 , wherein the program instructions to stimulate the cell sample further comprise:
 program instructions to stimulate the cell sample using at least one electrode.   
     
     
         12 . The computer system of  claim 10 , wherein the program instructions to stimulate the cell sample further comprise:
 program instructions to stimulate the cell sample using biomolecules released from a microfluidic structure.   
     
     
         13 . The computer system of  claim 10 , wherein the program instructions to stimulate the individual cell further comprise:
 program instructions to stimulate the cell sample using biomolecules released from a microfluidic structure and using at least one electrode.   
     
     
         14 . The computer system of  claim 10 , further comprising:
 program instructions to sense, using at least one electrode, a voltage differential across a cell membrane of the cell sample;   program instructions to record, using the computer chip, the voltage differential; and   program instructions to send, using the antenna, the voltage differential to a remote server.   
     
     
         15 . The computer system of  claim 10 , wherein the program instructions to sense the presence of biomolecules further comprise:
 program instructions to sense, by an amperometric chemical sensor of the at least two chemical sensors of the biomedical device, the electrical current arising from an interaction between a bioenzyme coated on the amperometric chemical sensor and a biomolecule released by the cell sample; and   program instructions to sense, by a resistivity chemical sensor of the at least two chemical sensors of the biomedical device, the resistivity arising from the interaction between the biomolecule and the resistivity chemical sensor.   
     
     
         16 . The computer system of  claim 10 , wherein the program instructions to record the data collected by the at least two chemical sensors further comprise;
 program instructions to record, by the computer chip of the biomedical device, the electrical current arising from the interaction between the amperometric chemical sensor and the biomolecule; and   program instructions to record, by the computer chip of the biomedical device, the resistivity arising from the interaction between the resistivity chemical sensor and the biomolecule.   
     
     
         17 . The computer system of  claim 10 , further comprising:
 wherein the program instructions to stimulate the individual cell further comprise program instructions to stimulate, using a first electrode, the cell sample;   program instructions to sense, using a second electrode, a voltage differential across a cell membrane of the cell sample;   program instructions to record, by the computer chip, the voltage differential; and   program instructions to send, by the antenna, the voltage differential to a remote server.   
     
     
         18 . A computer program product comprising:
 one or more computer readable storage media and program instructions stored on the one or more computer readable storage media, the program instructions comprising:   program instructions to stimulate a cell sample;   program instructions to sense, by at least two chemical sensors of a biomedical device, the presence of at least two types of biomolecules released by the cell sample;   program instructions to record, by a computer chip of the biomedical device, data collected by the at least two chemical sensors; and   program instructions to send, by an antenna of the biomedical device, the recorded data to a remote server.   
     
     
         19 . The computer program product of  claim 18 , wherein the program instructions to sense the presence of biomolecules further comprise:
 program instructions to sense, by an amperometric chemical sensor of the at least two chemical sensors of the biomedical device, the electrical current arising from an interaction between a bioenzyme coated on the amperometric chemical sensor and a biomolecule released by the cell sample; and   program instructions to sense, by a resistivity chemical sensor of the at least two chemical sensors of the biomedical device, the resistivity arising from the interaction between the biomolecule and the resistivity chemical sensor.   
     
     
         20 . The computer program product of  claim 18 , wherein the program instructions to record the data collected by the at least two chemical sensors further comprise;
 program instructions to record, by the computer chip of the biomedical device, the electrical current arising from the interaction between the amperometric chemical sensor and the biomolecule; and   program instructions to record, by the computer chip of the biomedical device, the resistivity arising from the interaction between the resistivity chemical sensor and the biomolecule.