Analgesic composition containing a mixture of 6-chloro-α-methyl-carbazole-2-acetic acid plus an opiate as the active agent

Abstract

A method of producing analgesia by administering an opiate alkaloid such as morphine, codeine, oxycodone or a pharmaceutically acceptable acid addition salt thereof together with a carbazole compound, 6-chloro- alpha -methyl-carbazole-2-acetic acid, or a salt thereof with a pharmaceutically acceptable base and composition therefor.

We claim: 
     
       1. A method for producing analgesia which comprises administering to a subject suffering from pain a composition comprising a therapeutically effective dose of a mixture of 6-chloro-α-methyl-carbazole-2 -acetic acid or a salt thereof with a pharmaceutically acceptable base and an opiate compound selected from the group consisting of codeine, morphine, oxycodone or a pharamaceutically acceptable acid addition salt thereof wherein the weight ratio of 6-chloro-α-methyl carbazole-2-acetic acid and said opiate compound is from 1:10 to 10:1. 
     
     
       2. The method of claim 1 wherein the weight ratio of 6-chloro-α-methyl-carbazole-2-acetic acid and said opiate is from 1:5 to 5:1. 
     
     
       3. The method of claim 1 wherein the opiate compound is codeine. 
     
     
       4. The method of claim 1 wherein the opiate compound is morphine. 
     
     
       5. The method of claim 1 wherein the opiate compound is oxycodone. 
     
     
       6. An analgesic composition which comprises a pharmaceutically acceptable carrier and, as an active ingredient, a therapeutically effective amount of a mixture of 6-chloro-α-carbazole-2-acetic acid or a salt thereof with a pharmaceutically acceptable base and an opiate compound selected from the group consisting of codeine, morphine, oxycodone, or a pharmaceutically acceptable acid addition salt thereof wherein the weight ratio of 6-chloro-α-methyl-carbazole-2-acetic acid and said opiate compound is from 1:10 to 10:1. 
     
     
       7. The composition of claim 1, wherein the weight ratio of 6-chloro-α-methyl-carbazole-2-acetic acid and said opiate is from 1:5 to 5:1. 
     
     
       8. The composition of claim 7, wherein the opiate compound is codeine. 
     
     
       9. The composition of claim 7, wherein the opiate compound is morphine. 
     
     
       10. The composition of claim 7, wherein the opiate compound is oxycodone.