Polynucleotides encoding interleukin-17 receptor homologue

Abstract

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”

1. An isolated polynucleotide that encodes a Zcytor14 polypeptide comprising amino acid residues 21 to 452 of SEQ ID NO:2. 
     
     
       2. The isolated polynucleotide of  claim 1 , wherein the polynucleotide comprises a nucleotide sequence selected from the group consisting of: SEQ ID NO:1 and SEQ ID NO:3. 
     
     
       3. The isolated polynucleotide of  claim 1 , wherein the polynucleotide encodes a polypeptide comprising an amino acid sequence selected from the group consisting of:
 (a) amino acid residues 21 to 677 of SEQ ID NO:2, and 
 (b) amino acid residues 1 to 692 of SEQ ID NO:2. 
 
     
     
       4. The isolated polynucleotide of  claim 1 , wherein the encoded polypeptide consists of an amino acid sequence selected from the group consisting of:
 (a) amino acid residues 21 to 452 of SEQ ID NO:2, 
 (b) amino acid residues 21 to 677 of SEQ ID NO:2, and 
 (c) amino acid residues 1 to 692 of SEQ ID NO:2. 
 
     
     
       5. An isolated polynucleotide consisting of a nucleotide sequence selected from the group consisting of: (a) SEQ ID NO:1, and (b) SEQ ID NO:3. 
     
     
       6. An isolated polynucleotide that encodes a fusion protein, said fusion protein comprising:
 amino acid residues 21 to 452 of SEQ ID NO:2; and 
 an immunoglobulin heavy chain constant region. 
 
     
     
       7. The isolated polynucleotide of  claim 6 , wherein the immunoglobulin heavy chain constant region is an F c  fragment. 
     
     
       8. The isolated polynucleotide of  claim 7 , wherein the F c  fragment is a human F c  fragment. 
     
     
       9. An isolated polynucleotide that encodes a polypeptide comprising at least 100 contiguous amino acid residues of the polypeptide consisting of amino acid residues 21 to 452 of SEQ ID NO:2.