US7019002B2ExpiredUtilityPatentIndex 34
Pyridopyrimidinones derivatives as telomerase inhibitors

Assignee: PHARMACIA & UPJOHN SPAPriority: Dec 11, 2001Filed: Dec 4, 2002Granted: Mar 28, 2006
Est. expiryDec 11, 2021(expired)· nominal 20-yr term from priority
Inventors:ANGIOLINI MAURO BALLINARI DARIO BASSINI DOMENICO FUSAR BONOMINI LUISELLA GUDE MARKUS MENICHINCHERI MARIA MOLL JURGEN TROSSET JEAN-YVES
A61K 31/519C07D 471/04A61P 35/00
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References
Claims
Abstract

The invention provides pyrido[2,3-d]pyrimidin-7(8H)-one telomerase inhibitors of the formula where R1, R2 are as defined herein. The invention also provides methods for preparing the compounds of formula I, methods of using the compounds to treat diseases such as cancer, and pharmaceutical compositions comprising the compounds.
Claims

exact text as granted — not AI-modified
1. A pyrido[2,3-d]pyrimidin-7(8H)-one derivative having the following formula (I):                  
 
       wherein
 R represents C1–C6 alkyl or C1–C6 arylalkyl; 
 R1 represents NR3R4, wherein
 R3 represents hydrogen, C1–C6 alkyl, alkenyl, aryl or acyl; and R4 represents hydrogen; unsubstituted C1–C10 alkyl; C1–C10 alkyl substituted by cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, alkylarylamino, hydroxy, carboxy, cyano, nitro, acylamino, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, alkylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl or arylsulfonyl; C1–C10 alkyl substituted by phenyl unsubstituted or substituted by from 1 to 3 substituents chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; C1–C10 alkyl substituted by heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; alkenyl; cycloalkyl; cycloalkenyl; phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, or with heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, and piperidines; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyl; monocyclic heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines and pyrrolidines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or benzoheterocycles selected from the group consisting of benzofuranyl, benzothiazolyl, benzothiophenyl and benzimidazolyl, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or 
 NR3R4 represent a ring of the following type:                  
 
  wherein 
 the symbol - - - - - represents a single or a double bond; 
 A represents a saturated, unsaturated or aromatic six-membered ring; 
 R6 represents hydrogen; C1–C6 alkyl unsubstituted or substituted by alkoxy, dialkylamino, arylamino, alkylcarbonyl, arylcarbonyl, substituted or unsubstituted aryl, unsubstituted or substituted heterocycle, alkoxycarbonyl, carboxy, acylamino; alkenyl; cycloalkyl; cyano; alkoxycarbonyl; carboxy; alkylsulfanyl; arylsulfanyl; carbamoyl; alkylcarbamoyl; dialkylcarbamoyl; arylcarbamoyl; acylamino; phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, morpholines, piperidines, piperazines, pyrrolidines, indoles, benzofurans, benzothiazoles, benzothiophenes, benzimidazoles and phthalimido, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; 
 R7 and R8 represent, independently, hydrogen, C1–C6 alkyl (unsubstituted or substituted by alkoxy, hydroxy, amino, monoalkylamino, dialkylamino, arylamino, alkylcarbonyl, unsubstituted or substituted arylcarbonyl, substituted or unsubstituted aryl, unsubstituted or substituted heterocycle, alkoxycarbonyl, carboxy, acylamino); alkenyl; alkynyl; cycloalkyl; hydroxy; alkoxy; aryloxy; amino; alkylamino; arylamino; dialkylamino; diarylamino; alkylarylamino; acyloxy; alkoxycarbonyl; formyl; acyl; carboxy; acylamino; carbamoyl; alkylcarbamoyl; dialkylcarbamoyl; arylcarbamoyl; arylsulfonylamino; alkylaminosulfonyl; arylaminosulfonyl and cyano; phenyls unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; heterocycles; selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, pyrrolidines, indoles, benzofurans, benzothiazoles, benzothiophenes and benzimidazoles, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or 
 R7 and R8 taken together represent oxygen, a spirocyclized substituent selected from the group consisting of ethylidendioxy, propylidendioxy, or cycloalkylidene; 
 R9 represents hydrogen; unsubstituted C1–C10 alkyl; C1–C10 alkyl substituted by cycloalkyl, C1–C6 alkoxy optionally substituted by hydroxy, C1–C6 acyl, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, alkylarylamino, hydroxy, carboxy, cyano, nitro, acylamino, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl or arylsulfonyl; C1–C10 alkyl substituted by phenyl unsubstituted or substituted by from 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy optionally substituted by hydroxy, methylenedioxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl; C1–C10 alkyl substituted by heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, pyrrolidines, indoles, benzofuranes, benzothiazoles, benzothiophenes, benzimidazoles, and quinolines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; alkenyl; cycloalkyl; cycloalkenyl; formyl; acyl comprising optionally substituted C1–C6 alkylcarbonyl, optionally substituted arylcarbonyl and optionally substituted heterocyclylcarbonyl; C1–C6 alkoxycarbonyl optionally substituted by phenyl; carbamoyl; optionally substituted alkylcarbamoyl; dialkylcarbamoyl; optionally substituted arylcarbamoyl; alkylsulfonyl; arylsulfonyl; phenyl unsubstituted or substituted by from 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 acyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, and piperidines, unsubstituted or substituted aryl, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; fused bicycles selected from the group consisting of 1-naphthyl and 2-naphthyl and dihydronaphthalenyls; heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, pyrrolidines, indoles, benzofuranes, benzothiazoles, benzothiophenes, benzimidazoles, and quinolines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl and 
 
