Pyridazodiazepine derivatives

Abstract

Compounds of the formula <IMAGE> I wherein R1 and R2 each independently represent hydrogen, C1-C10-alkyl, adamantyl-(C1-C4-alkyl) or (C2-C6-alkanoyloxy)-(C1-C4-alkyl), and pharmaceutically acceptable salts thereof possess antihypertensive activity and can be used as theraputic or prophylactic agents in pharmaceutical preparations. Intermediates for the production of such compounds are also provided.

We claim: 
     
       1. A compound of the formula ##STR11## wherein R 1  and R 2  each individually are hydrogen, C 1  -C 10  -alkyl, adamantyl-(C 1  -C 4  -alkyl) or (C 2  -C 6  -alkanoyloxy)-(C 1  -C 4  -alkyl), R 3  is hydrogen or benzyl, and S is nitro, amino or 2-nitroguanidino. 
     
     
       2. A compound according to claim 1, in which R 1  is hydrogen. 
     
     
       3. A compound according to claim 1, in which R 1  is ethyl. 
     
     
       4. A compound according to claim 1, in which R 1  is n-decyl. 
     
     
       5. A compound according to claim 1, in which R 1  is 1-adamantylethyl. 
     
     
       6. A compound according to claim 1, in which R 2  is hydrogen. 
     
     
       7. A compound according to claim 1, in which R 2  is pivaloyloxymethyl. 
     
     
       8. A compound according to claim 1, in which S is 2-nitroguanidino in the para-position.