D-Homopregnanes

Abstract

D-Homopregnanes of the formula <IMAGE> wherein X is hydrogen, Y is hydroxy or X and Y taken together denote an oxygen to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon-to-carbon bond or a pharmaceutically acceptable basic addition salt thereof when Y is hydroxy having diuretic activity are disclosed.

We claim: 
     
       1. A compound of the formula ##STR4## wherein X is hydrogen, Y is hydroxy or X and Y taken together denotes an oxygen to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon to carbon bond or a pharmaceutically acceptable basic addition salt thereof when Y is hydroxy. 
     
     
       2. The compound of claim 1 wherein X is hydrogen, Y is hydroxy and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single carbon to carbon bond. 
     
     
       3. The compound of claim 2 which is 17a-hydroxy-6β,7β-methylene-3-oxo-D-homo-17aα-pregna-4,16-diene-21-carboxylic acid. 
     
     
       4. The compound of claim 1 wherein X and Y taken together denotes an oxygen to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon to carbon bond. 
     
     
       5. The compound of claim 4 which is 6β,7β-methylene-3-oxo-D-homo-17aα-pregna-4,16-diene-21,17a-carbolactone. 
     
     
       6. The compound of claim 4 which is 6α,7α-methylene-3-oxo-D-homo-17aα-pregna-4,16-diene-21,17a-carbolactone.