 R2 represents OR′, wherein R′ is hydrogen, C1C6 alkyl, alkenyl, or aryl; NR″R′″, wherein R″ represents hydrogen or C1–C6 alkyl, and R′″ represents hydrogen; unsubstituted C1–C10 alkyl; alkenyl; cycloalkyl; cycloalkenyl; C1–C6 alkyl substituted with cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, monoalkylamino and monoalkylamino-N-oxides, monoarylamino and monoarylamino N-oxides, dialkylamino and dialkylamino N-oxides, alkylarylamino and alkylarylamino N-oxides, mono heterocycles selected from the group consisting of unsubstituted or substituted morpholinyl, furyl, tetrahydrofuryl, pyridinyl, pyrimidinyl, imidazolyl, pyrazolyl, oxazolyl, pyrrolyl, thiazolyl, piperazinyl, N-alkyl piperazinyl, and the corresponding N-oxides); fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; C1–C6 alkyl substituted by phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; C1–C6 alkyl substituted by heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides; phenyls unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides. 
 
     
     
       2. A pyrido[2,3-d]pyrimidin-7(8H)-one derivative of  claim 1 , 
       wherein
 R1 represents OR5, SR5, SOR5 or SO2R5, and wherein R5 represents unsubstituted C1–C6 alkyl; C1–C6 alkyl substituted by cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, alkylarylamino, hydroxy, carboxy, cyano, nitro, acylamino, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl; C1–C6 alkyl substituted by phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl; C1–C6 alkyl substituted by heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; alkenyl; cycloalkyl; cycloalkenyl; phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkyl substituted by aminocarbonyl or by OH, C1–C6 alkoxy, hydroxy, C1–C6 acyl, carboxy, cyano, nitro, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, C1–C6 trialkylammonium halides, C1–C4 acylamino, (C1–C6 alkoxy)carbonyl, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; mono heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines and pyrrolidines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or benzoheterocycles selected from the group consisting of benzofuranyl, benzothiazolyl, benzothiophenyl, benzimidazolyl, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; and wherein 
 R2 represents OR′, wherein R′ is hydrogen, C1C6 alkyl, alkenyl, or aryl; NR″R′″, wherein R″ represents hydrogen or C1–C6 alkyl, and R′″ represents hydrogen; unsubstituted C1–C10 alkyl; alkenyl; cycloalkyl; cycloalkenyl; C1–C6 alkyl substituted with cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, monoalkylamino and monoalkylamino-N-oxides, monoarylamino and monoarylamino N-oxides, dialkylamino and dialkylamino N-oxides, alkylarylamino and alkylarylamino N-oxides, mono heterocycles selected from the group consisting of unsubstituted or substituted morpholinyl, furyl, tetrahydrofuryl, pyridinyl, pyrimidinyl, imidazolyl, pyrazolyl, oxazolyl, pyrrolyl, thiazolyl, piperazinyl, N-alkyl piperazinyl and the corresponding N-oxides; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; C1–C6 alkyl substituted by phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; C1–C6 alkyl substituted by heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides; phenyls unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and corresponding N-oxides. 
 
     
     
       3. A pharmaceutically acceptable salt of a pyrido[2,3-d]pyrimidin-7(8H)-one of formula I                  
 
       wherein
 R represents C1–C6 alkyl or C1–C6 arylalkyl; 
 R1 represents NR3R4, wherein
 R3 represents hydrogen, C1–C6 alkyl, alkenyl, aryl or acyl; and R4 represents hydrogen; unsubstituted C1–C10 alkyl; C1–C10 alkyl substituted by cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, ammo, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, alkylarylamino, hydroxy, carboxy, cyano, nitro, acylamino, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl or arylsulfonyl; C1–C10 alkyl substituted by phenyl unsubstituted or substituted by from 1 to 3 substituents chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, ammo, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; C1–C10 alkyl substituted by heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; alkenyl; cycloalkyl; cycloalkenyl; phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, or with heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, and piperidines; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyl; monocyclic heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines and pyrrolidines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or benzoheterocycles selected from the group consisting of benzofuranyl, benzothiazolyl, benzothiophenyl and benzimidazolyl, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or 
 NR3R4 represent a ring of the following type:                  
 
