Aqueous solution containing a quinolone carboxylic acid

Abstract

A stable isotonic aqueous solution of the compound 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquino line-3-carboxylic acid, or a pharmaceutically-acceptable salt thereof, having a pH of 3 to 6.5 and isotonized with a polyalcohol or boric acid is disclosed.

What is claimed is: 
     
       1. A stable isotonic aqueous solution consisting essentially of an effective microbiocidal amount of the compound, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid or a pharmaceutically-acceptable salt as essential active microbiocidal ingredient thereof, and an isotonizing amount of a compound selected from the group consisting of a polyalcohol, selected from the group consisting of glycerine, mannitol, glucose, xylitol, xylose, sorbitol, and propylene glycol, and boric acid as isotonizing agent for the solution, the solution being adjusted to a pH of about 3 to 6.5. 
     
     
       2. Solution of claim 1 wherein the amount of the essential active microbiocidal ingredient is 0.01 to 10 percent weight per volume. 
     
     
       3. Solution of claim 2 wherein the amount of the essential active microbiocidal ingredient is 0.3 to about 5 percent weight per volume. 
     
     
       4. Solution of claim 3 wherein the pH is 4-6.5. 
     
     
       5. Solution of claim 4 wherein the essential active microbiocidal ingredient is 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride. 
     
     
       6. Solution of claim 5, wherein the isotonizing compound is selected from the group consisting of glycerine, mannitol, and glucose. 
     
     
       7. Solution of claim 5, wherein the isotonizing agent is glycerine.