US5106731AExpiredUtility

Kaposi's sarcoma endothelial cells and growth factor

42
Assignee: US HEALTHPriority: Oct 21, 1988Filed: Oct 21, 1988Granted: Apr 21, 1992
Est. expiryOct 21, 2008(expired)· nominal 20-yr term from priority
Inventors:Syed Z. SalahuddinShuji NakamuraRobert C. Gallo
Y10S530/828Y10S435/804C07K 14/475
42
PatentIndex Score
8
Cited by
14
References
6
Claims

Abstract

The present invention relates to a growth factor found in HTLV-II conditioned media and to compositions containing same. The growth factor of the present invention supports the growth of Kaposi's sarcoma endothelial-like cells. The factor has a molecular weight of 30K to 35K in monomeric form and a molecular weight of about 70K in dimeric form.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A purified growth factor which supports growth of Kaposi's sarcoma endothelial-like cells (KSEL) having a molecular weight of 30 K to 35 K in the monomeric form or about 70 K in the dimeric form. 
     
     
       2. A composition of matter comprising a growth factor of claim 1 in a carrier. 
     
     
       3. A composition of matter comprising a growth factor of claim 1 in a growth media. 
     
     
       4. A composition of claim 2 wherein the growth factor exists primarily as a dimer. 
     
     
       5. A kit for diagnosing Kaposi's sarcoma comprising a composition of claim 3 and a Kaposi's sarcoma endothelial cell line. 
     
     
       6. A composition of matter comprising a growth media and a cell line which is KSEL 3.

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