  wherein 
 the symbol - - - - - represents a single or a double bond; 
 A represents a saturated, unsaturated or aromatic six-membered ring; 
 R6 represents hydrogen; C1–C6 alkyl unsubstituted or substituted by alkoxy, dialkylamino, arylamino, alkylcarbonyl, arylcarbonyl, substituted or unsubstituted aryl, unsubstituted or substituted heterocycle, alkoxycarbonyl, carboxy, acylamino; alkenyl; cycloalkyl; cyano; alkoxycarbonyl; carboxy; alkylsulfanyl; arylsulfanyl; carbamoyl; alkylcarbamoyl; dialkylcarbamoyl; arylcarbamoyl; acylamino; phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, morpholines, piperidines, piperazines, pyrrolidines, indoles, benzofurans, benzothiazoles, benzothiophenes, benzimidazoles and phthalimido, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; 
 R7 and R8 represent, independently, hydrogen, C1–C6 alkyl (unsubstituted or substituted by alkoxy, hydroxy, amino, monoalkylamino, dialkylamino, arylamino, alkylcarbonyl, unsubstituted or substituted arylcarbonyl, substituted or unsubstituted aryl, unsubstituted or substituted heterocycle, alkoxycarbonyl, carboxy, acylamino); alkenyl; alkynyl; cycloalkyl; hydroxy; alkoxy; aryloxy; amino; alkylamino; arylamino; dialkylamino; diarylamino; alkylarylamino; acyloxy; alkoxycarbonyl; formyl; acyl; carboxy; acylamino; carbamoyl; alkylcarbamoyl; dialkylcarbamoyl; arylcarbamoyl; arylsulfonylamino; alkylaminosulfonyl; arylaminosulfonyl and cyano; phenyls unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; heterocycles, selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, pyrrolidines, indoles, benzofurans, benzothiazoles, benzothiophenes and benzimidazoles, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or 
 R7 and R8 taken together represent oxygen, a spirocyclized substituent selected from the group consisting of ethylidendioxy, propylidendioxy, or cycloalkylidene; 
 R9 represents hydrogen; unsubstituted C1–C10 alkyl; C1–C10 alkyl substituted by cycloalkyl, C1–C6 alkoxy optionally substituted by hydroxy, C1–C6 acyl, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, alkylarylamino, hydroxy, carboxy, cyano, nitro, acylamino, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl or arylsulfonyl; C1–C10 alkyl substituted by phenyl unsubstituted or substituted by from 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy optionally substituted by hydroxy, methylenedioxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl; C1–C10 alkyl substituted by heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, pyrrolidines, indoles, benzofuranes, benzothiazoles, benzothiophenes, benzimidazoles, and quinolines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; alkenyl; cycloalkyl; cycloalkenyl; formyl; acyl comprising optionally substituted C1–C6 alkylcarbonyl, optionally substituted arylcarbonyl and optionally substituted heterocyclylcarbonyl; C1–C6 alkoxycarbonyl optionally substituted by phenyl; carbamoyl; optionally substituted alkylcarbamoyl; dialkylcarbamoyl; optionally substituted arylcarbamoyl; alkylsulfonyl; arylsulfonyl; phenyl unsubstituted or substituted by from 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 acyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, and piperidines, unsubstituted or substituted aryl, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; fused bicycles selected from the group consisting of 1-naphthyl and 2-naphthyl and dihydronaphthalenyls; heterocycles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines, pyrrolidines, indoles, benzofuranes, benzothiazoles, benzothiophenes, benzimidazoles, and quinolines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl and 
 
 R2 represents OR′, wherein R′ is hydrogen, C1C6 alkyl, alkenyl, or aryl; NR″R′″, wherein R″ represents hydrogen or C1–C6 alkyl, and R′″ represents hydrogen; unsubstituted C1–C10 alkyl; alkenyl; cycloalkyl; cycloalkenyl; C1–C6 alkyl substituted with cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, monoalkylamino and monoalkylamino-N-oxides, monoarylamino and monoarylamino N-oxides, dialkylamino and dialkylamino N-oxides, alkylarylamino and alkylarylamino N-oxides, mono heterocycles selected from the group consisting of unsubstituted or substituted morpholinyl, furyl, tetrahydrofuryl, pyridinyl, pyrimidinyl, imidazolyl, pyrazolyl, oxazolyl, pyrrolyl, thiazolyl, piperazinyl, N-alkyl piperazinyl and the corresponding N-oxides); fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; C1–C6 alkyl substituted by phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; C1–C6 alkyl substituted by heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides; phenyls unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides. 
 
