P
US5283346AExpiredUtilityPatentIndex 58

Dioxolanes

Assignee: HOFFMANN LA ROCHEPriority: Mar 23, 1989Filed: Dec 14, 1992Granted: Feb 1, 1994
Est. expiryMar 23, 2009(expired)· nominal 20-yr term from priority
Inventors:BARNER RICHARDHUEBSCHER JOSEPFWIRZ BEAT
C07D 317/20C12P 41/004C07D 317/24C07D 317/72C12P 17/04
58
PatentIndex Score
4
Cited by
8
References
16
Claims

Abstract

Alcohols of the formula ##STR1## wherein R 1 and R 2 are each independently methyl or ethyl or together signify pentamethylene, formed by the enzymatic hydrolysis of a corresponding (RS) alkanoic acid ester are intermediates for Vitamin E.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. The compound of the formula ##STR10## where R1 and R2 are each independently methyl or ethyl or taken together form pentamethylene; R3' is alkanoyl containing from 2 to 9 carbon atoms. 
     
     
       2. The compound of claim 1, wherein said compound is an RS racemate. 
     
     
       3. The compound of claim 2, wherein said compound is {(R,S)-2-methyl-1,4-dioxaspiro[4,5]dec-2-yl}methyl butyrate. 
     
     
       4. The compound of claim 2, wherein said compound is {(R,S)-2,2,4-trimethyl-1,3-dioxolan-4-yl}methyl butyrate. 
     
     
       5. The compound of claim 1, wherein said compound is in the (S)-enantiomeric form. 
     
     
       6. The compound of claim 5, wherein said compound is {(S)-2-methyl-1,4-dioxaspiro[4,5]dec-2-yl}methyl butyrate. 
     
     
       7. The compound of claim 5, wherein said compound is {(S)-2,2,4-trimethyl-1,3-dioxolan-4-yl}methyl butyrate. 
     
     
       8. The compound {(S)-2-methyl-1,4-dioxaspiro[4,5]dec-2-yl}methanol. 
     
     
       9. The compound {(R)-2-methyl-1,4-dioxaspiro[4,5]-dec-2-yl}methanol. 
     
     
       10. The compound of formula ##STR11## wherein R 1  and R 2  are each independently methyl or ethyl or taken together form pentamethylene; and R 3"  is alkanesulfonyl or arylsulfonyl. 
     
     
       11. The compound of claim 10, wherein said compound is in the (R)-enantiomeric form. 
     
     
       12. The compound of claim 11, wherein said compound is {(R)-2-methyl-1,4-dioxaspiro[4,5]dec-2-yl}methyl tosylate. 
     
     
       13. The compound of claim 11, wherein said compound is {(R)-2,2,4-trimethyl-1,3-dioxolan-4-yl}methyl tosylate. 
     
     
       14. The compound of claim 10, wherein said compound is in the (S)-enantiomeric form. 
     
     
       15. The compound of claim 14, wherein said compound is {(S)-2-methyl-1,4-dioxaspiro[4,5]dec-2-yl}methyl tosylate. 
     
     
       16. The compound of claim 14, wherein said compound is {(S)-2,2,4-trimethyl-1,3-dioxolan-4-yl}methyl tosylate.

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