     
     
       4. A pharmaceutically acceptable salt of a pyrido[2,3-d]pyrimidin-7(8H)-one of formula I                  
 
       wherein
 R1 represents OR5, SR5, SOR5 or SO2R5, and wherein R5 represents unsubstituted C1–C6 alkyl; C1–C6 alkyl substituted by cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, alkylarylamino, hydroxy, carboxy, cyano, nitro, acylamino, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl; C1–C6 alkyl substituted by phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino, monoarylamino, dialkylamino, alkylarylamino, diarylamino, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl; C1–C6 alkyl substituted by heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; alkenyl; cycloalkyl; cycloalkenyl; phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkyl substituted by aminocarbonyl or by OH, C1–C6 alkoxy, hydroxy, C1–C6 acyl, carboxy, cyano, nitro, amino, C1–C6 monoalkylamino, monoarylamino, C1–C6 dialkylamino, diarylamino, C1–C6 trialkylammonium halides, C1–C4 acylamino, (C1–C6 alkoxy)carbonyl, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; mono heterocyles selected from the group consisting of imidazoles, pyrazoles, oxazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, pyridines, pyrimidines and pyrrolidines, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; or benzoheterocycles selected from the group consisting of benzofuranyl, benzothiazolyl, benzothiophenyl, benzimidazolyl, unsubstituted or substituted by C1–C6 alkyl, aryl, C1–C6 acyl, or arylalkyl; and wherein 
 R2 represents OR′, wherein R′ is hydrogen, C1C6 alkyl, alkenyl, or aryl; NR″R′″, wherein R″ represents hydrogen or C1–C6 alkyl, and R′″ represents hydrogen; unsubstituted C1–C10 alkyl; alkenyl; cycloalkyl; cycloalkenyl; C1–C6 alkyl substituted with cycloalkyl, C1–C6 alkoxy, C1–C6 acyl, amino, monoalkylamino and monoalkylamino-N-oxides, monoarylamino and monoarylamino N-oxides, dialkylamino and dialkylamino N-oxides, alkylarylamino and alkylarylamino N-oxides, mono heterocycles selected from the group consisting of unsubstituted or substituted morpholinyl, furyl, tetrahydrofuryl, pyridinyl, pyrimidinyl, imidazolyl, pyrazolyl, oxazolyl, pyrrolyl, thiazolyl, piperazinyl, N-alkyl piperazinyl and the corresponding N-oxides); fused bicycles selected from the group consisting of 1-naphtyl, 2-naphthyl and dihydronaphthalenyls; C1–C6 alkyl substituted by phenyl unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy or arylalkyl; C1–C6 alkyl substituted by heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides; phenyls unsubstituted or substituted by 1 to 3 substituents, chosen independently from halogen, C1–C6 alkyl, perhalogenated C1–C6 alkyl, C1–C6 alkoxy, hydroxy, carboxy, cyano, nitro, amino, monoalkylamino and the corresponding N-oxides, monoarylamino and the corresponding N-oxides, dialkylamino and the corresponding N-oxides, alkylarylamino and the corresponding N-oxides, diarylamino and the corresponding N-oxides, C1–C6 trialkylammonium halides, alkylsulfanyl, arylsulfanyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, C1–C6 acylamino, (C1–C6 alkoxy)carbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylsulfonylamino, arylsulfonylamino, alkylaminosulfonyl, arylaminosulfonyl, aryloxy, arylalkyl, cycloalkyls, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and the corresponding N-oxides, phenyl unsubstituted or substituted by from one to three of the following groups: halogen, C1–C4 alkoxy, hydroxyl, cyano, nitro, straight or branched C1–C6 alkyl, carboxy, (C1–C6 alkoxy)carbonyl, aryloxycarbonyl, amino, C1–C4 dialkylamino, heterocycles selected from the group consisting of imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines and piperidines; fused bicycles selected from the group consisting of 1-naphthyl, 2-naphthyl and dihydronaphthalenyls; heterocycles selected from the group consisting of unsubstituted or substituted imidazoles, pyrazoles, oxadiazoles, pyrroles, furans, thiadiazoles, oxazoles, thiazoles, triazoles, tetrazoles, piperazines, N-alkyl piperazines, triazines, morpholines, pyridines, pyrimidines, pyrrolidines, piperidines and corresponding N-oxides. 
 
     
     
       5. A pyrido[2,3-d]pyrimidin-7(8H)-ones derivative selected from the group consisting of:
 tert-butyl 4-(4-methyl-2-(methylsulfanyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (1) 
 tert-butyl 4-(4-methyl-2-(methylsulfonyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (2) 
 tert-butyl 4-(2-[4-(ethoxycarbonyl)anilino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (3) 
 tert-butyl 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (4) 
 tert-butyl 4-(2-[4-(4-fluorophenyl)-1-piperazinyl]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (5) 
 tert-butyl 4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (6) 
 tert-butyl 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (7) 
 tert-butyl 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate (8) 
 4-(2-[4-(ethoxycarbonyl)anilino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid (9) 
 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid (10) 
 4-(2-[4-(4-fluorophenyl)-1-piperazinyl]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid (11) 
 4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid (12) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid (13) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid (14) 
 N-benzyl-4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (15) 
 N-(2-furylmethyl)-4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (16) 
 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3-pyridinylmethyl)benzamide (17) 
 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(1-naphthylmethyl)benzamide (18) 
 N-(3,4-dimethoxybenzyl)-4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (19) 
 N-benzyl-4-(2-[4-(4-fluorophenyl)-1-piperazinyl]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (20) 
 4-(2-[4-(4-fluorophenyl)-1-piperazinyl]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (21) 
 N-benzyl-4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (22) 
 4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3-pyridinylmethyl)benzamide (23) 
 N-(2-furylmethyl)-4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (24) 
 N-(3,4-dimethoxybenzyl)-4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (25) 
 4-(4-methyl-7-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-naphthylmethyl)benzamide (26) 
 N-benzyl-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (27) 
 N-(2-furylmethyl)-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (28) 
 N-(3,4-dimethoxybenzyl)-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (29) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3-pyridinylmethyl)benzamide (30) 
 N-(2,4-difluorobenzyl)-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (31) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(1-naphthylmethyl)benzamide (32) 
 N-cyclopropyl-4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (33) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3,4-dimethoxyphenyl)benzamide (34) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N,N-dimethylbenzamide (35) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3,4-dimethoxybenzyl)benzamide (36) 
 Ethyl 4-{[4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoyl]amino}benzoate (37) 
 N-(3-cyanophenyl)-4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyridol[2,3-d]pyrimidin-8(7H)-yl)benzamide (38) 
 N-cyclohexyl-4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (39) 
 N-(3,4-dichlorophenyl)-4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (40) 
 methyl 4-({8-[4-(methoxycarbonyl)phenyl]-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl}amino)benzoate (41) 
 Ethyl 4-({8-[4-(ethoxycarbonyl)phenyl]-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl}amino)benzoate (42) 
 4-(2-Isobutylamino-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-N-octyl-benzamide (43) 
 4-(2-Isobutylamino-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-N-phenyl-benzamide (44) 
 4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-[2-(4-oxy-morpholin-4-yl)-ethyl]-benzamide (45) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[3-(dimethylamino-N-oxido)propyl]benzamide (46) 
 4-[2-(2-Methoxy-ethylamino)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-[2-(4-oxy-morpholin-4-yl)-ethyl]-benzamide (47) 
 N-[3-(dimethylamino-N-oxido)propyl]-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (48) 
 N-[3-(dimethylamino-N-oxido)propyl]-4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (49) 
 4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (50) 
 4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (51) 
 N-[3-(dimethylamino-N-oxido)propyl]-4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (52) 
 4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (53) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[3-(dimethylamino-N-oxido)propyl]benzamide (54) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (55) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[3-(dimethylamino-N-oxido)propyl]benzamide (56) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (57) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[3-(dimethylamino-N-oxido)propyl]benzamide (58) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (59) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[2-(4-oxido-4-morpholinyl)ethyl]benzamide (60) 
 N-[3-(dimethylamino-N-oxido)propyl]-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (61) 
 4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[2-(4-oxido-4-morpholinyl)ethyl]benzamide (62) 
 4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[2-(4-oxido-4-morpholinyl)ethyl]benzamide (63) 
 4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (64) 
 4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-[2-(4-oxido-4-morpholinyl)ethyl]benzamide (65) 
 N-[3-(dimethylamino-N-oxido)propyl]-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (66) 
 N-(2-furylmethyl)-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (67) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (68) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (69) 
 N-benzyl-4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (70) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (71) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (72) 
 4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (73) 
 N-(cyclohexylmethyl)-4-(2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (74) 
 N-cyclopropyl-4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (75) 
 4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (76) 
 N-(2-furylmethyl)-4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (77) 
 N-(3,4-dimethoxyphenyl)-4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (78) 
 N-benzyl-4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (79) 
 4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (80) 
 N-isobutyl-4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (81) 
 4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (82) 
 N-(cyclohexylmethyl)-4-(4-methyl-2-{[2-(4-morpholinyl)ethyl]amino}-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (83) 
 N-cyclopropyl-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (84) 
 4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (85) 
 N-(2-furylmethyl)-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (86) 
 N-(3,4-dimethoxyphenyl)-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (87) 
 N-benzyl-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (88) 
 4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (89) 
 N-isobutyl-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (90) 
 4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (91) 
 N-(cyclohexylmethyl)-4-(2-[(2-methoxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (92) 
 N-cyclopropyl-4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (93) 
 4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (94) 
 N-(2-furylmethyl)-4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (95) 
 N-(3,4-dimethoxyphenyl)-4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (96) 
 N-benzyl-4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (97) 
 4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (98) 
 N-(cyclohexylmethyl)-4-(2-[(2-furylmethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (99) 
 N-cyclopropyl-4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (100) 
 N-benzyl-4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (101) 
 4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (102) 
 N-(3,4-dimethoxyphenyl)-4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (103) 
 4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (104) 
 N-(cyclohexylmethyl)-4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (105) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-cyclopropylbenzamide (106) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (107) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (108) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3,4-dimethoxyphenyl)benzamide (109) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-benzylbenzamide (110) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (111) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (112) 
 4-(2-{[2-(acetylamino)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(cyclohexylmethyl)benzamide (113) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-cyclopropylbenzamide (114) 
 4-(2-(benzylamino)-4-methyl-7-oxopyridol[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (115) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (116) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3,4-dimethoxyphenyl)benzamide (117) 
 N-benzyl-4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (118) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (119) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (120) 
 4-(2-(benzylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(cyclohexylmethyl)benzamide (121) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-cyclopropylbenzamide (122) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (123) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3,4-dimethoxyphenyl)benzamide (124) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-benzylbenzamide (125) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (126) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (127) 
 N-cyclopropyl-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (128) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(cyclohexylmethyl)benzamide (129) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (130) 
 N-(3,4-dimethoxyphenyl)-4-(4-methyl-7-oxo-2-yl)benzamide (131) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (132) 
 N-isobutyl-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (133) 
 4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (134) 
 N-(cyclohexylmethyl)-4-(4-methyl-7-oxo-2-[4-(2-pyrimidinyl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (135) 
 N-cyclopropyl-4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (136) 
 4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (137) 
 N-(2-furylmethyl)-4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (138) 
 N-(3,4-dimethoxyphenyl)-4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (139) 
 N-benzyl-4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (140) 
 4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (141) 
 N-isobutyl-4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (142) 
 4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (143) 
 N-(cyclohexylmethyl)-4-(4-methyl-7-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (144) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-cyclopropylbenzamide (145) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (146) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (147) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(3,4-dimethoxyphenyl)benzamide (148) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-benzylbenzamide (149) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (150) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (151) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (152) 
 4-(2-(allylamino)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(cyclohexylmethyl)benzamide (153) 
 N-cyclopropyl-4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (154) 
 4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (155) 
 N-(2-furylmethyl)-4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (156) 
 N-(3,4-dimethoxyphenyl)-4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (157) 
 N-benzyl-4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (158) 
 4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (159) 
 N-isobutyl-4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (160) 
 4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (161) 
 N-(cyclohexylmethyl)-4-(4-methyl-7-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (162) 
 N-benzyl-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (163) 
 N-cyclopropyl-4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (164) 
 4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (165) 
 N-(2-furylmethyl)-4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (166) 
 N-(3,4-dimethoxyphenyl)-4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (167) 
 N-benzyl-4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (168) 
 4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (169) 
 4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (170) 
 N-(cyclohexylmethyl)-4-(2-[(2-hydroxyethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (171) 
 N-cyclopropyl-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (172) 
 4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (173) 
 N-(3,4-dimethoxyphenyl)-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyridol[2,3-d]pyrimidin-8(7H)-yl)benzamide (174) 
 4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (175) 
 N-isobutyl-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (176) 
 4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (177) 
 N-(cyclohexylmethyl)-4-(2-{[2-(2-methoxyphenyl)ethyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (178) 
 (2S)-1-(8-{4-[(cyclopropylamino)carbonyl]phenyl}-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-pyrrolidinecarboxylic acid (179) 
 (2S)-1-(4-methyl-8-{4-[(octylamino)carbonyl]phenyl}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-pyrrolidinecarboxylic acid (180) 
 (2S)-1-[8-(4-{[(2-furylmethyl)amino]carbonyl}phenyl)-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]-2-pyrrolidinecarboxylic acid (181) 
 (2S)-1-(8-{4-[(3,4-dimethoxyanilino)carbonyl]phenyl}-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-pyrrolidinecarboxylic acid (182) 
 (2S)-1-(8-{4-[(benzylamino)carbonyl]phenyl}-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-pyrrolidinecarboxylic acid (183) 
 (2S)-1-[4-methyl-7-oxo-8-(4-{[(2-phenylethyl)amino]carbonyl}phenyl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]-2-pyrrolidinecarboxylic acid (184) 
 (2S)-1-(8-{4-[(isobutylamino)carbonyl]phenyl}-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-pyrrolidinecarboxylic acid (185) 
 (2S)-1-[4-methyl-7-oxo-8-(4-{[(tetrahydro-2-furanylmethyl)amino]carbonyl}phenyl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]-2-pyrrolidinecarboxylic acid (186) 
 (2S)-1-[8-(4-{[(cyclohexylmethyl)amino]carbonyl}phenyl)-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]-2-pyrrolidinecarboxylic acid (187) 
 N-cyclopropyl-4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (188) 
 4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (189) 
 4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-furylmethyl)benzamide (190) 
 N-(3,4-dimethoxyphenyl)-4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (191) 
 N-benzyl-4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (192) 
 4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(2-phenylethyl)benzamide (193) 
 4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-isobutylbenzamide (194) 
 4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (195) 
 N-(cyclohexylmethyl)-4-(2-{[3-(dimethylamino)propyl]amino}-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzamide (196) 
 4-(2-[(2-ethylhexyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-octylbenzamide (197) 
 4-(2-[(2-aminoethyl)amino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)-N-(tetrahydro-2-furanylmethyl)benzamide (198) 
 4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[4-Methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[4-Methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[8-(4-Carbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid ethyl ester; 
 4-[4-Methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Formyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{2-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{8-[4-(3,4-Dimethoxy-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid ethyl ester; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[2-(4-formyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-Benzyl-4-[2-(4-benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide 
 N-Benzyl-4-[4-methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-[4-methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[8-(4-Benzylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid ethyl ester; 
 N-Benzyl-4-[4-methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-[2-(4-formyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-Benzyl-4-{2-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 N-Cyclopropyl-4-[4-methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-[4-methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[8-(4-Cyclopropylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid ethyl ester; 
 N-Cyclopropyl-4-[4-methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-Cyclopropyl-4-{2-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[4-Methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[4-Methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{4-Methyl-7-oxo-8-[4-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid ethyl ester; 
 4-[4-Methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Formyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{2-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-({4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[4-Methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[4-Methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-{8-[4-(4-Methoxycarbonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid ethyl ester; 
 4-({4-[4-Methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[(4-{2-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{8-[4-(2,4-Difluoro-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid ethyl ester; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-{2-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-7-oxo-2-(4-phenyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-2-(4-methyl-piperazin-1-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{8-[4-(4-Methanesulfonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid ethyl ester; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-7-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-{2-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(5-Benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{2-[5-(4-Fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[8-(4-Carbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid benzyl ester; 
 4-(2-{4-[2-(2-Hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-benzamide; 
 4-[4-Methyl-7-oxo-2-(4-quinolin-2-yl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 4-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(3,4-dimethoxy-benzyl)-benzamide; 
 4-[2-(5-Benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[5-(4-fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[4-(2-hydroxy-ethyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(3,4-Dimethoxy-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid benzyl ester; 
 N-(3,4-Dimethoxy-benzyl)-4-(2-{4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-benzamide; 
 N-Benzyl-4-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-Benzyl-4-[2-(4-benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-benzyl-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-benzyl-benzamide; 
 N-Benzyl-4-[2-(5-benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-{2-[5-(4-fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-benzyl-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-benzyl-benzamide; 
 N-Benzyl-4-{2-[4-(2-hydroxy-ethyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Benzylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid benzyl ester; 
 N-Benzyl-4-(2-{4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-benzamide; 
 N-Cyclopropyl-4-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-cyclopropyl-benzamide; 
 4-[2-(5-Benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 N-Cyclopropyl-4-{2-[5-(4-fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 N-Cyclopropyl-4-{2-[4-(2-hydroxy-ethyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Cyclopropylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid benzyl ester; 
 4-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(5-Benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{2-[5-(4-Fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{4-Methyl-7-oxo-8-[4-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid benzyl ester; 
 4-(2-{4-[2-(2-Hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[(4-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-({4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[(4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-({4-[2-(5-Benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[(4-{2-[5-(4-Fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-({4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[(4-{2-[4-(2-Hydroxy-ethyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-{8-[4-(4-Methoxycarbonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid benzyl ester; 
 4-{[4-(2-{4-[2-(2-Hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-benzoylamino]-methyl}-benzoic acid methyl ester; 
 N-(2,4-Difluoro-benzyl)-4-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 4-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(2,4-difluoro-benzyl)-benzamide; 
 4-[2-(5-Benzyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-{2-[5-(4-fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 4-{8-[4-(2,4-Difluoro-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid benzyl ester; 
 N-(2,4-Difluoro-benzyl)-4-(2-{4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl)-benzamide; 
 4-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Benzyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-{2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-{2-[5-(4-Fluoro-phenyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Acetyl-4-phenyl-piperidin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Acetyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-{8-[4-(4-Methanesulfonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid benzyl ester; 
 4-[2-(4-Acetylamino-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[8-(4-Carbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yloxy]-benzoic acid ethyl ester; 
 4-[4-Methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{2-[4-(4-Hydroxy-benzenesulfonyl)-phenoxy]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[2-(4-fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[4-(4-hydroxy-benzenesulfonyl)-phenoxy]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-Benzyl-4-[2-(4-carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-[2-(4-fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-benzyl-benzamide; 
 4-[2-(4-Acetylamino-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[2-(4-fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-[4-methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-[2-(4-fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-[2-(4-fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[4-Methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-({4-[4-Methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[2-(4-Fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-[2-(4-fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 N-Cyclopropyl-4-[4-methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-[2-(4-fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-{2-[4-(4-hydroxy-benzenesulfonyl)-phenoxy]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{4-Methyl-7-oxo-8-[4-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yloxy}-benzoic acid ethyl ester; 
 4-[4-Methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-({4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[4-Methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 4-[2-(4-Carbamoylmethyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-{8-[4-(4-Methanesulfonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yloxy}-benzoic acid ethyl ester; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-7-oxo-2-(4-trifluoromethyl-phenoxy)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Acetyl-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[4-Methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Benzyl-4-[4-methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-[4-methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[4-Methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-({4-[4-Methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-2-(octahydro-isoquinolin-2-yl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[4-Methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-711-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Fluoro-phenylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[4-Methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-Benzyl-4-[4-methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-benzyl-benzamide; 
 N-Cyclopropyl-4-[4-methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[4-Methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-({4-[4-Methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-2-(1-methyl-1H-imidazol-2-ylsulfanyl)-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-7-oxo-2-(5-phenyl-1H-[1,2,4]triazol-3-ylsulfanyl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[2-(1H-Benzoimidazol-2-ylsulfanyl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Fluoro-phenoxy)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-{4-methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(2,4-Difluoro-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid cyclohexylamide; 
 4-{8-[4-(2,4-Difluoro-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide; 
 N-(4-Methanesulfonyl-benzyl)-4-{4-methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(4-Methanesulfonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 4-{2-[4-(Furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-methanesulfonyl-benzyl)-benzamide; 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-methanesulfonyl-benzyl)-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-[4-methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(4-Methanesulfonyl-benzyl)-4-{4-methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(4-Methanesulfonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid cyclohexylamide; 
 4-{8-[4-(4-Methanesulfonyl-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide; 
 4-{2-[4-(Furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{4-Methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{4-methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(3,4-Dimethoxy-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 N-(3,4-Dimethoxy-benzyl)-4-{2-[4-(furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(3,4-dimethoxy-benzyl)-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-[4-methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-(3,4-Dimethoxy-benzyl)-4-{4-methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(3,4-Dimethoxy-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid cyclohexylamide; 
 N-Benzyl-4-{4-methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Benzylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 N-Benzyl-4-{2-[4-(furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-benzyl-benzamide; 
 N-Benzyl-4-[4-methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{8-[4-(3,4-Dimethoxy-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide; 
 N-Benzyl-4-{4-methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Benzylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide; 
 N-Cyclopropyl-4-{4-methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Cyclopropylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 N-Cyclopropyl-4-{2-[4-(furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-cyclopropyl-benzamide; 
 N-Cyclopropyl-4-[4-methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 N-Cyclopropyl-4-{4-methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Cyclopropylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid cyclohexylamide 
 4-[8-(4-Cyclopropylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide 
 4-{4-Methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{4-Methyl-7-oxo-8-[4-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid cyclohexylamide; 
 4-{4-Methyl-7-oxo-8-[4-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide; 
 4-[(4-{4-Methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-[(4-{2-[4-(3,4-Difluoro-phenylcarbamoyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-[(4-{2-[4-(Furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-({4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-({4-[4-Methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[(4-{4-Methyl-7-oxo-2-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 4-({4-[2-(4-Cyclohexylcarbamoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzoylamino}-methyl)-benzoic acid methyl ester; 
 4-[(4-{4-Methyl-7-oxo-2-[4-(3-trifluoromethyl-phenylcarbamoyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzoylamino)-methyl]-benzoic acid methyl ester; 
 N-(2,4-Difluoro-benzyl)-4-{4-methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-{8-[4-(2,4-Difluoro-benzylcarbamoyl)-phenyl]-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 4-[8-(4-Carbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide; 
 N-(2,4-Difluoro-benzyl)-4-{2-[4-(furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(2,4-difluoro-benzyl)-benzamide; 
 N-(2,4-Difluoro-benzyl)-4-[4-methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-{4-Methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-benzamide; 
 4-[8-(4-Carbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 4-[4-Methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-benzamide; 
 4-[8-(4-Carbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid cyclohexylamide; 
 4-[8-(4-Benzylcarbamoyl-phenyl)-4-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carboxylic acid cyclohexylamide; 
 4-{4-Methyl-7-oxo-2-[4-(pyridine-3-carbonyl)-piperazin-1-yl]-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-{4-Methyl-7-oxo-8-[4-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperazine-1-carboxylic acid (3,4-difluoro-phenyl)-amide; 
 4-{2-[4-(Furan-2-carbonyl)-piperazin-1-yl]-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl}-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[2-(4-Benzoyl-piperazin-1-yl)-4-methyl-7-oxo-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; 
 4-[4-Methyl-7-oxo-2-(4-phenylacetyl-piperazin-1-yl)-7H-pyrido[2,3-d]pyrimidin-8-yl]-N-(4-trifluoromethyl-benzyl)-benzamide; and 
 4-(4-methyl-2-(methylsulfanyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid. 
 
     
     
       6. A method for inhibiting telomerase enzyme comprising contacting the telomerase enzyme with an effective amount of the pyrido[2,3-d]pyrimidin-7(8H)-ones derivative of  claim 1 . 
     
     
       7. A method for inhibiting telomerase enzyme comprising contacting the telomerase enzyme with an effective amount of the pyrido[2,3-d]pyrimidin-7(8H)-ones derivative of  claim 2 . 
     
     
       8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, diluent, or both a pharmaceutically acceptable carrier and a diluent and a pyrido[2,3-d]pyrimidin-7(8H)-one of  claim 1 . 
     
     
       9. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, diluent, or both a pharmaceutically acceptable carrier and a diluent and a pyrido[2,3-d]pyrimidin-7(8H)-one derivative of  claim 2 .
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